ライフサイエンスコーパス: H5N1 influenza virus

1 into recombinant A/Vietnam/1203/04 (VN1203) H5N1 influenza virus.

2 ckens (B(2)/B(2)) protected them from lethal H5N1 influenza virus.

3 protected mice from a lethal challenge with H5N1 influenza virus.

4 ted with a lethal dose of A/Vietnam/1203/04 (H5N1) influenza virus.

5 ed with 10-100 MLD50 of H1N1, H3N1, H3N2 and H5N1 influenza viruses.

6 otential as live attenuated vaccines against H5N1 influenza viruses.

7 ogens and stimulate cross-protection against H5N1 influenza viruses.

8 1) against antigenically distinct strains of H5N1 influenza viruses.

9 duck has become the "Trojan horse" of Asian H5N1 influenza viruses.

10 uation and spread of these highly pathogenic H5N1 influenza viruses.

11 d create a situation for the perpetuation of H5N1 influenza viruses.

12 we developed two antibodies that neutralize H5N1 influenza viruses.

13 se the transmissibility of highly pathogenic H5N1 influenza viruses.

14 le in the pathogenicity of highly pathogenic H5N1 influenza viruses.

15 caused by the highly pathogenic avian (HPAI) H5N1 influenza viruses.

16 and risk assessment of currently circulating H5N1 influenza viruses.

17 ion of the lethally infected mice by H1N1 or H5N1 influenza viruses.

18 ng the pandemic potential of recent Egyptian H5N1 influenza viruses.

19 mic virus as well as heterosubtypic H3N2 and H5N1 influenza viruses.

20 ent neutralizing antibody responses to avian H5N1 influenza viruses.

21 for a few persistent host markers than avian H5N1 influenza viruses.

22 enuated vaccine strains based on recombinant H5N1 influenza virus A/Viet Nam/1203/04 was generated.

23 In this report, the natural history of the H5N1 influenza virus A/Vietnam/1203/04 influenza infecti

24 ponse to human infections caused by an avian H5N1 influenza virus, A/Hong Kong/213/03.

25 he pandemic potential of widely disseminated H5N1 influenza viruses, a ferret contact model using exp

26 e dose of an antigenically variant strain of H5N1 influenza virus and could be a useful strategy for

27 tively replicate in macrophages is unique to H5N1 influenza viruses and may contribute to their incre

28 H5 HA receptor-binding site that neutralized H5N1 influenza viruses and pseudoviruses carrying the HA

29 e immunity against the currently circulating H5N1 influenza viruses and that this protective immunity

30 eriodic outbreaks of highly pathogenic avian H5N1 influenza viruses and the current H1N1 pandemic hig

31 The high pathogenicity of H5N1 influenza viruses and their capacity for transmissi

32 specificities of two highly efficacious anti-H5N1 influenza virus antibodies into a bispecific FcDART

33 results show that the PA and PB1 genes of HP H5N1 influenza viruses are associated with lethality in

34 Highly pathogenic avian H5N1 influenza viruses are now widespread in poultry in

35 We also show that human H5N1 influenza viruses are significantly more likely to

36 , clinical, and laboratory data suggest that H5N1 influenza viruses are transmitted through and predo

37 The spread of avian H5N1 influenza viruses around the globe has become a wor

38 This study is the first to characterize H5N1 influenza viruses as the only subtype of influenza

39 ot be as effective against highly pathogenic H5N1 influenza viruses as they are against less pathogen

40 To determine whether avian H5N1 influenza viruses associated with human infections

41 ed complete protection against a spectrum of H5N1 influenza viruses at a single low dose.

42 of malaria falciparum (LSA-NRC) or HA1 from H5N1 influenza virus ('avian flu'), the system selected

43 If H5N1 influenza viruses become transmissible among humans

44 e substantial efforts to control and contain H5N1 influenza viruses, bird flu viruses continue to spr

45 earlier survived the lethal challenge of an H5N1 influenza virus, but infected birds shed H5N1 influ

46 n subject demonstrates that vaccination with H5N1 influenza virus can elicit B cells expressing stem

47 in late 2002, outbreaks of highly pathogenic H5N1 influenza virus caused deaths among wild migratory

48 tected ferrets against lethal heterosubtypic H5N1 influenza virus challenge despite the absence of de

49 otection against a lethal A/Duck/Laos/25/06 (H5N1) influenza virus challenge, with no evidence of mor

50 ction against heterosubtypic H1N1, H3N2, and H5N1 influenza virus challenges.

51 r of human infections with highly pathogenic H5N1 influenza viruses continues to rise, these viruses

52 ted that exposure of the digestive system to H5N1 influenza viruses could initiate infection either t

53 Avian H5N1 influenza viruses currently circulating in southeas

54 H274Y NA mutation affects the fitness of two H5N1 influenza viruses differently.

55 us to ask whether waterfowl are resistant to H5N1 influenza virus disease and whether they can still

56 Currently circulating highly pathogenic H5N1 influenza viruses encode an NS1 protein with the ES

57 on the contribution of HA acid stability to H5N1 influenza virus fitness and transmissibility in mam

58 The data suggest that adaptation of avian H5N1 influenza virus for infection in mammals is support

59 The isolation of a highly pathogenic H5N1 influenza virus from poultry indicates that such vi

60 The transmission of H5N1 influenza viruses from birds to humans poses a sign

61 hallenge with mouse-adapted EBOV or selected H5N1 influenza viruses from clades 0, 1, and 2.

62 Animals challenged with H5N1 influenza virus greater than 3 months after recover

63 n IAVs, recent isolates of highly pathogenic H5N1 influenza viruses had a high proportion of PB1-F2 t

64 s of oseltamivir-resistant highly pathogenic H5N1 influenza viruses has important clinical implicatio

65 Although the pathogenic mechanism(s) of H5N1 influenza viruses has not been fully elucidated, it

66 ction of humans with highly pathogenic avian H5N1 influenza viruses has suggested viral mutation as o

67 uch mechanisms and virulent determinants for H5N1 influenza viruses have not been fully elucidated.

68 Highly pathogenic avian H5N1 influenza viruses have sporadically transmitted to

69 rus-like particles (VLP) (M8-VLP) expressing H5N1 influenza virus hemagglutinin (HA) and neuraminidas

70 e backbone of DNA vaccine vectors expressing H5N1 influenza virus hemagglutinin (HA).

71 HA protein influence the fitness of an avian H5N1 influenza virus in a mammalian model, we infected C

72 Recurrent outbreaks of the avian H5N1 influenza virus in Asia represent a constant global

73 We show that inhalation of aerosolized H5N1 influenza virus in cynomolgus macaques results in f

74 fluences the properties of highly pathogenic H5N1 influenza virus in mammalian hosts.

75 influenza virus did not cross-react with an H5N1 influenza virus in neutralization or hemagglutinati

76 acheal inoculation of a liquid suspension of H5N1 influenza virus in nonhuman primates likely results

77 d with recent, widely circulating strains of H5N1 influenza virus in poultry, the recurring introduct

78 tation was found to enhance the growth of an H5N1 influenza virus in the mammalian upper respiratory

79 5N1 influenza virus, but infected birds shed H5N1 influenza virus in their feces.

80 vestigated serologic evidence of exposure to H5N1 influenza virus in Vietnamese pigs in 2004.

81 lay critical roles in the virulence of avian H5N1 influenza viruses in a mammalian host in vitro and

82 Outbreaks of highly pathogenic H5N1 influenza viruses in avian species began in Asia an

83 The widespread incidence of H5N1 influenza viruses in bird populations poses risks t

84 read distribution of highly pathogenic avian H5N1 influenza viruses in domesticated and wild birds co

85 otein plays a key role in the propagation of H5N1 influenza viruses in ducks and may be a novel molec

86 Despite the prevalence of H5N1 influenza viruses in global avian populations, comp

87 findings indicate that the human and poultry H5N1 influenza viruses in Hong Kong in 1997 were reassor

88 Since the reemergence of highly pathogenic H5N1 influenza viruses in humans in 2003, these viruses

89 plain the mechanism of the high virulence of H5N1 influenza viruses in humans.

90 temic replication and pathogenicity of these H5N1 influenza viruses in mice.

91 rotected chickens from lethal infection with H5N1 influenza viruses in the Hong Kong markets in 1997

92 he likely determinants of virulence of human H5N1 influenza viruses in this model.

93 current great genetic diversity in H9N2 and H5N1 influenza viruses in this region.

94 The 2004 outbreaks of H5N1 influenza viruses in Vietnam and Thailand were high

95 ntinuing evolution of highly pathogenic (HP) H5N1 influenza viruses in wild birds with transmission t

96 ng lethal infection with highly pathogenic A(H5N1) influenza virus in mice.

97 We conclude that H5N1 influenza virus-induced pathology is affected by a

98 tes, and administration of STAg 2 days after H5N1 influenza virus infection enhanced survival, lowere

99 asma gondii prior to highly pathogenic avian H5N1 influenza virus infection led to decreased lung vir

100 Patients receiving NA inhibitors for H5N1 influenza virus infection should be closely monitor

101 enous IFN-gamma alone enhanced survival from H5N1 influenza virus infection, although not to the same

102 Following H1N1 or H5N1 influenza virus infection, ferrets were found to re

103 atory cytokines are markedly elevated during H5N1 influenza virus infection, the "cytokine storm" is

104 TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be import

105 he protective immune response against severe H5N1 influenza virus infections even when a single dose

106 y differs from human highly pathogenic avian H5N1 influenza virus infections, there is a similar rapi

107 a viruses in protecting chickens from lethal H5N1 influenza virus infections.

108 The A/VN/1203/04 strain of the H5N1 influenza virus is capable of infecting the CNS of

109 Control of highly pathogenic avian H5N1 influenza viruses is a major public-health concern.

110 olution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and ot

111 type, we cloned the human A/Vietnam/1203/04 (H5N1) influenza virus isolate that is highly pathogenic

112 Here, we propose that the PA of an H5N1 influenza virus isolated from a human in Vietnam (A

113 report that the polymerase PB2 protein of an H5N1 influenza virus isolated from a human in Vietnam (A

114 ared to those of a highly pathogenic chicken H5N1 influenza virus isolated from Hong Kong in April 19

115 ulated mallards with antigenically different H5N1 influenza viruses isolated between 1997 and 2003.

116 cell-mediated immune responses against avian H5N1 influenza viruses isolated from people.

117 ra tested, 8 (0.25%) were positive for avian H5N1 influenza viruses isolated in 2004 by virus neutral

118 oculated juvenile mallards with 23 different H5N1 influenza viruses isolated in Asia between 2003 and

119 Despite harboring lethal H5N1 influenza viruses, most chickens in the Hong Kong p

120 After intranasal challenge with H5N1 influenza virus, naive ferrets rapidly succumbed to

121 A/Goose/Guangdong/1/96-like H5N1 influenza viruses now circulating in southeastern C

122 There were no cross-reactions with non-H5N1 influenza viruses or other avian viruses.

123 Since the 1997 H5N1 influenza virus outbreak in humans and poultry in H

124 In 1997, an H5N1 influenza virus outbreak occurred in chickens in Ho

125 ong poultry and wild birds in the face of an H5N1 influenza virus outbreak.

126 ntification of amino-acid mutations in avian H5N1 influenza virus polymerase complexes that confer in

127 H5N1 influenza viruses pose a pandemic threat but have n

128 Avian A/H5N1 influenza viruses pose a pandemic threat.

129 Highly pathogenic avian H5N1 influenza viruses preferentially infect alveolar ty

130 Highly pathogenic avian H5N1 influenza viruses remain a pandemic threat.

131 the digestive tract is not the main site of H5N1 influenza virus replication in ducks and that the f

132 The threat posed by the highly pathogenic H5N1 influenza virus requires public health authorities

133 Highly pathogenic avian H5N1 influenza viruses sometimes transmit to humans and

134 ith the highly pathogenic A/Vietnam/1203/04 (H5N1) influenza virus strain; the vaccines encoded influ

135 y a subset of highly pathogenic avian (HPAI) H5N1 influenza virus strains could productively replicat

136 09 H1N1 and 1918), and potentially pandemic (H5N1) influenza virus strains.

137 l genes of Qa/HK/G1/97 virus to those of the H5N1 influenza viruses suggests that the quail virus may

138 searchers announced that they had created an H5N1 influenza virus that was transmissible between ferr

139 The origin of the H5N1 influenza viruses that killed six of eighteen infec

140 recent emergence of highly pathogenic avian (H5N1) influenza viruses, their epizootic and panzootic n

141 n of DNA target sequences derived from avian H5N1 influenza virus to gold surface-attached single-str

142 is essential for the adaptation of pandemic H5N1 influenza virus to humans.

143 onal transmission of highly pathogenic avian H5N1 influenza viruses to humans causes severe pneumonia

144 Multiple cases of transmission of avian H5N1 influenza viruses to humans illustrate the urgent n

145 The factors that enable avian H5N1 influenza viruses to replicate in humans are not co

146 In 1997, avian H5N1 influenza virus transmitted from chickens to humans

147 H5N1 influenza viruses transmitted from poultry to human

148 The H5N1 influenza viruses transmitted to humans in 1997 wer

149 Here we show that lethal H5N1 influenza viruses, unlike other human, avian and sw

150 In 1997, a highly pathogenic avian H5N1 influenza virus was transmitted directly from live

151 oadly specific against antigenically drifted H5N1 influenza viruses, we developed two neutralizing mo

152 late the acid stability of the HA protein of H5N1 influenza viruses, we performed a mutational analys

153 or by aerosols with a human (H3N2) or avian (H5N1) influenza virus, we demonstrate that aerosol inocu

154 The H5N1 influenza virus, which killed humans and poultry in

155 H5N1 influenza viruses, which cause disease in humans, h