ライフサイエンスコーパス: HAT

1 brucei causes human African trypanosomiasis (HAT).

2 fatal illness human African trypanosomiasis (HAT).

3 cond stage of human African trypanosomiasis (HAT).

4 otection from human African trypanosomiasis (HAT).

5 tic) stage of human African trypanosomiasis (HAT).

6 mplex (4) after the initial H atom transfer (HAT).

7 development of strategies aimed at reducing HAT.

8 in 23, and in the remainder this was "late" HAT.

9 ivals were significantly worse in cases with HAT.

10 risk factors, to identify risk factors for E-HAT.

11 nts with an MA less than 65 mm experienced E-HAT.

12 patients with increased risk of developing E-HAT.

13 1 as a lead for development of drugs against HAT.

14 Twenty-one (3.2%) patients developed HAT.

15 ative HAT were independently associated with HAT.

16 chemoselective 1,6-HAT over a competing 1,5-HAT.

17 eactivation of the C-H bond of amides toward HAT.

18 d a partial cure in a stage 2 mouse model of HAT.

19 2-yl)amino)benzamide] as potential drugs for HAT.

20 viding evidence for early CNS involvement in HAT.

21 n vivo curative activity in a mouse model of HAT.

22 the inflammatory pathogenesis of late-stage HAT.

23 the same electronic-structure changes during HAT.

24 (Gcn5-related N-acetyltransferase) family of HATs.

25 of the conserved W residue in both MULEs and hATs.

26 T)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, HAT= 1,4,5,8,9,12-hexaazatriphenylene) by hydroquinone (

27 reen (32.7% vs 35.5%; F = 5.36; P = .02) and hats (15.6% vs 17.9%; F = 4.72; P = .03).

28 The excited-state quenching of [Ru(TAP)2(HAT)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, HAT= 1,4,

29 Collectively, 2-dimensional HAT-7 cell cultures on permeable supports 1) form tight

30 We therefore propose that the HAT-7 cell line is a useful functional model for studyin

31 HAT-7 cells formed epithelial layers with measureable tr

32 Microfluorometry showed that the HAT-7 cells were polarized with a high apical membrane C

33 HAT-7 cells were seeded onto Transwell permeable filters

34 a polarized 2-dimensional culture system for HAT-7 cells, a rat cell line of ameloblast origin.

35 maturation ameloblasts were also present in HAT-7 cells.

36 to-apical bicarbonate transport in polarized HAT-7 cells.

37 45.1%, and 38.1%, respectively) and wearing hats (74.7%, 68.2%, and 58.2%, respectively).

38 ken together, our results establish that the HAT activity of MOF is required to sustain MLL-AF9 leuke

39 onal change and significantly increases p300 HAT activity on histone H3K18 residues, which, in turn,

40 rate that all subunits are important for its HAT activity.

41 ue to CBP/p300-allows RNA to stimulate CBP's HAT activity.

42 Loss of the histone acetyltransferase (HAT) activity blocks oogenesis, while loss of the H2B de

43 A alters HDAC and histone acetyltransferase (HAT) activity, which suggests a role for HAT/HDAC homeos

44 Whilst causes of hepatic artery thrombosis (HAT) after liver transplantation (LT) are multifactorial

45 kynurenine pathway is activated in clinical HAT and associated with CNS inflammatory responses.

46 No difference was observed between the SERO/HAT and HAT groups.

47 This article describes the risk factors for HAT and outcomes after LT.

48 minant mechanism in nonpolar solvents, while HAT and SPLET are competitive pathways in polar media.

49 gated reacted with hydroxyl radical via both HAT and SPLET in the solvents investigated.

50 tioxidant and it can be better understood by HAT and TMC mechanisms as it has low BDE, DeltaHacidity

51 the evolutionary relationships between MULE, hAT and Transib elements and the V(D)J recombinase.

52 recombination reaction and the mechanism of hAT and Transib transposases including the importance of

53 tive mutants are capable of interacting with HATs and other components of HAT complexes but are defic

54 mechanisms underlying the regulation of KAT6 HATs and their roles in cell cycle progression.

55 n the form of human African trypanosomiasis (HAT) and Chagas disease.

56 ysine and histone acetyltransferase (KAT and HAT) and deacetylase (KDAC and HDAC) activities.

57 ules, which house histone acetyltransferase (HAT) and deubiquitinase (DUB) activities.

58 ionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the bet

59 emodeling through histone acetyltransferase (HAT) and histone deactylase (HDAC) enzymes affects funda

60 photoredox-mediated hydrogen atom transfer (HAT) and nickel catalysis, we have developed a highly se

61 We found that second hydrogen atom transfer (HAT) and second sequential proton loss electron transfer

62 on via its histone acetyltransferase domain (HAT) and, as a result, activates gene expression by alte

63 Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modula

64 ns, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epige

65 ties, full cures in a stage 1 mouse model of HAT, and a partial cure in a stage 2 mouse model of HAT.

66 f recipients at greater risk of developing E-HAT, and intense surveillance and anticoagulation prophy

67 domain (BRD), CH2 (comprising PHD and RING), HAT, and ZZ domains at 2.4-A resolution.

68 ion practices, including the use of eyewear, hats, and protective clothing.

69 Current drugs for HAT are difficult to administer and have severe side eff

70 In summary, we provide evidence that both HATs are bona fide tumor suppressors that control MHCII

71 In addition, the human KAT6 HATs are recurrently mutated in leukemia and solid tumor

72 both forms of human African trypanosomiasis (HAT) are confined to spatially stable foci in Sub-Sahara

73 KAT6 histone acetyltransferases (HATs) are highly conserved in eukaryotes and are involve

74 ases (HDACs) and histone acetyltransferases (HATs) are involved in MSH2 deacetylation/acetylation is

75 microstructures will reveal the relevance of HAT as a basic scaffold in the areas of organic material

76 These results point to HAT as implausible for the reaction with nitric oxide ra

77 In vitro HAT assays suggest that the RING domain, the autoregulat

78 erent, HAT complexes we carried out in vitro HAT assays.

79 sing steady-state histone acetyltransferase (HAT) assays, we show that an RNA binding region in the H

80 The HAT at unactivated C(sp(3))-H sites is enabled by the ea

81 Mutational studies further demonstrate that HAT-B binding to the histone tail regions is not suffici

82 HAT-B is a multisubunit complex composed of the histone

83 We also demonstrate that HAT-B is significantly more active against an intact H3-

84 nd Asf1 is only capable of interactions with HAT-B through contacts with histones H3-H4.

85 through different modes and independently to HAT-B, whereby Hif1 binds directly to Hat2, and Asf1 is

86 Based on these data, we propose a model for HAT-B/histone chaperone assembly and acetylation of H3-H

87 energetically inaccessible using traditional HAT-based approaches.

88 loyed to control the reaction selectivity in HAT-based procedures for the functionalization of C-H bo

89 tone rings within the CD framework via a 1,8-HAT-beta-scission tandem mechanism.

90 core is structurally homologous to the Gcn5 HAT, but contains unique additional features including a

91 re further probed by evaluating the rates of HAT by the corresponding Cu(III)-hydroxide complexes fro

92 gh the concave surface of HAT-C, whereas the HAT-C convex surface binds USP15 in a novel bipartite mo

93 RT3 dimerizes through the concave surface of HAT-C, whereas the HAT-C convex surface binds USP15 in a

94 ts, organized into two subdomains, HAT-N and HAT-C.

95 Despite advances in hydrogen atom transfer (HAT) catalysis, there are currently no molecular HAT cat

96 toredox, enamine and hydrogen-atom transfer (HAT) catalysis-enables an enantioselective alpha-aldehyd

97 s mild approach takes advantage of a tunable HAT catalyst that exhibits predictable reactivity patter

98 catalysis, there are currently no molecular HAT catalysts that are capable of homolysing the strong

99 proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting

100 Human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense can be diagn

101 n particular (human African trypanosomiasis (HAT), Chagas disease, cutaneous leishmaniasis, and malar

102 , a proxy for the highest astronomical tide (HAT), changes over seasonal and interannual time scales.

103 ficantly higher in patients diagnosed with E-HAT compared with those who did not (71.2 mm vs 57.9 mm;

104 enes by interfering with the function of the HAT complex during infection.

105 PsAvh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interferin

106 ain is required for the MOZ-BRPF1-ING5-hEaf6 HAT complex to be recruited to chromatin and to acetylat

107 recruits the MOF histone acetyltransferase (HAT) complex to ERalpha target gene promoters to deposit

108 ubunit of the MOZ histone acetyltransferase (HAT) complex, critical for normal developmental programs

109 in is similar to that of acyl-CoA-bound p300 HAT complexes and shows that the acetyl-CoA binding site

110 nteracting with HATs and other components of HAT complexes but are deficient in their ability to rest

111 Given the key importance of ADA3-containing HAT complexes in the regulation of various biological pr

112 nstrated that the subunit environment of the HAT complexes into which GCN5 incorporates determines th

113 regulated in the two related, but different, HAT complexes we carried out in vitro HAT assays.

114 nsferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly conserved from yeast to higher

115 onent of specific histone acetyltransferase (HAT) complexes.

116 co-activator and histone acetyltransferase (HAT) complexes.

117 etylation, a small-molecule inhibitor of the HAT component MYST blocked the growth of both murine and

118 nolinium salts under hydrogen atom transfer (HAT) conditions, and an expanded scope for the coupling

119 ng mostly compounds originating from two 1,8-HAT consecutive processes.

120 ing sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA

121 es encoding the histone acetyl-transferases (HATs) CREB binding protein (CREBBP) and EP300 are recurr

122 es that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornit

123 principles and synthetic strategies towards HAT derivatives will be established and their use in n-t

124 strongly suggest the involvement of HLA-G in HAT disease progression.

125 lpha gene, and inactivating mutations in its HAT domain abolished its ability to regulate ERalpha, su

126 Partial deletion of the HAT domain in the CBP gene, blocked these effects.

127 The structure of the apo-CBP HAT domain is similar to that of acyl-CoA-bound p300 HAT

128 s, we show that an RNA binding region in the HAT domain of CBP-a regulatory motif unique to CBP/p300-

129 ain, the autoregulatory loop (AL) within the HAT domain, and the ZZ domain do not directly influence

130 ally disordered AL are autoacetylated by the HAT domain.

131 The BRD, PHD, and HAT domains form an integral structural unit to which th

132 The pyrrolopyrimidine AEE788 (a hit for anti-HAT drug discovery) associates with three trypanosome pr

133 thine, which is antagonistic to another anti-HAT drug, suramin.

134 f which affect sensitivity to important anti-HAT drugs.

135 ansplantation (LT) are multifactorial, early HAT (E-HAT) remains pertinent complication impacting on

136 Overall, 79 (9.5%) patients experienced HAT, E-HAT was diagnosed in 23, and in the remainder thi

137 hree reaction types: hydrogen atom transfer (HAT), electron transfer (ET), and oxygen atom transfer (

138 lly distinct African populations residing in HAT endemic regions identified eight single nucleotide p

139 s and evidence implicating human genetics in HAT epidemiology.

140 es a member of the Half-A-Tetratricopeptide (HAT) family of super-helical repeat proteins, some of wh

141 pronged methodology, involved performing top-hat filtering, second order statistical filtering, and t

142 y observed rate increase of H-atom transfer (HAT) for Mn(IV)(O)(TBP8Cz(*+)):LA with phenols.

143 Instead, initial HAT from a metal hydride to directly generate a carbon-c

144 measured insulin-dependent glucose uptake by hAT from nondiabetic and T2DM subjects, mimicking the po

145 Preferential HAT from proline was also observed in the reactions of C

146 kH values for HAT from tertiary equatorial C-H bonds were found to be

147 With leucine, HAT from the alpha- and gamma-C-H bonds was observed.

148 t 1 order of magnitude higher than those for HAT from the corresponding tertiary axial C-H bonds (kH(

149 e rate constants for hydrogen atom transfer (HAT) from cycloalkanes and decalins to the cumyloxyl rad

150 Here we show that in hydrogen atom transfer (HAT) from the aliphatic C-H bonds of alkane, ether, alco

151 f solvent effects on hydrogen atom transfer (HAT) from the C-H bonds of N,N-dimethylformamide (DMF),

152 e rate constants for hydrogen atom transfer (HAT) from the C-H bonds of N-Boc-protected amino acids t

153 he rate constant for hydrogen atom transfer (HAT) from the C-H bonds of these substrates (kH) was mea

154 yltransferase (HAT) module that contains the HAT, Gcn5, bound to Sgf29, Ada2, and Ada3.

155 nce of coordinated actions of its associated HATs, GCN5, PCAF, and p300, and a new partner that we de

156 are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads

157 nt for the catastrophic epidemics of Gambian HAT (gHAT) seen over the past century.

158 Within the HAT group, specific haplotypes (HG010102 and HG0103) dis

159 erence was observed between the SERO/HAT and HAT groups.

160 N5 inhibitor and forebrain tissue from (Gcn5(hat/hat) ) embryos, we demonstrate that GCN5, RARalpha/g

161 on and transcriptional defects seen in (Gcn5(hat/hat) ) mutants can be rescued with gestational RA su

162 ctivity of the acetyltransferase GCN5 ((Gcn5(hat/hat) )), which were previously characterized with re

163 of care medications currently used to treat HAT have severe limitations, and there is a need to find

164 Although histone acetyltransferases (HATs) have been well characterized both structurally and

165 TSP), e.g., TMPRSS2, TMPRSS4, and TMPRSS11d (HAT), have been shown to cleave influenza virus HA for v

166 MA of 65 mm or greater went on to develop E-HAT (hazard ratio, 5.28; 95% confidence interval, 2.10-1

167 se (HAT) activity, which suggests a role for HAT/HDAC homeostasis in neuroprotection.

168 ibitory scaffolds within the GlaxoSmithKline HAT (Human African Trypanosomiasis) and Chagas chemical

169 ation of the major antioxidative mechanisms: HAT (Hydrogen Atom Transfer), SPLET (Sequential Proton-L

170 mising druggable target for the treatment of HAT in both stages 1 and 2 of the disease.

171 ovides novel insights into the roles of KAT6 HATs in cell cycle regulation through modulating PCNA le

172 We further focus on the roles of KAT6 HATs in regulating cell proliferation and stem cell main

173 as a modulator of histone acetyltransferase (HAT) in plants.

174 tramolecular 1,5-hydrogen atom transfer (1,5-HAT) in the decay of a PEGylated carbazyl (aminyl) radic

175 ssecting the role of single tissues, such as hAT, in the complex interwoven picture of metabolic dise

176 kynurenine pathway activation occurs during HAT, including cases prior to the current diagnostic cut

177 Hepatic artery thrombosis (HAT) increases morbidity and mortality after liver trans

178 Moreover, the Tip60/HAT inhibitor, NU9056, was able to block EtOH-induced H4

179 The histone acetyltransferase (HAT) inhibitor garcinol or vehicle was injected followin

180 We profile the most commonly used HAT inhibitors and confirm that the majority of them are

181 Several histone acetyltransferase (HAT) inhibitors with these liabilities are now routinely

182 ected silane solvolysis distributions in the HAT-initiated hydrogenation of alkenes reveal that pheny

183 Mechanistic experiments indicate HAT is rate-limiting, whereas intramolecular amination i

184 We find that the variability in HAT is significantly correlated with sea-level variabili

185 The results indicate that HAT is strongly influenced by structural and medium effe

186 Human adipose tissue (hAT) is a key player in metabolic disorders, such as Typ

187 o known as 1,4,5,8,9,12-hexaazatriphenylene (HAT) is an electron deficient, rigid, planar, aromatic d

188 In Western analysis, HAT-L4 expressed in transfected CHO cells appeared as a

189 Here we examined HAT-L4 expression and function in vitro and in vivo.

190 Flow cytometry confirmed HAT-L4 expression on the cell surface with the expected

191 In the skin, HAT-L4 expression was abundant in keratinocytes and seba

192 These results indicate that HAT-L4 is important in epidermal barrier function to pre

193 We generated HAT-L4 knockout mice by disrupting the Tmprss11f gene en

194 No defects were found in HAT-L4 knockout mice in hair growth, wound healing, wate

195 HAT-L4 knockout mice were viable and fertile.

196 nd immunostaining experiments indicated that HAT-L4 was expressed in epithelial cells and exocrine gl

197 Human airway trypsin-like protease 4 (HAT-L4) is a type II transmembrane serine protease.

198 In metabolic studies, HAT-L4-deficient adult mice drank water more frequently

199 Compared with wild-type controls, HAT-L4-deficient newborn mice had greater body fluid los

200 ce by disrupting the Tmprss11f gene encoding HAT-L4.

201 The identification of risk factors for HAT may aid transplant teams in the development of strat

202 It was suggested that HAT may be the predominant mechanism in nonpolar solvent

203 that both reactions proceed through a common HAT mechanism.

204 lly adiabatic, corresponding primarily to an HAT mechanism.

205 ADA2a, ADA3, and SGF29, whereas in the SAGA HAT module ADA2b is present instead of ADA2a.

206 The HAT module of ATAC is composed of GCN5, ADA2a, ADA3, and

207 We find that the SAGA HAT module preferentially acetylates H3K4me3 nucleosomes

208 regulate transcription independently of the HAT module.

209 plex known as the histone acetyltransferase (HAT) module that contains the HAT, Gcn5, bound to Sgf29,

210 y subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of

211 ing) analysis revealed that both the DUB and HAT modules bind most SAGA target genes even though many

212 r increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes.

213 nes was not changed when incorporated in the HAT modules of ATAC or SAGA complexes.

214 part of purified recombinant hATAC or hSAGA HAT modules or endogenous hATAC or hSAGA complexes using

215 covered the H4K16 histone acetyltransferase (HAT) MOF to be important for leukemia cell growth.

216 fections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection we

217 in the intervention group used wide-brimmed hats more at 7 weeks than control participants (23.8% vs

218 asma for patients in the SERO (n = 65), SERO/HAT (n = 14), or HAT (n = 268) group and in cerebrospina

219 in the SERO (n = 65), SERO/HAT (n = 14), or HAT (n = 268) group and in cerebrospinal fluid for patie

220 HAT) repeats, organized into two subdomains, HAT-N and HAT-C.

221 lanine, valine, norvaline, and tert-leucine, HAT occurs from the alpha-C-H bonds, and the stability o

222 Intraoperative HAT (odds ratio, 62.63; 95% confidence interval, 12.64-3

223 cidic and neutral media 5CQA can take either HAT or RAF pathways.

224 ive agent for human African trypanosomiasis (HAT) or sleeping sickness.

225 In a murine model of HAT, oral administration of compound 1 cured the disease

226 nths following their initial diagnosis (SERO/HAT), others remain parasitologically negative for long

227 This has enabled a chemoselective 1,6-HAT over a competing 1,5-HAT.

228 ermore, this allows for a chemoselective 1,5-HAT over competing direct cyclizations and beta-fragment

229 a significant reduction in the incidence of HAT over time, as well as the increased use of 2 hepatic

230 celerate the desired hydrogen atom transfer (HAT) over competing pathways.

231 The MS-CPET and HAT oxidations of TEMPOH at the same driving force occur

232 ntly higher in HAT (P = 6 x 10(-7)) and SERO/HAT (P = .007) than SERO patients.

233 ysis revealed a decrease in the incidence of HAT (P = 0.008) and an increase in the use of 2-arterial

234 a sHLA-G levels were significantly higher in HAT (P = 6 x 10(-7)) and SERO/HAT (P = .007) than SERO p

235 This likely indicates that HAT-P-26b's atmosphere is primordial and obtained its ga

236 ance as a proxy for metallicity, we measured HAT-P-26b's atmospheric heavy element content ([Formula:

237 udy of the transiting Neptune-mass exoplanet HAT-P-26b.

238 nontoxic inhibitor of proliferation for the HAT pathogen (Trypanosoma brucei), we have now tested th

239 Histone acetyl transferases (HATs) play a crucial role in eukaryotes by regulating ch

240 , of the 98 responding organizations, only 8 hat policies (8%), 10 eyewear policies (10%), and 7 clot

241 dicals with toluene, which indicate that the HAT process is characterized by a significant degree of

242 Consequently, the HAT process performed by 1 occurs on the triplet surface

243 radicals mediate 1,6-hydrogen-atom transfer (HAT) processes to guide gamma-C(sp(3) )-H chlorination.

244 e intramolecular 1,8-hydrogen atom transfer (HAT) promoted by the 6(I)-O-yl radical, which abstracts

245 nvestigations of the hydrogen atom transfer (HAT), radical adduct formation (RAF), sequential proton

246 From large to very large increases in the HAT rate constant (kH) were measured on going from MeOH

247 The HAT rate constants are significantly higher than those o

248 nced by the 10(4)-10(7)-fold decrease in the HAT rate constants in acetonitrile following addition of

249 dant capacity of GA can be explained through HAT rather than the SET-PT mechanism.

250 ponent reactions are compared with a related HAT reaction of TEMPOH, with the 2,4,6-tri-tert-butylphe

251 overn reactivity and selectivity patterns in HAT reactions from amino acid C-H bonds.

252 been observed in the hydrogen atom transfer (HAT) reactions from 4-alkyl-N,N-dimethylbenzylamines (al

253 kinetic study of the hydrogen atom transfer (HAT) reactions from a series of organic compounds to the

254 kinetic study of the hydrogen atom transfer (HAT) reactions from a series of secondary N-(4-X-benzyl)

255 kinetic study on the hydrogen atom transfer (HAT) reactions from the aliphatic C-H bonds of a series

256 d kinetics of its hydrogen-atom abstraction (HAT) reactions.

257 nt and allowing for careful control over the HAT reactivity of amide substrates.

258 An increase in the HAT reactivity of QINO was observed in the presence of 0

259 ntal insights regarding the relative OAT and HAT reactivity of valence tautomers such as M(V)(O)(porp

260 n redox potentials, which appear to dominate HAT reactivity.

261 f substrates via C-H hydrogen atom transfer (HAT), reducing 1 to [(PyPz)Fe(II)(OH2)2](4+) (2).

262 tation (LT) are multifactorial, early HAT (E-HAT) remains pertinent complication impacting on graft a

263 SART3 contains 12 half-a-tetratricopeptide (HAT) repeats, organized into two subdomains, HAT-N and H

264 in the epidemiologies of gHAT and Rhodesian HAT (rHAT) impact on strategies for disease control.

265 After the HAT-selection and cloning, we established nine hybridoma

266 With DMF, a solvent-induced change in HAT selectivity was observed, suggesting that solvent ef

267 of free radical scavenging activity, namely HAT, SET-PT and SPLET.

268 n compound 6 gives rise to an unusual wizard hat shaped structure, which represents a promising key i

269 alization was studied by dynamically-loading hat-shaped specimens to induce forced shear localization

270 Compound 1 features a hat-shaped structure with the parent wheel-shaped {Mo150

271 tion that proline residues represent favored HAT sites in the reactions of peptides and proteins with

272 ical approaches, such as a facile remote C-H HAT step, with that of transition-metal-catalyzed chemis

273 a redox-active beta-diketonate ligand in the HAT step.

274 ndant cut-and-paste transposons are from the hAT superfamily.

275 nger than that for 1-H, which decays via 1,5-HAT (tau1/2 = 48 s, DeltaH(double dagger) = 10.0 +/- 0.3

276 as explained in terms of polar effects, with HAT that predominantly occurs from the delta-C-H bonds,

277 N, indicative of alpha-CH2 deactivation with HAT that predominantly occurs from the most remote methy

278 n of the strongly activating NH2 group, with HAT that shifts to the C-H bonds that are adjacent to th

279 tramolecular 1,5-hydrogen atom transfer (1,5-HAT) that was observed in its constitutional isomer 1-H

280 closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene tra

281 e C-H bonds, deactivating these bonds toward HAT to an electrophilic radical such as CumO(*), indicat

282 tes the C-H bonds of these substrates toward HAT to CumO(*), providing a powerful method for selectiv

283 on of the C-H bonds alpha to nitrogen toward HAT to PINO as evidenced by the 10(4)-10(7)-fold decreas

284 ide, leading to C-H bond deactivation toward HAT to the electrophilic radical CumO(*).

285 ctivity of TEMPOH by hydrogen atom transfer (HAT) to a single e(-)/H(+) acceptor.

286 ability of seven histone acetyltransferases (HATs) to catalyze acylations on histones in vitro using

287 nd order (NEVPT2), provided insight into the HAT trajectories of 1 and A.

288 employed an innovative progressive black top hat transformation method to estimate them on a global s

289 Increase in torsional strain in the HAT transition state accounts instead for tertiary axial

290 n terms of 1,3-diaxial strain release in the HAT transition state.

291 We found that the hAT transposase TcBuster from Tribolium castaneum formed

292 The two additional novel suppressors, hat-trick and xmas-2, function in chromatin modeling and

293 Loss of shaggy/GSK3, hat-trick, or xmas-2 does not suppress Wallerian degener

294 erall, 79 (9.5%) patients experienced HAT, E-HAT was diagnosed in 23, and in the remainder this was "

295 ght ratio of 1.1% or less and intraoperative HAT were independently associated with HAT.

296 lable ethers through hydrogen atom transfer (HAT), were coupled with a range of electron-deficient he

297 brucei causes Human African trypanosomiasis (HAT), which threatens millions of people in sub-Saharan

298 the curve of 0.750 (P < 0.001) predicting E-HAT with a sensitivity of 70%.

299 ) complex is moderately more reactive toward HAT with substituted phenol and shows superior activity

300 RAF pathways are faster, but HAT yields thermodynamically more stable radical product