ライフサイエンスコーパス: HCH

1 alpha-HCH and dissolved phase trans-chlordanes showed depletio

2 alpha-HCH concentrations were 3 - 9 times higher in melt ponds

3 alpha-HCH showed enhancing effects on the peak current in alph

4 rocyclohexane (alpha-HCH) and (13)C(6)-alpha-HCH, trans-chlordane (TC), and (13)C(10)-TC.

5 a-TBECH, beta-TBCO, DPTE), BDE-17, and alpha-HCH ((13)C-labeled and nonlabeled) was evident in soils

6 and and -1.7 +/- 0.2 per thousand) and alpha-HCH (epsilon(c) = -1.0 +/- 0.2 per thousand and -1.6 +/-

7 ported values for anaerobic gamma- and alpha-HCH degradation.

8 .0 +/- 0.1 per thousand for (-) and (+)alpha-HCH, respectively, while those for the beta-, gamma-, de

9 nd and 2.9 per thousand for (-) and (+)alpha-HCH, respectively.

10 o well-characterized POPs, PCB153, and alpha-HCH.

11 For example, alpha-HCH was found to have the largest concentrations of all

12 Discrepancies observed for alpha-HCH and gamma-HCH in PUF disk versus SIP disk are attrib

13 pha-HCH enantiomers was higher for (+) alpha-HCH (epsilon(c) = -2.4 +/- 0.8 per thousand and -3.3 +/-

14 far lower concentrations (~3 times for alpha-HCH).

15 E), OCPs: alpha-hexachlorocyclohexane (alpha-HCH) and (13)C(6)-alpha-HCH, trans-chlordane (TC), and (

16 llowed by alpha-hexachlorocyclohexane (alpha-HCH) and alpha-endosulfan.

17 inity for alpha-hexachlorocyclohexane (alpha-HCH) concentrations and enantiomer fractions (EFs) in th

18 The C. hyperboreus alpha-HCH chiral signature also reflects ambient seawater and

19 ncentrations up to 0.75 +/- 0.06 ng/L. alpha-HCH pond enrichment may lead to substantial concentratio

20 ctic returned higher concentrations of alpha-HCH and HCB through both the atmospheric (polar easterli

21 IA for assessing the biodegradation of alpha-HCH at contaminated field sites.

22 s deposition results in an increase of alpha-HCH concentration from 0.07 +/- 0.02 ng/L (old ice) to 0

23 Isotope fractionation of alpha-HCH enantiomers was higher for (+) alpha-HCH (epsilon(c)

24 We identify two routes of alpha-HCH enrichment in the ice over the summer.

25 ncentration and isotope composition of alpha-HCH from the Quaternary and Tertiary aquifers were analy

26 over 70% of measured concentrations of alpha-HCH in air and ocean water within factors of 3 and 5, re

27 ion to characterize the degradation of alpha-HCH in the areas downstream of a former disposal and pro

28 ult in a significant redistribution of alpha-HCH in the water column, this process could have a signi

29 CH) ratios and enantiomer fractions of alpha-HCH indicated that a single water mass was sampled throu

30 hexane (HCH) as well as enantiomers of alpha-HCH using two aerobic bacterial strains: Sphingobium ind

31 Concentration of alpha-HCH was 2-3 times higher in individuals from the summer

32 Melt pond concentrations of alpha-HCH were relatively high prior to the late 1980-s, with

33 higher surface water concentrations of alpha-HCH within 3-4 weeks with about 60% of bioconcentration

34 thawing at the bottom of ponds permit alpha-HCH rich seawater (~0.88 ng/L) to replenish pond water,

35 beta-HCH is declining more slowly than alpha-HCH due to its higher persistence, and we hypothesize th

36 xperiment (no feeding) suggesting that alpha-HCH concentration in C. hyperboreus is maintained throug

37 he microbial fractionation between the alpha-HCH enantiomers was quantified by the Rayleigh equation

38 m the Amundsen Gulf and measured their alpha-HCH concentrations, enantiomeric compositions, and bioac

39 0.8 per thousand) in comparison to (-) alpha-HCH (epsilon(c) = -0.7 +/- 0.2 per thousand and -1.0 +/-

40 responds to the change in exposure to alpha-HCH.

41 oped and their degradation, along with alpha-HCH ((13)C-labeled and nonlabeled) was enantioselective.

42 of Ctr1 is a 13-residue peptide harboring an HCH motif that is thought to interact with Cu.

43 Here we show that LinB, an HCH-converting haloalkane dehalogenase from Sphingobium

44 d-feeding, and that the genes of the LCH and HCH are tightly clustered.

45 mRNA levels for both LCH- and HCH-genes increase with iron, H2O2 and hemin treatment,

46 pump due to settling of particle-associated HCHs are estimated; the removal fluxes are within a fact

47 beta-HCH had little or no effect on the peak current in alpha

48 beta-HCH is declining more slowly than alpha-HCH due to its h

49 beta-HCH may represent a new class of xenobiotic that produce

50 d OR (AOR) = 1.27; 95% CI: 1.01, 1.59]; beta-HCH was the only significant predictor in the population

51 chlorine compounds such as o,p'-DDT and beta-HCH are concentrated in body fat.

52 ed data on concentrations of alpha- and beta-HCH in the atmosphere and oceans, including spatial and

53 However, alpha- and beta-HCH showed differential effects on GABA-induced chloride

54 Both o,p'DDT and beta-HCH stimulated proliferation in a dose-dependent manner

55 oncentrations of p,p'-DDT, p,p'-DDE and beta-HCH were not associated with diabetes or prediabetes.

56 SOD activity, and PCB-138, PCB-180, and beta-HCH were the main contributors to the index.

57 two of its major components, alpha- and beta-HCH, are still ubiquitous in the environment.

58 tested in a competitive binding assay, beta-HCH did not displace 17beta-[3H]estradiol from the ER ev

59 Transcriptional activation by beta-HCH occurs in estrogen-responsive GH3 rat pituitary tumo

60 vehicle (DMSO), 17beta-estradiol (E2), beta-HCH, or o,p'-DDT.

61 The initial 3-day treatment with either beta-HCH or o,p'-DDT doubled the relative dry weight of the u

62 eight (BW) and 104 +/- 4.4 mg/kg BW for beta-HCH and o,p'-DDT, respectively, compared to 49 +/- 1.9 m

63 reased concentrations of p,p'-DDE, HCB, beta-HCH, dicofol, and PCBs (congeners -138, -153, and -180)

64 p'-DDT) and beta-hexachlorocyclohexane (beta-HCH) act as weak estrogens, producing uterotrophic respo

65 e compound, beta-hexachlorocyclohexane (beta-HCH), exerts estrogen-like effects in human breast cance

66 m levels of beta-hexachlorocyclohexane (beta-HCH), p,p -DDE, dichlorodiphenyltrichloroethane (p,p -DD

67 However, beta-HCH is ineffective in stimulating a reporter construct d

68 g show that during periods of lipolysis beta-HCH can be released in quantities sufficient to stimulat

69 ific Northwest, serum concentrations of beta-HCH and mirex were positively associated with endometrio

70 over 70% of measured concentrations of beta-HCH within factors of 8 and 20, respectively.

71 and dry weights showed that fasting of beta-HCH-loaded animals also increased water imbibition in th

72 ted animals (51 +/- 2.9 mg/kg BW) or of beta-HCH-loaded, fed animals (59 +/- 4.6 mg/kg BW).

73 with the exception that cell heights of beta-HCH-loaded, fed animals were slightly higher (P < 0.05)

74 The association between serum beta-HCH concentrations and endometriosis was stronger in ana

75 ment with beta-HCH; this indicates that beta-HCH nether activates the ER, nor is it converted intrace

76 ata are consistent with the notion that beta-HCH stimulation of cell proliferation and gene expressio

77 Thus, beta-HCH cannot act on a simple, single estrogen response ele

78 t (per 1-SD increase in log-transformed beta-HCH: AOR = 1.72; 95% CI: 1.09, 2.72).

79 Animals that had been loaded with beta-HCH and fasted had uterine weights (88 +/- 12 mg/kg BW)

80 eta-estradiol but not by treatment with beta-HCH; this indicates that beta-HCH nether activates the E

81 A substitution of the putative metal-binding HCH C-terminal tripeptide (thought to be required for tr

82 ence of the effects between gamma- and delta-HCH in any of the three subunit combinations.

83 exane (HCH), alpha-, beta-, gamma- and delta-HCH insecticides, modulated the kinetics of the GABAA re

84 amplitude of GABA-induced current, and delta-HCH strongly enhanced it in the alpha 1 beta 2 gamma 2s,

85 mineralization also convert beta- and delta-HCH to a variety of mainly hydroxylated metabolites.

86 to reactions with alpha-, gamma-, and delta-HCH, both LinA enzymes converted epsilon-HCH to a mixtur

87 ly, while those for the beta-, gamma-, delta-HCH isomers were -29.0 +/- 0.3 per thousand, -29.5 +/- 0

88 lta-HCH, both LinA enzymes converted epsilon-HCH to a mixture of 1,2,4-, 1,2,3-, and 1,3,5-trichlorob

89 o minor components of technical HCH, epsilon-HCH, and heptachlorocyclohexane (HeCH), and we present d

90 LinB hydroxylated epsilon-HCH to pentachlorocyclohexanol and tetrachlorocyclohexan

91 gnificantly increases the amount of ferritin HCH messages and dramatically shifts the balance toward

92 Synthesis of ferritin HCH subunit mRNAs that lack an IRE may be important unde

93 ent with half-lives of 3.4 and 5.7 years for HCHs and PCBs, respectively.

94 oral trend was observed for alpha- and gamma-HCH concentrations, which are decreasing in both the atm

95 screpancies observed for alpha-HCH and gamma-HCH in PUF disk versus SIP disk are attributed to lack o

96 ansformations, whereby only alpha- and gamma-HCH undergo complete mineralization.

97 ggest that hexachlorobenzene (HCB) and gamma-HCH were depositing from air to water whereas heavier OC

98 (7.76E+06) and from Paso de Ovejas for gamma-HCH (1.50E+05) during rainy season.

99 pe enrichment factors (epsilon(c)) for gamma-HCH (epsilon(c) = -1.5 +/- 0.1 per thousand and -1.7 +/-

100 and they ranged from about 4 years for gamma-HCH at Chicago to about 60 years for PCB-52 at Chicago.

101 decreasing relationship was found for gamma-HCH concentrations with increasing delta(15)N at Terneuz

102 TMFs ranged from 0.64 for gamma-HCH up to 1.60 for PCB 194.

103 nd -1400 and -200 (pg.m(-2).d(-1)) for gamma-HCH, dieldrin, and chlorpyrifos, respectively.

104 When co-applied with GABA, gamma-HCH strongly suppressed the peak amplitude of GABA-induc

105 e cohort, gamma-hexachlorocyclohexane (gamma-HCH) was the only POP with a significant positive associ

106 pesticide gamma-hexachlorocyclohexane (gamma-HCH), commonly known as lindane.

107 olved in the initial steps of lindane (gamma-HCH) biotransformation, was cloned and overexpressed in

108 yclohexane (HCH) mixtures and Lindane (gamma-HCH) have been produced in Bitterfeld-Wolfen, Germany, f

109 Estimated daily intakes of gamma-HCH and Sigma-DDT (3.35 and 1.22mug/kg bw/day) through c

110 azard Ratios estimated corresponded to gamma-HCH (3.97) and Sigma-DDT (4.39) detected in muscle sampl

111 [per 1-SD increase in log-transformed gamma-HCH: adjusted OR (AOR) = 1.27; 95% CI: 1.01, 1.59]; beta

112 ereoisomers (alpha-, beta-, delta- and gamma-HCHs) from a sample collection based on worldwide manufa

113 of gamma- and alpha- hexachlorocyclohexane (HCH) as well as enantiomers of alpha-HCH using two aerob

114 oncentrations of beta-hexachlorocyclohexane (HCH) (third vs. lowest quartile: OR = 1.7; 95% CI: 1.0,

115 ta, gamma-, and delta-Hexachlorocyclohexane (HCH), the four major isomers of technical HCH, are susce

116 ding the enzyme gamma-hexachlorocyclohexane (HCH) dehydrochlorinase (LinA2), involved in the initial

117 constant alpha/gamma-hexachlorocyclohexane (HCH) ratios and enantiomer fractions of alpha-HCH indica

118 to all the isomers of hexachlorocyclohexane (HCH) and to pentachlorocyclohexane (PCCH) but did not re

119 t the four isomers of hexachlorocyclohexane (HCH), alpha-, beta-, gamma- and delta-HCH insecticides,

120 Technical hexachlorocyclohexane (HCH) mixtures and Lindane (gamma-HCH) have been produced

121 Technical hexachlorocyclohexane (HCH) was one of the most widely used pesticides during t

122 rt of the year in the hexachlorocyclohexane (HCH) enriched surface water and for part of the year at

123 and alpha- and gamma-hexachlorocyclohexane (HCHs), and the sites of interest were Lakes Erie, Michig

124 rce identification of hexachlorocyclohexane (HCHs), we provide a data set of carbon, hydrogen, and ch

125 a on the 1,2,3,4,5,6-hexachlorocyclohexanes (HCHs) have been analyzed by Abraham's linear free energy

126 odecanes (HBCDs) and hexachlorocyclohexanes (HCHs) are polyhalogenated hydrocarbons with similar ster

127 orobenzene (HCB) and hexachlorocyclohexanes (HCHs) has been studied in the North Atlantic and Arctic

128 he concentrations of hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), and 26 polychlorinated b

129 ssion of the ferritin heavy-chain homologue (HCH) is induced following blood feeding.

130 g and sequence of the heavy chain homologue (HCH) of Drosophila melanogaster ferritin subunit have be

131 t human skeletal diseases hypochondroplasia (HCH), achondroplasia (ACH) and thanatophoric dysplasia (

132 g/L to the detection limit of the individual HCH isomers (0.01 mug/L) after one year of operation.

133 nt organochlorine (OC) insecticides lindane (HCH) and dieldrin (HEOD) to the development of neurodege

134 In 2009, the major HCH stereoisomers came under regulation of the Stockholm

135 The differential actions of HCH isomers may produce variable effects on different re

136 We studied the natural attenuation of HCH in these groundwater systems through a combination o

137 bioscreen for the in situ biodegradation of HCH and its intermediates is demonstrated at a contamina

138 through the bioscreen, the concentration of HCH in the groundwater decreased from 600 mug/L to the d

139 ng decrease in atmospheric concentrations of HCH is consistent with the estimated atmospheric deposit

140 nt paper reports the differential effects of HCH isomers of the GABA-induced chloride currents in thr

141 eventually become the predominant isomer of HCH in the environment.

142 served for alpha, beta, and gamma isomers of HCH, trans- and cis-chlordane, oxychlordane, or SigmaCHB

143 contribute to the overall toxic potential of HCH contaminations and may constitute serious, yet unkno

144 stration of the stimulated transformation of HCH to intermediates in a full scale anaerobic in situ b

145 spp. suggests that aerobic biodegradation of HCHs can be monitored in situ by compound-specific stabl

146 emporal trend in the isotope compositions of HCHs was found at the global scale.

147 Concentrations of HCHs and HCB were measured simultaneously in the atmosph

148 The atmospheric concentrations of HCHs decrease during transport over the Greenland Curren

149 enantiomeric carbon isotope fractionation of HCHs with Sphingobium spp. suggests that aerobic biodegr

150 ints facilitate the source identification of HCHs at the regional scale and can be used to assess tra

151 The widespread occurrence of HCHs has led to the evolution of bacterial degradation p

152 s and production facilities, large plumes of HCHs persist within two aquifer systems.

153 Stable isotope ratios of HCHs cover the ranges from -233 per thousand to +1 per t

154 The removal of HCHs from the surface ocean by the degradative pump due

155 radative pump in the overall oceanic sink of HCHs.

156 Uptake of HCHs, HCB, PCBs, and DDT plus metabolites was studied (l

157 The levels of PCBs, HCHs, and HCB are low in comparison to the few previous

158 There is a large variability of PCBs, HCHs, and HCB concentrations in water and phytoplankton

159 Despite their persistence, HCHs are susceptible to bacterial biotransformations.

160 , during the rainy season, Lindane and Sigma-HCH in muscle and lung samples from Paso de Ovejas (995.

161 re formed from minor components of technical HCH mixtures.

162 e (HCH), the four major isomers of technical HCH, are susceptible to biotic transformations, whereby

163 olation of two minor components of technical HCH, epsilon-HCH, and heptachlorocyclohexane (HeCH), and

164 ration regime, it is conclusively shown that HCH removal is the result of the biological degradation

165 Cu interacts in a 1:1 stoichiometry with the HCH motif with an affinity, KD, of approximately 10(-14)

166 Values of B for the HCHs are larger than many functionally substituted aliph

167 We find that B is 0.62-0.72 for the HCHs compared to 0.45 for propanone and 0.70 for ethylam

168 ogaster RNA were probed with a cDNA for this HCH, three bands were observed.

169 ater and for part of the year at depth where HCH undergoes significant microbial degradation resultin

170 eate an anaerobic infiltration zone in which HCH is converted.

171 greater than that for XCH(2)* compared with HCH(2)*.

172 environmental field sites contaminated with HCHs.