ライフサイエンスコーパス: HFD

1 HFD also increased behavioral responses and paw swelling

2 HFD altered skeletal muscle lipid profiles and up-regula

3 HFD did not affect body weight or glucose metabolism in

4 HFD did not increase phosphorylated mixed lineage kinase

5 HFD feeding induced more weight gain and higher plasma l

6 HFD markedly induced expression of immune and inflammato

7 HFD resulted in higher body weight, development of insul

8 HFD significantly increased amyloid plaques and worsened

9 HFD-fed mice exhibited insulin resistance with reduced l

10 HFD-islet analysis revealed clear trends toward global r

11 HFD-islets demonstrated evidence of oxidative stress and

12 Following 2 (MCD groups) or 3 (HFD groups) weeks of treatment with G49, partial hepatec

13 diet, (2) normal diet plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid.

14 rmal diet plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid.

15 ysis of islets from mice fed 16-weeks of 42% HFD.

16 ; mean (95% CI)] did not differ (P = 0.877): HFD [3781 (2513, 5050)], HFS [4006 (2711, 5302), and UF

17 We report that mice consuming a HFD have reduced levels of acetyl-CoA and/or acetyl-CoA:

18 d exacerbated fatty liver disease when fed a HFD compared with WT mice.

19 Mice fed a HFD displayed increased fasting insulin levels, hepatost

20 d chow diet (SCD); WT/HFD, six WT mice fed a HFD; NOX2(-/-)/SCD, six NADPHox-deficient mice on a SCD;

21 After only 6 weeks on a HFD, in vivo chemotactic activity of monocytes was alrea

22 f dietary administration of lipoic acid on a HFD-induced obesity model in terms of (a) insulin signal

23 X2(-/-)/HFD, six NADPHox-deficient mice on a HFD.

24 Male offspring were weaned onto a HFD and maintained on this diet for 11 weeks.

25 re fed a standard laboratory diet (SLD) or a HFD for 12 weeks.

26 usion, while short-term Ex did not prevent a HFD-induced inflammatory response, it provoked a genomic

27 muscle force and exercise performance upon a HFD regimen.

28 on histone acetylation were observed with a HFD despite lower acetyl-CoA levels.

29 Importantly, knockout of Nlrp3 ablated HFD-induced insulin resistance and inflammation in Nrp1(

30 In addition, HFD increased binding of DNA methyl-transferases (DNMTs)

31 ent as an exogenous factor, while in adipose HFD's impact roughly coincides with the endogenous eigen

32 The glucose tolerance response after HFD significantly varied among CC lines (P <0.01), with

33 c pathway in mesenteric adipose tissue after HFD and/or OVX, independent of previous postnatal progra

34 olar bone change and glucose tolerance after HFD consumption.

35 MiR-204-I protected against HFD-induced downregulation of endothelial Cav1.

36 ent beneficial effects in protecting against HFD-induced obesity and metabolic disorders.

37 ompared with control mice after consuming an HFD.

38 ic Nrp1 knockout (Nrp1(myel-KO)) mice fed an HFD (60% kcal) for 16 weeks.

39 WT, p40(-/-), and p35(-/-) mice fed an HFD become obese after 12 weeks and exhibit glucose into

40 JNK1(-/-) mice fed an HFD for the long term had reduced expression of antioxid

41 Mice fed an HFD had normal cardiac structure and function.

42 L-selectin antibody-treated mice were fed an HFD, and hepatocellular injury was assessed by histology

43 ed impaired glucose tolerance in mice fed an HFD.

44 fed A2AAR-knockout (KO) and control mice an HFD for 16 wk to initiate HFD-induced metabolic disorder

45 However, after 12 weeks of an HFD, blood flow recovery was compromised in WT mice, whe

46 After 12 weeks of an HFD, the femoral artery was ligated and blood flow recov

47 Hdc(-/-)) mice were fed a control diet or an HFD coupled with a high fructose corn syrup equivalent.

48 d either a control high-fat diet (HFD) or an HFD supplemented with 3% n-3 PUFAs from fish oil (HFD +

49 eeks and were subsequently transferred to an HFD (42% fat) for an additional 12 weeks.

50 In summary, beta cell adaptation to an HFD in C57BL/6NTac mice entails early insulin hypersecre

51 atty acids (FFA) in the HFD together with an HFD-induced alteration in gut microbiota contributes to

52 We found that both CR and HFD induce extensive transcriptional changes, in some ca

53 s of RIP140mvarphiKD donor animals and avoid HFD-induced insulin resistance, which is associated with

54 ce in white adipose tissue (WAT) and blocked HFD-induced obesity, insulin resistance, hyperlipidemia

55 Blocking HFD-induced cell proliferation by central delivery of th

56 Increased energy intake in both HFD and/or OVX groups, and decreased locomotor activity

57 lexes with At-NF-YB and At-NF-YC, broadening HFD combinatorial possibilities in terms of trimerizatio

58 tabolic and cognitive deficiencies caused by HFD were rescued by switching to a low fat diet for one

59 reased insulin content and release caused by HFD.

60 regulatory landscape in the liver induced by HFD is highly dynamic and can be reversed by weight loss

61 te to ameliorating retinal damage induced by HFD.

62 d not prevent renal complications induced by HFD.

63 dant enzymes activities of retina induced by HFD.

64 in the brain were significantly modulated by HFD.

65 Down-regulated by HFD were genes related to neuron projections and synapti

66 ice that were most metabolically challenged (HFD-consuming offspring of obese mothers).

67 a heretofore unappreciated effect of chronic HFD on beta-cells, wherein continued DNA damage owing to

68 However, continued HFD exposure results in cessation of gene hyperexpressio

69 istance, as Nod2 (-/-) BALB/c mice developed HFD-dependent obesity and hallmark features of metabolic

70 d the in vivo effect of a fat-enriched diet (HFD) on the expression and the epigenetic regulation of

71 High-fat diet (HFD) accelerates these effects in apoE4-TR mice at middl

72 to postnatal over nutrition, high-fat diet (HFD) after weaning, followed later by ovariectomy (OVX;

73 keletal muscle to 9 days of a high-fat diet (HFD) alone (Sed-HFD) or in combination with resistance e

74 Maternal high-fat diet (HFD) alters hypothalamic developmental programming and d

75 A maternal high-fat diet (HFD) alters the offspring's feeding regulation, leading

76 s of two different diets-very high fat diet (HFD) and moderately high fat plus cholesterol diet (HFC)

77 nriched mushrooms extracts on high-fat diet (HFD) animal model of non-alcoholic steatohepatitis (NASH

78 stinct features of mice fed a high-fat diet (HFD) as well as obese patients.

79 n in transgenic CCDC3 mice on high-fat diet (HFD) by reducing the expression of hepatic PPARgamma and

80 ated that a brief (two weeks) high fat diet (HFD) caused insulin resistance in rat skeletal muscle.

81 Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when b

82 sed by 3 weeks of a high-saturated fat diet (HFD) consumption.

83 the negative consequences of high fat diet (HFD) consumption.

84 S2HET) were challenged with a high-fat diet (HFD) containing 45% of kilocalories from fat.

85 Feeding a high-fat diet (HFD) coupled with sugar, mimicking a Western diet, cause

86 In addition, high-fat diet (HFD) feeding induced vascular miR-204 and reduced endoth

87 rinsulinaemia associated with high-fat diet (HFD) feeding on the cardiac beta2 -adrenergic receptor s

88 During high-fat diet (HFD) feeding, macrophage-specific JAK2 knockout (M-JAK2(

89 changes induced by long-term high-fat diet (HFD) feeding.

90 ses excess weight gain during high-fat diet (HFD) feeding.

91 Mice fed a high-fat diet (HFD) for 10 weeks were divided into groups: HFD and H+G4

92 -) (p35(-/-)) mice were fed a high-fat diet (HFD) for 12 weeks.

93 xes that were maintained on a high-fat diet (HFD) for 6 weeks prior to DRG inflammation.

94 re, we report that mice fed a high-fat diet (HFD) for as little as 1-3 days show increased differenti

95 In this study we fed mice a high fat diet (HFD) for seven weeks followed by additional five weeks o

96 6) mice, obesity induced by a high-fat diet (HFD) has major effects on visceral epididymal adipose ti

97 s in the obesity induced by a high-fat diet (HFD) in rodents.

98 ificant weight reduction in a high-fat diet (HFD) induced diabetic mouse model and a genetically engi

99 BSTRACT: The consumption of a high-fat diet (HFD) is associated with myenteric neurodegeneration, whi

100 xamined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months ol

101 to understand the impacts of high-fat diet (HFD) on the insulin-adrenergic receptor signal network i

102 ild-type (WT) mice were fed a high-fat diet (HFD) or a control diet and studied at 6 months of age.

103 ice were fed either a control high-fat diet (HFD) or an HFD supplemented with 3% n-3 PUFAs from fish

104 in C57BL/6NTac mice fed a 60% high-fat diet (HFD) or control diet for up to 16 weeks.

105 from outbred mice fed with a high-fat diet (HFD) or regular chow at weeks 1, 9, and 18.

106 o HF diabetic mice induced by high fat diet (HFD) plus streptozotocin (STZ) in C57BL/6J mice for 13 w

107 Maternal obesity and high-fat diet (HFD) predisposes offspring to obesity and metabolic dise

108 fects after placing mice on a high fat diet (HFD) regimen demonstrated that running distance is great

109 Consumption of a high-fat diet (HFD) results in suppression of ATP citrate-lyase levels

110 s using parabiotic mice fed a high-fat diet (HFD) showed differential trafficking of AT1-ILCs, partic

111 erosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing

112 fed a control diet (CON) or a high-fat diet (HFD) with or without 0.2% (w/w) RES during pregnancy and

113 l, (ii) Control + L/Zi, (iii) High Fat Diet (HFD), and (iv) HFD+ L/Z.

114 High-fat diet (HFD), body weight (BW) gain, and impaired glucose tolera

115 cumulation in mice exposed to high-fat diet (HFD), injected with streptozotocin, or both in combinati

116 Despite becoming obese on a high-fat diet (HFD), mice lacking FcgammaRIIB globally or selectively i

117 r a chow diet (CD), a 16 week high-fat diet (HFD), or a CR diet to compare and contrast the effects o

118 When fed a high-fat diet (HFD), the transgenic mice displayed a significant decrea

119 a reperfusion injury (IRI) in high-fat diet (HFD)-fed mice.

120 In a mouse model, high-fat diet (HFD)-fed offspring have cognitive and executive function

121 harmful cognitive effects of high fat diet (HFD)-induced IR due to apoE isoform-specific differences

122 yz2-Cre mice largely reversed high-fat diet (HFD)-induced M1-M2 imbalance in white adipose tissue (WA

123 rkedly protected mice against high-fat diet (HFD)-induced metabolic syndrome, the effect was not sign

124 nses and markedly exacerbated high-fat diet (HFD)-induced NAFLD pathogenesis.

125 HEP) mice were protected from high-fat diet (HFD)-induced NASH.

126 We used a mouse model of high-fat diet (HFD)-induced obesity and assessed immune responses to al

127 metabolites in response to a high-fat diet (HFD)-induced obesity and/or exercise.

128 High-fat diet (HFD)-induced obesity is accompanied by insulin resistanc

129 adipose tissue ERalpha during high-fat diet (HFD)-induced obesity using female aP2-Cre(-/+)/ERalpha(f

130 against a cold challenge and high-fat diet (HFD)-induced obesity with associated insulin resistance

131 are known to be resistant to high fat diet (HFD)-induced obesity, however the genetic cause remains

132 isease exacerbation caused by high-fat diet (HFD)-induced obesity.

133 a standardized mouse model of high fat diet (HFD)-induced steatosis followed by Omega3FA treatment an

134 se-tolerant, and resistant to high fat diet (HFD)-induced toxicity.

135 butions of macrophage Nrp1 in high-fat diet (HFD)-instigated insulin resistance in vivo.

136 islet dysfunction with age or high-fat diet (HFD).

137 ion and oxidative damage upon high fat diet (HFD).

138 during weight gain induced by high-fat diet (HFD).

139 notype when challenged with a high-fat diet (HFD).

140 role of A2AARs in regulating high-fat-diet (HFD)-induced metabolic derangements is unknown.

141 nalysis of the eigenvectors revealed diverse HFD impact on the three tissues over time.

142 trimer is composed of a Histone Fold Domain (HFD) dimer (NF-YB/NF-YC) and NF-YA, which confers DNA se

143 Enriching HFD with inulin restored microbiota loads, interleukin-2

144 in combination with resistance exercise (Ex-HFD), using genome-wide profiling of gene expression and

145 muscles from LFD rats significantly exceeded HFD values (P < 0.005).

146 ver regeneration were also found in mice fed HFD and treated with G49.

147 While both E3 and E4 mice fed HFD displayed impairments in peripheral metabolism and c

148 ion of AT-LSK sorted from high fat diet-fed (HFD) mice is sufficient to induce ATM accumulation, and

149 ) mice that developed steatosis upon feeding HFD.

150 Finally, HFD-fed AdSod2 KO mice were protected from hepatic steat

151 Finally, HFD-islets demonstrated reduced expression of multiple r

152 ted marked DNA methylation changes following HFD alone and in combination with Ex.

153 For HFD versus LFD rats, GU of insulin-stimulated single fib

154 hematopoietic stem and progenitor cells from HFD-fed mice, but mice lacking either NE or C/EBPalpha a

155 F2 male offspring derived from HFD-fed maternal grandfathers exhibited increased adipos

156 ned that F1 female offspring (B6D2F1/J) from HFD-fed dams have decreased motivation (decreased progre

157 Isolated myocytes from HFD-fed mice also displayed a reduced contractile respon

158 nstrated a reversal of effects observed from HFD alone.

159 C18:0), a fatty acid elevated in plasma from HFD-fed atERalphaKO mice, blocks M2-polarization, a proc

160 l (M-JAK2(+/+)) mice and were protected from HFD-induced systemic insulin resistance.

161 yte alphaMbeta2-integrin were protected from HFD-induced weight gain and elevated adiposity.

162 erfering RNA provided marked protection from HFD-induced NASH in WT mice.

163 aling, whereas the lack of HDC protects from HFD-induced fibrosis and cholangiocyte damage.

164 Further, HFD-fed Nrp1(myel-KO) mice displayed accentuated insulin

165 eks were divided into groups: HFD and H+G49 (HFD plus G49).

166 (HFD) for 10 weeks were divided into groups: HFD and H+G49 (HFD plus G49).

167 Hdc(-/-) HFD mice are susceptible to obesity via dysregulated lep

168 Hdc(-/-) HFD mice had increased steatosis compared with WT HFD mi

169 In Hdc(-/-) HFD mice, serum leptin levels increased, whereas biliary

170 l activation, which were reduced in Hdc(-/-) HFD mice.

171 ntaining three different lipid levels (high [HFD], medium [MFD], and low [LFD]) were administered wit

172 y additional five weeks of chow, to identify HFD-mediated changes to the hepatic transcriptional prog

173 In HFD-fed mice, supplementation with the sialic acid precu

174 unction and white adipose tissue browning in HFD+RES compared with HFD offspring.

175 eased CD8(+) /CD62L(+) (L-selectin) cells in HFD-fed mice after IRI.

176 The metabolic and physiological changes in HFD-fed mice, including insulin resistance, brain glucos

177 These signals are dampened in HFD mice and exhibit circadian variations inversely with

178 hat A2AARs control pancreatic dysfunction in HFD-induced obesity.

179 of HFD and streptozotocin mice eliciting, in HFD, DNA demethylation, glucose uptake, and insulin resp

180 e the binding locations for these factors in HFD and CR livers.

181 ptide in HFD-P and attenuated weight gain in HFD-P and MFD-P fed zebrafish, but not in LFD-P group.

182 h AT-inflammation and glucose homeostasis in HFD mice.

183 L-selectin ligand MECA-79 was increased in HFD-fed mice undergoing IRI.

184 nism of the exaggerated uterine infection in HFD-fed atERalphaKO mice, a marked reduction of uterine

185 ge was detected in plasma cytokine levels in HFD rats.

186 istone H3 lysine 23 acetylation was lower in HFD-fed mice.

187 ion of methyl donors increased motivation in HFD-fed offspring and those who previously received supp

188 feeding also decreased nesfatin-1 peptide in HFD-P and attenuated weight gain in HFD-P and MFD-P fed

189 dy we demonstrate an unexpected phenotype in HFD-fed atERalphaKO involving severe uterine bacterial i

190 ning the absence of a metabolic phenotype in HFD-fed atERalphaKO mice.

191 and preserved cardiac contractile reserve in HFD-fed mice.

192 ance, and insulin resistance specifically in HFD-fed male mice.

193 RNA-seq results revealed that in HFD mice there was an increased expression of genes rela

194 e and have shown that high-fat diet-induced (HFD-induced) insulin resistance is mitigated in B cell-d

195 nd control mice an HFD for 16 wk to initiate HFD-induced metabolic disorder.

196 ls (ATB2) from wild-type HFD donor mice into HFD Bnull recipients completely restored the effect of H

197 + L/Zi, (iii) High Fat Diet (HFD), and (iv) HFD+ L/Z.

198 gatran, a direct thrombin inhibitor, limited HFD-induced obesity development and suppressed progressi

199 Maternal HFD also increased plasma leptin, IL-6, and MCP-1 in WT

200 Maternal HFD increased body weight in WT and KIKO, in part, due t

201 a signaling blocks the influence of maternal HFD on energy homeostasis, inflammation, and hypothalami

202 lly reestablishes susceptibility to maternal HFD.

203 d in offspring that were exposed to maternal HFD.

204 impairment of offspring BAT due to maternal HFD.

205 Ralpha would be more susceptible to maternal HFD.

206 tes a pivotal role for calpains in mediating HFD-induced adipose tissue remodeling by influencing mul

207 Compared with chow-fed mice, HFD-fed mice had a rapid increase in body weight and fat

208 Moreover, HFD-fed S2HET mice exhibited reduced beta-cell mass and

209 Moreover, HFD-regulated H3K27Ac and mRNA levels returned to simila

210 Nod2 (-/-) HFD mice developed hyperlipidemia, hyperglycemia, glucos

211 Nod2 (-/-) HFD mice exhibited changes in the composition of the gut

212 Furthermore, microbiota from Nod2 (-/-) HFD mice transferred sensitivity to weight gain, steatos

213 Notably, HFD- and agonist-activated PPAR-delta signalling endow o

214 DPHox-deficient mice on a SCD; (4) NOX2(-/-)/HFD, six NADPHox-deficient mice on a HFD.

215 recipients completely restored the effect of HFD to induce insulin resistance.

216 Here we examined the effects of HFD on levels of acyl-CoAs and histone acetylation in mo

217 level in diabetic CMSCs and in the heart of HFD and streptozotocin mice eliciting, in HFD, DNA demet

218 in diabetic CMSCs and in the whole heart of HFD mice.

219 In conclusion, RES supplementation of HFD-fed dams during pregnancy and lactation promoted whi

220 e markers and chemokines in liver and VAT of HFD-fed M-JAK2(-/-) mice.

221 markers in visceral adipose tissue (VAT) of HFD-fed M-JAK2(-/-) mice.

222 emia was maintained for the first 4 weeks of HFD feeding and then further increased through 16 weeks.

223 We showed that 8 weeks of HFD feeding leads to reductions in cardiac functional re

224 After 8 weeks of HFD feeding, mice exhibited diabetes, with elevated insu

225 ot significantly perturbed until 11 weeks of HFD feeding.

226 provement in glucose tolerance at 5 weeks of HFD whereas it lost this effect on glucose and insulin t

227 upplemented with 3% n-3 PUFAs from fish oil (HFD + FO) for 8 wk.

228 ovalbumin on alternate days and continued on HFD for another 10 weeks.

229 Despite the fact that AEKO mice on HFD display increased body weight, these mice have decre

230 Lipoic acid treatment in mice on HFD prevented several HFD-induced metabolic changes and

231 C57BL/6 mice on HFD were orally administered with vitamin D supplement,

232 patic expression of ectopic CCDC3 in mice on HFD.

233 of previous postnatal programming, yet only HFD evoked this effect in liver.

234 Female offspring weaned onto HFD were given treadmill exercise for 9 weeks, or NMN in

235 ne, female mice were fed either a control or HFD during lactation.

236 ation of hepatic CES2 expression in db/db or HFD-fed mice markedly ameliorates liver steatosis and in

237 In WAT and the pancreas, HFD also impacted the levels of histone acetylation; in

238 his vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN(+)

239 Furthermore, NE deletion prevents HFD-induced vascular leakage.

240 Upon prolonged HFD feeding, GLUT1 expression is restored, which is para

241 eeder chow diet (25% fat) or a semi-purified HFD (45% fat) 4 weeks prior to mating with WT/KO males o

242 Rather, HFD decimates gut microbiota, resulting in loss of enter

243 ndent increases in VAN activity in all rats; HFD attenuated the response to CCK, but not 5-HT.

244 These results revealed HFD-induced insulin resistance was attributable to fiber

245 Omega3FA reversed HFD-induced steatosis and markedly protected against I/R

246 CO physically interacts with the same HFD surface required for NF-YA association, as determine

247 o 9 days of a high-fat diet (HFD) alone (Sed-HFD) or in combination with resistance exercise (Ex-HFD)

248 d treatment in mice on HFD prevented several HFD-induced metabolic changes and preserved synaptic pla

249 ocin, or both in combination (streptozotocin/HFD).

250 STZ-HFD feeding induced a much higher incidence of HCC in ma

251 is using a streptozotocin-high fat diet (STZ-HFD) induced nonalcoholic steatohepatitis-hepatocellular

252 when mice of both sexes were exposed to STZ-HFD.

253 Treating STZ-HFD male mice with 2% cholestyramine led to significant

254 Surprisingly, HFD feeding markedly increased mortality in atERalphaKO

255 icularly in response to short- and long-term HFD and diet restriction.

256 This integrative approach demonstrates that HFD elicits a complex response at molecular, cellular an

257 The results imply that HFD influences the hepatic function or the pancreatic de

258 Together, these data indicate that HFD promotes phosphorylation of the beta2 AR, contributi

259 in chromatin accessibility, indicating that HFD-regulated gene transcription is primarily controlled

260 Here, we report that HFD-induced obesity in B6 mice also altered the activity

261 Interestingly, we revealed that HFD-fed mice display a dramatic accumulation of hepatic

262 The results suggest that HFD can increase pain even when it does not cause obesit

263 This suggested that HFD, rather than obesity per se, increased pain behavior

264 The HFD-fed with Sham therapy developed brain insulin resist

265 icant metabolic effects in male mice fed the HFD and both sexes of mice fed a chow diet.

266 However, the HFD-fed mice displayed a significant elevation of phosph

267 The dual eigen-analysis identified the HFD eigenvectors as well as the endogenous eigenvectors

268 ant with insulin or glucose tolerance in the HFD model of T2DM suggesting novel therapeutic targets.

269 ease in plasma free fatty acids (FFA) in the HFD together with an HFD-induced alteration in gut micro

270 After injury, the HFD liver showed increased necrosis, infiltrating CD8(+)

271 ted overexpression of catalase prevented the HFD-induced ischemic limb necrosis, myopathy, and mitoch

272 We conclude that the HFD-instigated Nrp1 reduction in macrophages exacerbates

273 fter a much shorter (1 week) exposure to the HFD but the effect was smaller.

274 re liver injury and fibrosis compared to the HFD diet.

275 n of the DRG was observed in response to the HFD, absent any pain model.

276 Thus, HFD feeding rapidly activates bone marrow myelopoiesis t

277 Thus, in mice, the exposure to HFD induces epigenetic silencing of the Ankrd26 gene, wh

278 with the appearance of reduced protection to HFD-induced obesity; at 18 months, LP progeny displays a

279 ing either NE or C/EBPalpha are resistant to HFD-induced myelopoiesis.

280 Finally, female mice, typically resistant to HFD-induced obesity and NAFLD, develop full disease char

281 biota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia.

282 mmunoreactivity in the cortex in response to HFD, most pronounced in female mice that correlated to t

283 prefrontal cognitive deficits in response to HFD.

284 ic complex imparting sequence specificity to HFD/DNA interactions.

285 dipose tissue B2 cells (ATB2) from wild-type HFD donor mice into HFD Bnull recipients completely rest

286 force measured after exercise decreases upon HFD in wild type mice while p66shc(-/-) animals are prot

287 in redox homeostasis/metabolic disease upon HFD exposure.

288 htened sensitivity to IGF-1 stimulation upon HFD feeding.

289 In visceral adipose tissue (VAT), HFD exposure determined a specific hyper-methylation of

290 At weaning, HFD offspring had lower thermogenesis in brown and white

291 Dawley rats despite the fact that the 6-week HFD exposure induced obesity (e.g., increased insulin, l

292 on glucose and insulin tolerance at 16 weeks HFD in obese mice.

293 muscle the influence of a brief (two weeks) HFD on glucose uptake (GU) +/- insulin in single fibers

294 ose tissue browning in HFD+RES compared with HFD offspring.

295 ity when on an obesogenic diet compared with HFD offspring.

296 treated with pioglitazone concurrently with HFD demonstrated a reversal of effects observed from HFD

297 Rats fed with HFD exhibited increased oxidative stress and upregulatio

298 WT HFD mice had increased biliary mass, biliary proliferati

299 ice had increased steatosis compared with WT HFD mice.

300 (WT) mice fed a standard chow diet (SCD); WT/HFD, six WT mice fed a HFD; NOX2(-/-)/SCD, six NADPHox-d