ライフサイエンスコーパス: HFV

1 HFV glycoproteins encoding seven different dilysine moti

2 HFV productively infects a variety of human myeloid and

3 About 55,000 HFV sequences exist in the public domain today.

4 ietic cells are efficiently transduced by an HFV vector that encodes alkaline phosphatase (AP).

5 Simian and human foamy viruses (SFV and HFV) encode a transcriptional transactivator, Tas, which

6 Both HFV and HBV express their Pol protein independently of t

7 Both HFV and HBV express their Pol proteins independently fro

8 d microglial cells, were readily infected by HFV.

9 sed vaccines to treat the diseases caused by HFVs.

10 572T mutant env into a replication-competent HFV molecular clone.

11 some aspects of the viral replicative cycle, HFV more closely resembles pararetroviruses such as hepa

12 -control studies, and case series evaluating HFV vs. conventional mechanical ventilation in adult ARD

13 requirements for synthesis of extracellular HFV particles by constructing mutants with either the po

14 We have examined possible mechanisms for HFV Pol incorporation, including the role of proteolysis

15 Inactivation protocols for HFV should be validated with serum and whole blood.

16 transport signal, they are not required for HFV replication and it is unlikely that nuclear localiza

17 aled that in single-cell clones derived from HFV-infected erythroleukemia-derived cells (H92), there

18 t study, expression of recombinant human FV (HFV) glycoprotein and analyses of oligosaccharide modifi

19 X), that functions to localize the human FV (HFV) glycoprotein to the ER.

20 Infectious HFV particles contain double-stranded DNA similar in siz

21 esults suggest that the assembly of Pol into HFV particles must occur by a mechanism different from t

22 well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.

23 Application of HFV with PLV provides no clear acute physiologic advanta

24 in-driven virion budding, a unique aspect of HFV assembly, occurred despite the absence of Env cleava

25 ike HBV, Pol is not required for assembly of HFV core particles or for packaging of viral RNA.

26 fected with an infectious molecular clone of HFV.

27 he context of infectious molecular clones of HFV that encoded mutations in the dilysine motif.

28 Our results show that the NC domain of HFV Gag binds with high affinity to both RNA and DNA, in

29 emonstrated that the LTR promoter element of HFV contains a DNA binding site for Bel-1 that is critic

30 We have expressed the carboxyl end of HFV Gag containing the GR boxes (the NC domain equivalen

31 We conclude that the dilysine motif of HFV imposes a partial restriction on the site of viral m

32 In contrast, the Pol protein of HFV is translated from a spliced messenger RNA and lacks

33 our results suggest that the Gag protein of HFV may be more analogous to the core protein of the hep

34 The transduction rates of HFV vectors compare favorably with those obtained by mur

35 al should be initiated to define the role of HFV in the treatment of adult ARDS.

36 Cell-free infectious viral stocks of HFV were prepared from the human kidney cell line 293 tr

37 ces within the zinc-fingerless C terminus of HFV Gag suggested that clusters of basic residues, but n

38 Weapons disseminating a number of HFVs could cause an outbreak of an undifferentiated febr

39 We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline

40 Gas exchange was not enhanced during PLV-HFV.

41 ntional techniques or PLV using the selected HFV technique as initial treatment.

42 Previous work indicated that HFV extracellular particles contain apparently full-leng

43 We have shown that HFV requires a functional integrase protein for infectiv

44 leukemia virus vectors, which suggests that HFV vectors may be effective in the treatment of hematol

45 The HFV sequence database collects and stores sequence data

46 The HFV website can be accessed via http://hfv.lanl.gov.

47 ctivate gene expression directed by both the HFV long terminal repeat (LTR) and internal (Int) promot

48 DNA binding site for Bel-1, derived from the HFV internal promoter element, and show that this short

49 e the Bel-1 DNA binding sites located in the HFV LTR and internal promoter elements.

50 ntal results established the location of the HFV Env proteolytic site; the effects of cleavage on Env

51 sion) assay revealed that proteolysis of the HFV Env was essential for viral infectivity.

52 in higher levels of forward transport of the HFV glycoprotein from the ER through the Golgi apparatus

53 However, transactivation of the HFV LTR by Bel-1 was observed to require not only the pr

54 al LTR is implicated in the synthesis of the HFV Pol polyprotein which encodes protease, reverse tran

55 hat is over 40% identical in sequence to the HFV Env.

56 is predicted to be only 28% identical to the HFV protein.

57 ys, the Bel-1 target site located within the HFV internal promoter binds Bel-1 with a significantly h

58 Thus, HFV infection produces differential cytopathology in a w

59 In addition, marked cytotoxicity due to HFV infection was seen in both human T-cell leukemia vir

60 transduced by a single overnight exposure to HFV vector stocks.

61 uences and analysis tools will be helpful to HFV researchers worldwide.

62 Wild-type HFV Env partially complemented the defective virus pheno

63 entional techniques and twice with PLV using HFV.

64 blood samples from hemorrhagic fever virus (HFV)-infected patients with 0.1% detergents has been rec

65 eas similar chimeras with human foamy virus (HFV) (containing no zinc fingers) Gag had at least two.

66 As with the human foamy virus (HFV) and feline foamy virus, we have detected a spliced

67 structed vectors based on human foamy virus (HFV) and found that they were able to transduce a wide v

68 ctivator, termed Bel-1 in human foamy virus (HFV) and Tas or Taf in the related simian foamy viruses,

69 transactivator encoded by human foamy virus (HFV) can efficiently activate gene expression directed b

70 tive cleavage site of the human foamy virus (HFV) envelope glycoprotein (Env) was altered.

71 ng the characteristics of human foamy virus (HFV) integration.

72 Human foamy virus (HFV) is a retrovirus of the spumavirus family.

73 Human foamy virus (HFV) is the prototype member of the spumaviruses.

74 Human foamy virus (HFV) is the prototype of the Spumavirus genus of retrovi

75 Human foamy virus (HFV) is the prototype of the Spumavirus genus of Retrovi

76 he spumaviruses, of which human foamy virus (HFV) is the prototype, are very similar to those of othe

77 The Gag protein of human foamy virus (HFV) lacks Cys-His boxes present in the nucleocapsid (NC

78 ed from the nonpathogenic human foamy virus (HFV) to transduce human CD34(+) cells and murine HSCs.

79 The infectivity of human foamy virus (HFV) was examined in primary and cultured human leukocyt

80 cytopathology characteristic of foamy virus, HFV-infected monocyte-derived macrophages failed to show

81 like vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they

82 Hemorrhagic fever viruses (HFVs) are a diverse set of over 80 viral species, found