ライフサイエンスコーパス: HHV-6A

1 HHV-6A and HHV-6B have recently been classified as two d

2 HHV-6A established a productive infection with CPE, visi

3 HHV-6A U51 has been reported to bind to CC chemokines in

4 HHV-6A-induced apoptosis was associated with activation

5 ntly infected with Epstein-Barr virus/HHV-4, HHV-6A, HHV-6B, HHV-7, and KSHV.

6 Here, we describe a human herpesvirus 6 (HHV-6A) chemokine, U83A, which binds CCR5 with higher af

7 The genomes of human herpesvirus 6A (HHV-6A) and HHV-6B have the capacity to integrate into t

8 e been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has preven

9 Human herpesvirus 6A (HHV-6A) strain U1102 was previously shown to contain a 1

10 ation is infected with human herpesvirus 6A (HHV-6A), a betaherpesvirus family member.

11 Human herpesvirus 6A (HHV-6A), a member of the betaherpesvirus family, is asso

12 Human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 are classified as roseoloviru

13 Human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 are classified as roseoloviru

14 e human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus gen

15 T cells infected with human herpesvirus 6A (HHV-6A), the E2F1 protein and its cofactor DP1 increased

16 irus, BK polyomavirus, human herpesvirus 6B, HHV-6A, adenovirus, and Epstein-Barr virus between days

17 oloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establi

18 Accordingly, HHV-6A infection resulted in the depletion of both CD4(+

19 In addition, HHV-6A induced secretion of interleukin-6 (IL-6), tumor

20 , using phosphonoacetic acid, did not affect HHV-6A/B integration.

21 -6A(GS) B701 ORF (U16) was used to screen an HHV-6A(GS) cDNA library, and two different but overlappi

22 Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telom

23 As do human herpesvirus 6 variants A and B (HHV-6A and -6B), HHV-7 encodes a homolog of the alphaher

24 Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can

25 overall nucleotide sequence identity between HHV-6A and HHV-6B is 90%.

26 e response was highly cross-reactive between HHV-6A and HHV-6B variants.

27 ent an analysis of the relationships between HHV-6A and HHV-6B.

28 Our studies show that both HHV-6A (GS) and HHV-6B (Z-29) can infect highly purified

29 oded miRNAs, although an miRNA(s) encoded by HHV-6A has yet to be reported.

30 ein-Barr virus (EBV), cytomegalovirus (CMV), HHV-6A, HHV-6B, and HHV-8, using quantitative polymerase

31 In contrast, HHV-6A induced apoptosis primarily in T(N) and T(CM) CD4

32 sons and the complete viral genome of either HHV-6A or HHV-6B is present in every nucleated cell in t

33 suggest that viral miRNAs are important for HHV-6A and that they may serve as an important therapeut

34 new models have been established, mainly for HHV-6A, which reproduce some pathological features seen

35 cifically on developing an in vivo model for HHV-6A.

36 Organs and cells positive for HHV-6A DNA were the plasma and cellular blood fractions,

37 B701, found within a 22-kb HHV-6A strain GS [HHV-6A(GS)] genomic fragment and a 3.8-kb SalI subfragme

38 whereas in viral integration, 4 patients had HHV-6A and 17 patients HHV-6B.

39 ll RNA species isolated from cells harboring HHV-6A to identify five novel small noncoding RNA specie

40 Like all herpesviruses, HHV-6A establishes a lifelong, latent infection in its h

41 llular and viral factors that play a role in HHV-6A/B integration.

42 ession, as well as the release of infectious HHV-6A/B from the integrated state.IMPORTANCE The analys

43 ng and analyzed for chromosomally integrated HHV-6A/B (ciHHV-6A/B).

44 Reactivation of integrated HHV-6A virus from individuals' PBMCs as well as cell lin

45 viral genome identified the same integrated HHV-6A strain within members of families, confirming ver

46 (ORF) designated B701, found within a 22-kb HHV-6A strain GS [HHV-6A(GS)] genomic fragment and a 3.8

47 Two viral variants are known: HHV-6A and HHV-6B.

48 ed analysis using novel, fluorescent-labeled HHV-6A or HHV-6B reagents demonstrated strong G1/S phase

49 produce human T cells that express the major HHV-6A receptor, CD46.

50 ction, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the ho

51 and provided a model to study the effects of HHV-6A on AIDS progression.

52 ntribute to the less-defined epidemiology of HHV-6A infection.

53 event may have deregulated the expression of HHV-6A or 19q genes or else disrupted telomere function.

54 e sequence of the 3.8-kb genomic fragment of HHV-6A(GS) is nearly identical to the published sequence

55 ongly suggest that MRV is a mouse homolog of HHV-6A, HHV-6B, and HHV-7.IMPORTANCE Herein we describe

56 full reactivation.IMPORTANCE Inheritance of HHV-6A or HHV-6B integrated into a telomere occurs at a

57 The reactivation of HHV-6A did not affect disease severity and outcome.

58 Reactivation of HHV-6A is frequent within the immunosuppressed and immun

59 Reports of HHV-6A or HHV-6B encephalitis in immunocompetent older c

60 pectives for studying the pathogenic role of HHV-6A in humans.

61 early identical to the published sequence of HHV-6A strain U1102, with minor differences.

62 sociated and cell-free viral transmission of HHV-6A into the peritoneal cavity resulted in detectable

63 this virus in which differential tropism of HHV-6A and HHV-6B may be associated with different disea

64 IMPORTANCE The analysis and understanding of HHV-6A/B genome integration into host DNA is currently l

65 nteroviruses (including human parechovirus), HHV-6A, HPIV-1, and adenoviruses were not detected.

66 more closely related to the roseoloviruses, HHV-6A, HHV-6B, and HHV-7, than to another murine betahe

67 ate that humanized mice can be used to study HHV-6A in vivo infection and replication as well as aspe

68 nd reproducible cell culture models to study HHV-6A/B integration.

69 While the assay detects both subtypes, HHV-6A and HHV-6B, it is specific and does not cross-rea

70 Our results demonstrate that HHV-6A and HHV-6B have differential tropisms and pattern

71 itu hybridization, we could demonstrate that HHV-6A/B integrated in most human cell lines tested, inc

72 se findings provide additional evidence that HHV-6A may play a role in human immunodeficiencies.

73 HHV-6) encephalitis recognizing firstly that HHV-6A and HHV-6B are separate species with differing pr

74 We hypothesized that HHV-6A, like other members of the human herpesvirus fami

75 dds support to previous data indicating that HHV-6A and HHV-6B are distinct herpesvirus species.

76 Here we report that HHV-6A encodes at least one miRNA, which we named miR-U8

77 We show that HHV-6A induces cell division, as measured by 5,6-carboxy

78 The HHV-6A(GS) B701 ORF (U16) was used to screen an HHV-6A(G

79 In this study, we characterized the HHV-6A/B integration efficiencies in several human cell

80 Whether release of the HHV-6A genome from the telomere contributed to lymphomag

81 cell-free compartments was predominantly the HHV-6A variant, which has been reported to be neurotropi

82 viral miRNA candidate (miR-U86) targets the HHV-6A IE gene U86, thereby regulating lytic replication

83 -6B lysate, and fewer (33%) responded to the HHV-6A lysate.

84 that the lymphoproliferative response to the HHV-6A variant, which was recently reported to have grea

85 tion and biological characterization of this HHV-6A-specific miRNA is the first step to defining how

86 f viral and cellular factors contributing to HHV-6A/B integration and the screening of drugs influenc

87 e viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due

88 No disease has been linked to HHV-6A, whereas HHV-6B may cause encephalitis.

89 CD4(+) and CD8(+) T cells were resistant to HHV-6A-induced apoptosis.

90 tients had a lymphoproliferative response to HHV-6A, which is a significant increase in comparison wi

91 ve compared lymphoproliferative responses to HHV-6A (U1102)-, HHV-6B (Z29)-, and HHV-7 (H7SB)-infecte

92 may be due to differential susceptibility to HHV-6A-induced apoptosis.

93 C)-derived virus in Jjhan cells or wild-type HHV-6A strain U1102 virus in HSB2 cells and are associat

94 HHV-6B DNAemia was uncommon, HHV-6A DNAemia was not observed, and HHV-7 DNAemia was p

95 tterns of infection for HPDA in vitro, where HHV-6A results in a productive lytic infection.

96 We next asked whether HHV-6A infection of naive cell lines could lead to integ

97 Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may co

98 eal shedding by contacts was associated with HHV-6A or HHV-6B transmission.

99 Second, cells were infected with HHV-6A/B and allowed to grow in bulk for 4 weeks or long

100 T cells were efficiently infected only with HHV-6A.