ライフサイエンスコーパス: HIOMT

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1 HIOMT activity and mRNA were strongly reduced when FCS w

2 eviously reported for HIOMT enzyme activity, HIOMT mRNA levels were also greater in the pineal than i

3 As previously reported for HIOMT enzyme activity, HIOMT mRNA levels were also great

4 se protection assay revealed transcripts for HIOMT both in the pineal and retina.

5 n cycle, suggesting that the mRNA changes in HIOMT may be controlled at the transcriptional level.

6 The daily fluctuation in HIOMT mRNA persisted in constant darkness, verifying an

7 Investigating HIOMT mRNA levels in rat pineal and retina at 6 time-poi

8 melanocytes and immortalized keratinocytes; HIOMT activity was detected in human skin, keratinocytes

9 Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the last step in the synthesis of melat

10 NAT), and hydroxyindole-O-methyltransferase (HIOMT).

11 (NAT) and hydroxyindole-O-methyltransferase (HIOMT).

12 Hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4) catalyzes the methylation of acetylse

13 u hybridization were useful for detection of HIOMT mRNA in the pineal but not the retina, whereas the

14 soproterenol, induced a dramatic increase of HIOMT mRNA levels in the light-adapted pineal, in vivo.

15 methods, it has been shown that the level of HIOMT mRNA fluctuates daily in both the pineal gland and

16 hout a 24 h period revealed higher levels of HIOMT message during darkness.

17 ed, and used to evaluate day/night levels of HIOMT mRNA.

18 In the present study, the regulation of HIOMT expression was examined in the human Y-79 retinobl

19 The effect of FCS on HIOMT expression was relatively selective, because the a

20 The effect of serum on HIOMT expression was not duplicated by treatment with a

21 , prevented the nocturnal increase of pineal HIOMT mRNA.

22 ete 1728 nucleotide cDNA encoding rat pineal HIOMT was isolated, characterized, and used to evaluate

23 nd at least one copy in each of the putative HIOMT promoters A and B.

24 RNA was regulated by serum coordinately with HIOMT mRNA, suggesting that S-antigen expression is also

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