ライフサイエンスコーパス: HIV integrase

1 rs active against mammalian topoisomerase or HIV integrase.

2 hesized which have improved activity against HIV integrase.

3 ruplexes exhibit inhibitory activity against HIV integrase.

4 anspositional recombination, such as that of HIV integrase.

5 antially reduced level of inhibition against HIV integrase.

6 embles RSS cleavage and 3' end processing by HIV integrase and Mu transposase in that these reactions

7 lexibility and conformational preferences of HIV integrase and to (2) study raltegravir binding in th

8 r (LEDGF/p75) binds both chromosomal DNA and HIV integrase, and might therefore direct integration by

9 Inhibitors of HIV integrase are currently being sought as potential ne

10 tly approved antiviral compound that targets HIV integrase, can inhibit the nuclease function of huma

11 HIV integrase catalyses the incorporation of virally der

12 However, published X-ray structures of HIV integrase do not include the DNA; thus, there is a n

13 The HIV integrase enzyme (IN) catalyzes the initial DNA brea

14 Human immunodeficiency virus (HIV) integrase enzyme is required for the integration of

15 re, although clinically useful inhibitors of HIV integrase have been developed, their mechanism of ac

16 A series of HIV integrase (HIV-1 IN) inhibitors were synthesized to

17 of divalent ion dependent strand transfer by HIV integrase in antiviral therapy.

18 primary requirement for inhibition of HIV-1 HIV integrase (IN) activity.

19 o-hybrid screen as an interaction partner of HIV integrase (IN) and in two independent siRNA screens

20 has been implicated in inhibiting homologous HIV integrase (IN) and influenza endonuclease via metal

21 discovery has been increasingly focusing on HIV integrase (IN) as a potential therapeutic target.

22 HIV integrase (IN) catalyzes the insertion into the geno

23 o determine the architectures of full-length HIV integrase (IN) dimers in solution.

24 n IBD overlaps with the binding site for the HIV integrase (IN), and IN was capable of efficiently se

25 s step is catalyzed by a 32-kDa viral enzyme HIV integrase (IN).

26 inhibitors of human immunodeficiency virus (HIV) integrase (IN).

27 l DNA into the host genome is carried out by HIV-integrase (IN) and is a critical step in viral repli

28 The HIV integrase inhibitor d[G(3)(TG(3))(3)] forms an extre

29 synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished.

30 ction between boceprevir and raltegravir, an HIV integrase inhibitor.

31 leads for the development of a new class of HIV integrase inhibitor.

32 ravir (DTG), a human immunodeficiency virus (HIV) integrase inhibitor (INI), would be efficacious in

33 riority of the human immunodeficiency virus (HIV) integrase inhibitor elvitegravir to comparator rito

34 structural leads for the development of new HIV integrase inhibitors which do not rely on this poten

35 te inhibitors were quinolone antibiotics and HIV integrase inhibitors, which share common structural

36 -benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV-integrase inhibitors are disclosed.

37 HIV integrase is essential for HIV replication.

38 or (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for ant

39 unintegrated DNA likely contributed to SV40-HIV integrase mutant replication.

40 t the direct interaction between TRN-SR2 and HIV integrase predominantly involves the catalytic core

41 Unlabelled RAP1 GTPase and HIV integrase proteins were selectively detected from va

42 two-metal binding pharmacophore required for HIV integrase strand transfer inhibition represents a vi

43 The HIV integrase strand transfer inhibitor elvitegravir (EV

44 Specific HIV integrase strand transfer inhibitors are thought to

45 e we present the discovery of a new class of HIV integrase strand transfer inhibitors based on the 2-

46 nanomolar IC(50) values were achieved in an HIV-integrase strand transfer assay with both carboxylic

47 w "minor" polymorphisms and substitutions in HIV integrase that are associated with these subtypes ca

48 HIV integrase, the enzyme that inserts the viral DNA int

49 ain antibody mimics the effect of binding of HIV integrase to LEDGF which is crucial for HIV propagat

50 rst described as 'foldback' reversal for the HIV integrase, was also observed upon disassembly/reasse

51 es of L-chicoric acid, a potent inhibitor of HIV integrase, were studied.