ライフサイエンスコーパス: HIV reverse transcriptase

1 strate or zalcitabine, an inhibitor used for HIV reverse transcriptase.

2 effectively depletes the dNTP substrates of HIV reverse transcriptase.

3 han the corresponding reaction observed with HIV reverse transcriptase.

4 toxicity of anti-retroviral drugs targeting HIV reverse transcriptase.

5 ymerase, T7 DNA-dependent RNA polymerase and HIV reverse transcriptase.

6 centrations and temperatures and apply it to HIV reverse transcriptase.

7 anism of RNase H and drug design targeted to HIV reverse transcriptase.

8 IV activity, and they also failed to inhibit HIV reverse transcriptase.

9 ncy virus, type I (HIV) RNase H, a domain of HIV reverse transcriptase.

10 recognized by the ribonuclease H function of HIV reverse transcriptase.

11 merase-alpha and polymerase-beta, as well as HIV reverse transcriptase.

12 a significant and dose-dependent increase of HIV reverse transcriptase activity in human blood monocy

13 role of induced fit in enzyme specificity of HIV reverse transcriptase and many other enzymes.

14 Expression of the HIV reverse transcriptase and other essential viral enzy

15 ynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerase

16 The HIV reverse transcriptase and protease sequence database

17 The HIV Reverse Transcriptase and Protease Sequence Database

18 delity of DENV polymerase is comparable with HIV reverse transcriptase and the poliovirus polymerase.

19 , apply it to family A and B polymerases and HIV reverse transcriptase, and discuss factors that may

20 hybrid decreases the rate of both human and HIV reverse transcriptase-associated RNase H-mediated cl

21 Inhibitors of HIV reverse transcriptase, but not integrase, abrogated

22 tor of HBV and human immunodeficiency virus (HIV) reverse transcriptases, but substitutions of isoleu

23 The isolated RNase H domain from HIV reverse transcriptase can be expressed independently

24 HIV reverse transcriptase could elongate DNA primers aft

25 The RNA/DNA hybrid produced by HIV reverse transcriptase during (-) strand synthesis pr

26 of the class I MHC-HLA2 complex bound to the HIV reverse transcriptase epitope, ILKEPVHGV, and in the

27 Sequence analysis of a portion of the HIV reverse transcriptase gene demonstrated a disproport

28 udies here show that at the same shift motif HIV reverse transcriptase generates -1 and +1 indels wit

29 Structural modeling of HIV reverse transcriptase has permitted key insights int

30 compound 35 in the active site of wild type HIV reverse transcriptase (HIV-RT).

31 bacteriophage T7 DNA polymerase (T7(-)) and HIV reverse transcriptase (HIV-RT).

32 essential for the synthesis of viral DNA by HIV reverse transcriptase (HIV-RT).

33 en developed for determining the activity of HIV reverse transcriptase (HIV-RT).

34 d to select ssDNA aptamers with affinity for HIV reverse transcriptase (HIVRT).

35 ninyl phenyl ester prodrug of the nucleotide HIV reverse transcriptase inhibitor tenofovir (TFV; 9-[(

36 istant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with impro

37 everal lavendamycins were found to be potent HIV reverse transcriptase inhibitors with very low toxic

38 Non-nucleoside inhibitors of HIV reverse transcriptase (NNRTIs), albeit not the mains

39 inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (NNRTIs).

40 atrix peptide (a model recall antigen) or an HIV reverse transcriptase peptide (a model novel antigen

41 HIV reverse transcriptase plays a central role in viral

42 ted HIV strains resistant to drugs targeting HIV reverse transcriptase, protease, integrase, and core

43 Of three enzymes encoded by HIV-reverse transcriptase, protease, and integrase-only

44 of toxicity to human cells, incorporation by HIV reverse transcriptase, resistance to repair when inc

45 In vitro reaction conditions using HIV reverse transcriptase (RT) and nucleocapsid protein

46 clovir in HIV-infected cells is validated as HIV reverse transcriptase (RT) by the emergence of the R

47 The mechanism of HIV reverse transcriptase (RT) catalyzed strand transfer

48 V naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish betw

49 mation systems, we have examined variants of HIV reverse transcriptase (RT) for their ability to synt

50 e analogues leads to a novel class of potent HIV reverse transcriptase (RT) inhibitors, alpha-carboxy

51 s (NNRTIs) with activity against variants of HIV reverse transcriptase (RT) is crucial for overcoming

52 Structural studies of authentic HIV reverse transcriptase (RT) suggest a role for the p5

53 Binding of HIV reverse transcriptase (RT) to unique substrates that

54 Strand transfer catalyzed by HIV reverse transcriptase (RT) was examined.

55 Deep sequencing of HIV reverse transcriptase (RT) was performed (Roche/454)

56 Modeling of HIV reverse transcriptase (RT) with RNA/DNA in its RNase

57 rimer for synthesis of the (+) DNA strand by HIV reverse transcriptase (RT), and which is not digeste

58 n(2+), and Zn(2+) have been shown to inhibit HIV reverse transcriptase (RT), presumably by competitiv

59 The dimerization of HIV reverse transcriptase (RT), required to obtain the a

60 ive antiretroviral (HAART) therapy targeting HIV reverse transcriptase (RT).

61 ranslocation of triazoles into the P-site of HIV reverse transcriptase (RT).

62 phate (rac-1h-TP) for its ability to inhibit HIV reverse transcriptase (RT).

63 tion of human immunodeficiency virus type 1 (HIV) reverse transcriptase (RT) and protease (PT) sequen

64 riation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, th

65 riation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, th

66 d drug-related human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease sequence va

67 ctions between human immunodeficiency virus (HIV) reverse transcriptase (RT) and structures mimicking

68 Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the t

69 Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease

70 suggested that human immunodeficiency virus (HIV) reverse transcriptase (RT) binds to the 5' end of R

71 he fidelity of human immunodeficiency virus (HIV) reverse transcriptase (RT) has been a subject of in

72 Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease

73 , derived from human immunodeficiency virus (HIV)-reverse transcriptase (RT) residues 309-317, are mo

74 HIV-reverse transcriptase (RT) extended the DNA and clea

75 identified through a virtual screening using HIV-reverse transcriptase (RT), adenylate/guanylate kina

76 Single turnover studies on HIV reverse transcriptase suggest that nucleoside analog

77 work ideas to build a detailed model for the HIV reverse transcriptase that is consistent with existi

78 readily incorporated into a DNA template by HIV reverse transcriptase to act as a DNA chain terminat

79 predictable drug resistance mutation in the HIV reverse transcriptase to label and track cells infec

80 With in-house assays for HIV reverse transcriptase, we evaluated the yield of gen

81 HTBS recruits HIV reverse transcriptase, which nucleates DNA synthesis

82 The triphosphate (N-MCD4TTP) inhibits HIV reverse transcriptase with a 10-fold higher IC(50) t