ライフサイエンスコーパス: HMT

1 HMT altered the X-ray pattern from A+B-->A.

2 HMT clones expressing > or = 9-fold the parental levels

3 HMT used alone or in dual modifications promoted the str

4 zation, 28 patients were excluded leaving 47 HMT and 43 DUN long-term (55 +/- 35 months) evaluable pa

5 t E(z) protein was found to be inactive in a HMT assay.

6 we have gone on to test whether DmHMT-1, an HMT-1 from a new source, Drosophila, whose genome lacks

7 ly, G9a represses PPARgamma expression in an HMT activity-dependent manner but facilitates Wnt10a exp

8 This strategy, based at least in part on an HMT-dependent inhibitory histone code, imposes a require

9 phila ovary, and demonstrate in vivo that an HMT, the product of the eggless (egg) gene, is required

10 Using an HMT-modified TFO to direct ICLs to a specific site, we f

11 crease the peak viscosity of single ANN- and HMT-treated starches.

12 RIP140 serves as a scaffold for both DNA and HMT activities to inhibit gene transcription by two key

13 l gene expression profiles show that MMT and HMT are co-expressed in leaves, roots and reproductive t

14 MMT and HMT together have been proposed to constitute a futile S

15 The oxidised and HMT starches had lower viscosity and swelling power comp

16 The films made of native, oxidised and HMT starches were characterised by thickness, water solu

17 ots and developing seeds all express MMT and HMTs, and can metabolize [35S]Met to [35S]SMM and vice v

18 these treatments (ANN-HMT, ANN-SNT, HMT-ANN, HMT-SNT, SNT-ANN, SNT-HMT).

19 The ANN, HMT and SNT did not provide visible cracks, notches or g

20 ed by a combination of these treatments (ANN-HMT, ANN-SNT, HMT-ANN, HMT-SNT, SNT-ANN, SNT-HMT).

21 ong SET domain proteins known to function as HMTs (reviewed in ).

22 ly binds HCF-1 associated with the Set1/Ash2 HMT complex in the absence of the Sin3 HDAC complex.

23 The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the

24 We discuss how an autosomally associated HMT may participate in silencing genes on the X chromoso

25 adjusting the moisture content to 25% before HMT (100 degrees C, 1h).

26 show that ZFPs linked to a minimal catalytic HMT domain affect local methylation of histone H3K9 and

27 2) derived from phenotypically normal cells (HMT-3522) and led to growth arrest in a three-dimensiona

28 human tumorigenic mammary epithelial cells, HMT-3522-T4-2, with those of their immediate premalignan

29 in vivo role of the Saccharomyces cerevisiae HMT, Set2.

30 WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC

31 In contrast, HMT-d(CCGGTACCGG) forms a sequence-dependent junction.

32 ance in C. elegans demonstrate PC-dependent, HMT-1-mediated heavy metal detoxification not only in S.

33 scherichia coli yagD mutant and by detecting HMT activity in complemented cells.

34 tural reorganisation of starch chains during HMT temperature was influenced by starch chain flexibili

35 sistently, deletion of G9a or inhibiting G9a HMT activity promotes adipogenesis.

36 Silencing H3K9 HMT, but not H3K27 HMT, impaired oligodendrocyte differentiation and functi

37 methyltransferases (H3K9 HMT), but not H3K27 HMT, increased more prominently upon exposure to oligode

38 s to Saccharomyces cerevisiae Set2, an H3K36 HMT that prevents the ectopic initiation of transcriptio

39 HP1 and the NuRD complex act with this H3K36 HMT to prevent ectopic transcriptional initiation.

40 hus distinguishing it from other known H3K36 HMTs.

41 met-2 is homologous to human SETDB1, an H3K9 HMT that represses transcription.

42 nd activity of H3K9 methyltransferases (H3K9 HMT), but not H3K27 HMT, increased more prominently upon

43 Silencing H3K9 HMT, but not H3K27 HMT, impaired oligodendrocyte differe

44 Chp1 and Clr4 (H3K9-HMT), bind transcriptionally active heterochromatin, whe

45 ts should be treated with hemithyroidectomy (HMT) or with a more extensive procedure.

46 ologically, impairment of KLF11-mediated HP1-HMT recruitment abolishes tumor suppression, providing d

47 increasing the specificity of targeting HP1-HMT complexes to gene promoters.

48 pression, providing direct evidence that HP1-HMTs act in a sequence-specific manner to achieve this f

49 The recruitment of the hSETD1A HMT complex confers promoter-associated H3K4me3 that lea

50 )CH(2))(3)N]Mo(NH(3))][BAr'(4)] (Ter = HTBT, HMT, or pBrHIPT and Ar' = 3,5-(CF(3))(2)C(6)H(3))).

51 systemically delivered doxycycline hyclate (HMT; 20 mg, twice a day) plus locally delivered doxycycl

52 In HMT-3522 cells, the bulk of AZU-1 protein resided in a d

53 ltransferases (HMTs) and its applications in HMT drug discovery, including analyzing the activity of

54 Overexpression of the DG cDNA in HMT-3522-T4-2 cells elevated alpha-DG levels and altered

55 e (9.2 vs 1.8%, P = 0.2) were more common in HMT, mostly because of undiagnosed cancer requiring comp

56 dium dodecyl sulfate (SDDS) were observed in HMT samples.

57 r MyoD in proliferating muscle cells and its HMT activity, which is associated with MyoD, diminishes

58 ne expression and this property required its HMT activity.

59 y unliganded TR and in so doing requires its HMT activity.

60 Another H3-K27 HMT functions in adult somatic cells, oocytes, and the P

61 we show that the histone 3/lysine 4 (H3/K4) HMT and the transcriptional regulator MLL associate with

62 endogenous PTIP associates with a Set1-like HMT complex of unique subunit composition.

63 omplex that is shared by all human Set1-like HMT complexes.

64 Rap1 activity in malignant HMT-3522 T4-2 cells is appreciably higher than in S1 cel

65 that MES-4 has histone H3 methyltransferase (HMT) activity in vitro, and is required for histone H3K3

66 and inhibits the MLL H3K4 methyltransferase (HMT) activity with an IC50 value of 12.7 nM.

67 o identify native histone methyltransferase (HMT) activities from Saccharomyces cerevisiae.

68 ains, has similar histone methyltransferase (HMT) activity, and belongs in the same phylogenetic subg

69 possess intrinsic histone methyltransferase (HMT) activity.

70 a small number of histone methyltransferase (HMT) and histone demethylase (HDM) enzymes as regulators

71 , methylated by a histone methyltransferase (HMT) and then bound by a chromodomain-containing protein

72 ts of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY

73 hanges in cognate histone methyltransferase (HMT) complexes on the Il12p35 and Il12p40 promoters.

74 a core subunit of histone methyltransferase (HMT) complexes.

75 c deletion of the histone methyltransferase (HMT) Ezh2 from all retinal progenitors resulted in progr

76 repression of the histone methyltransferase (HMT) G9a has recently been implicated in transcriptional

77 nesis regulators, histone methyltransferase (HMT) G9a-mediated repressive epigenetic mark H3K9me2 is

78 d inactivation of histone methyltransferase (HMT) multiple myeloma SET domain (MMSET) in mouse B cell

79 MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)+ multiple myeloma (MM) pat

80 Histone methyltransferase (HMT)(1) class enzymes that methylate lysine residues of

81 an H3-K9-specific histone methyltransferase (HMT), SUV39H1.

82 related Set1/Ash2 histone methyltransferase (HMT).

83 e of plants, homocysteine methyltransferase (HMT) catalyzes the formation of two molecules of methion

84 talyzed by homocysteine S-methyltransferase (HMT).

85 lysine-9 (H3-K9) specific methyltransferase (HMT) that is associated with gene silencing through chro

86 > Met reaction (SMM:Hcy S-methyltransferase, HMT) were identified by homology and authenticated by co

87 etylases (HDAC), histone methyltransferases (HMT) and histone demethylases.

88 (TrxG) family of histone methyltransferases (HMT) that methylate H3K4 at promoters of active genes.

89 ward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methyl

90 ection assay for histone methyltransferases (HMTs) and its applications in HMT drug discovery, includ

91 A number of histone methyltransferases (HMTs) are known to influence telomeric chromatin status;

92 Histone methyltransferases (HMTs) catalyze the S-adenosylmethionine (AdoMet)-depende

93 out the roles of histone methyltransferases (HMTs) in the establishment of heterochromatin, little is

94 embly of DNA and histone methyltransferases (HMTs) on the Ucp1 enhancer and leads to methylation of s

95 ts of inhibitory histone methyltransferases (HMTs) to impose gene-specific gatekeeper functions that

96 ta in recruiting histone methyltransferases (HMTs) to specific gene targets, such as Hoxc8.

97 mia (MLL) family histone methyltransferases (HMTs), revealing a unique regulatory feature for the MLL

98 eracting to H3K9 histone methyltransferases (HMTs), such as SUV39H1, which methylate this residue on

99 teins are histone lysine methyltransferases (HMTs) that play essential roles in development.

100 ses [HDACs], and histone methyltransferases [HMTs]), evidence points to the use of chromatin remodele

101 oped and optimized a new AlphaLISA-based MLL HMT functional assay to facilitate the functional evalua

102 modified by annealing (ANN), heat-moisture (HMT) or sonication (SNT) treatments.

103 rived from cells transfected with DNA MTase (HMT) expressed 1- to 50-fold the level of DNA MTase prot

104 homologs regulate vulval development, but no HMT is known to act in this process.

105 cation and characterization of Set2, a novel HMT that is site-specific for lysine 36 (Lys36) of the H

106 say allows rapid and facile determination of HMT kinetics and can be adapted to measure the enzymatic

107 our current understanding of the function of HMT-1 proteins and invoke a PC-independent role for thes

108 ar structure of starch during the process of HMT was suggested.

109 rch content decreased at all temperatures of HMT, whereas resistant starch content increased at HMT80

110 se proteins are members of a small family of HMTs that contain bifurcated SET domains.

111 nse interest in elucidating the functions of HMTs in transcriptional regulation, these enzymes have r

112 ns, selectivity profiling against a panel of HMTs, and studying mode of action of select hits.

113 Thirty percent of HMTs developed hypothyroidism and required long-term T4

114 on, little is known about the recruitment of HMTs to regulatory regions of chromatin.

115 To investigate the role of HMTs and specifically H3K9 methylation in gene repressio

116 Most of our knowledge of the role of HMTs in trimethylating lysine 4 of histone H3 (H3K4me3)

117 To characterize the substrate specificity of HMTs, we have developed a coupled-fluorescence-based ass

118 Structural changes on HMT were monitored by microscopy, HPAEC-PAD, ATR-FTIR, W

119 rystallites and acid hydrolysis decreased on HMT.

120 s it decreased slightly in other starches on HMT.

121 bution remained unchanged in all starches on HMT.

122 drothermal modifications followed the order: HMT>dual modifications>ANN.

123 ut the mechanism by which ATX1, or any other HMT of plant origin, affects transcription.

124 Plant HMT is known to transfer the pro-R methyl group of SMM.

125 methyl-p-terphenyl polymethylbenzimidazoles (HMT-PMBI), charge balanced by hydroxide ions (IEC from 2

126 lycomb repressive complex (PRC) 2, possesses HMT activity with specificity for Lys 9 (K9) and Lys 27

127 of their immediate premalignant progenitors, HMT-3522-S2.

128 We surveyed all 38 putative HMT genes in C. elegans and identified met-1 and met-2 a

129 hin a reconstituted basement membrane (rBM), HMT-3522 cells form polarized and growth-arrested tissue

130 ared with 64.9 months for those who received HMT ( P < .001).

131 dian PFS was superior for those who received HMT (81.1 v 30.0 months; P < .001 and 38.1 v 15.2 months

132 o IV low-grade serous carcinoma who received HMT after primary treatment had significantly longer PFS

133 Women who received HMT had a significantly lower risk of disease progressio

134 ts-133 who underwent OBS and 70 who received HMT-were seen at our institution.

135 PTIP complex carries robust HMT activity and specifically methylates lysine 4 (K4) o

136 ANN-treated starches and decreased in single HMT- and SNT-treated starches.

137 ation of these treatments (ANN-HMT, ANN-SNT, HMT-ANN, HMT-SNT, SNT-ANN, SNT-HMT).

138 HMT, ANN-SNT, HMT-ANN, HMT-SNT, SNT-ANN, SNT-HMT).

139 Combination therapy, including SRP, HMT, and TAT, provided significantly greater clinical be

140 valuate a combination therapy involving SRP, HMT, and TAT in the treatment of moderate to severe CP.

141 In all starches, HMT increased crystallinity and gelatinisation temperatu

142 inger transcription factors (ZFPs) to target HMT activity to a specific endogenous gene.

143 udies in C. elegans, however, suggested that HMT-1 and PCS-1 do not necessarily act in concert in met

144 covery and with our previous suggestion that HMT-1 and PCS-1 do not operate in a simple linear metal

145 The HMT (18%-60min) promoted an increase in resistant starch

146 The HMT activity of PRC2 is dependent on an intact SET domai

147 The HMT activity of the MES complex appears to be dependent

148 The HMT model can be initialized to learn a user-defined num

149 The HMT promoted a reduction of the amylose content, the swe

150 The HMT starch increased the tensile strength and WVP of the

151 The HMT-adduct of d(CCGCTAGCGG) forms a psoralen-induced Hol

152 increase in resistant starch content and the HMT (16%-60min) caused an increase in the slowly digesti

153 Our findings suggest a role for the HMT MMSET in promoting AID-mediated DNA breaks during CS

154 In the HMT clones, methylation reached nearly 100% at susceptib

155 xamined 12 endogenous CpG island loci in the HMT clones.

156 Constraining the directionality in the HMT model leads to a reduction in precursor diversity fo

157 The full posterior of the HMT parameters is determined and the underflow problems

158 ule ATP-binding cassette transporters of the HMT-1 (heavy metal tolerance factor 1) subfamily are req

159 t of this repression is mediated through the HMT activity of the SET domain.

160 e crucial to the control of flux through the HMT reaction and the SMM cycle.

161 hermore, amino acid substitutions within the HMT that ablate its catalytic activity effectively elimi

162 ssociated with hormonal maintenance therapy (HMT) compared with routine observation (OBS) after prima

163 studies showed that host modulation therapy (HMT) or topical antimicrobial therapy (TAT) provided sig

164 maize have one MMT gene, and at least three HMT genes that belong to two anciently diverged classes

165 3 years) were included and randomized: 65 to HMT and 53 to DUN.

166 d on neck ultrasonography were randomized to HMT or Dunhill (DUN).

167 DUN appears superior to HMT for the treatment of AMG in terms of early reoperati

168 of Suvar39h, the histone methyl transferase (HMT) responsible for heterochromatic H3-K9 trimethylatio

169 n [PB]) starches were heat-moisture treated (HMT) at 80, 100 and 120 degrees C for 12h at a moisture

170 native, oxidised and heat-moisture treated (HMT) starches were evaluated.

171 to 18.5-23.9% after heat-moisture treatment (HMT) and to 19.5-26.9% after annealing treatment (ANN).

172 the effects of the heat-moisture treatment (HMT) applied to paddy rice grains on the physicochemical

173 zers applied during heat-moisture treatment (HMT) on the properties of canna starch were investigated

174 ostly influenced by Heat-moisture treatment (HMT).

175 s (VBEMS) algorithm for hidden Markov trees (HMT) is proposed for incomplete tree structured data.

176 ine learning method for Hidden Markov Trees (HMTs), which can be applied to large datasets to classif

177 d 4'-hydroxymethyl-4,5',8-trimethylpsoralen (HMT) and scored for normal passage into mitosis.

178 4'-(hydroxymethyl)-4,5',8-trimethylpsoralen (HMT) ICLs by the UvrABC nuclease.

179 y 4'-hydroxymethyl-4,5',8-trimethylpsoralen (HMT).

180 4'-(hydroxymethyl)-4,5',8-trimethylpsoralen (HMT).

181 ed event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expr

182 s association of ATP-remodeling factors with HMT CARM1 defines a new component of regulation in the n

183 ability to utilize AdoMet or SMM to a yeast HMT mutant.