ライフサイエンスコーパス: HNF-3alpha

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1 HNF-3alpha does not appear to act as a classic biochemic

2 HNF-3alpha. and HFH-8 inhibited the activation of TTF-1-

3 The hepatocyte nuclear factor 3alpha (HNF-3alpha) and 3beta proteins have homology in the wing

4 TTF-1) and hepatocyte nuclear factor 3alpha (HNF-3alpha) binding sites, two spatially separate DNA se

5 1 (TTF-1), hepatocyte nuclear factor 3alpha (HNF-3alpha), and HNF-3beta regulate the transcription of

6 vity suggesting that Sp1, Sp3, and TTF-1 and HNF-3alpha interact cooperatively with SP-B promoter to

7 Mice lacking one or both HNF-3alpha alleles also show impaired insulin secretion

8 died in embryoid bodies in which one or both HNF-3alpha or HNF-3beta alleles were inactivated.

9 Regulation of HNF-4/HNF-1 expression by HNF-3alpha and HNF-3beta was studied in embryoid bodies

10 h HNF-3beta, activated to a lesser extent by HNF-3alpha, but not activated by HFH-8.

11 In contrast, HNF-3alpha acts as a negative regulator of HNF-4alpha/HN

12 peat DNA polymorphisms in the genes encoding HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 and the map

13 Foxa1, 2 and 3 (formerly HNF-3alpha, -beta and -gamma) constitute a sub-family of

14 HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with o

15 ctor-3/forkhead) proteins but different from HNF-3alpha or HNF-3beta.

16 Hypoglycemia in HNF-3alpha-null mice leads to physiological counter-regu

17 FH-11 expression and reciprocal increases in HNF-3alpha and HNF-3beta mRNA levels.

18 g pancreatic alpha cells develop normally in HNF-3alpha-/- mice, but proglucagon mRNA levels are redu

19 e of HNF-3alpha, we generated mice that lack HNF-3alpha by homologous recombination in embryonic stem

20 e hepatic expression of the endogenous mouse HNF-3alpha,-3beta, -3gamma, and -6 transcription factors

21 F-3beta was also necessary for expression of HNF-3alpha.

22 actor binding protein-1, and hexokinase I of HNF-3alpha-null mice.

23 ortly after birth, implying a direct role of HNF-3alpha in the expression of these genes.

24 To study the physiological role of HNF-3alpha, we generated mice that lack HNF-3alpha by ho

25 FoxA1 and FoxA2 (previously HNF-3alpha and HNF-3beta) are Forkhead Box transcription

26 of HNF-4alpha/HNF-1alpha demonstrating that HNF-3alpha and HNF-3beta have antagonistic transcription

27 Our results indicate that HNF-3alpha plays a critical role in the regulation of gl

28 In this study, we show that HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 are express

29 In addition, the HNF-3alpha/HNF-3beta ratio is modulated by the presence

30 he clara cell secretory protein gene and the HNF-3alpha gene, a winged helix family member involved i

31 Mice homozygous for a null mutation in the HNF-3alpha gene develop a complex phenotype that is char

32 how that HFH-4 potentiates expression of the HNF-3alpha and clara cell secretory protein promoter reg

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