ライフサイエンスコーパス: HNF-3beta

1 HNF-3beta positively regulated the expression of HNF-4al

2 HNF-3beta was also necessary for expression of HNF-3alph

3 In addition, the HNF-3alpha/HNF-3beta ratio is modulated by the presence of insulin,

4 identified hepatocyte nuclear factor 3beta (HNF-3beta), a liver-enriched member of the HNF-3/forkhea

5 , including hepatocyte nuclear factor 3beta (HNF-3beta), HNF-6alpha, CCAAT/enhancer binding protein a

6 o mammalian hepatocyte nuclear factor 3beta (HNF-3beta), the secretory primordia are not internalized

7 actor-1 and hepatocyte nuclear factor 3beta (HNF-3beta).

8 sion of the hepatocyte nuclear factor-3beta (HNF-3beta) protein was used to assess its role in hepato

9 t expressed hepatocyte nuclear factor-3beta (HNF-3beta), GATA4, cytokeratin 19 (CK19), transthyretin,

10 ion factor, hepatocyte nuclear factor-3beta (HNF-3beta), mediates the hepatocyte-specific transcripti

11 usly called hepatocyte nuclear factor 3beta [HNF-3beta]), which caused diminished hepatocyte glycogen

12 ding sites with the more efficient activator HNF-3beta.

13 dgehogs in intestinal epithelial cells in an HNF-3beta (Foxa2)-dependent fashion.

14 HNF-1alpha demonstrating that HNF-3alpha and HNF-3beta have antagonistic transcriptional regulatory f

15 n and reciprocal increases in HNF-3alpha and HNF-3beta mRNA levels.

16 of HNF-4/HNF-1 expression by HNF-3alpha and HNF-3beta was studied in embryoid bodies in which one or

17 FoxA1 and FoxA2 (previously HNF-3alpha and HNF-3beta) are Forkhead Box transcription factors that p

18 cyte nuclear factor 3alpha (HNF-3alpha), and HNF-3beta regulate the transcription of genes expressed

19 In non-hepatic CV-1 cells, HNF-4 and HNF-3beta activated this minimal enhancer synergisticall

20 ergistic relationships with HNF-1, HNF-4 and HNF-3beta and with C/EBPbeta.

21 the differential regulation of genes such as HNF-3beta, Pax3, Pax6 and snail.

22 ity involves a cooperative interplay between HNF-3beta and at least one other enhancer 1-binding prot

23 l embryos at days 7.5 and 8.5 expressed both HNF-3beta and Brachyury in a pattern similar to those of

24 istochemical staining demonstrated that both HNF-3beta and TTF-1 were detected in bronchiolar and alv

25 ibited the activation of TTF-1-luciferase by HNF-3beta.

26 lyses was used to demonstrate that the Ciona HNF-3beta homologue is expressed in the ventralmost epen

27 nsfection of an expression vector containing HNF-3beta coding sequence increases the expression of th

28 educed HNF-6 levels contribute to diminished HNF-3beta-specific transcriptional activity.

29 e for the lung-specific transcription factor HNF-3beta and an E-box element in the distal enhancer ad

30 The winged-helix transcription factor HNF-3beta has been implicated in the regulation of expre

31 activity of the hepatocyte-enriched factors HNF-3beta and HNF-4, two transcription factors essential

32 elements that recognize the nuclear factors HNF-3beta and BETA-2.

33 t distinct from the cognate binding site for HNF-3beta, a more distantly related winged-helix protein

34 d helix transcription factor Foxa2 (formerly HNF-3beta) in the pancreatic primordium during midgestat

35 d helix transcription factor Foxa2 (formerly HNF-3beta) is a major upstream regulator of Pdx1, a home

36 rkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha)

37 g a TATA box, and putative interferon-gamma, HNF-3beta and AP1 sites.

38 patterns of gene expression (e.g. goosecoid, HNF-3beta, Sonic hedgehog) and, most importantly, by its

39 chromatin immunoprecipitation analysis, less HNF-3beta was recruited to the apo A-I promoter in DHA-t

40 DHA or PA had a similar nuclear abundance of HNF-3beta.

41 f DNA did not affect simultaneous binding of HNF-3beta and HNF-4 nor did it influence their functiona

42 mobility shift assays showed less binding of HNF-3beta to the -180 to -140 sequence of the apo A-I pr

43 oma HepG2 cells, DHA inhibits the binding of HNF-3beta to the apo A-I promoter, resulting in the repr

44 f an interference of DHA with the binding of HNF-3beta to the apo A-I promoter.

45 ion may result from the disruptive effect of HNF-3beta on the hepatic expression of the endogenous mo

46 RNA in situ analyses of the expression of HNF-3beta and Brachyury, two molecular markers for gastr

47 Here we analyze the expression of HNF-3beta and snail homologues in the ascidian, Ciona in

48 The patterns of expression of HNF-3beta and Sonic hedgehog are also restored, as is th

49 ous studies we increased liver expression of HNF-3beta by using either transgenic mice (transthyretin

50 order to examine the regulatory function of HNF-3beta, we created transgenic mice in which the -3-kb

51 to those reported for knockout mutations of HNF-3beta in the mouse, suggesting that HNF-3/forkhead g

52 Overexpression of HNF-3beta suppressed glucocorticoid receptor-mediated in

53 However, the in vivo role of HNF-3beta in regulating these genes remains unknown beca

54 id bodies in which one or both HNF-3alpha or HNF-3beta alleles were inactivated.

55 d) proteins but different from HNF-3alpha or HNF-3beta.

56 or as the forkhead protein Foxa2 (previously HNF-3beta).

57 n 1), C/EBP (CCAAT/enhancer binding protein)/HNF-3beta (hepatocyte nuclear factor 3) and AP-1(activat

58 of ventral neural tube markers such as Ptc, HNF-3beta, and Shh; to the suppression of dorsal markers

59 injections of adenovirus expressing the rat HNF-3beta (AdHNF3beta) cDNA efficiently increased its le

60 to increase hepatocyte expression of the rat HNF-3beta protein.

61 n most similar to zebrafish axial and rodent HNF-3beta.

62 Additional evidence indicates that HNF-3beta and PBF cooperatively interact with enhancer 1

63 MODY genes, suggesting that mutations in the HNF-3beta gene (HNF3B) may also cause MODY.

64 ent the first in vivo demonstration that the HNF-3beta transcriptional network regulates expression o

65 using either transgenic mice (transthyretin HNF-3beta) or recombinant adenovirus infection (AdHNF3be

66 , a cellular protein(s) that copurified with HNF-3beta specifically interacts with a novel sequence m

67 tructs were activated by cotransfection with HNF-3beta, activated to a lesser extent by HNF-3alpha, b

68 iferase constructs after cotransfection with HNF-3beta.

69 ss STF-1 gene expression by interfering with HNF-3beta activity on the islet-specific enhancer.