ライフサイエンスコーパス: HRV

1 HRV accumulation and replication inside the B lymphocyte

2 HRV infection and RV enterotoxin treatment of HIEs cause

3 HRV infection induces the phosphorylation of PKD, and in

4 HRV infection of LAD2 MCs induced expression of IFN-beta

5 HRV infection was significantly more common among infant

6 HRV is the causative agent of the common cold, which in

7 HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA175

8 HRV was the most common virus identified at recruitment

9 HRV, found in most of the children at the time of their

10 HRV-C is not a new virus but has been significantly asso

11 HRV-C, compared with any other virus, was associated wit

12 HRV-C-related wheezing illnesses were associated with an

13 HRV-conditioned medium was chemotactic for fibroblasts.

14 HRVs infect at higher rates and grow to higher titers th

15 HRVs infect differentiated enterocytes and enteroendocri

16 HRVs remain a major worldwide cause of diarrhea-associat

17 HRVs were less likely than DNA viruses to be codetected

18 mon cold virus (human rhinovirus serotype 2, HRV-A2) and (ii) the analysis of subviral HRV-A2 particl

19 ants were age-eligible for vaccination in 71 HRV villages, and 5,791 in 71 non-HRV villages.

20 protection by the current monovalent G1P[8] HRV vaccine against emerging G9 strains should be evalua

21 acing the natural furin cleavage site with a HRV 3C protease site, we show how the protein gains its

22 Little is known about HRVs, as they generally replicate poorly in transformed

23 ned whether changes in cardiac ANS activity (HRV) during a daytime nap were related to performance on

24 After HRV challenge, RB-fed pigs had significantly lower ileal

25 Early after HRV infection, low levels of type III IFN protein activa

26 ighly effective therapeutic approach against HRV and potentially a variety of other diarrhea-inducing

27 a, but not IFN-lambda, protected MCs against HRV infection.

28 ignalling offered limited protection against HRV.

29 All HRV species were represented among 138 children with ARI

30 Although HRV 3A was previously shown to interact with ACBD3, our

31 strate a clear difference between HRV 14 and HRV 16 and the source of PBMCs, in up or down regulation

32 were markedly lower than titers to HRV-A and HRV-B in both asthmatic and nonasthmatic children (P < .

33 states of stress vs. health, HR control, and HRV, and more importantly, the physiologic requirements

34 ant associations between these cytokines and HRV (p < 0.05), and IQR increases in BDNF and CRP were a

35 lation between influenza virus detection and HRV detection.

36 ep features (model 1) vs. sleep features and HRV during sleep (model 2).

37 for interactions between 17q21 genotypes and HRV and RSV wheezing illnesses with respect to the risk

38 HR and HRV were similar in patients across groups.

39 Echocardiography, blood pressure and HRV were examined.

40 s were used to test associations of PTSD and HRV between and within twin pairs.

41 k In Communities) cohort with heart rate and HRV measures obtained from 2-min electrocardiogram recor

42 -mediated QTc prolongation, HR reduction and HRV increase otherwise masked by sedation.

43 interference, we evaluated cases of RSV and HRV codetection by polymerase chain reaction in 2 prospe

44 s, 24.5% (798) and 37.3% (1216) were RSV and HRV positive, respectively.

45 ns, and the link between allergic status and HRV responsiveness, remains incompletely understood.

46 xpression of 17q21 genes in unstimulated and HRV-stimulated peripheral-blood mononuclear cells (PBMCs

47 of asthmatic children and their higher anti-HRV-A and -B titers show their development of a heighten

48 tify a novel host target as a potential anti-HRV therapy.

49 The higher total anti-HRV antibody titers of asthmatic children and their high

50 ction of gastrointestinal infections such as HRV infection.

51 D at baseline (1987-1989) and with available HRV data (mean age = 54 years, 57% women).

52 ily on the use of animal rotaviruses because HRV growth is limited in most transformed cell lines and

53 tudy sought to study the association between HRV and risk of AF.

54 sults demonstrate a clear difference between HRV 14 and HRV 16 and the source of PBMCs, in up or down

55 inhibitors of this kinase effectively block HRV replication at an early stage of the viral life cycl

56 ntributors to fibroblast migration caused by HRV-conditioned medium.

57 dominant transcriptional pathway induced by HRV infection is a type III IFN-regulated response.

58 attern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma.

59 emonstrate that similar to epithelial cells, HRVs induce the production of pro-inflammatory cytokines

60 is the serotype most widely used in clinical HRV challenge studies; consequently, to address the issu

61 The clinical, HRV, and EEG parameters of postcatheterization EEG alpha

62 ne cells to infection by G9 and other common HRV/PRV genotypes.

63 RV replication because replication-competent HRV antagonizes the type III IFN response at pre- and po

64 eart rate data were analyzed by conventional HRV and heart rhythm complexity analysis including detre

65 The conventional HRV parameters did not change.

66 The conventional HRV parameters were comparable between PA and EH patient

67 In this prospective cohort, decreased HRV was associated with an increased risk of PD.

68 her cytokines were associated with decreased HRV, but additional human and potential mechanistic stud

69 pattern recognition receptors (PRRs) detect HRV replication products that are generated within the c

70 yte-derived dendritic cells (MoDCs) than did HRV Wa G1P[8].

71 riation in disease associated with different HRV species including variation in their link to asthma

72 elderly people with coronary artery disease, HRV was not associated with exposure in most of our part

73 among 138 children with ARI, and 74 distinct HRV types were cocirculating.

74 ducing nAb responses to numerous and diverse HRV types.

75 The two-dose HRV rotavirus vaccination program significantly reduced

76 l-like receptor 3, CNTO3157, on experimental HRV-16 inoculation in healthy subjects and asthmatic pat

77 rs specific to HRV-A, and to a lesser extent HRV-B, were higher than in nonasthmatic controls.

78 ely associated with specific, more favorable HRV indices, including higher 24-hour standard deviation

79 at least 4 cycles lower than the HRV CT for HRV-positive samples or any EV-D68 CT value for HRV-nega

80 Significant genetic correlation is found for HRV with heart rate (-0.74<rg<-0.55) and blood pressure

81 However, LAD2 MCs were permissive for HRV replication and release of infectious HRV particles.

82 -positive samples or any EV-D68 CT value for HRV-negative samples.

83 Fourth, HRV genome replication was reduced in HAP1 cells in whic

84 investigate whether conditioned medium from HRV-infected epithelial cells can trigger directed migra

85 CXCL10 and CXCL8 produced from HRV-infected epithelial cells are chemotactic for fibrob

86 Furthermore, HRV was associated with activity patterns in the ventrom

87 y be the optimal molecular method for future HRV quantification studies and for quantitating other vi

88 In this randomized trial in rural Ghana, HRV was administered at ages 6 and 10 weeks (group 1), 1

89 mains by testing the hypothesis that greater HRV would be associated with better dietary self-control

90 sociated with asthma in children who had had HRV wheezing illnesses and with expression of two genes

91 thma were restricted to children who had had HRV wheezing illnesses, resulting in a significant inter

92 rophylaxis might increase the risk of having HRV infection.

93 HF-HRV was assessed at rest and during a cognitive task pro

94 between ADSCT and both HF-HRV at rest and HF-HRV reactivity.

95 ated relationships between ADSCT and both HF-HRV at rest and HF-HRV reactivity.

96 gnitive task protocol designed to capture HF-HRV reactivity.

97 Higher HF-HRV at rest was significantly related to both more sever

98 re also related to greater suppression of HF-HRV reactivity.

99 S (high frequency heart rate variability; HF-HRV).

100 self-control, with individuals having higher HRV being better able to downregulate their cravings in

101 Specifically, higher HRV was associated with more effective downregulation of

102 We found that higher HRV was associated with better self-control and improved

103 Specifically, individuals with higher HRV showed both higher overall vmPFC blood-oxygen-level-

104 of both physical activity and 24-hour Holter HRV over 5 years among 985 older US adults in the commun

105 ificantly decreased blood pressure, improved HRV and LV function, decreased cardiac MDA, TNF-alpha an

106 In HRV villages, 4,808 (73.7%) infants received at least on

107 role of autonomic nervous system balance in HRV patterns, the responsible deeper physiological, clin

108 first evidence of a ventilatory component in HRV similar to mammalian respiratory sinus arrhythmia in

109 nd CRP were associated with >8% decreases in HRV.

110 ed a reduction in mean HR and an increase in HRV over 24h at 10 dpa, accompanied by QT prolongation a

111 ages compared to 2.8 per 100 person-years in HRV villages, indicating an overall effectiveness of 29.

112 howed that a monovalent formalin-inactivated HRV vaccine can be protective, and virus-neutralizing an

113 virus input titres in polyvalent inactivated HRV vaccine may result in broad nAb responses.

114 es can be induced by polyvalent, inactivated HRVs plus alhydrogel (alum) adjuvant.

115 lterations in heart rate dynamics, including HRV and complexity.

116 or HRV replication and release of infectious HRV particles.

117 try was employed to obtain spectra of intact HRV-A2 virions and empty viral capsids (B-particles).

118 with significantly reduced small intestinal HRV IgA Ab responses in EcN-colonized compared with unco

119 MCs) were infected with HRV or UV-irradiated HRV at increasing multiplicities of infection (MOI) with

120 e study of complex biological phenomena like HRV requires a framework which facilitates inclusion of

121 or deployment-related combat exposure, lower HRV before deployment as measured by an increased low-fr

122 nt in mice and 50-valent in rhesus macaques, HRV vaccine immunogenicity was related to sufficient qua

123 However, co-circulation of many HRV types discouraged further vaccine efforts.

124 minute electrocardiogram was used to measure HRV.

125 We measured HRV and arrhythmia with ambulatory electrocardiograms in

126 e greater effectiveness of EcN in moderating HRV infection may also be explained by the binding of Ec

127 y cells that detect and are utilized by most HRV group A and B, but not C serotypes are known, how en

128 exposure was inversely associated with most HRV frequencies, but this association mostly diminished

129 d dose of human rotavirus vaccine (HRV; MR + HRV), compared with MR given alone.

130 ting rotavirus IgA/IgG seroresponses in MR + HRV recipients.

131 s after vaccination, 75.3% and 74.3% of MR + HRV and MR recipients, respectively, had seroprotective

132 In the MR + HRV group, antirotavirus immunoglobulin A and IgG seropo

133 tion in 71 HRV villages, and 5,791 in 71 non-HRV villages.

134 D was 4.10 cases per 100 person-years in non-HRV villages compared to 2.8 per 100 person-years in HRV

135 time-domain, frequency-domain, and nonlinear HRV measures in older adults.

136 However, the ability of HRV infections to trigger exacerbations, and the link be

137 ly affected by concomitant administration of HRV.

138 ding to HRV viral capsid protein antigens of HRV-A, -B, and -C were tested in the plasma from nonasth

139 we demonstrate a strong and quick binding of HRV types 16 and 1B to monocytes, and slower interaction

140 However, the sequence diversity of HRV genotypes poses challenges for developing robust mol

141 A third dose of HRV resulted in increased seroconversion frequencies and

142 73.7%) infants received at least one dose of HRV.

143 lternative schedules and additional doses of HRV have been proposed and may improve vaccine performan

144 Surveillance System to include two doses of HRV with the standard infant vaccines at 6 and 10 wk of

145 was ineffective in attenuating the effect of HRV-16 challenge on lung function, asthma control, and s

146 acilities, we evaluated the effectiveness of HRV against acute diarrhea associated with enterotoxigen

147 The total effectiveness of HRV against ARD among vaccinees was 41.4% (95% CI, 23.2%

148 The clinical features of HRV infection and its association with asthma exacerbati

149 rease in the high-frequency (HF) fraction of HRV in the presence of propranolol, and a decrease in ex

150 Frequency-domain measures of HRV were generated.

151 ficacy in a gnotobiotic (Gn) piglet model of HRV diarrhea.

152 The odds of HRV infection were significantly lower in RSV-infected i

153 ation was prevented, even in the presence of HRV.

154 ures that recapitulate in vivo properties of HRV infection.

155 primers and probes for the quantification of HRV, RT-dPCR outperformed RT-qPCR by consistently and ac

156 idence intervals (CIs) of PD by quartiles of HRV measurements.

157 equency (LF) to high-frequency (HF) ratio of HRV was associated with risk of PTSD diagnosis after dep

158 e events were identified among recipients of HRV, but none were considered related to receipt of stud

159 obe set targeting the 5' noncoding region of HRV.

160 ermissive for the replication and release of HRV, which is prevented by exogenous IFN-beta treatment.

161 mutant MDA5, showed increased replication of HRV but not influenza or RSV.

162 all molecules can inhibit the replication of HRV, PV, and FMDV, and therefore, PKD may represent a no

163 this manuscript, we investigated the role of HRV on alternans formation in isolated cardiac myocytes

164 bronchial epithelium being the major site of HRV infection and replication.

165 ease season and severity based on species of HRV infection.

166 e valuable tools in physiological studies of HRV.

167 iological model that will allow the study of HRV biology, including host restriction, cell type restr

168 HIEs will allow the study of HRV biology, including human host-pathogen and live, att

169 onocytes and lymphocytes, and the ability of HRVs to induce the activation of in vitro-cultured human

170 i Nissle (EcN), and the resulting effects on HRV diarrhea, gut epithelial health, permeability and in

171 little is known about respiratory effects on HRV in lower vertebrates.

172 A negative association of RSV on HRV codetection was consistently observed across populat

173 erentiate EV-D68 from other enteroviruses or HRV, and improved rapid diagnostic tools are needed.

174 ng of EcN but not LGG to Wa HRV particles or HRV 2/4/6 virus-like particles but not 2/6 virus-like pa

175 Lower overall HRV as well as increased sympathetic/parasympathetic ton

176 Predeployment HRV was measured via finger photoplethysmography during

177 RB completely prevented HRV diarrhea in LGG+EcN colonized pigs.

178 Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1.

179 R by consistently and accurately quantifying HRV RNAs across more genotype groups, despite the presen

180 iption-digital PCR (RT-dPCR) for quantifying HRV RNA using genotype-specific primers and probes and a

181 bited eaters were characterised by a reduced HRV which was related to greater BG excursions (B = 0.40

182 Second, PKD inhibitors reduced HRV genome replication, protein expression, and titers i

183 subjects with MetS had significantly reduced HRV, including SDNN and pNN20 in time domain, VLF, LF an

184 It is not clear, however, whether reduced HRV before trauma exposure contributes to the risk for d

185 exposure substantially increases HR, reduces HRV, and increases WBC.

186 jects under 4 different inoculation regimes (HRV, RSV, H1N1, H3N2).

187 This raises the possibility that repeated HRV infections in childhood could contribute to the init

188 tion of epithelial chemoattractants required HRV replication.

189 Area 25 inactivation also increased resting HRV.

190 , this endogenous response does not restrict HRV replication because replication-competent HRV antago

191 ld-type but not knockdown of MDA5 restricted HRV infection while increasing IFN-stimulated gene expre

192 contrast, exogenous IFN treatment restricts HRV replication, with type I IFN being more potent than

193 Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIbeta to replication sites.

194 tions with asthma and with human rhinovirus (HRV) and respiratory syncytial virus (RSV) wheezing illn

195 syncytial virus (RSV) and human rhinovirus (HRV) are the most common viruses associated with acute r

196 fection of HeLa cells with human rhinovirus (HRV) induced the phosphorylation of PKD.

197 Human rhinovirus (HRV) infection is a common trigger for childhood wheezin

198 ations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are assoc

199 agent of the common cold, human rhinovirus (HRV) is the leading cause of human infectious disease.

200 ith different serotypes of human rhinovirus (HRV) is unclear.

201 atory samples positive for human rhinovirus (HRV) or negative for all respiratory viruses by a labora

202 Human rhinovirus (HRV) replication triggers exacerbation of asthma and cau

203 aused by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (

204 spiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83

205 Human rhinoviruses (HRV) comprise 3 species representing more than 150 genot

206 Human rhinoviruses (HRV) have been linked to the development of childhood as

207 Human rhinoviruses (HRVs) are a major trigger of asthma exacerbations, with

208 Human rhinoviruses (HRVs) are one of the main causes of virus-induced asthma

209 Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations.

210 m multiple individuals with human rotavirus (HRV) and assessed the host epithelial response by using

211 ran (RB) was able to reduce human rotavirus (HRV) diarrhea in gnotobiotic pigs.

212 patients are susceptible to human rotavirus (HRV) infection.

213 innate immune responses and human rotavirus (HRV) vaccine efficacy in a gnotobiotic (Gn) piglet model

214 act of commonly used probiotics on human RV (HRV) infection.

215 protection between this strain and human RV (HRV) Wa G1P[8] in gnotobiotic pigs.

216 ed and Repeated conditions, model 2 (sleep + HRV) predicted performance significantly better (73% and

217 n with asthma exacerbation suggest that some HRV disease results from virus-induced host immune respo

218 The low species-specific HRV-C titers found in all groups, even when the virus wa

219 2, HRV-A2) and (ii) the analysis of subviral HRV-A2 particles derived from such a preparation.

220 ysfunction denoted by low resting short-term HRV was associated with higher AF incidence.

221 l virus shedding and RV RNAemia in pigs than HRV Wa G1P[8] and generated complete short-term cross-pr

222 We found that HRV explained a significant portion of the individual va

223 We hypothesized that HRV-infected epithelial cells release chemoattractants t

224 Our results suggest that HRV may serve as an easily acquired, noninvasive, and lo

225 across experimental conditions suggests that HRV may serve as both a readily obtainable and robust bi

226 We prove with ISH that HRVs can enter B cells, form their viral replication cen

227 Importantly, we show that HRVs induce the proliferation of B cells, while the addi

228 results demonstrate for the first time that HRVs enter and form viral replication centers in B lymph

229 The HRV dose increases antirotavirus serum antibody titers a

230 a clinical trial dataset (N = 2302) for the HRV risk measure LF/HF (the ratio of low frequency to hi

231 A well-marked peak in the HRV signal matching lung inflation cycle was verified in

232 Overall effectiveness of the HRV vaccination program (primary objective) was measured

233 c risk scores account for 0.9 to 2.6% of the HRV variance.

234 py and detrended fluctuation analysis of the HRV were used to quantify nonstationary and nonlinear dy

235 eshold (CT) at least 4 cycles lower than the HRV CT for HRV-positive samples or any EV-D68 CT value f

236 We have previously shown that the HRV-C-specific antibody response is low in healthy adult

237 r convalescence were not associated with the HRV genotype detected during the exacerbation.

238 o monocytes, and slower interaction of these HRVs with CD4+ T cells, CD8+ T cells, and CD19+ B cells.

239 Third, HRV replication was significantly reduced in HeLa cells

240 of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ances

241 Thus, HRV represents a substantial health care and economic bu

242 s into the immune responses of the airway to HRV, focusing on neutrophilic inflammation that is a pot

243 adult sera and that most of the antibody to HRV-C is cross-reactive with HRV-A.

244 Total and specific IgG(1) binding to HRV viral capsid protein antigens of HRV-A, -B, and -C w

245 ovel mechanism whereby MCs may contribute to HRV-induced asthma exacerbations.

246 among older adults prospectively relates to HRV, including nonlinear indices of erratic sinus patter

247 evels of both genes increased in response to HRV stimulation, although the relative increase was not

248 The species-specific responses to HRV-C were markedly lower than titers to HRV-A and HRV-B

249 d Pellinos in the regulation of responses to HRV.

250 ic children had higher antibody responses to HRV.

251 The titers specific to HRV-A, and to a lesser extent HRV-B, were higher than in

252 igs are the only animal model susceptible to HRV diarrhea.

253 to HRV-C were markedly lower than titers to HRV-A and HRV-B in both asthmatic and nonasthmatic child

254 Specifically, we examined whether total HRV at sedentary rest (measured as the SD of normal-to-n

255 Using HRVs, including the Rotarix RV1 vaccine strain, and ARVs

256 r receipt of 2-dose human rotavirus vaccine (HRV) coincides with receipt of the first and second dose

257 and a third dose of human rotavirus vaccine (HRV; MR + HRV), compared with MR given alone.

258 ose schedule of the human rotavirus vaccine (HRV; Rotarix) given early at 6 and 10 wk of age.

259 such as heart rate (HR) and HR variability (HRV), and cardiac cycle phase shifts triggered by the pr

260 Conventional heart rate variability (HRV) analysis, and complexity index (CI1-20) calculated

261 eraction between the heart rate variability (HRV) and electroencephalography (EEG) require a computat

262 etabolic parameters, heart rate variability (HRV) and LV function in obese-insulin resistant rats.

263 y domain measures of heart rate variability (HRV) are associated with adverse events after a myocardi

264 oning as measured by heart rate variability (HRV) has been associated with posttraumatic stress disor

265 Decreased heart rate variability (HRV) is a major risk factor for sudden death and cardiov

266 rol reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbid

267 Heart rate variability (HRV) provides indices of autonomic function and electrop

268 healthy states with heart rate variability (HRV) using time series analyses is well documented.

269 heart rate (HR) and heart rate variability (HRV) with electrocardiogram, and white blood cell (WBC)

270 tory interaction) on heart rate variability (HRV) with heartbeats increasing and decreasing within a

271 ting and vagal tone (heart rate variability (HRV)) on hunger and the postprandial response to GL.

272 ctive association of heart rate variability (HRV), a marker of autonomic function, with PD risk.

273 as been reported for heart-rate variability (HRV), a marker of physiological flexibility.

274 sted whether resting heart-rate variability (HRV), a physiological indicator of psychological and phy

275 king, as measured by heart rate variability (HRV), have been correlated with memory improvement.

276 alysis, derived from heart rate variability (HRV), is a powerful tool to quantify the complex regulat

277 er low heart rate or heart rate variability (HRV), which are noninvasive measures of cardiac autonomi

278 ns in time, known as heart rate variability (HRV), which introduces deviations from periodic stimulat

279 rocarbons (PAHs) and heart rate variability (HRV).

280 heart rate (HR) and heart rate variability (HRV).

281 tality and decreased heart-rate variability (HRV).

282 It classified infants with RSV LRTI versus HRV or influenza LRTI with 95% accuracy.

283 and innate immune responses during virulent HRV challenge.

284 y with 10(5) focus-forming-units of virulent HRV at 33 days of age.

285 ined by the binding of EcN but not LGG to Wa HRV particles or HRV 2/4/6 virus-like particles but not

286 We show that when HRV is incorporated in the periodic pacing protocol, it

287 e-eligible for vaccination in villages where HRV was introduced to that among such children in villag

288 o that among such children in villages where HRV was not introduced.

289 in pigs challenged with HRV or PRV, whereas HRV Wa G1P[8] induced only partial protection against PR

290 ronchial epithelium, we investigated whether HRV infection of MCs generated innate immune responses w

291 However, the mechanisms through which HRVs modulate the immune responses of monocytes and lymp

292 ore severe exacerbations are associated with HRV-C.

293 Remitted PTSD was not associated with HRV.

294 the behavioral and neural associations with HRV were consistent across both our stress induction and

295 erm cross-protection in pigs challenged with HRV or PRV, whereas HRV Wa G1P[8] induced only partial p

296 cterial genera between infants infected with HRV and those infected with RSV.

297 blood-derived MCs (CBMCs) were infected with HRV or UV-irradiated HRV at increasing multiplicities of

298 ere exposed to medium alone or infected with HRV-16.

299 respectively, and were then inoculated with HRV-16 within 72 hours.

300 the antibody to HRV-C is cross-reactive with HRV-A.

301 to provide standard infant vaccines without HRV.