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1 ma (FL) undergo histological transformation (HT).
2 ologically relevant high-throughput screens (HTS).
3 platform for high-throughput drug screening (HTS).
4 8%]) were randomly assigned to either A+I or HT.
5 ejections occurred within 3 months following HT.
6 modality for rejection beyond 6 months post-HT.
7 SUVmax > 10, with 3.3% of these experiencing HT.
8 no temporal relationship between bSUVmax and HT.
9 (1.4%) patients with bSUVmax > 20 underwent HT.
10 hanisms leading to the beneficial effects of HT.
11 op of contractions induced by KCl, ACh and 5-HT.
12 be sensed by EC cells, inducing release of 5-HT.
13 des and practices surrounding pregnancy post-HT.
14 pressures measured in the first 12 mo after HT.
15 ent DOX release profiles in response to mild HT.
16 formal policy regarding pregnancy following HT.
17 MBs, not only during the first 6 months post-HT (1.6% vs. 33.3%, P < .0001), but more so during the 6
18 d competition experiments on FAP-transfected HT-1080 (HT-1080-FAP) or on mouse FAP-expressing (HEK-mu
19 tion experiments on FAP-transfected HT-1080 (HT-1080-FAP) or on mouse FAP-expressing (HEK-muFAP) and
21 erved in HT+M (47.1 cells/mm(2)) compared to HT (123.8 cells/mm(2)) (p = 0.0003) and HT+V (97.5 cells
26 sults show that intra-mPFC infusion of the 5-HT(1A) receptor agonist 8-OH-DPAT induces rapid and long
27 in the mPFC, and provide evidence for the 5-HT(1A) receptor as a target for the treatment of MDD.
28 lts indicate that selective stimulation of 5-HT(1A) receptor in the mPFC exerts rapid and sustained a
31 e dependent manner, while binding to D(3), 5-HT(1A) receptors and SERT was not detectable with the ra
32 igh affinity and selectivity for serotonin 5-HT(1A) receptors were obtained and tested in four functi
34 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT(1A)) receptors, may represent a new class of psychotr
35 udy (NCT01854944) was to assess D(2)/D(3), 5-HT(1A), 5-HT(2A) and serotonin transporter (SERT) occupa
36 zed to: (i) Cooling 1-13 h (HT; n = 6); (ii) HT+ 2.5% ethanol vehicle (HT+V; n = 7); (iii) HT + Melat
37 munoenzymatic biosensor for the detection of HT-2 mycotoxin based on carbodiimide linking of the micr
39 de linking of the microelectrode surface and HT-2 toxin antigen binding fragment of antibody (anti-HT
42 ivalenol, fumonisin B1, zearalanone, T-2 and HT-2 toxin) and emerging mycotoxins (enniatins, beauveri
43 ve regulators of innate immune signaling, in HT-29 intestinal epithelial cells challenged with TNF-al
44 coelastic moduli and mass of adherent colon (HT-29) and breast cancer (MCF-7) cells from the interpha
46 ation, growth at stressful high temperature (HT; 29 degrees C) is highly mutagenic, increasing the mu
47 th spatial gene expression patterns of the 5-HT(2A) (5-hydroxytryptamine 2A) and 5-HT(1A) (5-hydroxyt
48 854944) was to assess D(2)/D(3), 5-HT(1A), 5-HT(2A) and serotonin transporter (SERT) occupancies of b
49 up-regulation of frontal cortex serotonin 5-HT(2A) receptor (5-HT(2A)R) density in the adult offspri
51 Here, we showed that the class A serotonin 5-HT(2A) receptors (5-HT(2A)Rs) affected the localization
52 ated in vivo binding to D(2) receptors and 5-HT(2A) receptors at steady state after 10 days of daily
55 terobivalent ligands were characterized in 5-HT(2A)-, mGlu(2)/Gqo5-, 5-HT(2A)/mGlu(2)-, and 5-HT(2A)/
57 characterized in 5-HT(2A)-, mGlu(2)/Gqo5-, 5-HT(2A)/mGlu(2)-, and 5-HT(2A)/mGlu(2)/Gqo5-expressing HE
59 A)-, mGlu(2)/Gqo5-, 5-HT(2A)/mGlu(2)-, and 5-HT(2A)/mGlu(2)/Gqo5-expressing HEK293 cells using a Ca(2
62 pairment, but not increased frontal cortex 5-HT(2A)R density or psychedelic-induced head-twitch behav
64 cellular compartments, and coexpression of 5-HT(2A)R with mGluR2 increased the intracellular distribu
65 rontal cortex serotonin 5-HT(2A) receptor (5-HT(2A)R) density in the adult offspring, a phenotype pre
66 fects of specific serotoninergic receptor (5-HT(2A)R) stimulation with psilocybin in healthy humans.
67 dition to the serotonin 5-HT(2A) receptor (5-HT(2A)R), the dopamine D(2) receptor (D(2)R) is a key th
68 the class A serotonin 5-HT(2A) receptors (5-HT(2A)Rs) affected the localization and trafficking of c
70 he expression of serotonin receptors, with 5-HT(2B) and 5-HT(7) expression restricted to M-CSF-primed
71 hat the 5-HT-mediated activation of AhR is 5-HT(2B) dependent because it is abrogated by the 5-HT(2B)
73 nstrate the existence of a functional 5-HT/5-HT(2B)/AhR axis in human macrophages and indicate that 5
75 2 to potentiate the effects of a selective 5-HT(2C)R agonist was established in a drug discrimination
76 Compound 12 (CTW0415) was discovered as a 5-HT(2C)R PAM with improved pharmacokinetics and reduced o
77 ng the serotonin (5-HT) 5-HT(2C) receptor (5-HT(2C)R) allosteric site to potentiate endogenous 5-HT t
79 sing a simplified model of the pore of the 5-HT(3) receptor (5HT3R) which restrains the backbone stru
81 the activation and modulation of the human 5-HT(3) type A receptor has been based only on macroscopic
83 only extend our knowledge about the human 5-HT(3)A molecular function but also provide novel insight
84 timulation of beta-cells were blocked by a 5-HT(3)R antagonist and were enhanced by increasing seroto
86 CD is required for the interaction between 5-HT(3A) and the chaperone protein resistance to inhibitor
87 s of the homomeric 5-hydroxytryptamine 3A (5-HT(3A)) serotonin receptor for 15 to 20 mus to demonstra
88 ude longer than any previous simulation of 5-HT(3A), allow us to observe the dynamic binding and unbi
89 g enough to observe complete activation of 5-HT(3A), the allosteric regulation of ion gating elements
91 entify a 24-amino-acid-long segment of the 5-HT(3A)-ICD as a molecular determinant for the interactio
92 eraction, we developed different MBP-fused 5-HT(3A)-ICD constructs by deleting large segments of its
94 Previously, we have demonstrated that the 5-HT(3A)-ICD is required for the interaction between 5-HT(
95 ees of conformational change in the setron-5-HT(3A)R structures, throughout the channel and particula
98 fects that bupropion exerts on heteromeric 5-HT(3AB) receptors, in particular when constantly present
99 at antagonizing serotonin (5-HT) type 3AB (5-HT(3AB)) receptors in brain areas involved in mood regul
102 ts in heteromeric 5-HT type 3AB receptors (5-HT(3AB)Rs) (IC(50) = 840 and 526 muM, respectively).
104 itoneally) or intra-mPFC infusion with the 5-HT(4)R agonist, RS67333 (0.5 mug/side), were examined in
105 tion of serotonin (5-HT) type 4 receptors (5-HT(4)Rs) has been shown to have anxiolytic effects in a
107 demonstrate the existence of a functional 5-HT/5-HT(2B)/AhR axis in human macrophages and indicate t
108 of serotonin receptors, with 5-HT(2B) and 5-HT(7) expression restricted to M-CSF-primed monocyte-der
113 terplays with discriminant bacterial taxa in HT and NT subjects highlight the potential role of speci
114 in Uvalde in 2017 while in 2018, these were HT and OF in Lubbock (LU-HT, LU-OF), Overton (OV-HT, OV-
117 vel, type 2 diabetes mellitus, hypertension (HT), and metabolic syndrome (MS) were investigated.
118 dorsal raphe nucleus, the major source of 5-HT, and expresses 5-HT receptor subtypes (e.g., 5-HT2C a
120 ytoskeletal effector Adducin/Hu-li tai shao (Hts) as proteins whose synaptic expression is restricted
121 ehensive activity summaries across all Tox21 HTS assay targets provide an overall picture of chemical
122 consortium in 971 high-throughput screening (HTS) assays whose targets were mapped onto human organs
123 ll subjects <21 years old who received first HT at Boston Children's Hospital during 1986-2015 with a
124 in yeast is a promising tool to overproduce HT at the expense of endogenous tyrosol through central
127 le benefit in rebiopsy of lesions to exclude HT based on SUVmax alone before initiating therapy in pa
128 of pediatric HT recipients who had undergone HT between January 2010 and December 2015 at Lucile Pack
129 teric regulation of ion gating elements by 5-HT binding is indicative of a preactive state, which pro
135 present hydroxytyrosol synthetic derivative HT C6 as a new antiangiogenic compound and as a good can
136 Furthermore, the antiangiogenic activity of HT C6 was confirmed in vivo in the chick chorioallantoic
137 that citalopram (which increases levels of 5-HT) caused sustained activation in key limbic regions du
140 panel of pruritogens (C48/80, endothelin, 5-HT, chloroquine, histamine, lysophosphatidic acid, tryps
141 tool compound, swinholide A, we demonstrate HTS compatibility with an excellent Z'-factor of 0.67 +/
142 utilizing external fluorescent probes, is an HTS compatible technique, but high protein concentration
144 y which it might be associated with plasma 5-HT concentrations and SSRI clinical response remained un
145 AN5 were associated with plasma serotonin (5-HT) concentrations which were themselves associated with
146 one, markedly reduced placental serotonin (5-HT) concentrations, and lowered 5-HT GC immunoreactivity
147 ficantly associated with plasma serotonin (5-HT) concentrations, which were themselves associated wit
149 a type of tannin acyl-hydrolase hydrolyzing HTs, CT monomer gallates and depsides - has been reporte
150 s can import their own or publicly available HTS data into LabxDB seq to manage them from production
154 cancer patients, our data demonstrated that HT-DBP could be used to generate personalized pharmacoty
159 hy volunteers were randomly allocated to a 5-HT depletion (N = 24), DA depletion (N = 24), or placebo
160 modeling-based fMRI analyses revealed that 5-HT depletion altered social reward prediction signals in
162 firing rate of DRN 5-HT neurons, cerebral 5-HT depletion, and optogenetic activation and silencing w
163 tion of bupropion or hydroxybupropion with 5-HT dose dependently inhibited 5-HT-induced currents in h
167 ts 18:2 fatty acids to 18:3) decreased under HT for the heat-tolerant genotype SPT 06-07 but not for
168 with altered dopamine (DA) and serotonin (5-HT) functioning, the current study aimed to elucidate th
170 o- to threefold higher at HT than at ST, and HT-growth causes an ~19- to 23-fold increase in indel fr
171 was performed to examine if heat treatment (HT) has beneficial effects on the exaggerated exercise p
172 around one of the high-throughput screening (HTS) hits, N(2)-(thiophen-3-yl)-N(6)-(2,2,2-trifluoroeth
173 ding and unbinding of 5-hydroxytryptamine (5-HT) (i.e., serotonin) to the binding pocket located on t
176 addition, we comprehensively characterized 5-HT-immunoreactive (-ir) innervation throughout the brain
178 es exhibit higher sensing activity towards 5-HT in accordance to its higher surface area, lower parti
179 Neither bSUVmax nor bSUVrange predicted HT in GALLIUM, suggesting that there may be little benef
183 g addressed using high-throughput screening (HTS) in vitro approaches and computational modeling.
185 opion with 5-HT dose dependently inhibited 5-HT-induced currents in heteromeric 5-HT type 3AB recepto
189 ucleosome-free regions, suggesting that much HT-induced mutational damage occurs during cell-cycle ph
191 To date, however, no one has examined how 5-HT influences the dynamics of facial-emotion processing
193 binding of the neurotransmitter serotonin (5-HT) into a transient cation current that mediates fast e
194 ons in the superior raphe, an intermediate 5-HT-ir cell cluster, and an extensive inferior raphe popu
196 vocal midbrain nuclei showed considerable 5-HT-ir innervation, as did thalamic and hindbrain auditor
203 It may thus be the case that decreased 5-HT levels contribute to social learning deficits in depr
204 in 2018, these were HT and OF in Lubbock (LU-HT, LU-OF), Overton (OV-HT, OV-OF), Uvalde (UV-HT, UV-OF
205 verall TUNEL positive cells were observed in HT+M (47.1 cells/mm(2)) compared to HT (123.8 cells/mm(2
206 rsus HT (p = 0.036) and internal capsule for HT+M compared to HT (p = 0.001) and HT+V versus HT (p =
207 ized protection was seen in white matter for HT+M versus HT (p = 0.036) and internal capsule for HT+M
208 xchangeable phosphate were higher at 48 h in HT+M versus HT (p = 0.036, p = 0.049 respectively).
210 n of AhR target genes in M-MO and that the 5-HT-mediated activation of AhR is 5-HT(2B) dependent beca
213 ir age-matched littermate WT controls, Keap1 Ht mice showed significant increase in bone formation ra
214 lets were randomized to: (i) Cooling 1-13 h (HT; n = 6); (ii) HT+ 2.5% ethanol vehicle (HT+V; n = 7);
215 f hemodynamics, we implanted serotonergic (5-HT(+)) neuron-enriched embryonic raphe nucleus-derived n
216 results indicate that adiponectin acts on 5-HT neurons through AdipoR1 receptors to regulate depress
217 , in vivo recordings of firing rate of DRN 5-HT neurons, cerebral 5-HT depletion, and optogenetic act
218 r pathways regenerated into the graft, and 5-HT(+) neurons within graft and host brainstem neurons we
221 fers new insights into the organization of 5-HT nuclei in teleosts and provides neuroanatomical evide
223 We performed high-throughput screening (HTS) of a chemical library to identify binders of mircoR
224 nd OF in Lubbock (LU-HT, LU-OF), Overton (OV-HT, OV-OF), Uvalde (UV-HT, UV-OF), and Weslaco (WE-HT, W
228 ion was seen in white matter for HT+M versus HT (p = 0.036) and internal capsule for HT+M compared to
231 the range of intracardiac pressures in these HT patients is important for the clinical interpretation
232 ic assessment in pediatric heart transplant (HT) patients, expected intracardiac pressure measurement
233 iac pressures are elevated in the early post-HT period and decrease to levels typical of the native h
234 urements were elevated in the immediate post-HT period and decreased to a stable level by post-HT day
238 xis in human macrophages and indicate that 5-HT potentiates the activity of a transcription factor (A
240 anslate environmental cues into serotonin (5-HT) production, contributing to intestinal physiology.
242 intake, genetically predisposed irregular 5-HT receptor density, or change in sensory bombardment ma
243 s, the major source of 5-HT, and expresses 5-HT receptor subtypes (e.g., 5-HT2C and 5-HT1A) criticall
244 l secretagogues, drugs acting on opioid or 5-HT receptors, or minimally absorbed antibiotics (all of
245 ed a retrospective chart review of pediatric HT recipients who had undergone HT between January 2010
246 ated that pregnancy should be avoided in all HT recipients, and only 43% (n=52) reported that their c
255 ion of BMSC-induced hormone independence and HT resistance in anchorage-independent cells revealed di
256 nmental biomarkers in metastatic biopsies of HT-resistant patients can help refine treatment approach
259 onship between baseline SUVmax (bSUVmax) and HT risk was assessed using cutoff values for SUVmax >10
263 ) using chitosan as cross-linked agent for 5-HT sensing studies; conducted through cyclic voltammetry
265 ase was attenuated, suggesting blunted CeA 5-HT sensitivity, which partially recovered in protracted
266 itters, estimation of 5-hydroxytryptamine (5-HT; Serotonin) release has proved to be challenging.
271 These changes presumably lead to decreased 5-HT synthesis and/or increased 5-HT reuptake, thereby red
272 hts into modulation of CeA activity by the 5-HT system and unravels the vulnerability of the CeA 5-HT
273 and unravels the vulnerability of the CeA 5-HT system to chronic alcohol and protracted withdrawal.S
274 is approximately two- to threefold higher at HT than at ST, and HT-growth causes an ~19- to 23-fold i
277 ) allosteric site to potentiate endogenous 5-HT tone may provide novel therapeutics to alleviate the
278 onal knockout male mice supports deficient 5-HT transmission underlying depression-related phenotypes
283 bited 5-HT-induced currents in heteromeric 5-HT type 3AB receptors (5-HT(3AB)Rs) (IC(50) = 840 and 52
284 Twelve metabolites had discordant effects by HT type and were associated with incident CHD in the WHI
285 dies indicate that antagonizing serotonin (5-HT) type 3AB (5-HT(3AB)) receptors in brain areas involv
288 d to HT (123.8 cells/mm(2)) (p = 0.0003) and HT+V (97.5 cells/mm(2)) compared to HT (p = 0.012).
295 To better understand compound behavior in HTS, we assessed an existing binomial survivor function
297 adult mice with reduced DAT expression (DAT-HT) were hypersensitive to short active (SA; 19:5 L:D) p
299 led release profile in combination with mild HT, which correlated well with their cytotoxicity studie