ライフサイエンスコーパス: HTH motif

1 residue adjacent to either one or the other HTH motif.

2 e surface area threshold value of 990 A2 per HTH motif.

3 d the homeodomain (HD), made up from another HTH motif.

4 region of this protein family, including the HTH motif.

5 ically affect the binding specificity of its HTH motif.

6 ocated in the second helix of the C-terminal HTH motif.

7 which protrudes the recognition helix of the HTH motif.

8 20 which is located in the helix-turn-helix (HTH) motif.

9 twined dimer with a winged helix-turn-helix (HTH) motif.

10 n the putative DNA-binding helix-turn-helix (HTH) motif.

11 e-binding (OB) folds and a helix-turn-helix (HTH) motif.

12 mily, including a putative helix-turn-helix (HTH) motif.

13 sts a classic DNA-binding, helix-turn-helix (HTH) motif.

14 that lacks the DNA-binding helix-turn-helix (HTH) motif.

15 ided access to the decapeptides with "hybrid HTH" motifs.

16 protein structures that include a functional HTH motif and have no apparent sequence similarity to ea

17 distort its DNA substrate through use of its HtH motifs and control gene expression.

18 of DNA is recognized by a helix-turn-helix (HTH) motif and the adjacent minor grooves are contacted

19 r37/Pro39 of the repressor helix-turn-helix (HTH) motif and the methyl groups of specific thymine bas

20 is of peptides with hybrid helix-turn-helix (HTH) motif and their conformational analysis (NMR, MD, a

21 y diversity for DNA-binding proteins with an HTH motif, and much smaller diversity for those with an

22 haS-CTD substitutions clustered in the first HTH motif, and suggested that l-rhamnose induces improve

23 n the orientation of binding of the two MelR HTH motifs, and the juxtaposition of the different bound

24 domain (PD), which has two helix-turn-helix (HTH) motifs, and the homeodomain (HD), made up from anot

25 possess an unusual architecture in which the HTH motifs are displayed in a ring, distinct from the cl

26 we proposed a model to describe how the two HTH motifs are positioned.

27 helix 6, the recognition helices of the dual HTH motifs, are important to DNA binding and transcripti

28 n used to determine the positions of the two HTH motifs at target sites.

29 clustered at a single residue in the second HTH motif, at a position consistent with improved RNAP c

30 by itself, so it may be that the DNA-binding HTH motif becomes rigidly defined only when FlhD forms a

31 ence discrimination, which suggests that the HTH motif binds DNA as a folded domain and thus cleaves

32 Each HTH motif can bind to DNA separately or in combination w

33 DNA using small contiguous helix-turn-helix (HTH) motifs comprise a significant number of all DNA-bin

34 trary single-site substrate suggest that the HTH motif contacts DNA similarly to how certain HTH prot

35 nce and that residue K202, also in the first HTH motif, contacts the cytosine.

36 , Y250, T252, and R257 located in the second HTH motif contribute to the recognition of the TGnnA seq

37 Seven other proteins containing a HTH motif, do not have operator-like sequences in the DN

38 ny of these proteins therefore contain three HTH motifs each able to recognize DNA.

39 romoter's robbox, we determined that the two HTH motifs each bind a recognition element in vivo.

40 we investigate how such a circular array of HTH motifs enables specific recognition of the viral gen

41 The helix-turn-helix (HTH) motif features frequently in protein DNA-binding as

42 inding domain folds into a helix-turn-helix (HTH) motif flanked on either side by "wings" of polypept

43 The HTH motif forms a tetramerization domain that results in

44 id sequence similar to the helix-turn-helix (HTH) motif found in other DNA-binding proteins.

45 tection of the DNA-binding helix-turn-helix (HTH) motif from sequence.

46 A structural template library of seven HTH motifs has been created from non-homologous DNA-bind

47 containing the DNA-binding helix-turn-helix (HTH) motif has been developed.

48 ed mutagenesis of the AmpR helix-turn-helix (HTH) motif identified residues critical for binding and

49 the active site motif to a helix-turn-helix (HTH) motif implicated in DNA binding.

50 (dT)9, (iii) provide data that implicate the HTH motif in dsDNA binding, and (iv) show that BRCA2 sti

51 The two helix-turn-helix (HTH) motifs in Int proteins incorporate catalytic residu

52 One helix from each HTH motif inserts into the major groove of the DNA to ma

53 nition element 1 (RE1), while the C-terminal HTH motif interacts with the less conserved recognition

54 sembling the characterized helix-turn-helix (HTH) motif involved in DNA recognition by many phage and

55 While the HTH motif is essential for the Metnase-TIR interaction,

56 hat corresponds to the functionally relevant HTH motif itself.

57 e sulfenic acid oxidation of a cysteine in a HTH-motif leads to differential effects on gene expressi

58 to its cognate DNA may involve both putative HTH motif-like regions.

59 While both N and C-terminal HTH motifs make essential contributions to binding site

60 Alternative conformations of the HTH motif may permit adjustment of the structure for opt

61 sequences in the DNA sequences encoding the HTH motif; none of them, except MerR, are known to be au

62 he GnC in site 1 and recognized by the first HTH motif of an ExsA monomer.

63 ate that residues L198 and T199 in the first HTH motif of ExsA contact the guanine in the GnC sequenc

64 Evidence suggests that the N-terminal HTH motif of SoxS interacts with a highly conserved regi

65 er with the recognition alpha-helices of the HTH motifs of each monomer separated by a distance of 34

66 The amino acids that comprise the HTH motifs of ExsA are nearly identical to those in LcrF

67 importance of different residues in the two HTH motifs of MelR.

68 lytical ultracentrifugation, that individual HTH motifs of the Bacillus phage SF6 small terminase bin

69 bound to site 1, the first helix-turn-helix (HTH) motif of ExsA interacts with the conserved GnC sequ

70 ructural similarity to the helix-turn-helix (HTH) motif of the lambda repressor DNA-binding domain.

71 between the marbox and two helix-turn-helix (HTH) motifs on the monomeric MarA.

72 et of protein sequences, some containing the HTH motifs, others not.

73 g motifs, and it has been proposed that each HTH motif recognizes a highly conserved recognition elem

74 of the protein (region I) or in the putative HTH motif (region II).

75 binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcrip

76 bp target sites using two helix-turn-helix (HTH) motifs that are both located in its C-terminal doma

77 he AraC family contain two helix-turn-helix (HTH) motifs that contact two segments of the DNA major g

78 e DNA-binding domains, which incorporate the HTH motif, the second library included shorter models of

79 ing domain composed of two helix-turn-helix (HTH) motifs,the PAI and RED domains.

80 ns, CodY appears to have a helix-turn-helix (HTH) motif thought to be critical for interaction with D

81 st cell, GSH induces the correct fold of the HTH motifs, thus priming the PrfA protein for DNA intera

82 facilitated by an arginine finger within the HTH motif to stabilize the extrahelical O(6)-alkylguanin

83 The protein sequence shows a HTH motif typical of that found in many transcriptional

84 This putative HTH motif was found to be highly conserved in the CodY h

85 metries of the EF-hand and helix-turn-helix (HTH) motifs was investigated by NMR and CD spectroscopy

86 edicted to be in the recognition helix of an HTH motif, was challenged with altered att sites created

87 ese variables detect 78% of proteins with an HTH motif, which is a substantial improvement over previ

88 ortunity for the design and study of "hybrid HTH" motifs with more than one kind of helical structure