ライフサイエンスコーパス: HTLV

1 HTLV-1 and HTLV-2 antibodies were measured by enzyme imm

2 HTLV-1 and HTLV-2 encode auxiliary proteins that play im

3 HTLV-1 cell-to-cell transmission is dependent on the rel

4 HTLV-1 encodes a protein from the antisense strand of it

5 HTLV-1 infection can lead to many different and often fa

6 HTLV-1 infection is endemic to Central African populatio

7 HTLV-1 infection is the etiological agent of ATL and, un

8 HTLV-1 infection of monocytes inhibited TLR3- and TLR4-i

9 HTLV-1 is a complex retrovirus that causes two distinct

10 HTLV-1 is now known to infect at least 4-10 million peop

11 HTLV-1 prevalence was 8.6% (23/269) in individuals with

12 HTLV-1 protease (HTLV-1 PR) is an aspartic protease whic

13 HTLV-1 serology was performed by Western blot on plasma

14 HTLV-1 seropositivity was associated with female sex, ol

15 HTLV-1-associated myelopathy (HAM; HTLV-1 is human T-lym

16 HTLV-2 MA also binds NAs with higher affinity than HTLV-

17 HTLV-2 MA binds with high affinity and specificity to RN

18 HTLV-2 MA displays higher NA binding affinity and better

19 HTLV-2 seropositivity was associated with female sex, ol

20 HTLV-I has been clinically linked to the development of

21 HTLVs arose from interspecies transmission between nonhu

22 fected by human T-lymphotropic virus type 1 (HTLV-1) and can spread HTLV-1 to susceptible cells.

23 such as human T-cell leukemia virus type 1 (HTLV-1) and HIV-1.

24 Human T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 are prevalent at low levels among US

25 Human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play i

26 ith both human T-cell leukemia virus type 1 (HTLV-1) and human immunodeficiency virus type 1 (HIV-1)

27 s of human T-cell lymphotropic virus type 1 (HTLV-1) and human immunodeficiency virus type 1 (HIV-1),

28 Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviru

29 Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviru

30 against human T-cell leukemia virus type 1 (HTLV-1) basic leucine zipper (bZIP) factor (HBZ) could b

31 ion with human T-cell leukemia virus type 1 (HTLV-1) can cause a rare form of leukemia designated adu

32 trovirus human T-cell leukemia virus type 1 (HTLV-1) contains identical DNA sequences, known as long

33 orf-I gene of human T-cell leukemia type 1 (HTLV-1) encodes p8 and p12 and has a conserved cysteine

34 Human T-cell leukemia virus type 1 (HTLV-1) expression depends on the concerted action of Ta

35 ple, human T-cell lymphotropic virus type 1 (HTLV-1) has been reported to infect up to 25 million peo

36 from Human T-cell Lymphotropic Virus Type 1 (HTLV-1) infection to lethal Adult T-cell Leukaemia (ATL)

37 Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus, and, as such, its genome become

38 Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus that induces a fatal

39 cture of human T-cell leukemia virus type 1 (HTLV-1) is poorly characterized.

40 Human T-cell lymphotropic virus type 1 (HTLV-1) is the agent of HTLV-1-associated myelopathy/tro

41 Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia

42 Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemi

43 that the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax induces an epigenetic-dependent

44 human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p30 protein, essential for virus infectivity in

45 able for human T-cell leukemia virus type 1 (HTLV-1) particle biogenesis.

46 Human T cell leukemia virus, type 1 (HTLV-1) replication and spread are controlled by differe

47 ected by human T-cell leukemia virus type 1 (HTLV-1) that recapitulate adult T-cell leukemia (ATL)-li

48 ins from human T-cell leukemia virus type 1 (HTLV-1) were resistant to the antiviral effects of all t

49 cted with Human T Lymphotropic Virus type 1 (HTLV-1) which together with existing data allows us to s

50 n, NC of human T-cell leukemia virus type 1 (HTLV-1), a deltaretrovirus, displays weaker NA binding a

51 Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus type 1

52 Tax from human T-cell leukemia virus type 1 (HTLV-1), an etiological factor that causes adult T-cell

53 erved for human T-lymphotropic virus type 1 (HTLV-1), the first isolated human-pathogenic retrovirus.

54 Human T-cell leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia and T-cell lymp

55 Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic parapares

56 h as human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic parapares

57 in a human T-cell lymphotropic virus type 1 (HTLV-1)-endemic area of Central Australia, and report on

58 and human T-cell lymphotropic virus type 1 (HTLV-1)-infected cells with 2-10 muM P27 caused cell mem

59 Most human T-lymphotropic virus type 1 (HTLV-1)-infected HeLa and SupT1 cells cease proliferatio

60 en in 22 human T cell leukemia virus type 1 (HTLV-1)-infected individuals by assessing their infectiv

61 0 million human T-lymphotropic virus type 1 (HTLV-1)-infected people, and many of them will develop s

62 h is human T-cell lymphotropic virus type 1 (HTLV-1).

63 and human T cell lymphotropic virus type 1 (HTLV-1).

64 SHV), and human T-lymphotropic virus type 1 (HTLV-1).

65 trovirus human T-cell leukemia virus type 1 (HTLV-1).

66 aused by human T-cell leukemia virus type 1 (HTLV-1).

67 Human T-cell leukemia virus type 1 (HTLV-I) is associated with adult T-cell leukemia (ATL),

68 -kappaB by the human T-lymphotropic virus 1 (HTLV-1) oncoprotein Tax immediately triggers a host sene

69 ies, including human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic parapares

70 ctively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).

71 like the distantly related lentivirus HIV-1, HTLV-1 causes disease in only 5-10% of infected people,

72 everal regulatory/accessory genes in HTLV-1, HTLV-1 bZIP factor (HBZ) is the only viral gene constitu

73 a panel of Gag proteins with chimeric HIV-1/HTLV-1 CA domains.

74 Five subjects with HAM and 2 HTLV-1 asymptomatic carriers were studied.

75 uman T cell lymphotropic virus type 1 and 2 (HTLV-1 and HTLV-2) and bovine leukaemia virus (BLV).

76 l leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that have distin

77 l leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T

78 The 23 HTLV-1-positive bitten individuals reported being bitten

79 Human T-cell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses.

80 Mother-to-child infection was excluded in 6 HTLV-1-infected bitten individuals.

81 (C. agilis in one case) were infected with a HTLV-1 subtype F strain very similar to the STLV-1 strai

82 d retained robust oncolytic activity against HTLV-1 actuated ATL cells.

83 ather moderate affinity of Indinavir against HTLV-1 PR and provides the basis for further structure-g

84 ortant aspects of the human response against HTLV-1 and could be an important tool for the developmen

85 ytotoxic T-lymphocyte (CTL) response against HTLV-I-infected cells, but ultimately fail to effectivel

86 e evaluated as privileged structures against HTLV-1 protease (HTLV-1 PR).

87 t be useful for developing a vaccine against HTLV-1.

88 raction of the brain stem was reduced in all HTLV-1-infected patients compared with controls (P < 0.0

89 Here we report an HTLV-1 recombinant virus among infected individuals in N

90 ave used cryo-electron tomography to analyze HTLV-1 particle morphology.

91 have shown for the first time that HIV-1 and HTLV-1 Gag domains outside the CA (e.g., matrix and nucl

92 HTLV-1 and HTLV-2 antibodies were measured by enzyme immunoassay (E

93 HTLV-1 and HTLV-2 encode auxiliary proteins that play important rol

94 The HTLV-1 and HTLV-2 prevalences among US blood donors has declined si

95 Functional comparisons of HTLV-1 and HTLV-2 proteins provide a better understanding about how

96 lymphotropic virus type 1 and 2 (HTLV-1 and HTLV-2) and bovine leukaemia virus (BLV).

97 man T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 are prevalent at low levels among US blood donors

98 -cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play important rol

99 on to the seemingly nonpathogenic HTLV-3 and HTLV-4 viruses, and studies of their antisense proteins

100 ell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses.

101 We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3 and APH-4,

102 cal agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesi

103 Although both BLV and HTLV-1 infection are characterised by large expansions o

104 V-1 infection is associated with disease and HTLV-2 infection is not.

105 6.8 nM and 8.5 nM for HIV gene, HBV gene and HTLV-I gene, respectively.

106 viously, our group found that HTLV-1 HBZ and HTLV-2 APH-2 had distinct effects in vivo and hypothesiz

107 Iatrogenic transmission of HCV and HTLV-1 occurred in mid-20th century Kinshasa, at the sam

108 causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesi

109 B'-PP2A and HTLV-1 IN display nuclear co-localization, and the B' su

110 drug target for the discovery of novel anti-HTLV-1 drugs.

111 an T-cell leukemia virus (HTLV; now known as HTLV-1) produced by a T-cell line from a lymphoma patien

112 e receptor expression did not differ between HTLV-1-infected and uninfected individuals.

113 Here, we examined the interaction between HTLV-2 and HIV-1 MA proteins and various NAs in vitro.

114 n allowing us to understand the link between HTLV-1 HBZ and ATL in infected individuals.

115 ces may affect how HTLV-1 causes disease but HTLV-2 generally does not.

116 eukemia (ATL), a T-cell malignancy caused by HTLV-1 infection.

117 malignant or inflammatory diseases caused by HTLV-1.

118 vent the senescence and G1 arrest induced by HTLV-1 Tax and vFLIP, respectively.

119 rm that hunters in Africa can be infected by HTLV-1 that is closely related to the strains circulatin

120 HOS) cell line to be chronically infected by HTLV-1.

121 ome senescent immediately after infection by HTLV-1 or transduction of the HTLV-1 tax gene.

122 interaction between persistent infection by HTLV-I and virus-specific host immunity.

123 rt the notion that infection of monocytes by HTLV-1 is likely a requisite for viral persistence in hu

124 We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3

125 In contrast, HTLV-2, which expresses Tax2, is non-leukemogenic.

126 Together with their simian counterparts, HTLVs form the primate T-lymphotropic viruses.

127 A key issue in current HTLV-I research is to better understand the dynamic inte

128 requirement for Rex to export Rex-dependent HTLV-1 transcripts.

129 requirement for Rex to export Rex-dependent HTLV-1 transcripts.

130 We detected HTLV-1 DNA in all three monocyte subsets and found that

131 mia (ATL)-like leukemic symptoms and display HTLV-1-specific adaptive immune responses.

132 As a first step in designing an effective HTLV-1 vaccine, we defined the CD8(+) and CD4(+) T cell

133 st defense responses, which may help explain HTLV-1-related pathogenesis and oncogenesis.

134 Higher cerebrospinal fluid HTLV-1 proviral load (p = 0.01) was associated with thin

135 Different genotypes exist for HTLV-1: Genotypes b and d to g are restricted to central

136 The risk factors for HTLV-1 acquisition in humans via the interspecies transm

137 Risk factors for HTLV-1 seropositivity included intravenous injections at

138 PCR was carried out for HTLV-1 provirus on buffy-coat DNAs.

139 ic explanation of the requirement of p30 for HTLV-1 infectivity in vivo, suggest that dampening inter

140 s have been described, such a regulation for HTLV-1 has not been reported.

141 first-time donors, 104 were seropositive for HTLV-1 (prevalence, 5.1 cases/per 100 000; 95% confidenc

142 CI], 4.1-6.1), and 300 were seropositive for HTLV-2 (prevalence, 14.7 cases/per 100 000; 95% CI, 13.0

143 e development of a therapeutic treatment for HTLV-1-mediated disease.

144 We hypothesized that exosomes derived from HTLV-1-infected cells contain unique host and viral prot

145 detectable in most primary lymphocytes from HTLV-2-infected patients.

146 he antisense transcript-encoded protein from HTLV-1, is now well recognized as a potential factor for

147 ore, we observed that exosomes released from HTLV-1-infected Tax-expressing cells contributed to enha

148 All three monocyte subsets sorted from HTLV-1-infected individuals were positive for viral DNA,

149 role in extracellular delivery of functional HTLV-1 proteins and mRNA to recipient cells.

150 fs of five retroviruses of different genera: HTLV-1, HIV-1, murine leukaemia virus (MLV), avian sarco

151 HTLV-1-associated myelopathy (HAM; HTLV-1 is human T-lymphotropic virus type 1) is a chroni

152 ins provide a better understanding about how HTLV-1 infection is associated with disease and HTLV-2 i

153 these functional differences may affect how HTLV-1 causes disease but HTLV-2 generally does not.

154 Human T-cell lymphotropic virus type I (HTLV-1) is an oncogenic retrovirus considered to be the

155 Human T-cell leukemia virus type I (HTLV-1) replication relies on the clonal expansion of it

156 The human T-cell lymphotropic virus type I (HTLV-1) Tax transactivator initiates transformation in a

157 Human T-lymphotropic virus type I (HTLV-I) causes chronic infection for which there is no c

158 gene and human T-lymphotropic virus type I (HTLV-I) gene.

159 d by human T cell lymphotropic virus type-I (HTLV-I) without curative treatment at present.

160 a defined capsid core, which likely impacts HTLV-1 particle infectivity.

161 of miR-124a, is constitutively activated in HTLV-I-transformed cells and ATL cells, and activating S

162 ion of TrkB signaling increases apoptosis in HTLV-1-infected T cells and reduces phosphorylation of g

163 ing factor for dysregulation of autophagy in HTLV-1-transformed T cells and Tax-immortalized CD4 memo

164 this effect, BDNF expression is elevated in HTLV-1-infected T-cell lines compared to uninfected T ce

165 are often the only viral genes expressed in HTLV-infected T cells.

166 Among several regulatory/accessory genes in HTLV-1, HTLV-1 bZIP factor (HBZ) is the only viral gene

167 contribute to determining the role of HBZ in HTLV-1-associated diseases.

168 CX3CR1 in classical monocytes were higher in HTLV-1-infected individuals than uninfected individuals;

169 Expression of TrkB is also higher in HTLV-1-infected T-cell lines than in uninfected T cells.

170 assical patrolling monocytes is increased in HTLV-1-infected individuals, and they have increased exp

171 F/TrkB autocrine/paracrine signaling loop in HTLV-1-infected T cells that enhances the survival of th

172 that is downregulated by miR17 and miR21 in HTLV-1-infected CD4(+) T cells.

173 hting the importance of the HTLV-1 CA NTD in HTLV-1 immature particle morphology.

174 hat, albeit rare, recombination can occur in HTLV-1 and may play a role in the evolution of this retr

175 otein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be discovered, is unknown.

176 sence of ORFs encoding auxiliary proteins in HTLV-3 or STLV-3 genomes was unknown.

177 demonstrate the presence of recombinants in HTLV-1.

178 Mutation of two basic residues in HTLV-2 MA alpha-helix II, previously implicated in BLV g

179 ng that miR-28 may play an important role in HTLV-1 transmission.

180 ell-to-cell transmission, a critical step in HTLV-1 transmission and pathogenesis.

181 s have important implications for infectious HTLV-1 spread, particularly in the context of cell-to-ce

182 this study, we found that miR-28-3p inhibits HTLV-1 virus expression and its replication by targeting

183 ata provide further mechanistic insight into HTLV-1-mediated subversion of cellular host defense resp

184 nsfected with Rex-wild-type and Rex-knockout HTLV-1 molecular clones using splice site-specific quant

185 reading frames (ORFs) in HTLV-3, the latest HTLV to be discovered, is unknown.

186 Despite low prevalence, many HTLV-1-infected patients who do not fulfill criteria for

187 Moreover, HTLV-1 infection was linked to bite severity.

188 n in relation to the seemingly nonpathogenic HTLV-3 and HTLV-4 viruses, and studies of their antisens

189 protective role of miR-28-3p against de novo HTLV-1 infection.

190 at Gag proteins with a chimeric HIV-1 CA NTD/HTLV-1 CA CTD did not result in Gag oligomerization rega

191 P patients, 4 asymptomatic carriers (ACs) of HTLV-1, 18 MS patients, and 10 HVs from a 3T magnetic re

192 the differences in transforming activity of HTLV-1 and -2.

193 tropic virus type 1 (HTLV-1) is the agent of HTLV-1-associated myelopathy/tropical spastic paraparesi

194 Analysis of HTLV-1 integrations in two cell lines, HuT 102 and MJ, i

195 lassical monocytes was lower in the blood of HTLV-1-infected individuals than in that of uninfected i

196 The brains of HTLV-1-infected patients, with and without HAM but no cl

197 controls [HCs], 17 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 relapsing-remitting MS [RRMS

198 ant designed to mimic the basic character of HTLV-2 MA alpha-helix II dramatically improves binding a

199 g its expression within a molecular clone of HTLV-1.

200 Functional comparisons of HTLV-1 and HTLV-2 proteins provide a better understandin

201 gy to deregulate autophagy in the context of HTLV-1 transformation of T cells.

202 However, the technology for discovery of HTLV and acknowledgment of the existence of pathogenic h

203 to examine in depth the molecular events of HTLV-1 replication and the mechanisms of action of viral

204 ase class III resulted in impaired growth of HTLV-1-transformed T cells, indicating a critical role o

205 igh prevalence might reduce the incidence of HTLV-1-induced disease.

206 evidence that the known poor infectivity of HTLV-1 particles may correlate with HTLV-1 particle popu

207 ge, the most potent nonpeptidic inhibitor of HTLV-1 PR described so far.

208 Given the lack of HTLV-3-infected cell lines, we took advantage of STLV-3-

209 er with prior findings in a macaque model of HTLV-1 infection, support the notion that infection of m

210 unately, there are very few animal models of HTLV-1 infection useful for testing vaccine approaches.

211 A number of HTLV-1 subtypes have been described in different populat

212 perimental hypotheses for the persistence of HTLV-I in vivo have led to the development of mathematic

213 c activity when expressed in the presence of HTLV-I Tax, mutated p53 R276H, or c-Myc F138C found in h

214 A higher prevalence of HTLV-2 in the west and southwest may be attributed to en

215 n, while both Tax-3 and antisense protein of HTLV-3 (APH-3) promoted cellular transformation.

216 bjective measures of gait, quantification of HTLV-1 proviral load in peripheral blood mononuclear cel

217 erived from the putative packaging signal of HTLV-2 relative to nonspecific NA.

218 The X-ray structure of HTLV-1 PR in complex with the well-known and approved HI

219 Such a system can facilitate the study of HTLV-1 replication in cell culture.

220 ammatory myelopathy occurring in a subset of HTLV-1-infected individuals.

221 The p9 localization is similar to that of HTLV-1 p12 and induced a strong decrease in the calretic

222 We hypothesized that transformation of HTLV-1-infected CCR4+ T cells into Th1-like cells plays

223 s can be used to quantify and study HIV-1 or HTLV-1 cell-mediated infection in a simple one-step tran

224 Here we demonstrate that ATL-derived or HTLV-1-transformed cells are dependent on continuous Tax

225 comparison to antisense proteins from other HTLV viruses is important.

226 ia/lymphoma and tropical spastic paraparesis/HTLV-1-associated myelopathy in about 5% of infected ind

227 esent an essential early step for permissive HTLV-1 infection and persistence.

228 The ease with which chronic and productive HTLV-1 infection can be established in cell culture thro

229 HTLV-1 protease (HTLV-1 PR) is an aspartic protease which represents a pr

230 ivileged structures against HTLV-1 protease (HTLV-1 PR).

231 As a retrovirus, HTLV-1 integrates its genome into a host cell chromosome

232 The human-pathogenic retroviruses HTLV-1 and HIV-1 can be transmitted more efficiently in

233 ared the effects of HBZ and APH-2 on several HTLV-relevant cellular pathways, including the TGF-beta

234 ling the expression of alternatively spliced HTLV-1 mRNAs and suggest a link between the cycling prop

235 of the complete set of alternatively spliced HTLV-1 mRNAs.

236 otropic virus type 1 (HTLV-1) and can spread HTLV-1 to susceptible cells.

237 Stable HTLV-1-producing HOS cell clones can be readily establis

238 r B' incapable of binding to and stimulating HTLV-1 and -2 IN strand transfer activity.

239 ory mechanism may be important for long-term HTLV-1 infection.

240 MA also binds NAs with higher affinity than HTLV-2 NC and displays more robust chaperone function.

241 Our results demonstrate that HTLV-1 Gag is capable of membrane targeting and particle

242 sion electron microscopy to demonstrate that HTLV-1 particles produced from a distinct chronically in

243 Our results demonstrate that HTLV-encoded antisense proteins behave differently, and

244 in Japan, provided conclusive evidence that HTLV was the cause of this disease.

245 Previously, our group found that HTLV-1 HBZ and HTLV-2 APH-2 had distinct effects in vivo

246 In addition, we found that HTLV-1, subtype 1A isolates corresponding to the Japanes

247 We show here that HTLV-1 may be able to successfully infect the T cells an

248 These studies indicated that HTLV-I-transformed and ATL cells, but not normal periphe

249 Importantly, we revealed that HTLV-1 bZIP factor (HBZ) protein which is expressed in a

250 Evidence suggests that HTLV-1, via the viral protein Tax, exploits CD4+ T cell

251 The HTLV genome antisense-strand genes hbz and aph-2 are oft

252 The HTLV-1 and HTLV-2 prevalences among US blood donors has

253 The HTLV-1 particle structure is still poorly understood, an

254 The HTLV-1 transactivator protein Tax controls many critical

255 All the HTLV-1-positive hunters bitten by a gorilla or chimpanze

256 on, infected target cell activation, and the HTLV-I-specific CTL response.

257 s highly divergent and was designated as the HTLV-4 subtype-b prototype.

258 antisense strand of its proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), which inhibits

259 respectively, which, in contrast to HBZ, the HTLV-1 homologue, do not contain a typical bZIP domain.

260 Indeed, the HTLV-1 strains currently present in North Africa have or

261 To more clearly define the roles of the HTLV-1 CA amino-terminal domain (NTD) and CA CTD in part

262 articles, highlighting the importance of the HTLV-1 CA NTD in HTLV-1 immature particle morphology.

263 ing experimental system for the study of the HTLV-1 particle structure.

264 r infection by HTLV-1 or transduction of the HTLV-1 tax gene.

265 The antisense strand of the HTLV-2 proviral genome also encodes a protein termed APH

266 CTD, but the HIV-1 CA NTD cannot replace the HTLV-1 CA CTD, indicating that the HTLV-1 CA subdomains

267 In this study, the HTLV-1 capsid amino-terminal domain was found to provide

268 observations support the conclusion that the HTLV-1 CA NTD can functionally replace the HIV-1 CA CTD,

269 place the HTLV-1 CA CTD, indicating that the HTLV-1 CA subdomains provide distinct contributions to G

270 In this study, we found that the HTLV-1-encoded protein HBZ activates expression of BDNF,

271 Furthermore, chimeric Gag proteins with the HTLV-1 CA NTD produced particles phenotypically similar

272 y structures of two representatives bound to HTLV-1 PR were determined, and the structural basis of t

273 st and viral proteins that may contribute to HTLV-1-induced pathogenesis.

274 lia, and report on 53 individuals exposed to HTLV-1 with no transmissions documented (95% confidence

275 virus type 3 (STLV-3) is almost identical to HTLV-3.

276 type 1 (STLV-1), a virus closely related to HTLV-1, in olive baboons (Papio anubis).

277 d in resting T cells, which are resistant to HTLV-1 infection, we investigated a potential protective

278 ttributed to the cellular immune response to HTLV-1-infected lymphocytes.

279 produced particles phenotypically similar to HTLV-1 immature particles, highlighting the importance o

280 ase in the calreticulin signal, similarly to HTLV-1 p12.

281 and Env proteins persistently; and transmit HTLV-1 to naive HOS, SupT1, and Jurkat T reporter cell l

282 In arsenic/interferon-treated HTLV-1 transformed or ATL cells, Tax is recruited onto N

283 Human T-cell leukemia virus (HTLV) type 1, the etiological agent of adult T-cell leuk

284 acterization of human T-cell leukemia virus (HTLV; now known as HTLV-1) produced by a T-cell line fro

285 associated with human T lymphotropic virus (HTLV) infection.

286 ica identified 2 human T-lymphotropic virus (HTLV)-4-infected individuals.

287 cination against human T lymphotropic virus (HTLV).

288 s (HCV) and human T-cell lymphotropic virus (HTLV-1) can be used to investigate past iatrogenic trans

289 re infected with human T lymphotropic virus (HTLV-1).

290 25.9%) were HCV seropositive; 26 (3.1%) were HTLV-1-seropositive.

291 A vaccine is urgently needed in areas where HTLV-1 is endemic.

292 These data suggest a model whereby HTLV-1 infection augments the number of classical monocy

293 tly impact the global burden associated with HTLV infections.

294 ivity of HTLV-1 particles may correlate with HTLV-1 particle populations containing few virus particl

295 hocytic cell lines chronically infected with HTLV-1, particularly the MT-2 cell line, which harbors t

296 ysregulation of CD4(+) T cells infected with HTLV-1.

297 FACT proteins also interfere with HTLV-1 Tax-LTR-mediated transcription and viral latency,

298 ion and disease progression in patients with HTLV-1-associated inflammatory diseases.

299 to that of cells isolated from patients with HTLV-I-associated adult T-cell leukemia or with progeria

300 ne responses all parallel what are seen with HTLV infection of humans.