ライフサイエンスコーパス: HTS

1 HTS and FC showed similar 5-year EFS and OS for MRD-posi

2 HTS and phylogenetic analysis of paired specimens confir

3 HTS circuits operating at liquid-nitrogen temperatures (

4 HTS is the result of dysregulated wound healing, where e

5 HTS of 2560 small molecules to search for inhibitory com

6 HTS screening identified compound 2a (piperazinone deriv

7 HTS screening led to identification of five distinct sub

8 HTS-based methods can simultaneously identify multiple g

9 og units higher), and furthermore, for 14/23 HTS screens, the average clogD was higher than the scree

10 showing a 50-fold increase over those from a HTS (high-throughput screen).

11 This class of compounds, identified in a HTS campaign against recombinant VCP, has been progressi

12 backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12

13 CSR recombination junctions sequenced with a HTS-based protocol (Ion Torrent technology).

14 In this Letter we demonstrate all-HTS Josephson superconducting tunnel junctions created b

15 An HTS campaign using an RNA-dependent ATPase assay and ini

16 We have developed an HTS-compatible assay based on AlphaLISA technology that

17 ine benzimidazole series was derived from an HTS hit and optimized by utilization of a docking model,

18 Thus, an HTS campaign on the proprietary Nerviano Medical Science

19 velopment of PDE10A inhibitors began with an HTS screening hit (1) that exhibited both high p-glycopr

20 aved as frequent hitters under both FBDD and HTS settings, although the problem was more pronounced i

21 The ARE-bla computational model and HTS data from a big data source (PubChem) were used to p

22 ermore, hybrid genome assembly with RTnS and HTS reads substantially improved upon a genome assembled

23 The output from 23 antibacterial HTS screens illustrated that when compared to the proper

24 ARQiv-HTS thus enables large-scale whole-organism drug discove

25 ocess of establishing and implementing ARQiv-HTS: (i) assay design and optimization, (ii) calculation

26 col for a recently completed inaugural ARQiv-HTS effort, which involved the identification of compoun

27 strategies for leveraging the power of ARQiv-HTS for zebrafish-based drug discovery, and address tech

28 th customized robotics, and is termed 'ARQiv-HTS'.

29 ond this initial example, however, the ARQiv-HTS platform is adaptable to almost any reporter-based a

30 ese results suggest that the AlphaLISA-based HTS assay is robust and sensitive and can be used to scr

31 The cell-based HTS allowed us to identify an anti-cancer drug of bis-bi

32 The cost of traditional cell-based HTS is dictated by the library size, which is typically

33 sing an in vitro fluorescence and cell-based HTS, we evaluated 10,240 small molecules.

34 r reported from any lengths of cuprate-based HTS wire or conductor.

35 lls, with shallow, multiple identifier-based HTS of ASTs identified by activation marker upregulation

36 We describe an MS-based HTS workflow that addresses these challenges.

37 we provide an intermediary platform between HTS and mice by adapting mouse models of pediatric brain

38 ymorphisms (SNPs) with severity of post-burn HTS, we conducted a prospective cohort study of burned a

39 th day 29 MRD <0.1% by FC) were evaluated by HTS and FC for event-free (EFS) and overall survival (OS

40 ands predicted in silico as well as found by HTS, were identified.

41 ividuals and short read lengths generated by HTS technologies.

42 Of the 167 ligands identified by HTS, five were predicted to potentially cause clinical d

43 t caution when interpreting data obtained by HTS of these remains.

44 to examining antigen receptor repertoires by HTS, and discuss inherent biological and technical chall

45 Combined HTS (11000 compounds) and in-house screening of a limite

46 robes, including divergent species concepts, HTS tools used to eliminate errors and population-level

47 A repository of curated HTS training materials would support trainers in materia

48 cells in psoriasis, we carried out TCR/delta HTS.

49 In a differential HTS analysis including the human AChE, several structura

50 g HTS etiology and developing more effective HTS therapies.

51 role of CSMD1 in wound healing may elucidate HTS pathophysiology.

52 en in vivo, which is critical to elucidating HTS etiology and developing more effective HTS therapies

53 may be easily developed for certain enzymes, HTS assays designed to identify ligands that block prote

54 1 month after device removal; an excisional HTS model was also imaged at 6 months after injury to in

55 th in the optimally doped nodeless s-wave Fe-HTS Ba0.65Rb0.35Fe2As2.

56 n-based high-temperature superconductors (Fe-HTSs) is non-universal.

57 er unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries

58 ophobicity was often the dominant driver for HTS actives but, more often than not, precluded whole ce

59 polarization provide a robust signature for HTS.

60 e to develop a cell-based assay suitable for HTS to rapidly identify inhibitors arenavirus multiplica

61 inherent in enzymatic assays widely used for HTS.

62 Our FP-HTS identified eight inhibitors that blocked the MDM2 pr

63 (MS) is potentially powerful for label-free HTS due to its high sensitivity, speed, and resolution.

64 ification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into pot

65 Eight structurally related analogues from HTS libraries were similarly reactive.

66 tially improved upon a genome assembled from HTS reads alone.

67 as a powerful tool to triage drug-leads from HTS for formal efficacy testing in mice.

68 lpiperidine compounds, which originated from HTS of approximately 288000 small molecules.

69 CYP2D6 genotype at basepair resolution from HTS data.

70 sha (preprocessing of aligned sequences from HTS analyses) allows easy manipulation of aligned reads

71 Starting from HTS hit 5, IDO-1 inhibitor 6 (EOS200271/PF-06840003) has

72 The mechanisms guiding HTS formation are multifactorial and complex.

73 Herein, we review how HTS has led to the discovery of novel nucleic acid speci

74 es from 75 patients with DLBCL, comparing Ig-HTS from the cellular (circulating leukocytes) and acell

75 We prospectively evaluated the utility of Ig-HTS within 311 blood and 105 tumor samples from 75 patie

76 llance time points before relapse, plasma Ig-HTS demonstrated improved specificity (100% vs 56%, P <

77 mmunoglobulin high-throughput sequencing (Ig-HTS) from peripheral blood provides an alternate strateg

78 Given its high specificity, Ig-HTS from plasma has potential clinical utility for surve

79 at various sources of experimental biases in HTS confound read-depth estimation, and note that bias c

80 rrect position-specific nucleotide biases in HTS short read data.

81 These biases are particularly evident in HTS assays for identifying regulatory regions in DNA (DN

82 centrations and their activities reported in HTS assays, we developed a probabilistic model for estim

83 tedly high demand for training scientists in HTS data analysis.

84 ross-contamination was highly significant in HTS.

85 on of the assay enabled its efficient use in HTS (Z' = 0.7 in the 384-well format).

86 O), and it has a Z-score of 0.71, indicating HTS compatibility.

87 to gain significant biological insights into HTS remodeling by enabling longitudinal assessment of co

88 Optimization of KDM6B (JMJD3) HTS hit 12 led to the identification of 3-((furan-2-ylme

89 fferent laboratories, presenting the largest HTS assessment of charred archaeobotanical specimens to

90 A mini-HTS on 4000 compounds selected using 2D fragment-based s

91 ased on extensive calibration using multiple HTS data sets, we conclude that our method outperforms e

92 assessment of collagen remodeling in murine HTS.

93 To minimize such grain boundary obstacles, HTS conductors such as REBa2Cu3O(7-x) and (Bi, Pb)2Sr2Ca

94 re available, either for general analysis of HTS data or targeted to a specific sequencing technology

95 represents a next step in the QC analysis of HTS data.

96 Application of HTS techniques has led to many key discoveries, includin

97 to enable more complete characterizations of HTS chemical matter.

98 Therefore, the collapse of HTS with overdoping is not caused by competing ferromagn

99 an alternative explanation - competition of HTS with ferromagnetic order, fluctuating in superconduc

100 nd antioxidants impinge on the complexity of HTS-induced responses over different genetic backgrounds

101 this has been argued to cause the demise of HTS with overdoping.

102 The destruction of HTS with overdoping is therefore caused neither by the g

103 end on race, but the genetic determinants of HTS are unknown.

104 We describe the evolution of HTS hits derived from Jak2/Tyk2 inhibitors into selectiv

105 he data and displaying important features of HTS data and hit selection results.

106 Here we report the findings of HTS and target enrichment on four important archaeologic

107 Worldwide growth of HTS data has prompted the development of compression met

108 In the first published GWAS of HTS, we report that a common intronic variant in the CSM

109 To achieve accurate interpretation of HTS data, however, one needs to overcome several obstacl

110 However, until recently, the lack of HTS-compatible assay technologies precluded large scale

111 The management of HTS has been challenging for clinicians, since current t

112 tunities in the prevention and management of HTS.

113 aligner that can handle the multi-mapping of HTS reads very efficiently.

114 ng-site preference for the growing number of HTS-based epigenetic assays.

115 sensitivity and lower false-negative rate of HTS improves upon FC for MRD detection in pediatric B-AL

116 ware to analyze and visualize the results of HTS of chemical libraries.

117 th a focus on the current and future role of HTS-based assays.

118 ition, the increased analytic sensitivity of HTS permitted identification of 19.9% of SR patients wit

119 ompression methods on a comprehensive set of HTS data using an automated framework.

120 different from biases seen in other types of HTS data sets, and in some cases the most constrained po

121 In addition, the use of HTS allows the recovery of multiple sequences per specim

122 More important, this well-optimized HTS assay for DHOase, the first of its kind, should make

123 of this acid-labile product by BMA or other HTS methods.

124 rate tool for analysis of sequences from our HTS-based protocol for CSR junctions, thereby facilitati

125 plate readers' formats, computes the overall HTS matrix, automatically detects hits and has different

126 Here, we report extremely high performance HTS wires based on 5 mum thick SmBa2Cu3O7--delta (SmBCO)

127 ndings suggest that mixture-based phenotypic HTS can significantly reduce cost and hit-to-lead time w

128 eader" that couples standard multiwell plate HTS workflow to droplet ESI-MS.

129 retardation and low degree of polarization, HTS was characterized by an initially low local retardat

130 associated with reduced severity of postburn HTS.

131 Risk of severe postburn HTS is known to depend on race, but the genetic determin

132 The SAR of a moderately potent HTS hit was investigated resulting in the discovery of p

133 From a modestly potent HTS hit (4), we identified molecules such as 6-[6-(metho

134 Here, benzamide analogues based on previous HTS hits have been purchased or synthesized.

135 ics pipeline (ezVIR) was designed to process HTS data from any of the standard platforms and to evalu

136 n of each read provide a fast way to process HTS data, they are not suitable for many types of downst

137 oenvironment can be adapted for quantitative HTS and may improve the disease relevance of assays used

138 ion methods that aim to significantly reduce HTS data size.

139 Most reported HTS QC metrics are designed for plate level or single we

140 scovery and other related areas of research, HTS methodology has yet to be exploited for use in a cli

141 Tdp2 and developed a homogeneous and robust HTS assay.

142 Hypertrophic scar (HTS) formation is a frequent postoperative complication

143 rminants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor (MC1R) los

144 Hypertrophic scars (HTS), frequently seen after traumatic injuries and surge

145 ing a high-throughput small-molecule screen (HTS), we find that analogs of the small molecule harmine

146 ain to a large-scale high-throughput screen (HTS) drug discovery campaign, allowing multicycle infect

147 arting point after a high-throughput screen (HTS) for receptor agonists.

148 Starting from a high-throughput screen (HTS) hit (1), a systematic structure-activity relationsh

149 We have conducted a high throughput screen (HTS) of 17,500 compounds for inhibition of the essential

150 In a high throughput screen (HTS) of 230000 small molecules designed to identify bioa

151 ulfhydryl-scavenging high-throughput screen (HTS) targeting the histone acetyltransferase Rtt109 were

152 ls, we carried out a high throughput screen (HTS) using an ApoC-III homogenous time resolved fluoresc

153 al temperature for a high-throughput screen (HTS) was determined to be 30 degrees C, the assay tolera

154 A high-throughput screen (HTS) was undertaken against the respiratory chain dehydr

155 A high-throughput screen (HTS), using an assay of Ca(2+)-induced mitochondrial swe

156 Demonstrating the high-throughput screening (HTS) adaptability, the gamma9 assay performed using an i

157 s and amenable to high-throughput screening (HTS) applications.

158 No target-based high-throughput screening (HTS) assay for this enzyme has been reported to date.

159 d host cell-based high throughput screening (HTS) assay to screen and characterize FDA-approved, off-

160 ely by a chemical high-throughput screening (HTS) assay.

161 However, most high throughput screening (HTS) assays for drug discovery use cancer cells grown in

162 In vitro high-throughput screening (HTS) assays have emerged as a potential tool for priorit

163 ds using in vitro high throughput screening (HTS) assays to prioritize chemicals for EDSP Tier 1 scre

164 he development of high-throughput screening (HTS) assays with increased sensitivity for the identific

165 ming a cell-based high throughput screening (HTS) campaign, we identified several potential small mol

166 sing a cell-based High Throughput Screening (HTS) campaign, we identified that 2-[4-[(4-methoxyphenyl

167 t can be used for high-throughput screening (HTS) campaigns for modulators of protein palmitoylation.

168 d and performed a high-throughput screening (HTS) capable of identifying genes that play active roles

169 can achieve true high-throughput screening (HTS) capacities.

170 lyses translating high-throughput screening (HTS) data to human relevance have been limited.

171 New sources of high-throughput screening (HTS) data, such as the ToxCast database, which contains

172 e GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened

173 Large high-throughput screening (HTS) efforts are widely used in drug development and che

174 ection results in high-throughput screening (HTS) experiments.

175 quinoline hit via high throughput screening (HTS) followed by optimization provided a 4-phenyl-3-aryl

176 High-throughput screening (HTS) for biological activity allows the ToxCast research

177 High-throughput screening (HTS) has enabled millions of compounds to be assessed fo

178 says suitable for high-throughput screening (HTS) have not been widely reported.

179 l optimization of high-throughput screening (HTS) hit 1 led to the identification of 3, which demonst

180 t emanated from a high throughput screening (HTS) hit and progressed via iterative cycles of structur

181 an indazole amide high throughput screening (HTS) hit followed by truncation to its minimal pharmacop

182 d change from the high-throughput screening (HTS) hit is described.

183 ng of biochemical high-throughput screening (HTS) hits led to the discovery of a series of ligands th

184 tudy, we utilized high-throughput screening (HTS) in vitro data of PAHs to predict health risks assoc

185 assay amenable to high-throughput screening (HTS) is developed.

186 High throughput screening (HTS) is important for identifying molecules with desired

187 sent a risk-based high-throughput screening (HTS) method to identify chemicals for potential health c

188 Using high-throughput screening (HTS) methodology, DMF and NaHCO3 were rapidly identified

189 hydrophobicity by high-throughput screening (HTS) methods is a major issue in drug discovery.

190 eloping effective high-throughput screening (HTS) methods is of paramount importance in the early sta

191 urrent cell-based high-throughput screening (HTS) models to identify molecules affecting ECM accumula

192 evelopment of the high-throughput screening (HTS) Navigator software to analyze and visualize the res

193 s from whole cell high-throughput screening (HTS) of a SoftFocus kinase library against the malaria p

194 on (FP) assay for high-throughput screening (HTS) of chemical libraries.

195 same approach in high-throughput screening (HTS) of large compound libraries to find novel scaffolds

196 on may facilitate high-throughput screening (HTS) of novel anti-infectives.

197 Utilizing high-throughput screening (HTS) of the T cell receptor (TCR) and immunostaining, we

198 We developed a high throughput screening (HTS) platform to identify small molecule inhibitors of F

199 s are critical in high throughput screening (HTS) platforms to ensure reliability and confidence in a

200 Using high throughput screening (HTS) platforms, we showed that the oxidative stress-depe

201 ncy (EPA) ToxCast high-throughput screening (HTS) program.

202 icular cell-based high-throughput screening (HTS) studies, have provided the research community with

203 was optimized for high-throughput screening (HTS) to identify specific inhibitors of RNase P from a 2

204 High-throughput screening (HTS) using multiwell plates and fluorescence plate reade

205 In parallel, high-throughput screening (HTS) was conducted using the fluorescent probe substrate

206 High-throughput screening (HTS) was employed to discover APOBEC3G inhibitors, and m

207 than M2-targeted high-throughput screening (HTS), and direct measurement of its activity has been li

208 harmacophore of a high throughput screening (HTS)-derived series of compounds described previously.

209 rhagic fever, for high-throughput screening (HTS).

210 ibraries used for high-throughput screening (HTS).

211 avy dependency on high-throughput screening (HTS).

212 dentified through high-throughput screening (HTS).

213 y is suitable for high throughput screening (HTS).

214 new technique for high-throughput screening (HTS).

215 entified out of a high-throughput screening (HTS).

216 whole-cell-based high-throughput screening (HTS).

217 of the success of high-throughput screening (HTS).

218 sed on a hit from high-throughput screening (HTS).

219 Cast(TM) high throughput in vitro screening (HTS) program.

220 High-throughput screens (HTS) of compound toxicity against cancer cells can ident

221 in both screens were confirmed in secondary HTS and low-throughput assays.

222 High-throughput sequence (HTS) data exhibit position-specific nucleotide biases th

223 High-throughput DNA sequencing (HTS) now facilitates examination of immunoglobulin and T

224 High throughput DNA sequencing (HTS) technologies generate an excessive number of small

225 High-throughput sequencing (HTS) and bioinformatics have expanded our understanding

226 olution, enables High Throughput Sequencing (HTS) assembly projects to consistently run to completion

227 High-throughput sequencing (HTS) data are commonly stored as raw sequencing reads in

228 e for processing high-throughput sequencing (HTS) data.

229 High-throughput sequencing (HTS) enhances the power of comparative sequence analysis

230 While high-throughput sequencing (HTS) has been used successfully to discover tumor-specif

231 advances such as high-throughput sequencing (HTS) have changed conceptions about the magnitude of div

232 High-throughput sequencing (HTS) is now a widely used and accessible technology that

233 laboratory-based high-throughput sequencing (HTS) methods for species level identification and phylog

234 Here, we compare high-throughput sequencing (HTS) of IGH and TRG genes vs flow cytometry (FC) for mea

235 High-throughput sequencing (HTS) of in vitro selected populations offers a large sca

236 nt tissues using high-throughput sequencing (HTS) of the gene encoding the T cell receptor (TCR) beta

237 have shifted to High-Throughput Sequencing (HTS) or Next-Generation Sequencing (NGS) technologies, s

238 High throughput sequencing (HTS) platforms generate unprecedented amounts of data th

239 Although high-throughput sequencing (HTS) promises to significantly facilitate systematic evo

240 High-throughput sequencing (HTS) provides the means to analyze clinical specimens in

241 e advancement of high-throughput sequencing (HTS) technologies and the rapid development of numerous

242 n suggested that high-throughput sequencing (HTS) technologies coupled with DNA enrichment techniques

243 cent advances in high throughput sequencing (HTS) technologies have transformed our ability to examin

244 In this context, high-throughput sequencing (HTS) technologies provide a promising time-efficient and

245 velopment of new high-throughput sequencing (HTS) technologies, the complete spectrum of mobile eleme

246 combination with high-throughput sequencing (HTS) technology, it can be used to infer genome-wide lan

247 ch combines deep high-throughput sequencing (HTS) within functional CD4 T cell compartments, such as

248 nces produced by high-throughput sequencing (HTS), we designed CSReport, a software program dedicated

249 By high throughput sequencing (HTS), we obtained the first de novo transcriptome of mah

250 available tests, high-throughput sequencing (HTS)-based approaches are increasingly attractive for no

251 confirmed using high-throughput sequencing (HTS).

252 The prevalence of severe HTS (VSS>7) was 49%, and the mean itch score was 3.9.

253 Testing for association with severe HTS (VSS>7) and itch severity (0-10) was based on multiv

254 gnificantly (P<0.001) associated with severe HTS.

255 ce were independently associated with severe HTS.

256 wheat cultivars to high temperature stress (HTS).

257 In this study, HTS was induced with a mechanical tension device for 4-1

258 density in high temperature superconducting (HTS) wires based on epitaxial YBa2Cu3O7-delta (YBCO) fil

259 ng-length, high-temperature superconducting (HTS) wires capable of carrying high critical current, Ic

260 hat show high-temperature superconductivity (HTS), the critical temperature (Tc) has a dome-shaped do

261 he high-temperature cuprate superconductors (HTSs) has proved difficult because of the presence of hi

262 scovery of high-temperature superconductors (HTSs), most efforts of researchers have been focused on

263 high-transition-temperature superconductors (HTSs), researchers have explored many methods to fabrica

264 Another challenge of targeted HTS is the risk of specimen-to-specimen cross-contaminat

265 The HTS identified PanK inhibitors exemplified by the detail

266 The HTS Navigator processes output files from different plat

267 The HTS resulted in the identification of four candidate com

268 The HTS-based discovery and structure-guided optimization of

269 the sharing of teaching experience among the HTS trainers' community.

270 erties of known antibacterial agents and the HTS active starting point, (b) the probability of plasma

271 sensus descriptions are also revealed by the HTS analysis.

272 of the antibacterial project compounds, the HTS actives were significantly more hydrophobic than ant

273 The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, tri

274 es with mGlu2 PAM activity starting from the HTS hit 5.

275 Dose-response assays with 1 from the HTS sample, as well as commercial material, yielded simi

276 nique chemicals with curated activity in the HTS data using high-quality dose-response model fits and

277 n of a systematic series of analogues of the HTS hit 15.

278 enza A/H3N2 samples were sequenced using the HTS protocol and were compared against a Sanger-based se

279 eral prominent chemotypes identified by this HTS, including some pan-assay interference compounds (PA

280 o help assess the predictive utility of this HTS platform.

281 pared to actives found from high throughput (HTS) screens conducted on both biochemical and phenotypi

282 f the previously identified high-throughput (HTS) hit 1 (ESI-09).

283 lated in 384-well plates has been adapted to HTS/HCS assays of 7 d.

284 main obstacle to applying previous assays to HTS.

285 EPA ToxCast HTS assays for estrogen, androgen, steroidogenic, and th

286 We used the extensive ToxCast HTS binding data set to show that OASIS ER and AR QSAR m

287 ents was significantly lower than in typical HTS.

288 A significant obstacle to understanding HTS etiology is the lack of tools to monitor scar remode

289 To make multiple uniform HTS junctions, control at the atomic level is required.

290 s for virtually any tyrosine kinase that use HTS-compatible lanthanide-based detection.

291 Using HTS data from a variety of ChIP-seq, DNase-seq, FAIRE-se

292 lot study, the pipeline was challenged using HTS data from 20 clinical specimens representative of th

293 is reports, makes it worth considering using HTS for clinical diagnostics.

294 olomics can be used to evaluate and validate HTS leads.

295 als were evaluated in a panel of 13 in vitro HTS assays.

296 onclusion, by combining docking and in vitro HTS, competitive and noncompetitive ligands of OCT1 can

297 ed into a reliable 384- and 1,536-multi-well HTS assay that reproduces the human ovarian cancer (OvCa

298 ong microbial groups and the extent to which HTS tools designed for bacteria are useful for eukaryote

299 ed analysis of chemical occurrence data with HTS data offers new opportunities to prioritize chemical

300 wever, there was a high discordant rate with HTS identifying 55 (38.7%) more patients MRD positive at