ライフサイエンスコーパス: Hb

1 Hb bifunctionally regulates eve stripe 7, but it execute

2 Hb degradation is severely impaired and large amounts of

3 Hb response (increase in Hb of >/=1.0 g/dl from baseline

4 Hb S, rHb (betaE6V/alphaH20Q), rHb (betaE6V/alphaH50Q),

5 Hb values, although similar at randomization, improved b

6 [Hb] was reduced from 14.2 +/- 0.8 to 12.8 +/- 0.7 g dl(-

7 [Hb] was related (negatively) to VO2 kg(-1) (r = -0.45, P

8 RBC populations to a resolution of 1 x 10(7) Hb molecules per cell (4 x 10(7) atoms of Fe per cell or

9 of the alkaline process version yielded 93% Hb removal.

10 thod for direct detection of hemoglobin A1c (Hb(A1c)), a potent biomarker for diabetes diagnosis and

11 ival in reticulocytes with reduced or absent Hb digestion may imply a novel mechanism of drug resista

12 We demonstrate that this N9 NA has an active Hb site which binds to sialic acid, which enhances overa

13 lectrode surface morphology before and after Hb detection are monitored by electron microscopy.

14 Delay to HDC was done to allow Hb and platelets to approach 11 g/dL and 100 x 10(3)/muL

15 The polymer allowed Hb(A1c) selectively bound to its surface via forming the

16 aseline resolution is achieved between alpha-Hb, beta-Hb, and glycated beta-Hb.

17 The percentage of glycated alpha-Hb and beta-Hb was calculated from the microfluidic CE-M

18 Glycation on alpha-Hb is also detected in the alpha-Hb mass spectrum.

19 on on alpha-Hb is also detected in the alpha-Hb mass spectrum.

20 Although Hb itself was able to quench the fluorescence of CDs, ba

21 The cause and effect relationships among [Hb], QT, DM, and PCO2 remain to be elucidated.

22 ow that the IsdH protein, which serves as an Hb receptor in the Isd system, directly interferes with

23 e redox current of PAPBA decreased due to an Hb(A1c) binding-induced ion flux blocking mechanism, whi

24 His mother has Sickle cell anaemia (Hb SS) and his father is a carrier of heterozygous alpha

25 maquine developed moderately severe anaemia (Hb < 8 g/dL).

26 A comparison of the Hb-free and Hb-bound forms reveals that Hb binding alters the positi

27 nically-relevant concentrations of HbA1c and Hb were automatically measured on the integrated microfl

28 dic system is capable of detecting HbA1c and Hb with a good linear response.

29 agnitude larger than the prefactor of Mb and Hb ( approximately 10(9) s(-1)).

30 factors associated with CO binding in Mb and Hb.

31 tiple regression analysis, Q(peak), RBCV and Hb(mass) were found to be independent predictors of V(O2

32 , single-cell measurements of RBC volume and Hb concentration are taken millions of times per day by

33 RBCV, plasma volume and Hb(mass) all increased (P < 0.05) after ET (8 +/- 4, 4 +

34 hemoglobin (Hb) correction study in anemic (Hb</=10.0 g/dl) patients incident to hemodialysis (HD) o

35 kaline Bohr effect, and autoxidation rate as Hb S.

36 CE-MS method is capable of rapidly assessing Hb and HSA glycation from low volumes of whole blood wit

37 IsdB, the other S. aureus Hb receptor, failed to extract heme from Hb-Hp, and it w

38 near regression models adjusted for baseline Hb A1c, sociodemographic variables, diabetes-related var

39 Mean+/-SD baseline Hb was 8.3+/-1.0 g/dl in enrolled patients.

40 The percentage of glycated alpha-Hb and beta-Hb was calculated from the microfluidic CE-MS data using

41 the alpha and beta subunits (alpha- and beta-Hb), which are then separated via CE directly coupled to

42 isomer that is partially resolved from beta-Hb is detected in extracted ion electropherograms for gl

43 A second glycated beta-Hb isomer that is partially resolved from beta-Hb is det

44 The values for glycated beta-Hb were found to correlate well with the HbA1c levels de

45 cted ion electropherograms for glycated beta-Hb.

46 between alpha-Hb, beta-Hb, and glycated beta-Hb.

47 esolution is achieved between alpha-Hb, beta-Hb, and glycated beta-Hb.

48 Additional modifications to the beta-Hb are detected, including acetylation and a +57 Da spec

49 her our data indicate an association between Hb/iron levels and BCG growth in vitro, which may in par

50 The ability to assess both Hb and HSA glycation has the potential to provide a more

51 the delivery of SNO-based NO bioactivity by Hb redefines the respiratory cycle as a triune system (N

52 n HF can or cannot be generally inferred by [Hb] measurements and clinical correlates remains unclear

53 ed to high-level chimerism and near complete Hb replacement with normal donor Hb with this postnatal

54 metry (SpO2%), and hemoglobin concentration (Hb).

55 nosed according to hemoglobin concentration [Hb], hence may be the result of hemodilution or true red

56 om 9.1 to 10.3 g/dL; P < .001) and decreased Hb S (from 39.7% to 24.3%; P < .001).

57 that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the release of me

58 Early preclinical data have described Hb as a brain nucleus activated in anticipation of avers

59 There was no difference in discharge Hb levels, morbidity, mortality, or quality of life.

60 ar complete Hb replacement with normal donor Hb with this postnatal "boosting" strategy; and (3) high

61 new method for developing an electrochemical Hb(A1c) biosensor and can be extended to other label-fre

62 the first to demonstrate that extracellular Hb directly affects the GPIbalpha-VWF interaction in thr

63 were then investigated to further facilitate Hb-removal.

64 the globin chains: from paramagnetic ferrous Hb to diamagnetic ferrous oxyhemoglobin (oxyHb) with rev

65 Thus, highly oxidizing ferryl Hb and heme, the product of oxidation, may be central to

66 for sickle cell disease (SCD), induces fetal Hb production and can act as an NO donor.

67 mg/dL for PG, and -0.01% (-0.02%, 0.00%) for Hb A1c.

68 te could increase the adsorption ability for Hb, thus provides a facile direct electron transfer betw

69 IsdH(N2) accounted for the high affinity for Hb-Hp complexes.

70 from Hb-Hp, and it was a poor competitor for Hb-Hp binding to CD163.

71 es in patients have established evidence for Hb involvement in major depression, addiction, and schiz

72 range for Cyt c was found to be 0-10 muM for Hb/AuNCs and from 0 to 1 muM for DNA/AgNCs, with limits

73 Because free Hb interacts with VWF, we studied the effect of hemoglob

74 naling, and tissue distribution of cell-free Hb and its scavenger protein complexes.

75 Cell-free Hb depletes nitric oxide (NO) in the vasculature, causin

76 otect NO signaling by sequestering cell-free Hb in large protein complexes.

77 Extravascular translocation of cell-free Hb into interstitial spaces, including the vascular smoo

78 The effect of free Hb was effectively blocked by anti-glycoprotein Ibalpha

79 has its own mechanism to recapture the free Hb via haptoglobin (Hp) binding and uptake of Hb-Hp by t

80 Unexpectedly, free Hb also promoted firm platelet adhesion and stable micro

81 32, 570, 592, and 628 nm dissociated CO from Hb and doubled the CO elimination rate.

82 t is known to effectively dissociate CO from Hb, with a single photon dissociating one CO molecule.

83 Study 1: the bioavailability of heme Fe from Hb was similar to heme only ( approximately 13.0%).

84 eus Hb receptor, failed to extract heme from Hb-Hp, and it was a poor competitor for Hb-Hp binding to

85 tract the oxidized form of heme (hemin) from Hb, IsdH and IsdB.

86 nce resonance energy transfer mechanism from Hb/AuNCs to Cyt c and photoinduced electron transfer fro

87 er heme degradation and/or iron release from Hb and the subsequent reaction of hydroxyl radicals, as

88 chanisms that may promote hemin release from Hb by altering the position of its F helix.

89 propose a model for IsdB heme transfer from Hb that involves unfolding of Hb and heme iron ligand ex

90 bserved that patients with elevated glycated Hb levels also had higher levels of HSA glycation.

91 The habenula (Hb) is a central structure connecting forebrain to midbr

92 e kinase 1 (Sphk1) activity and haemoglobin (Hb) oxygen (O2) release capacity.

93 se, resulting in near sea-level haemoglobin (Hb) concentration.

94 ive intervention effect on mean haemoglobin (Hb) status (-2.6 g/l; 95% CI -4.5, -0.8; p = 0.005).

95 Furthermore, leakage of haemoglobin (Hb) inside the RBCs at high melittin concentration was a

96 ng the experimental addition of haemoglobin (Hb) or ferric iron, and reduced following addition of th

97 acid binding site, termed the hemadsorption (Hb) site, which is discrete from the enzymatically activ

98 Hemoglobin (Hb) Bart's hydrops fetalis syndrome (BHFS) resulting fro

99 Hemoglobin (Hb) multiplicity is common in fish, yet despite its ubiq

100 s the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma.

101 stems such as myoglobin (Mb) and hemoglobin (Hb).

102 ansported throughout the body by hemoglobin (Hb) in red blood cells (RBCs).

103 allogeneic engraftment and donor hemoglobin (Hb) expression with subsequent phenotypic correction of

104 immunochemical tests (FITs) for hemoglobin (Hb) are used in colorectal cancer screening.

105 s can acquire heme in vitro from hemoglobin (Hb) by a heme-sequestering mechanism that involves prote

106 s aureus that extracts heme from hemoglobin (Hb) to enable growth on Hb as a sole iron source.

107 Improved glycated hemoglobin (Hb A1c) delays the progression of microvascular and macr

108 postload insulin (PI), glycated hemoglobin (Hb A1c), and homeostasis model assessment of insulin res

109 o model systems tetrameric human hemoglobin (Hb) and human IgG4.

110 ctions, acquires iron from human hemoglobin (Hb).

111 ent outcomes included changes in hemoglobin (Hb) A1c (primary outcome), fasting plasma glucose (FPG),

112 ted to an evolutionary change in hemoglobin (Hb) function in high-altitude Andean house wrens (Troglo

113 Transfusions increased hemoglobin (Hb; from 9.1 to 10.3 g/dL; P < .001) and decreased Hb S

114 r the magnetic immobilization of hemoglobin (Hb) at a screen printed carbon electrode (SPCE).

115 work, the magnetic entrapment of hemoglobin (Hb) at the surface of a screen-printed carbon electrode

116 The magnetic characteristics of hemoglobin (Hb) changes with the binding of dioxygen (O2) to the hem

117 on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained i

118 Here, the distribution of hemoglobin (Hb) in the different fractions formed during pH-shift pr

119 e and selective determination of hemoglobin (Hb) in the presence of H2O2.

120 th VWF, we studied the effect of hemoglobin (Hb) on platelet adhesion to fibrin(ogen) under condition

121 r hemolysis and cell-free plasma hemoglobin (Hb) in pulmonary and systemic endothelial dysfunction in

122 formed an open-label, randomized hemoglobin (Hb) correction study in anemic (Hb</=10.0 g/dl) patients

123 d blood cell concentrate (RBCC), hemoglobin (Hb), RBCC+beef meat; study 2 on heme, heme+fish, chicken

124 yoglobin (Mb), characterize the "hemoglobin (Hb) superfamily." The long known and widely investigated

125 ein was detected relative to the hemoglobin (Hb) fraction.

126 poL1 (apolipoprotein L1) and the hemoglobin (Hb) scavenger Hpr (haptoglobin-related protein).

127 Using denaturing conditions, the hemoglobin (Hb) tetramer dissociates into the alpha and beta subunit

128 The reversible oxygen binding to hemoglobin (Hb) has been extensively studied in solution using a wid

129 ed hemoglobins (HbA1c) and total hemoglobin (Hb), which does not require a fasting blood sample and i

130 Secondary endpoints were various hemoglobin (Hb) levels, change in Hb between time points, length of

131 ercise capacity compared to those with high [Hb] as a result of beneficial changes in oxygen transpor

132 The IV iron group had higher Hb 4 weeks after discharge compared with the usual care

133 CMS subjects had lower SpO2, higher Hb, higher brain blood density, lower mean cerebral bloo

134 und that the iron-containing heme of the Hpr-Hb complex was not involved in TLF-1 lysis.

135 Previously, the Hpr-Hb complex was postulated to be a source of free radical

136 Human Hb research is still nascent but develops rapidly, along

137 V-Vis spectroscopy studies of adducted human Hb that revealed loss of alpha-helical content and deoxy

138 crystal structure of a complex between human Hb and IsdB.

139 y reported adduction of beta(93)Cys of human Hb, two novel sites of adduction were found; alpha(104)C

140 se phenotypes, we examined recombinant human Hb (rHb) Kirklareli containing the alpha H58L replacemen

141 Hunchback (Hb) is a bifunctional transcription factor that activate

142 Immunohistology identified Hb-laden MPs adherent to capillary endothelium in kidney

143 In addition to O2, ferrous (Fe(II)) Hb can bind CO.

144 The immobilized Hb on the surface of nanocomposite as an electrochemical

145 Three amino acids in Hb are strictly conserved in all mammals and birds, but

146 The primary end point was the change in Hb at day 7.

147 re various hemoglobin (Hb) levels, change in Hb between time points, length of stay, iron status, mor

148 Mean+/-SEM maximal change in Hb from baseline (DeltaHb(max)), the primary endpoint, w

149 The median decrease in Hb was 5.0 g/dL, with median Hb nadir of 7.0 g/dL.

150 y (CTV), we are able to detect difference in Hb concentration in two RBC populations to a resolution

151 This difference in Hb concentration was the result of routine RBC storage;

152 is responsible for an evolved difference in Hb-O2 affinity between high- and low-altitude house wren

153 In G6PD-deficient patients the drop in Hb was 0.63 g/dL (95% CI 0.03, 1.24) greater in those wh

154 However, the fall in Hb concentration at day 7 was greater in G6PD-deficient

155 Hb response (increase in Hb of >/=1.0 g/dl from baseline) was achieved in 96% of

156 The mean reduction in Hb at day 7 was similar in each group, a difference in t

157 In G6PD-normal patients, the reduction in Hb was 0.22 g/dL (95% CI -0.08, 0.52) less in those who

158 alkaline/acid pH-shift processing increased Hb removal up to 96/92%.

159 5b:WT enhanced the transport of internalized Hb to the lysosomes in comparison with control cells.

160 s transfusion of PRBCs for an intraoperative Hb level of 10 g/dL or greater or a postoperative Hb lev

161 ily." The long known and widely investigated Hb superfamily, however, has been enriched by the discov

162 of S. aureus, and a ternary complex of IsdB.Hb.Hp was observed.

163 Guidelines define a liberal Hb trigger as transfusion of PRBCs for an intraoperative

164 its of PRBCs were transfused using a liberal Hb trigger.

165 PaO2 was no different between CON and Low [Hb], although CaO2 was 10.4%, 9.2% and 9.8% lower at 18%

166 dies including HF patients with anemia (low [Hb]) (7 studies, n=127), whereas only 2 of 10 studies in

167 ncentration (isovolaemic haemodilution; Low [Hb]).

168 albumin-saline mixture) to reduce [Hb] (Low [Hb]).

169 l(-1) (10 +/- 2% reduction) from CON to Low [Hb] conditions.

170 osite is captured at SPCE by a super magnet (Hb/MHAM@Mag-NPs/SPCE).

171 cardiac output (Q(peak)), haemoglobin mass (Hb(mass)) and blood volumes were assessed prior to and f

172 A 3:1 ratio of Mb:Hb promoted lipid oxidation similarly compared to adding

173 milarly compared to adding a 1:1 ratio of Mb:Hb to washed muscle.

174 estoration of iron stores, and a higher mean Hb concentration 4 weeks after surgery.

175 Roxadustat at titrated doses increased mean Hb by >/=2.0 g/dl within 7 weeks regardless of baseline

176 ian decrease in Hb was 5.0 g/dL, with median Hb nadir of 7.0 g/dL.

177 idoxalated hemoglobin polyoxyethylene (20 mg Hb/kg/hr) or an equal volume of placebo, infused for up

178 ocess version could remove considerably more Hb (77%) compared to the acidic version (37%) when prote

179 n proteins were precipitated at pH 5.5; most Hb was removed during dewatering.

180 th 2 consecutive fHb concentrations of 0 mug Hb/g (P < .001).

181 nufacturers' thresholds (range, 2.0-17.0 mug Hb/g feces), at a uniform threshold (15 mug Hb/g feces),

182 baseline (below the cut-off value of 10 mug Hb/ g feces).

183 T result (hemoglobin concentration of 10 mug Hb/g feces) were invited for consultation and scheduled

184 Hb/g feces), at a uniform threshold (15 mug Hb/g feces), and at adjusted thresholds yielding defined

185 e FIT result was increased from 15 to 47 mug Hb/g feces halfway through 2014.

186 th 2 consecutive fHb concentrations of 8 mug Hb/g had a 14-fold increase in risk of AN compared with

187 a DeltaHb level of less than 50% and a nadir Hb level of 7 g/dL or greater, patients with a DeltaHb l

188 ltaHb concentration following surgery, nadir Hb level, and overall perioperative blood use were obtai

189 y ischemic adverse events, even if the nadir Hb level remained at 7 g/dL or greater.

190 of ischemic complications, even if the nadir Hb level was 7 g/dL or greater (OR, 5.68; 95% CI, 1.44-2

191 DeltaHb level of 50% or greater whose nadir Hb level was less than 7 g/dL were at a high risk of dev

192 on hemoglobin-stabilized gold nanoclusters (Hb/AuNCs) and aptamer-stabilized silver nanoclusters (DN

193 Results of experiments on native Hb variants and engineered, recombinant Hb mutants demon

194 revents Hb extravasation, which uncouples NO/Hb interaction and vasoconstriction.

195 Sequential compartmentalization of Hb by erythrocytes and scavenger protein complexes is an

196 Size-selective compartmentalization of Hb functions as a substitute for red blood cells after h

197 rformed two parallel assays for detection of Hb and HbA1c in a single chip.

198 proposed probe was used for determination of Hb in concentration range of 1-100 nM with a detection l

199 successfully applied to the determination of Hb in human blood samples.

200 esults show the excellent electroactivity of Hb.

201 The entrapment of Hb at MHAM@Mag-NPs was confirmed by cyclic voltammetry (

202 Expression of Hb genes correlated positively with mycobacterial growth

203 In contrast, about 50% inhibition of Hb endocytosis was observed in LdRab5b(+/-) cells withou

204 has a linear dependence on the logarithm of Hb(A1c) concentration ranging from 0.975 to 156 muM.

205 When multiplied over the number of Hb molecules in a red blood cell (RBC), the effect is de

206 in does not change NO dioxygenation rates of Hb; rather, the large size of the Hb:haptoglobin complex

207 The assay is based on the reaction of Hb with H2O2 that generates reactive oxygen species incl

208 rically inhibits the receptor recognition of Hb-Hp.

209 Novel recombinants of Hb S with single amino acid substitutions at the putativ

210 We also observe that atypical residues of Hb, His(58) and His(89) of alphaHb, coordinate to the he

211 in further improvement of the sensitivity of Hb detection.

212 ing enzymes involved in the initial steps of Hb proteolysis.

213 ning protein regions in the alpha subunit of Hb, revealing new protected Hb regions that were not obs

214 In this complex, the alpha subunits of Hb are refolded with the heme displaced to the interface

215 Therapeutic supplementation of Hb scavengers may restore vascular NO signaling and atte

216 he single mutants is comparable with that of Hb S.

217 Direct electron transfer of Hb incorporated into the biocomposite film was realized

218 transfer from Hb that involves unfolding of Hb and heme iron ligand exchange.

219 b via haptoglobin (Hp) binding and uptake of Hb-Hp by the CD163 receptor in macrophages.

220 The Michaelis-Menten constant (Km) value of Hb at the modified electrode is 55.4 microM, showing its

221 ically important both for in vitro growth on Hb and in infection models and is also highly up-regulat

222 eme from hemoglobin (Hb) to enable growth on Hb as a sole iron source.

223 Haptoglobin binds to a distinct site on Hb to inhibit heme transfer to IsdB and growth of S. aur

224 tion is more favorable for ESI-MS studies on Hb.

225 atus mainly concurs with diagnosis based on [Hb] and presents negative relationships with age, female

226 concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex.

227 Notably, [oxy-Hb] change in the left dorsolateral prefrontal cortex du

228 Our results suggest that [oxy-Hb] change in the prefrontal cortex during the sustained

229 The [oxy-Hb] change during the sustained attention task (SAT) was

230 We found that the [oxy-Hb] change during the verbal fluency task (VFT) was redu

231 rresponds to the maximum slope of the oxygen-Hb dissociation curve.

232 In this study, we examine Plasmodium Hb degradation in vivo in mice, using the parasite P. be

233 A total of 9.3% of participants had poor Hb A1c (value >/=9.5%) at baseline, which increased to 1

234 vel of 10 g/dL or greater or a postoperative Hb level of 8 g/dL or greater (to convert to grams per l

235 s the translational potential of preclinical Hb research.

236 size of the Hb:haptoglobin complex prevents Hb extravasation, which uncouples NO/Hb interaction and

237 alpha subunit of Hb, revealing new protected Hb regions that were not observed with pepsin.

238 Purified Hb auto-oxidized to metHb more rapidly than Hb in the he

239 Purified Hb promoted lipid oxidation in washed muscle slightly bu

240 f catalase and peroxiredoxin in the purified Hb.

241 titutions at the putative axial (recombinant Hb (rHb) (betaE6V/alphaH20R) and rHb (betaE6V/alphaH20Q)

242 tive Hb variants and engineered, recombinant Hb mutants demonstrate that a nonsynonymous mutation at

243 man serum albumin-saline mixture) to reduce [Hb] (Low [Hb]).

244 lococcus aureus, which utilizes the released Hb as an iron source.

245 erythrocyte S1P binds to deoxygenated sickle Hb (deoxyHbS), facilitates deoxyHbS anchoring to the mem

246 , 4-fold, and 3-fold increased risks of SMA (Hb < 50 g/L).

247 for nitrite () and S-nitrosohemoglobin (SNO-Hb) widely contested given their ability to transduce ni

248 bserve any gradients consistent with RBC SNO-Hb consumption and corresponding delivery of plasma S-ni

249 It seems to be the most stable Hb known to date, and His(117) is the dominant force hol

250 y holds promise for the production of stable Hb-based blood substitute.

251 ditional conformation changes to the T-state Hb.

252 Not surprisingly, Hb dysfunction has been associated with psychiatric diso

253 The unliganded tetrameric Hb S has axial and lateral contacts with neighbors and c

254 nd oxygen with slightly higher affinity than Hb S under the acidic conditions.

255 Hb auto-oxidized to metHb more rapidly than Hb in the hemolysate (P<0.05).

256 ization and forms polymers more readily than Hb S with a dextran-Csat value of 1.86 +/- 0.20 g/dl.

257 Because the lifetime of HSA is shorter than Hb, this could indicate a recent lapse in glycemic contr

258 lphaH20Q/alphaH50Q) is even more stable than Hb S under elevated temperature (60 degrees C).

259 Lastly, we determined that Hb interacts directly with the A1 domain.

260 Here, we investigate the hypothesis that Hb can activate and repress the same enhancer.

261 data provide support for the hypothesis that Hb isoform switching can provide a physiological benefit

262 Here we explore the hypothesis that Hb multiplicity plays a role in hypoxia tolerance using

263 We hypothesize that Hb-binding proteins may preserve vascular NO signaling d

264 This indicates that Hb recognition by IsdH, but not by IsdB, sterically inhi

265 Computational models predicted that Hb bifunctionally regulates the even-skipped (eve) strip

266 H(N1), IsdH(N2), and IsdH(N3), revealed that Hb binding of IsdH(N1) and IsdH(N2) accounted for the hi

267 the Hb-free and Hb-bound forms reveals that Hb binding alters the positioning of the N2 domain.

268 Voltammetric analyses showed that Hb(A1c) binding decreased the redox current of PAPBA; ho

269 The Hb/MHAM@Mag-NPs biocomposite is captured at SPCE by a su

270 facile direct electron transfer between the Hb and the substrate.

271 e an effective electron transfer between the Hb and the underlying electrode (high heterogeneous elec

272 the CD163-mediated clearance by binding the Hb-Hp complex and inhibiting CD163 recognition.

273 osmolarity, which suggests variation in the Hb to 2,3-diphosphoglycerate (2-3 DPG) ratio on a cellul

274 ox-dependent heme extraction, when Hb in the Hb-Hp complex was in the oxidized met form but not in th

275 Direct electron transfer of the Hb intercalated into the composite film showed a pair of

276 A comparison of the Hb-free and Hb-bound forms reveals that Hb binding alter

277 an literature on anatomy and function of the Hb.

278 n rates of Hb; rather, the large size of the Hb:haptoglobin complex prevents Hb extravasation, which

279 In vitro, HU partially reversed the Hb-mediated induction of endothelial proinflammatory cyt

280 vidence has now accumulated to show that the Hb encodes both rewarding and aversive aspects of extern

281 led that RBCs lose, on average, 17% of their Hb after 42 days of storage, the maximum FDA-approved le

282 miological data exist on the impact of these Hb variants on PAM.

283 on induces neutral ligand loss for all three Hb derivatives.

284 and +128 Da signals that can be assigned to Hb carrying two and four oxygen molecules, respectively.

285 CO binds to Hb, forming carboxyhemoglobin (COHb), and produces tissu

286 Lipid oxidation products due to Hb-mediated lipid oxidation were elevated 60-fold at pH

287 for the dual measurement of HbA1c and total Hb to provide useful % HbA1c values for better on-site d

288 otein precipitation at pH 6.5 improved total Hb removal up to 91% and 74% during alkaline and acid pr

289 The truncated Hb from the freshwater cyanobacterium Synechocystis exhi

290 ely impaired and large amounts of undigested Hb remains in the reticulocyte cytoplasm and in vesicles

291 at evolutionarily and structurally unrelated Hb-binding proteins, such as PIT54 found in avian specie

292 0.001, P = 0.003) associated with follow-up Hb A1c after adjustment for confounders.

293 during pH-shift processing was studied using Hb-fortified cod mince.

294 ibited redox-dependent heme extraction, when Hb in the Hb-Hp complex was in the oxidized met form but

295 ization of an archetypical function by which Hb scavenger proteins could preserve NO signaling during

296 Assay with Hb(A1c) by differential pulse voltammetry (DPV) indicate

297 me transfer yet formed a stable complex with Hb (Kd = 6 +/- 2 mum) in solution with spectroscopic fea

298 xygen affinity is positively correlated with Hb concentration but independent of osmolarity, which su

299 nal associations of nutritional factors with Hb A1c in youth with T1D.

300 alyses, RBCV was positively associated with [Hb] (B=6.10, SE=1.44) and negatively associated with age