ライフサイエンスコーパス: Hendra virus

1 , Crimean-Congo Hemorrhagic Fever, Nipah and Hendra viruses).

2 l as emerging viral threats (e.g., Nipah and Hendra viruses).

3 the zoonotic paramyxoviruses Nipah virus and Hendra virus.

4 to protect them from a lethal infection with Hendra virus.

5 l emerging pathogens such as Nipah virus and Hendra virus.

6 the zoonotic paramyxoviruses Nipah virus and Hendra virus.

7 red by envelope glycoproteins of the related Hendra virus and another paramyxovirus.

8 Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticle

9 at plasma membrane budding sites.IMPORTANCE Hendra virus and Nipah virus are zoonotic paramyxoviruse

10 ily, which includes emerging viruses such as Hendra virus and Nipah virus as well as many important h

11 athogens as well as emerging viruses such as Hendra virus and Nipah virus.

12 za virus type 5, measles virus, mumps virus, Hendra virus, and Nipah virus.

13 Highly lethal pathogens (e.g., hantaviruses, hendra virus, anthrax, or plague) pose unique public-hea

14 Nipah virus (NiV) and Hendra virus are the type species of the highly pathogen

15 Nipah virus and Hendra virus are two paramyxoviruses associated with hig

16 A Hendra virus attachment (G) glycoprotein subunit vaccine

17 mergent deadly viruses Nipah virus (NiV) and Hendra virus belong to the Henipavirus genus in the Para

18 The Hendra virus CBF(2) Y79A and P89A mutants showed signifi

19 For both Nipah virus and Hendra virus, contact between the V protein and the PLK1

20 C-terminal proline residues was observed in Hendra virus-derived peptides presented by Ptal-N*01:01

21 activity inhibited proteolytic processing of Hendra virus F but had no effect on simian virus 5 F pro

22 e examined the intracellular distribution of Hendra virus F following endocytosis and showed that it

23 somal protease cathepsin L, but the route of Hendra virus F following internalization and the recycli

24 To be fusogenically active, Hendra virus F must undergo endocytic recycling and clea

25 ed a nondetectable amount of cleavage of the Hendra virus F protein and significantly decreased membr

26 d to demonstrate that isolated TM domains of Hendra virus F protein associate in a monomer-trimer equ

27 that endocytosis is critically important for Hendra virus F protein cleavage, representing a new para

28 y identify the class of protease involved in Hendra virus F protein cleavage, Vero cells transfected

29 The Hendra virus F protein cytoplasmic tail contains a conse

30 the unique endocytic trafficking pathway of Hendra virus F protein is required for proper viral asse

31 leavage motif, cleavage of the newly emerged Hendra virus F protein occurs by a previously unidentifi

32 cessing and membrane fusion promotion of the Hendra virus F protein, mutation of tyrosine 525 to alan

33 Hendra virus F protein-promoted membrane fusion requires

34 of CBF1 in both the simian virus 5 (SV5) and Hendra virus F proteins.

35 created in both the simian virus 5 (SV5) and Hendra virus F proteins.

36 virus F TMDs correlated with alterations to Hendra virus F recycling, suggesting that appropriate TM

37 Y498 were found to be important for correct Hendra virus F recycling, with the hydroxyl group of S49

38 ched residues was found, and analysis of the Hendra virus F TM domain revealed a heptad repeat leucin

39 rt a model whereby the C-terminal end of the Hendra virus F TMD is an important regulator of TMD-TMD

40 addition, changes in association of isolated Hendra virus F TMDs correlated with alterations to Hendr

41 Hendra virus F transmembrane domain (TMD) residues S490

42 fusion peptide is an important regulator of Hendra virus F triggering.

43 The levels of surface expression for both Hendra virus F Y525A and Hendra virus F Y525F were highe

44 The rate of endocytosis of Hendra virus F Y525A was significantly reduced compared

45 rotein, mutation of tyrosine 525 to alanine (Hendra virus F Y525A) or phenylalanine (Hendra virus F Y

46 of proteolytic processing were observed for Hendra virus F Y525A, although initial transport to the

47 expression for both Hendra virus F Y525A and Hendra virus F Y525F were higher than that of the wt pro

48 ine (Hendra virus F Y525A) or phenylalanine (Hendra virus F Y525F) was performed.

49 ediate level of endocytosis was observed for Hendra virus F Y525F.

50 d human cathepsin L processed immunopurified Hendra virus F(0) into F(1) and F(2) fragments.

51 ory pathway trafficking than is observed for Hendra virus F.

52 The Hendra virus fusion (F) protein contains five potential

53 Triggering of the Hendra virus fusion (F) protein is required to initiate

54 The Hendra virus fusion (F) protein is synthesized as a prec

55 Proteolytic cleavage of the Hendra virus fusion (F) protein results in the formation

56 Results presented here demonstrate that Hendra virus G undergoes slower secretory pathway traffi

57 Instead, Hendra virus G was found to undergo intrinsically slow o

58 The V proteins of Nipah virus and Hendra virus have been demonstrated to bind to cellular

59 Hendra virus (HeV) and Nipah virus (NiV) are closely rel

60 Hendra virus (HeV) and Nipah virus (NiV) are closely rel

61 Hendra virus (HeV) and Nipah virus (NiV) are closely rel

62 Hendra virus (HeV) and Nipah virus (NiV) are deadly zoon

63 The emerging zoonotic pathogens Hendra virus (HeV) and Nipah virus (NiV) are in the genu

64 Hendra virus (HeV) and Nipah virus (NiV) are reportedly

65 Hendra virus (HeV) and Nipah virus (NiV) belong to the g

66 Hendra virus (HeV) and Nipah virus (NiV) constitute the

67 n henipaviruses (HNVs) related to pathogenic Hendra virus (HeV) and Nipah virus (NiV) from Southeast

68 The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), are emerging z

69 The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), are paramyxovi

70 The genus Henipavirus includes Hendra virus (HeV) and Nipah virus (NiV), for which frui

71 n infants, and the emerging zoonotic viruses Hendra virus (HeV) and Nipah virus (NiV), which cause le

72 viruses carried by the Pteropid fruit bats: Hendra virus (HeV) and Nipah virus (NiV).

73 ere tested for the presence of antibodies to Hendra virus (HeV) and Nipah virus, and tested for the p

74 Nipah virus (NiV) and Hendra virus (HeV) are closely related henipaviruses of

75 Nipah virus (NiV) and Hendra virus (HeV) are closely related, recently emerged

76 Nipah virus (NiV) and Hendra virus (HeV) are emerging zoonotic viruses and the

77 Nipah virus (NiV) and Hendra virus (HeV) are novel paramyxoviruses from pigs a

78 Nipah virus (NiV) and Hendra virus (HeV) are paramyxoviruses capable of causin

79 Nipah virus (NiV) and Hendra virus (HeV) are recently emergent zoonotic and hi

80 nal antibodies against Nipah virus (NiV) and Hendra virus (HeV) by panning a large nonimmune antibody

81 To examine the sequence dependence of the Hendra virus (HeV) fusion (F) protein FP, the first eigh

82 ation of structures of Nipah virus (NiV) and Hendra virus (HeV) G glycoproteins bound and unbound to

83 Hendra virus (HeV) is a member of the broadly tropic and

84 Hendra virus (HeV) is a recently identified paramyxoviru

85 Hendra virus (HeV) is a zoonotic emerging virus belongin

86 Hendra virus (HeV) is a zoonotic paramyxovirus that caus

87 Hendra virus (HeV) is an emerging paramyxovirus capable

88 Hendra virus (HeV) is an emerging pathogen of concern in

89 Hendra virus (HeV) is one of the two prototypical member

90 e show that the attachment glycoprotein G of Hendra virus (HeV), a deadly paramyxovirus, is N-glycosy

91 The henipaviruses, Nipah virus (NiV) and Hendra virus (HeV), are lethal emerging paramyxoviruses.

92 s a known reservoir of Nipah virus (NiV) and Hendra virus (HeV).

93 l cleavage site and efficient propagation of Hendra virus in a furin-deficient cell line indicate tha

94 were completely protected against subsequent Hendra virus infection and disease.

95 Hendra virus is a highly pathogenic paramyxovirus classi

96 The fusion (F) protein of Hendra virus is critical for promoting viral entry and c

97 We found that for both Nipah virus and Hendra virus, M protein expression in the absence of any

98 nsically disordered C-terminal domain of the Hendra virus nucleoprotein (NTAIL) and compared its inte

99 Hendra virus outbreaks in Australia, all involving horse

100 se cathepsin L is involved in converting the Hendra virus precursor F protein (F(0)) to the active F(

101 restingly, MDC-mediated capture of Nipah and Hendra virus (recently emerged zoonotic paramyxoviruses)

102 Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses

103 sidue 199 mediates the PLK1 interaction with Hendra virus V protein.