ライフサイエンスコーパス: Histoplasma

1 of infected mice, which contain all visible Histoplasma.

2 critically required for the host response to Histoplasma.

3 jor mechanism by which human DC mediate anti-Histoplasma activity is through the exposure of yeasts t

4 f the vacuolar ATPase, did not block DC anti-Histoplasma activity, indicating that phagosome acidific

5 ith microbial antigens (e.g., leishmania and histoplasma Ags) were capable of inducing proliferative

6 Most of the Histoplasma and most of the apoptotic cells are found in

7 ecific genes that may influence virulence in Histoplasma and other dimorphic fungal pathogens.

8 The MVista Histoplasma antibody EIA offers increased sensitivity ov

9 ry histoplasmosis and controls in the MVista Histoplasma antibody EIA.

10 greement (64.5%) with the MiraVista (MVista) Histoplasma antigen (Ag) quantitative EIA (MiraVista Dia

11 On hospital day 11, results of his CSF Histoplasma antigen and urine antigen tests were positiv

12 Histoplasma capsulatum endocarditis in which Histoplasma antigen assay and fungal blood cultures were

13 body-based in vitro diagnostic (IVD) kit for histoplasma antigen detection was released, as well as m

14 Urine Histoplasma antigen detection was the most sensitive dia

15 The Histoplasma antigen immunoassay utilizes an antibody san

16 ked immunoassay (EIA) for the measurement of Histoplasma antigen in banked urine specimens.

17 Both assays were capable of detecting histoplasma antigen in urine samples over a wide dynamic

18 multiple assays are available for measuring histoplasma antigen in urine, a monoclonal-antibody-base

19 interval {CI}, 1.06-14.60]) and higher urine Histoplasma antigen levels (OR, 1.14 [95% CI, 1.03-1.25]

20 eptable alternative to the RIA for measuring Histoplasma antigen levels in urine specimens.

21 Urinary histoplasma antigen measurement can be useful for diagno

22 Microplates coated with Histoplasma antigen were used for testing of serum from

23 luding cryptococcus capsular polysaccharide, histoplasma antigen, galactomannan, and beta-d-glucan, i

24 ning, and lactic acid, cryptococcal antigen, histoplasma antigen, herpes simplex virus polymerase cha

25 BG results for the 10 Histoplasma antigen-negative and the 32 Aspergillus gala

26 All six Histoplasma antigen-positive patients and 31 of 32 Asper

27 been tested for Aspergillus galactomannan or Histoplasma antigen.

28 d no detectable reaction with Blastomyces of Histoplasma antiserum by ID.

29 ity with a respiratory isolate thought to be Histoplasma but not morphologically consistent with H. c

30 ased system for silencing gene expression in Histoplasma by RNA interference (RNAi).

31 Ten cases of Histoplasma capsulatum (HC) infection were reported: 9 a

32 Histoplasma capsulatum (Hc) is a facultative intracellul

33 Histoplasma capsulatum (Hc) is a facultative intracellul

34 Histoplasma capsulatum (Hc) is a facultative, intracellu

35 Histoplasma capsulatum (Hc) is a pathogenic fungus that

36 rimary and secondary infection by the fungus Histoplasma capsulatum (HC) is multifactorial, requiring

37 Histoplasma capsulatum (Hc) maintains a phagosomal pH of

38 The intracellular fungal pathogen Histoplasma capsulatum (Hc) resides in mammalian macroph

39 genic fungi Cryptococcus neoformans (CN) and Histoplasma capsulatum (HC) to external gamma-radiation

40 ix proteins, and the intracellular growth of Histoplasma capsulatum (Hc) yeasts were quantified and c

41 e deficient in their capacity to phagocytose Histoplasma capsulatum (Hc) yeasts, and are more permiss

42 Histoplasma capsulatum (Hc), is a facultative intracellu

43 r host defense against the pathogenic fungus Histoplasma capsulatum (Hc).

44 imary and secondary pulmonary infection with Histoplasma capsulatum (Hc).

45 ), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces

46 statistically significantly more isolates of Histoplasma capsulatum (P = 0.004), but all of these iso

47 A monoclonal antibody (MAb) raised against a Histoplasma capsulatum 80-kDa hsp showed cross-reactivit

48 dermatitidis an extracellular pathogen, and Histoplasma capsulatum a facultative intracellular patho

49 We describe a case in which the Histoplasma capsulatum AccuProbe test displayed cross-re

50 We demonstrated the ability of the Histoplasma capsulatum AccuProbe to accurately identify

51 ffers from the epitopes that are shared with Histoplasma capsulatum and Blastomyces dermatitidis.

52 it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by di

53 f microarrays built with genomic elements of Histoplasma capsulatum and ESTs of Paracoccidioides bras

54 ular evidence suggests a direct link between Histoplasma capsulatum and presumed ocular histoplasmosi

55 nsformation system for the pathogenic fungus Histoplasma capsulatum and used it to examine the effect

56 egative for C. immitis, B. dermatitidis, and Histoplasma capsulatum antibodies.

57 Paracoccidioides brasiliensis and Histoplasma capsulatum are ancestral to most Emmonsia is

58 Blastomyces dermatitidis and Histoplasma capsulatum are dimorphic fungi that often ca

59 Improved methods for the detection of Histoplasma capsulatum are needed in regions with limite

60 The success of Histoplasma capsulatum as an intracellular pathogen depe

61 nction of HIF-1alpha in the host response to Histoplasma capsulatum because granulomas induced by thi

62 Histoplasma capsulatum can efficiently survive within ma

63 molecular cloning and characterization of a Histoplasma capsulatum cDNA (GH17) that encodes an antig

64 esented with a Mycobacterium haemophilum and Histoplasma capsulatum coinfection occurring 21 years af

65 ported that immunization with H antigen from Histoplasma capsulatum did not protect mice against an i

66 The fungus Histoplasma capsulatum displays an Hsp60 on its cell sur

67 dentified a secreted proteolytic activity in Histoplasma capsulatum effective toward DppIV-specific s

68 The YPS3 gene of Histoplasma capsulatum encodes a protein that is both su

69 We report a case of Histoplasma capsulatum endocarditis in which Histoplasma

70 The pathogenic fungus Histoplasma capsulatum escapes innate immune defenses an

71 The fungal pathogen Histoplasma capsulatum evades the innate and adaptive im

72 1990 through 1994, we fortuitously isolated Histoplasma capsulatum from six patients with AIDS whose

73 regulatory T cells (Tregs) using a model of Histoplasma capsulatum fungal infection.

74 library representing 10-fold coverage of the Histoplasma capsulatum G217B genome was used to construc

75 Here, we detail mapping the Histoplasma capsulatum genome comprehensively in fosmids

76 The human fungal pathogen Histoplasma capsulatum grows in a sporulating filamentou

77 The Histoplasma capsulatum H antigen is a major secreted gly

78 ponse to the intracellular pathogenic fungus Histoplasma capsulatum has increased dramatically.

79 Histoplasma capsulatum has not typically been associated

80 human fungal pathogens Candida albicans and Histoplasma capsulatum have been reported to protect aga

81 A real-time PCR assay to detect Histoplasma capsulatum in formalin-fixed, paraffin-embed

82 e examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN

83 n-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine rec

84 Histoplasma capsulatum induces a cell-mediated immune re

85 Histoplasma capsulatum induces a cell-mediated immune re

86 tion with heat shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune respo

87 Rising rates of Histoplasma capsulatum infection are an emerging problem

88 emonstrate that CCR5 controls the outcome of Histoplasma capsulatum infection by dictating thymic and

89 mmalian host specifically limits iron during Histoplasma capsulatum infection, and fungal acquisition

90 B6C3F(1) mice were infected by injection of Histoplasma capsulatum into the subarachnoid space.

91 Histoplasma capsulatum is a dimorphic fungal pathogen th

92 Histoplasma capsulatum is a dimorphic fungus that causes

93 Histoplasma capsulatum is a dimorphic fungus that is end

94 Histoplasma capsulatum is a fungal pathogen that causes

95 Histoplasma capsulatum is a fungal pathogen that require

96 Histoplasma capsulatum is a fungal respiratory pathogen

97 Histoplasma capsulatum is a pathogenic fungus that exist

98 Histoplasma capsulatum is a pathogenic fungus with two d

99 Histoplasma capsulatum is a respiratory pathogen that in

100 Histoplasma capsulatum is a significant respiratory and

101 Histoplasma capsulatum is a successful intracellular pat

102 Histoplasma capsulatum is an effective intracellular par

103 Histoplasma capsulatum is an infrequent but serious caus

104 cell-depleted mice infected with the fungus Histoplasma capsulatum is associated with impairment of

105 A fundamental feature of the fungal pathogen Histoplasma capsulatum is its ability to shift from a my

106 Histoplasma capsulatum is the best-studied of the primar

107 the pathogenesis of the respiratory pathogen Histoplasma capsulatum is the conversion from the mold f

108 Histoplasma capsulatum is the most common cause of funga

109 The yeast phase of Histoplasma capsulatum is the virulent form of this ther

110 The phylogeny of 46 geographically diverse Histoplasma capsulatum isolates representing the three v

111 Although more Histoplasma capsulatum isolates were recovered from Plus

112 ients with deficient cell-mediated immunity, Histoplasma capsulatum may disseminate throughout the bo

113 uconazole (Flu) and amphotericin B (AmB) for Histoplasma capsulatum meningitis, MICs were determined

114 The fungal pathogen Histoplasma capsulatum minimizes detection of beta-gluca

115 ronment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from

116 Primary infection to Histoplasma capsulatum often results in a self-limited u

117 tion of mice with heat shock protein 60 from Histoplasma capsulatum or a polypeptide from the protein

118 ombinant heat shock protein 60 (rHsp60) from Histoplasma capsulatum or a region of the protein design

119 Host defenses against Histoplasma capsulatum require the action of several cyt

120 The pathogenic fungus Histoplasma capsulatum requires iron for its survival du

121 Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines.

122 Infection with Histoplasma capsulatum results in a subclinical infectio

123 Histoplasma capsulatum should be considered in the diffe

124 ct several general DNA binding proteins from Histoplasma capsulatum strain G217B.

125 , yps-3, has been identified in the virulent Histoplasma capsulatum strain, G217B.

126 Many Histoplasma capsulatum strains have alpha-(1,3)-glucan i

127 Many Histoplasma capsulatum strains spontaneously give rise t

128 FM) is a rare complication of infection with Histoplasma capsulatum that can lead to obstruction of p

129 are consequence of infection with the fungus Histoplasma capsulatum that can lead to occlusion of lar

130 tested a real-time LightCycler PCR assay for Histoplasma capsulatum that correctly identified the 34

131 xpressed the gene encoding this protein from Histoplasma capsulatum to study its immunological activi

132 We cloned the Histoplasma capsulatum URA5 gene (URA5Hc) by using a pro

133 The Histoplasma capsulatum URA5 gene, which has recently bee

134 Detection of the Histoplasma capsulatum urinary antigen (UAg) is among th

135 be of limited use, whereas the detection of Histoplasma capsulatum var. capsulatum antigens may prov

136 We studied an aberrant culture of Histoplasma capsulatum var. capsulatum isolated from syn

137 ther the thermally dimorphic fungal pathogen Histoplasma capsulatum var. capsulatum produced melanin

138 Histoplasma capsulatum var. farciminosum, the causative

139 A sample of 30 clinical isolates of Histoplasma capsulatum was analyzed to determine (i) whe

140 nd ploidy of the dimorphic pathogenic fungus Histoplasma capsulatum was determined by using DNA renat

141 e H antigen of the dimorphic fungal pathogen Histoplasma capsulatum was first described over 40 years

142 )-alpha after intranasal exposure of mice to Histoplasma capsulatum was necessary for control of prim

143 yces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum were each ingested by amoebae and

144 ITS) regions of rRNA genes of 24 isolates of Histoplasma capsulatum were examined.

145 Two isolates of Histoplasma capsulatum were recovered from the Isolator

146 t (Y) phase of the dimorphic fungal pathogen Histoplasma capsulatum which are transcriptionally silen

147 ts with disseminated Coccidioides immitis or Histoplasma capsulatum with heterozygous missense mutati

148 can is present in the outermost layer of the Histoplasma capsulatum yeast cell wall and contributes t

149 potent and long-lasting fungistasis against Histoplasma capsulatum yeasts and that all of the fungis

150 During infection of the mammalian host, Histoplasma capsulatum yeasts survive and reside within

151 bility to bind calcium and its prevalence as Histoplasma capsulatum's most abundant secreted protein.

152 h chitin, in patterns ranging from circular (Histoplasma capsulatum) to punctate (Cryptococcus neofor

153 Histoplasma capsulatum, a fungal pathogen of humans, swi

154 D-1 in a mouse model of acute infection with Histoplasma capsulatum, a major human pathogenic fungus.

155 CBP is the most abundant protein secreted by Histoplasma capsulatum, a pathogenic fungus that causes

156 nt Candida species, Cryptococcus neoformans, Histoplasma capsulatum, and Blastomyces dermatitidis fro

157 ns in North America (Coccidioides posadasii, Histoplasma capsulatum, and Blastomyces dermatitidis), h

158 For the fungus Histoplasma capsulatum, and for other microbial pathogen

159 DCs) with Leishmania donovani promastigotes, Histoplasma capsulatum, and Mycobacterium kansasii impai

160 Rhizopus arrhizus, Blastomyces dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii.

161 s in the lungs of C57BL/6 mice infected with Histoplasma capsulatum, and the elimination of these cel

162 rmally dimorphic fungal pathogens, including Histoplasma capsulatum, are soil fungi that undergo dram

163 ribosomal DNA, were used to amplify DNA from Histoplasma capsulatum, Blastomyces dermatitidis, Coccid

164 r to a triglycosyl IPC (Hc-VI) reported from Histoplasma capsulatum, but differing in the anomeric co

165 nses against intracellular pathogens such as Histoplasma capsulatum, but its mode of action remains e

166 Except with Histoplasma capsulatum, chocolate agar incubated for onl

167 y significant episodes, the isolated fungus (Histoplasma capsulatum, Coccidioides immitis/posadasii,

168 The endemic fungi Histoplasma capsulatum, Coccidioides spp, Blastomyces de

169 In other fungi, such as Histoplasma capsulatum, however, more efficient gene dis

170 The zoopathogenic fungus Histoplasma capsulatum, like other eukaryotic aerobic mi

171 ve with IS only (three Candida albicans, one Histoplasma capsulatum, one Candida glabrata, and one Fu

172 ntiana, Fusarium oxysporum, Fusarium solani, Histoplasma capsulatum, Phialophora spp., Pseudallescher

173 sis, a systemic mycosis caused by the fungus Histoplasma capsulatum, primarily affects immune-suppres

174 The fungus, Histoplasma capsulatum, produces a persistent infection.

175 parasite of macrophages, the yeast phase of Histoplasma capsulatum, survives and proliferates within

176 For the dimorphic fungal pathogen Histoplasma capsulatum, susceptibility to echinocandins

177 ermatitidis, the agent of blastomycosis, and Histoplasma capsulatum, the agent of histoplasmosis, are

178 irulence mutants of Francisella novicida and Histoplasma capsulatum, we confirmed the applicability o

179 esii; and a more diverged pathogenic fungus, Histoplasma capsulatum, were sequenced and compared with

180 eople harbor latent infections of the fungus Histoplasma capsulatum.

181 control of infection by the dimorphic fungus Histoplasma capsulatum.

182 e human pathogens Coccidioides posadasii and Histoplasma capsulatum.

183 tective immunity in an Ag-specific manner to Histoplasma capsulatum.

184 elevated in the lungs of mice infected with Histoplasma capsulatum.

185 sis influenced host resistance to the fungus Histoplasma capsulatum.

186 role of these agents in host defense against Histoplasma capsulatum.

187 influenced protective and memory immunity to Histoplasma capsulatum.

188 these genes in vivo, mice were infected with Histoplasma capsulatum.

189 ve domain (F3) of heat-shock protein 60 from Histoplasma capsulatum.

190 ion in the lungs of naive mice infected with Histoplasma capsulatum.

191 ith class 5 or 6 organisms than with class 2 Histoplasma capsulatum.

192 omoters of two yeast phase-specific genes in Histoplasma capsulatum.

193 nt of heat shock protein 60 from the fungus, Histoplasma capsulatum.

194 ith recognition of the worldwide presence of Histoplasma capsulatum.

195 e during primary infection with the pathogen Histoplasma capsulatum.

196 of both primary and secondary infection with Histoplasma capsulatum.

197 ular genetic studies of the dimorphic fungus Histoplasma capsulatum.

198 lution of infection with the fungal pathogen Histoplasma capsulatum.

199 sponse against Mycobacterium tuberculosis or Histoplasma capsulatum.

200 are essential for controlling infection with Histoplasma capsulatum.

201 inst many intracellular infections including Histoplasma capsulatum.

202 ell as to the natural CR3 ligands, iC3b, and Histoplasma capsulatum.

203 laboratory evidence of recent infection with Histoplasma capsulatum.

204 recombinant (r) hsp60 protects mice against Histoplasma capsulatum.

205 fungal nitric oxide reductase (P450nor) from Histoplasma capsulatum.

206 TNF-alpha in CCR5(-/)(-) mice infected with Histoplasma capsulatum.

207 is) infected with the intracellular pathogen Histoplasma capsulatum.

208 charomyces cerevisiae, Candida albicans, and Histoplasma capsulatum.

209 tope in Blastomyces dermatitidis and also in Histoplasma capsulatum.

210 R5 during infection with the fungal pathogen Histoplasma capsulatum.

211 Fourteen samples grew Histoplasma capsulatum; both systems detected H. capsula

212 To probe the contribution of Histoplasma catalases in oxidative stress defense, we cr

213 In addition, human immune sera recognize the Histoplasma Cfp4 protein, confirming Cfp4 production dur

214 This intracellular Histoplasma-containing compartment imposes nutritional c

215 These results indicate that the Histoplasma-containing phagosome is limiting for ribofla

216 Among the secreted proteome of Histoplasma, culture filtrate protein 4 (Cfp4) is a heav

217 ve shown previously that these two phases of Histoplasma differ in their calcium requirements for gro

218 ttle is known about the molecular biology of Histoplasma dimorphism.

219 concept that the assay can be used to detect Histoplasma DNA in urine.

220 ia), mycobacterial, and fungal (Aspergillus, Histoplasma, etc.) infections.

221 Both CatB and CatP protected Histoplasma from peroxide challenge in vitro and from an

222 Infected by the same inoculum of Histoplasma, gal3(-/-) mice had lower fungal burden and

223 ctured by IMMY (Norman, OK) for detection of Histoplasma galactomannan (GM) in urine using an enzyme

224 vation of the selectable URA5 marker (native Histoplasma gene or a heterologous Podospora anserina ge

225 ed vitamin synthesis pathways encoded in the Histoplasma genome and confirmed by growth in minimal me

226 omas occurred in hilar lymph nodes, although histoplasma granulomas involved hilar lymph nodes of thr

227 The virulence of Histoplasma has been linked to cell wall alpha-(1,3)-glu

228 ified an insertion in the locus encoding the Histoplasma Hsp82 homolog.

229 xamination of host cellular responses in the Histoplasma-induced granuloma representing the specific

230 s of this article is the characterization of Histoplasma-induced granulomas.

231 Incubation of Histoplasma-infected DC at 18 degrees C also concomitant

232 Unlike Mphi, Histoplasma-infected DC exhibited marked PL-fusion.

233 Further, culture of Histoplasma-infected DC in the presence of bafilomycin,

234 In contrast, culture of Histoplasma-infected DC in the presence of inhibitors of

235 The addition of suramin to Histoplasma-infected DC inhibited PL-fusion and DC fungi

236 Our study showed that Histoplasma infection induced gal3(-/-) dendritic cells

237 the fungal burden and are more sensitive to Histoplasma infection than wild-type, Dectin-1-/-, or in

238 ted in 25 patients without evidence of prior Histoplasma infection.

239 low further analysis of key elements of host Histoplasma interactions at the site of chronic infectio

240 ne whether the mechanism(s) by which DC kill Histoplasma is via lysosomal hydrolases, via the product

241 g understanding of systemic immunity against Histoplasma, little is known about the local granulomato

242 To test the function of Cfp4 in Histoplasma pathogenesis, we generated Cfp4-deficient st

243 infection of host cells, supporting roles in Histoplasma pathogenesis.

244 antigen, or six urine specimens positive for Histoplasma polysaccharide antigens.

245 the calcium requirements of the two forms of Histoplasma, potentially implicating the phagolysosome a

246 ing a pyrimidine-rich motif found in several Histoplasma promoters.

247 ty patterns of multiple clinical isolates of Histoplasma representing different phylogenetic groups.

248 ined, in part because of the inefficiency of Histoplasma reverse genetics.

249 innate immune system are an integral part of Histoplasma's ability to survive during infection.

250 These results demonstrate that Histoplasma's dual catalases comprise a system that enab

251 es spp. (n = 10), Coccidioides spp. (n = 9), Histoplasma spp. (n = 7) and Blastomyces spp. (n = 3).

252 Linearized DNA and plasmids containing Histoplasma telomeric sequences showed the greatest tran

253 ual catalases comprise a system that enables Histoplasma to efficiently overcome the reactive oxygen

254 s of AMY1 function attenuated the ability of Histoplasma to kill macrophages and to colonize murine l

255 The mechanisms allowing Histoplasma to overcome toxic reactive oxygen molecules

256 IMMY GM ASR can be used to serially monitor Histoplasma UAg levels.

257 R is a reliable rapid assay for detection of Histoplasma UAg.

258 ble and quantifiable reporter gene by fusing Histoplasma URA5 with E. coli lacZ, resulting in express

259 Histoplasma urine antigen (UAg) detection is an importan

260 easts in macrophages and severely attenuated Histoplasma virulence in a murine model of respiratory h

261 aneous loss of both CatB and CatP attenuated Histoplasma virulence in vivo.

262 ing for riboflavin and pantothenate and that Histoplasma virulence requires de novo synthesis of thes

263 To identify new genes required for Histoplasma virulence, we employed these transgenic macr

264 -(1,3)-glucan is an important contributor to Histoplasma virulence.

265 o2 function (biotin synthesis) also impaired Histoplasma virulence.

266 To test the effectiveness of RNAi in Histoplasma, we depleted expression of a gfp transgene a

267 avin, pantothenate, and biotin auxotrophs of Histoplasma were generated to probe whether these vitami

268 ctor produced abundantly and specifically by Histoplasma yeast cells, suggesting its role in pathogen

269 6-well microtiter plate-based measurement of Histoplasma yeast growth in vitro.

270 ression markedly attenuates the virulence of Histoplasma yeast in vivo.

271 Histoplasma yeasts also secrete the putative glucanase E

272 d confirmed by growth in minimal medium that Histoplasma yeasts can synthesize all essential vitamins

273 Cfp4 does not confer a fitness advantage to Histoplasma yeasts during murine lung infection.

274 ular pathogens escape into the host cytosol, Histoplasma yeasts remain within the macrophage phagosom

275 These results show that Histoplasma yeasts secrete two beta1,3-glucanases and th

276 s forms, which highlights the need to employ Histoplasma yeasts, not hyphae, in antifungal susceptibi

277 monitor the effectiveness of antifungals on Histoplasma yeasts, the morphological form present in ma

278 of the total secreted glucanase activity of Histoplasma yeasts.

279 Sod3) did not further reduce the survival of Histoplasma yeasts.

280 l beta-glucans to minimize host detection of Histoplasma yeasts.