ライフサイエンスコーパス: Hoechst 33258

1 r groove binding with the bisbenzimide drug (Hoechst 33258).

2 wise combination with the DNA binding ligand Hoechst 33258.

3 zation of A.T rich duplexes when compared to Hoechst 33258.

4 , with the B-DNA minor groove binding ligand Hoechst 33258.

5 elated to the well-known minor groove agent, Hoechst 33258.

6 es in binding of the DNA minor groove binder Hoechst 33258.

7 minor groove-binding drugs, distamycin A and Hoechst 33258.

8 to a similar extent as ethidium bromide and Hoechst 33258.

9 , with the B-DNA minor groove binding ligand Hoechst 33258.

10 psins, and the classic monomeric DNA binders Hoechst 33258, 4'-diamino-2-phenylindole, pentamidine, b

11 The bibenzimidazoles, which include Hoechst 33258 and 33342, are a family of DNA minor groov

12 analyses to define the DNA binding site for Hoechst 33258 and a related derivative that results in o

13 ycin D) and minor groove binders (netropsin, Hoechst 33258 and distamycin) has shown the suitability

14 ults in loss of orientational specificity of Hoechst 33258 and formation of multiple bound species in

15 n cooperativity of binding for netropsin and Hoechst 33258 and have provided ligand:DNA binding ratio

16 the minor groove widths in the complexes of Hoechst 33258 and the meta-hydroxyl derivative as a resu

17 e, ethidium homodimer, bis-benzimide (DAPI), Hoechst 33258 and thiazole orange] to function as suitab

18 Apoptosis was assayed by Hoechst 33258 and TUNEL staining and DNA laddering.

19 escence employing the high-affinity DNA dyes Hoechst 33258 and YOYO-1 was able to resolve two sequent

20 nts including distamycin A, netropsin, DAPI, Hoechst 33258, and berenil is described.

21 of the novel conjugate containing neomycin, Hoechst 33258, and pyrene.

22 DAPI was more effective than distamycin and Hoechst 33258 at inhibiting the assembly of nucleosomes

23 romide and facilitate cooperative binding of Hoechst 33258 at the minor groove.

24 A series of Hoechst 33258 based mono- and bisbenzimidazoles have bee

25 We report herein novel neomycin- and Hoechst 33258-based conjugates developed in our laborato

26 In contrast, Hoechst 33258 binds approximately 20-fold more tightly t

27 e shown that the minor groove-binding ligand Hoechst 33258 binds to the two T4/A4 tracts within the d

28 Hoechst 33258 binds with a dissociation constant of 60 n

29 NA, surpassing the sensitivity achieved with Hoechst 33258 by 400-fold.

30 Both distamycin A and Hoechst 33258 can inhibit, to a similar extent, the bind

31 Described herein are novel neomycin-Hoechst 33258 conjugates developed for exploring B-DNA g

32 The multicyclic dyes Hoechst 33258, DAPI, and berenil bind to TAR RNA in a si

33 r AT-selective minor groove binding ligands (Hoechst 33258, distamycin, netropsin and berenil) with D

34 ound previously in other X-ray structures of Hoechst 33258-DNA complexes.

35 and DNA.DNG-H duplexes formed by DNG and DNG-Hoechst 33258 (DNG-H) conjugates with 30-mer double-stra

36 n fluorescent protein as a tumor marker, and Hoechst 33258 dye as an intravital endothelial stain.

37 es the phosphodiester linkages, tethering to Hoechst 33258 fluorophore by varying lengths has been sy

38 ynamics experiments of the fluorescent probe Hoechst 33258 (H33258) bound to DNA, we have generated 7

39 matically examined the bis-benzimidazole dye Hoechst 33258 (H33258) in terms of self-aggregation and

40 bis-benzimidazole minor groove binding agent Hoechst 33258 (H33258), has been studied by NMR and rest

41 its 2:1 complex with the bis -benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restr

42 Distamycin and Hoechst 33258 have long served as the model compounds fo

43 nase co-localized with the nuclear DNA stain Hoechst 33258 in each cell type.

44 ay showed greater dsDNA:RNA selectivity than Hoechst 33258 in low ionic strength buffer and better ds

45 GCG)2and an analogue of the DNA binding drug Hoechst 33258, in which the piperazine ring has been rep

46 In contrast, the known minor groove binder Hoechst 33258 inhibits the cross-link formation with a C

47 amino acid linkers and a bis-benzimidazole (Hoechst 33258) ligand at the 5'-terminus using PyBOP/HOB

48 d to improve the efficacy of pentamidine and Hoechst 33258 ligands that have been shown previously to

49 analysis of toxin-treated cells stained with Hoechst 33258 (or 33342) and 7-aminoactinomycin D allowe

50 Unlike Hoechst 33258, PicoGreen reagent fluorescence intensity

51 ing the DNA amplification was achieved using Hoechst 33258 redox molecule and linear sweep voltametry

52 Staining with Hoechst 33258 revealed that about 75% of cells exhibited

53 Hoechst 33258 shows a similar pattern of preference, wit

54 densation and DNA breaks were assessed using Hoechst 33258 staining and DNA nickend labeling, and DNA

55 ration, suppressed cell death as measured by Hoechst 33258 staining, induced peroxisomal beta-oxidati

56 orting on the basis of polyamide binding and Hoechst 33258 staining.

57 ed by annexin V staining, DNA laddering, and Hoechst 33258 staining.

58 orochrome bis (benzimide) trihydro-chloride (Hoechst 33258) staining.

59 ex with a tetrahydropyrimidinium analogue of Hoechst 33258 suggest that DNA minor groove recognition

60 ing to examine the ability of distamycin and Hoechst 33258 to discriminate between different arrangem

61 Since Hoechst 33258 was identified as a DM1 binder through ana

62 An analogue of the DNA binding compound Hoechst 33258, which has the para hydroxyl group altered

63 display a derivative of the bisbenzimidazole Hoechst 33258, which was identified by searching known R

64 benzimidazole DNA minor groove binding agent Hoechst 33258 with the decamer duplex d(GCAAATTTGC)2.

65 ed to examine the binding characteristics of Hoechst 33258 with the extended AT-tract DNA duplex d(CG

66 The role of water in the interaction of Hoechst 33258 with the minor groove binding site of the