ライフサイエンスコーパス: Holliday junction resolvase

1 ucture-specific endonuclease Mus81-Eme1 is a Holliday junction resolvase.

2 lateral strand cleavages characteristic of a Holliday junction resolvase.

3 fect is rescued by expression of a bacterial Holliday junction resolvase.

4 fect is rescued by expression of a bacterial Holliday junction resolvase.

5 hat Mus81 and Eme1 are subunits of a nuclear Holliday junction resolvase.

6 c residues in DNA binding and catalysis by a Holliday junction resolvase.

7 the gammaH2AX-binding protein Brc1 and Mus81 Holliday junction resolvase.

8 d-break repair and SOS induction, and RuvABC Holliday-junction resolvase.

9 family, including transposases and RuvC-like Holliday junction resolvases.

10 mation, offering a new type of substrate for Holliday junction resolvases.

11 The purified recombinant YDC2 exhibits Holliday junction resolvase activity and is, therefore,

12 n and gel filtration analyses, we found that Holliday junction resolvase activity associated tightly

13 These results provide evidence that the Holliday junction resolvase activity of Ydc2 is required

14 uclease Mus81-Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be

15 Mlh3 may not act like a canonical, RuvC-like Holliday junction resolvase and support a novel model in

16 of two pathways, one dependent on the RuvABC Holliday junction resolvase and the other on RecG helica

17 includes transposase, retroviral integrase, Holliday junction resolvase, and RISC nuclease Argonaute

18 ta indicate that the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with cros

19 ation with RuvA, and forms functional RuvABC-Holliday junction resolvase complexes.

20 This first structure of a eukaryotic Holliday junction resolvase confirms a distant evolution

21 Both SOS-deficient (lexA3) and Holliday junction resolvase-deficient (ruvC) cells were

22 Viral and bacterial Holliday junction resolvases differ in specificity with

23 o investigate the role of the vaccinia virus Holliday junction resolvase during an infection, we cons

24 g the expression of the RusA endonuclease, a Holliday junction resolvase encoded by a cryptic prophag

25 RusA is a Holliday junction resolvase encoded by the cryptic proph

26 ll shape and surface charge potential of the Holliday junction resolvases endo VII, RuvC, Ydc2, Hjc a

27 mosomal compaction, topoisomerase action and Holliday junction resolvases, ensure that all SCIs are r

28 tructure provides insights into how archaeal Holliday junction resolvases evolved to incise 5' flap s

29 RuvC is a well-characterized Holliday junction resolvase from E. coli.

30 structure of Ydc2 (also known as SpCce1), a Holliday junction resolvase from the fission yeast Schiz

31 The human Holliday junction resolvase, GEN1, and its yeast ortholo

32 double-strand break repair, and in ruvC, the Holliday junction resolvase gene, were synthetically let

33 Several Holliday junction resolvases have since been characteriz

34 is HP0334 (dprB), annotated to be a putative Holliday junction resolvase (HJR).

35 Holliday junction resolvases (HJRs) are key enzymes of D

36 sults demonstrate that Rap can function as a Holliday junction resolvase in addition to eliminating o

37 icated multiple roles for the vaccinia virus Holliday junction resolvase in the replication and proce

38 re resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase.

39 The virus-encoded Holliday junction resolvase is required to process conca

40 Another nuclease, the Mus81-Eme1 Holliday junction resolvase, is required to generate cro

41 In addition, our study revealed a Holliday junction resolvase-like activity in the liver t

42 contains two domains, a third OB fold and a Holliday junction resolvase-like domain.

43 tion of the four-stranded intermediate is by Holliday junction resolvase, predicts that hDNA will fre

44 The eukaryotic Holliday junction resolvases represent a new subclass of

45 leases and has been recently identified as a Holliday junction resolvase, results in increased sensit

46 f RNase H nucleases, bacterial transposases, Holliday junction resolvases, retroviral integrases and

47 positive supercoils could be cleaved by the Holliday junction resolvases RusA and RuvC.

48 logous to that shown by the Escherichia coli Holliday junction resolvase RuvC.

49 RuvC is a Holliday junction resolvase that cleaves the helical str

50 atemer substrate by employing a portal-bound Holliday junction resolvase that trims and releases thes

51 They also need RecA recombinase and a Holliday junction resolvase to survive rapid growth, but

52 aryote, we have targeted an Escherichia coli Holliday junction resolvase to the nuclei of fission yea

53 Therefore, the yeast CCE1 gene, encoding a Holliday junction resolvase, was introduced into cells c

54 Holliday junction resolvases with distinct properties ha

55 ll, of the expected properties of eukaryotic Holliday junction resolvases, with intriguing connection

56 l structure of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2 revealed significant st

57 dc14 and, using this insight, identified the Holliday junction resolvase Yen1 as a DNA repair target