ライフサイエンスコーパス: Homo

1 Homo floresiensis is an endemic hominin species that occ

2 Homo floresiensis, a primitive hominin species discovere

3 Homo naledi is a previously-unknown species of extinct h

4 Homo sapiens are genetically diverse, but dramatic demog

5 Homo sapiens chromosome 17 (HSA17) has two juxtaposed HO

6 Homo sapiens harbor two distinct, medically significant

7 Homo sapiens phylogeography begins with the species' ori

8 Homo sapiens' relationship with the tropical rainforests

9 Homo sp. increased the fraction of C4-based resources in

10 Homo species were exposed to a new biogeochemical enviro

11 Homo- and hetero-oligomeric proteolytic complexes exist,

12 Homo- and heterodivalent crown-ammonium pseudorotaxanes

13 Homo- and heterofunctionalized glycoclusters with galact

14 Homo- and heteromerization were confirmed by a FRET stud

15 Homo- and heteropolymeric tracts of A and T demarcate nu

16 Homo- and heterospectral correlation analysis are powerf

17 Homo- or heterozygosity at Ars1127354 or Crs7270101 , en

18 Homo- or heterozygous presence of the frequent [C] allel

19 Homo-FRET and its consequent energy migration cause the

20 Homo-FRET anisotropy experiments demonstrated that both

21 Homo-oligomeric proteins fulfill numerous functions in a

22 Homo-oligomerization is found in many biological systems

23 Homo-oligomerization of proteins is abundant in nature,

24 uctural models of Afar and date the LD 350-1 Homo mandible to 2.80 to 2.75 Ma.

25 to Homo rudolfensis and with the A.L. 666-1 Homo maxilla.

26 ontrols (anatomically modern humans), and 17 Homo erectus specimens.

27 r-old footprint assemblages, produced by 20+ Homo erectus individuals.

28 For example, GTRAC is able to compress a Homo sapiens dataset containing 1092 samples in 1.1 GB (

29 seums Lukenya Hill Hominid 1 (KNM-LH 1) is a Homo sapiens partial calvaria from site GvJm-22 at Luken

30 uorescence image spectroscopy (MFIS) using a Homo-FRET assay shows that the inducible multimerization

31 These inhibitors are selective against Homo sapiens NMT1 (HsNMT), have excellent ligand efficie

32 Approximately 700,000 years ago, Homo erectus in Africa was giving way to populations wit

33 cessful minimax strategy employed by ancient Homo sapiens subpopulations in a one-player game against

34 enorhabditis elegans, Loxodonta africana and Homo sapiens.

35 hort basicranium, as in Australopithecus and Homo.

36 nium co-existed with Paranthropus boisei and Homo habilis at Olduvai during Bed I times.

37 works, including Saccharomyces cerevisia and Homo sapien PPI networks collected from the Database of

38 herichia coli, Saccharomyces cerevisiae, and Homo sapiens sequences reveals how co- and post-translat

39 herichia coli, Saccharomyces cerevisiae, and Homo sapiens, respectively, and the conclusions are cons

40 herichia coli, Saccharomyces cerevisiae, and Homo sapiens, respectively.

41 ction of FBA models for Escherichia coli and Homo sapiens.

42 myces cerevisiae, Caenorhabditis elegans and Homo sapiens, and found that about 2-10% of proteins in

43 latta, Pan troglodytes, Gorilla gorilla, and Homo sapiens haplotypes using transient dual-luciferase

44 Escherichia coli, Pyrococcus horikoshii, and Homo sapiens.

45 genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have simil

46 scherichia coli, Drosophila melanogaster and Homo sapiens annotations and real gene expression data e

47 er, Caenorhabditis elegans, Mus musculus and Homo Sapiens.

48 Drosophila, Gallus gallus, Mus musculus, and Homo sapiens.

49 he region during this period-Neandertals and Homo sapiens.

50 changed much since the divergence of Pan and Homo from their common ancestor.

51 Comparison of soft tissues between Pan and Homo provides new insights into the function and evoluti

52 c senescence, might be different for Pan and Homo.

53 aditionally associated with Paranthropus and Homo appeared in the fossil record earlier than previous

54 rly evolutionary history of Paranthropus and Homo.

55 P. falciparum (Pf) and Homo sapiens (Hs) OPRTs are characterized by highly diss

56 mistry (Escherichia coli for prokaryotes and Homo sapiens for eukaryotes).

57 ecus africanus, Australopithecus sediba, and Homo erectus all had zygapophyseal facets that shift fro

58 ignatures of both Mus musculus (stromal) and Homo sapiens (epithelial) tissue origins.

59 PPI) networks between Epstein-Barr virus and Homo sapiens.

60 Among animals, Homo sapiens is unique in its capacity for widespread co

61 gued to result from the expansion of archaic Homo sapiens out of Africa.

62 Finally, a South African australopith + Homo clade is supported by four shared derived states, i

63 ers of the Ardipithecus + Australopithecus + Homo clade.

64 tic relationship with the Australopithecus + Homo clade based on nonhoning canine teeth, a foreshorte

65 ls that Eurasia was probably occupied before Homo erectus appears in the East African fossil record.

66 Besides Homo erectus (sensu lato), the eastern African fossil re

67 is well within the era of speciation between Homo sapiens and Neanderthals/Denisovans and around thre

68 and developmental time information from both Homo sapiens and Mus musculus.

69 get by yeast-two-hybrid screening using both Homo sapiens centrin 2 (Hscen2) and Chlamydomonas reinha

70 Along this same branch, Homo erectus shows a marked reduction in molar size that

71 stocene colonization of temperate Eurasia by Homo erectus was not only a significant biogeographic ev

72 acity for ecosystem engineering exhibited by Homo sapiens A crucial outcome of such behaviors has bee

73 icates repeated use of lakeshore habitats by Homo erectus.

74 If these artifacts were made by Homo sapiens, as has been suggested, then our age indica

75 d model organisms: Saccharomyces cerevisiae, Homo sapiens, Drosophila melanogaster, Caenorhabditis el

76 we hypothesized that sex of the human child (Homo sapiens), differences in physical activity, and tim

77 ich objects were used by preschool children (Homo sapiens) was examined by directly observing them ac

78 s to establish that all sediments containing Homo naledi fossils can be allocated to a single stratig

79 f primitive (australopith-like) and derived (Homo-like) features, the upper limbs (excluding the hand

80 Here the authors describe Homo-PROTACS: small molecules that can induce the homo-d

81 We describe Homo-PROTACs as an approach to dimerize an E3 ligase to

82 One AS, designated Homo sapiens keratin 7 (KRT7-AS), was selected due to it

83 ns is shared with Australopithecus and early Homo but not with modern humans suggesting that the mode

84 revealing that australopithecines and early Homo had more rapid ontogenies than recent humans.

85 Swartkrans, Homo neanderthalensis, and early Homo sapiens.

86 and consumption of fauna, probably by early Homo erectus sensu lato.

87 e show that reduction in molar size in early Homo (H. habilis and H. rudolfensis) is explicable by ph

88 n trabecular density first occurred in early Homo erectus, consistent with the shift toward a modern

89 Differences between species of early Homo appear to be characterized more by gnathic diversit

90 ikely to have limited the life span of early Homo because this effect was likely mediated by the prep

91 5 million years ago, three lineages of early Homo evolved in a context of habitat instability and fra

92 , the eastern African fossil record of early Homo has been interpreted as representing either a singl

93 are claimed to confirm a diversity of early Homo species.

94 overlap in brain size among species of early Homo.

95 ogical variation within a paleodeme of early Homo.

96 ot consistent with a single species of early Homo.

97 OH 7 mandible, and compare it to other early Homo fossils.

98 y from Australopithecus, Paranthropus, early Homo and from KNM-WT 15000 (H. erectus/ergaster) showing

99 hecus africanus, Paranthropus robustus/early Homo from Swartkrans, Homo neanderthalensis, and early H

100 naledi is unique, but most similar to early Homo species including Homo erectus, Homo habilis or Hom

101 most likely characteristic of pre-modern era Homo sapiens.

102 o early Homo species including Homo erectus, Homo habilis or Homo rudolfensis.

103 drogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P) dependent steroid dehydrogen

104 of multiple organisms, including Eukaryota, Homo sapiens, Viridiplantae, Gram-positive Bacteria, Gra

105 ic (Streptomyces coelicolor) and eukaryotic (Homo sapiens) FGEs contain a copper cofactor.

106 n Pan indicate that present-day Pan exhibits Homo-like technological competencies.

107 uding foci of the essential crossover factor Homo sapiens enhancer of invasion 10 (Hei10), occur at h

108 sil specimens and an eagerly awaited age for Homo naledi raise new questions and open fresh opportuni

109 The repository (currently available for Homo sapiens and Saccharomyces cerevisiae) and computati

110 r the best ensemble predictors available for Homo sapiens, Caenorhabditis elegans and Arabidopsis tha

111 RNA22-GUI is currently available for Homo sapiens, Mus musculus, Drosophila melanogaster and

112 less parietal expansion than is the case for Homo sapiens.

113 /CenH3/H4 complexes have been determined for Homo sapiens (Hs) and the budding yeasts Saccharomyces c

114 causing mandibular shape variation in fossil Homo and in modern human hunter-gatherer populations.

115 RNA interaction in PRC2 core complexes from Homo sapiens and Chaetomium thermophilum, for which crys

116 a central subject for human development from Homo erectus to date.

117 deacetylase, using recombinant enzymes from Homo sapiens (human) and Danio rerio (zebrafish).

118 The activities of Dnmt2 enzymes from Homo sapiens, Drosophila melanogaster, Schizosaccharomyc

119 Expression of subunit c homologues from Homo sapiens and Manduca sexta, both species sensitive t

120 Candida albicans and GlcNAc kinase NAGK from Homo sapiens, are required for rescue in this context.

121 collects data on >6000 bitopic proteins from Homo sapiens, Arabidopsis thaliana, Dictyostelium discoi

122 corresponding regions of GGPP synthases from Homo sapiens or S. cerevisiae.

123 glycans in more than a dozen cell types from Homo sapiens and Mus musculus.

124 elegans, Drosophila melanogaster, G. gallus, Homo sapiens, Mus musculus or Rattus norvegicus and iden

125 currently available for three model genomes (Homo sapiens, E. coli and baker's yeast), and the projec

126 distinctive longevity is a feature of genus Homo that long antedated the appearance of our species.

127 nd arose early in the evolution of the genus Homo and probably in Homo erectus sensu lato.

128 earliest stone tools were made by the genus Homo and that this technological development was directl

129 The origins of the genus Homo are murky, but by H. erectus, bigger brains and bod

130 ish Late Pleistocene clades within the genus Homo based on ancient protein evidence through the ident

131 omo sapiens as the only species of the genus Homo capable of modifying animal bones into specialised

132 Our understanding of the origin of the genus Homo has been hampered by a limited fossil record in eas

133 groups: specimens attributable to the genus Homo provide evidence for a diet with a ca. 65/35 ratio

134 eems to have varied little through the genus Homo, and it should not be used to account for other asp

135 configuration and function within the genus Homo.

136 ve produced the earliest record of the genus Homo.

137 the timing and place of origin of the genus Homo.

138 annot be unequivocally assigned to the genus Homo.

139 g deep-rooted species diversity in the genus Homo.

140 and thus is reasonably assigned to the genus Homo.

141 the origin and early evolution of the genus Homo.

142 nstant throughout the evolution of the genus Homo.

143 ) corresponds to the appearance of the genus Homo.

144 important role in the evolution of the genus Homo.

145 ory and dietary adaptations within the genus Homo.

146 mosaic design may be primitive for the genus Homo.

147 study the evolutionary history of the genus Homo.

148 thesized to be a close relative of the genus Homo.

149 within both the hominin clade and the genus Homo.

150 e earliest known representative of the genus Homo.

151 cerns the fate of archaic forms of the genus Homo: did they go extinct without interbreeding with ana

152 Extinct hominins, including pre-Holocene Homo sapiens, retain the high levels seen in nonhuman pr

153 te that a morphologically primitive hominin, Homo naledi, survived into the later parts of the Pleist

154 Human (Homo sapiens) micro-RNAs (hsa-miRNAs) regulate virus and

155 Eighty adult human (Homo sapiens) participants were presented with a task pr

156 yeast (Saccharomyces cerevisiae) and human (Homo sapiens), intermediate cleavage peptidase55 (ICP55)

157 alpha4 (GLRA4) subunits were found in human (Homo sapiens) and guinea pig (Cavia porcellus) tracheal

158 homolog of the nucleoporin NUP214 in human (Homo sapiens) and Nup159 in yeast (Saccharomyces cerevis

159 Mutations in human (Homo sapiens) ETHYLMALONIC ENCEPHALOPATHY PROTEIN1 (ETHE

160 of retroduplication-derived genes in human (Homo sapiens), fly (Drosophila melanogaster), rice (Oryz

161 e of the representation that mediates human (Homo sapiens) and rat (Rattus norvegicus) movement chara

162 y and tested functional robustness of human (Homo sapiens), rice (Oryza sativa) and budding yeast (Sa

163 dopsis thaliana, rice (Oryza sativa), human (Homo sapiens), and mouse (Mus musculus), we found that t

164 Oryza sativa], soybean [Glycine max], human [Homo sapiens], yeast [Saccharomyces cerevisiae], fruit f

165 Humans (Homo sapiens) anticipate the consequences of their forth

166 Pigeons (Columba livia) and humans (Homo sapiens) both showed response time facilitation at

167 rhesus monkeys (Macaca mulatta) and humans (Homo sapiens) on adjacent pairs (e.g., AB, BC, CD, DE, E

168 Previous research in humans (Homo sapiens) and in nonhuman animals suggests that male

169 to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosophila

170 er limb joints, spring-like plantar arch) in Homo was somewhat mosaic, with the full endurance suite

171 lection pressure for traits and behaviors in Homo such as bipedalism, flexible diets, and complex soc

172 hat it also confers reproductive benefits in Homo sapiens.

173 The development of endurance capabilities in Homo appears to parallel the evolutionary increase in br

174 RHEX is well conserved in Homo sapiens and primates but absent from mouse, rat, an

175 election for smaller masticatory features in Homo would have been initially made possible by the comb

176 ue buccal microwear pattern that is found in Homo antecessor (0.96-0.8 Myr), a well-known cannibal sp

177 s NUBPL (nucleotide binding protein-like) in Homo sapiens.

178 Loss of Neu5Gc in Homo likely had complex effects on immunity, providing g

179 This limitation was probably overcome in Homo erectus with the shift to a cooked diet.

180 e origins of these developmental patterns in Homo sapiens remain unknown.

181 ped for predicting nucleosome positioning in Homo sapiens, Caenorhabditis elegans and Drosophila mela

182 evolution of the genus Homo and probably in Homo erectus sensu lato.

183 the subcellular localizations of proteins in Homo sapiens (HS, human) and Arabidopsis thaliana (AT, t

184 r with estimates for tooth eruption times in Homo erectus.

185 explains many zoologically unusual traits in Homo sapiens, including our complex toolkit, wide range

186 on of a regulatory network of brain tumor in Homo sapiens takes 12 days with MEDUSA, FastMEDUSA obtai

187 rs, found in all kingdoms of life, including Homo sapiens.

188 most similar to early Homo species including Homo erectus, Homo habilis or Homo rudolfensis.

189 Dental development in later Homo species has been intensely debated, most notably th

190 us with derived morphology observed in later Homo, confirming that dentognathic departures from the a

191 apid pulses in the branches leading to later Homo species.

192 present the crystal structure of full-length Homo sapiens fascin-1, and examine its packing, conforma

193 odied (i.e., well within the range of living Homo) specimen that, at 3.58 Ma, also substantially ante

194 LB1 represents a pathological microcephalic Homo sapiens rather than a new species, (i.e., H. flores

195 epresent a pathological microcephalic modern Homo sapiens.

196 a" model, which posits a dispersal of modern Homo sapiens across Eurasia as a single wave at 60,000

197 The postcranial skeleton of modern Homo sapiens is relatively gracile compared with other h

198 nd around three times longer than the modern Homo sapiens divergence times.

199 e also evident between them and monophyletic Homo habilis/rudolfensis + H. erectus.

200 hecus and similar to that of the Nariokotome Homo erectus skeleton.

201 s have represented only approximately 10% of Homo sapiens' existence.

202 into the cognitive and hunting abilities of Homo erectus while indicating that their activities at t

203 we have constrained the depositional age of Homo naledi to a period between 236 ka and 335 ka.

204 adaptation some time after the appearance of Homo erectus.

205 sis than to the derived parabolic arcades of Homo sapiens or H. erectus.

206 howed that the two alpha satellite arrays of Homo sapiens Chromosome 17 (HSA17), D17Z1 and D17Z1-B, b

207 bstantially revises the timing of arrival of Homo into the Americas.

208 a melanogaster, a complex genome assembly of Homo sapiens and the low coverage Sanger sequence assemb

209 the large, metabolically expensive brains of Homo sapiens can be energetically afforded.

210 nted relative to the finished chromosomes of Homo sapiens and key model organisms generated by the Hu

211 We provide proof-of-concept of Homo-PROTACs using diverse molecules composed of two ins

212 led to a re-evaluation of the conception of Homo sapiens as the exclusive manufacturer of specialise

213 employer behavior in the northwest corner of Homo economicus, actual online hiring decisions tend to

214 Direct dating of Homo naledi fossils from the Dinaledi Chamber shows that

215 lies within the timeframe dating the dawn of Homo sapiens, suggesting that P. falciparum may have und

216 The designation of Homo floresiensis as a new species derived from an ancie

217 about 2.0 Ma--the emergence and dispersal of Homo erectus (sensu lato).

218 tral hominins, just before the divergence of Homo from australopithecines.

219 e at that time, paralleling the emergence of Homo erectus-like hominid morphology.

220 to arise later, likely with the emergence of Homo erectus.

221 ests that it appeared after the emergence of Homo sapiens and contributed to the great success of our

222 The earliest credible evidence of Homo sapiens in Europe is an archaeological proxy in the

223 olar size) originated after the evolution of Homo but before or concurrent with the evolution of H. e

224 cited as a critical step in the evolution of Homo sapiens, language, and human-level cognition.

225 ating of Neu5Gc loss during the evolution of Homo.

226 it has been hypothesized that the exodus of Homo sapiens out of Africa and into Eurasia between ~50-

227 sented here indicate a long-term exposure of Homo to these elements, via fires, fumes and their ashes

228 Here we describe the foot of Homo naledi from Dinaledi Chamber, South Africa, using 1

229 rliest fossil attributed to a modern form of Homo sapiens comes from eastern Africa and is approximat

230 South Africa, which contains the fossils of Homo naledi.

231 actor genes, comparing methylated genomes of Homo sapiens, Mus musculus, and Danio rerio with nonmeth

232 rial phytochrome with the effector module of Homo sapiens phosphodiesterase 2A.

233 The basic physiology and morphology of Homo sapiens sets boundaries to our eating habits, but w

234 that the key to understanding the origin of Homo lies in understanding how environmental changes dis

235 ssil evidence points to an African origin of Homo sapiens from a group called either H. heidelbergens

236 s and, for some loci, predates the origin of Homo sapiens.

237 , Ethiopia, that establishes the presence of Homo at 2.80 to 2.75 Ma.

238 m the presence of an unidentified species of Homo at the CM site during the last interglacial period

239 However, in species of Homo, including modern humans, there is a tight link bet

240 unctions, we solved the crystal structure of Homo sapiens COQ9 at 2.4 A.

241 Homo heidelbergensis, or to a subspecies of Homo erectus A recently discovered cranium (Aroeira 3) f

242 orgia represent a single regional variant of Homo erectus.

243 r Palaeolithic contexts favoured the view of Homo sapiens as the only species of the genus Homo capab

244 lestone projects such as Escherichia coli or Homo sapiens, teams of scientists were employed to manua

245 n of either Saccharomyces cerevisiae GAL4 or Homo sapien sapien PKR (respectively) to a truncation of

246 cies including Homo erectus, Homo habilis or Homo rudolfensis.

247 rsially identified as either Neanderthals or Homo sapiens.

248 IMP currently supports seven organisms (Homo sapiens, Mus musculus, Rattus novegicus, Drosophila

249 hree years in the seven supported organisms (Homo sapiens, Mus musculus, Rattus norvegicus, Drosophil

250 In contrast to our Homo sapiens-derived genes, the microbiome is much more

251 U-Th age for the oldest flowstone overlying Homo naledi fossils, we have constrained the depositiona

252 the Levant shortly before Upper Palaeolithic Homo sapiens populated the region.

253 few sufficiently complete Early Pleistocene Homo clavicles seem to have relative lengths also well w

254 o a population ancestral to Late Pleistocene Homo floresiensis.

255 met Neandertals, Denisovans, mid-Pleistocene Homo, and possibly H. floresiensis, with some degree of

256 Unique compared with recent and prehistoric Homo sapiens, Neandertal humeri are characterised by a p

257 ctions in the two eukaryotic reconstructions Homo sapiens Recon 1 and Yeast 5 are specified as irreve

258 liana, Drosophila melanogaster, Danio rerio, Homo sapiens, Mus musculus, Oryza sativa, Solanum lycope

259 oximately 2 million years ago in the species Homo erectus.

260 a have been assigned to a new human species, Homo naledi, which displays a unique combination of prim

261 ave allowed the definition of a new species, Homo antecessor.

262 graphic and adaptive history of our species, Homo sapiens, including its interbreeding with other hom

263 cause medicine pertains to a single species, Homo sapiens, functional human variation often involves

264 presenting either a single variable species, Homo habilis, or two species.

265 Two organisms are currently supported: Homo sapiens and Mus musculus.

266 thropus robustus/early Homo from Swartkrans, Homo neanderthalensis, and early Homo sapiens.

267 homolog of the spliceosomal proteins TFP11 (Homo sapiens) and Ntr1p (Saccharomyces cerevisiae) invol

268 le location, by a hominin species other than Homo sapiens, at an as-yet unknown date.

269 cal evidence now demonstrates, however, that Homo sapiens has actively manipulated tropical forest ec

270 The Homo sapiens and Arabidopsis thaliana genomes are believ

271 uggestive association on chromosome 6 at the Homo sapiens mediator complex subunit 23 gene/arginase I

272 at the progenitor K111 integrated before the Homo-Pan divergence and expanded in copy number during t

273 ica, and indicate a much younger age for the Homo naledi fossils than have previously been hypothesiz

274 e australopith pattern occurred early in the Homo lineage.

275 mate OH 7 partial hand skeleton (part of the Homo habilis holotype).

276 tal to evaluating the early evolution of the Homo lineage, and by priority names one or other of the

277 gene, possibly expediting divergence of the Homo lineage, due to a partial fertility barrier.

278 tion of HYDIN2 early in the evolution of the Homo lineage.

279 The sequence of the Homo sapiens Krr1 GXXGlp is evolutionarily conserved (16

280 assumptions regarding the morphotype of the Homo-Pan last common ancestor (LCA).

281 the inversion's ancestral origin within the Homo lineage, indicating that 8p23.1 inversion has occur

282 ficking in organisms ranging from archaea to Homo sapiens under both normal and stressed cellular con

283 H 7 is incompatible with fossils assigned to Homo rudolfensis and with the A.L. 666-1 Homo maxilla.

284 ncluding 97 hominin footprints attributed to Homo erectus.

285 al, the bones of this hand are attributed to Homo naledi.

286 ng a minimum of 15 individuals attributed to Homo naledi.

287 ears that can be unequivocally attributed to Homo sapiens are lacking.

288 g to the transition from Australopithecus to Homo and the beginning of neocortex expansion.

289 incipient stage of Neandertal evolution, to Homo heidelbergensis, or to a subspecies of Homo erectus

290 The target ODNs specific to Homo sapiens Breast and ovarian cancer cells were detect

291 soils might not have posed a major threat to Homo populations.

292 n the diet is not a characteristic unique to Homo.

293 may have provided a selective advantage when Homo transitioned to butchery using stone tools.

294 he late Pleistocene in Paranthropus, whereas Homo maintains a flexible diet.

295 additional perspective to the paradox of why Homo sapiens, particularly agriculturalists, appear to b

296 Many features associated with Homo sapiens, including our large linear bodies, elongat

297 high-predicted structural conservation with Homo sapiens.

298 omical dissections and compare the data with Homo sapiens.

299 inum proteins were evolutionary related with Homo sapiens proteins to sort out the non-human homologs

300 he earliest stages of diversification within Homo.