ライフサイエンスコーパス: Horner

1 Horner syndrome refers to the constellation of signs res

2 and employed a B-alkyl Suzuki coupling and a Horner-Wadsworth-Emmons olefination to accomplish their

3 The XF skeleton was synthesized by a Horner reaction to assemble the distyrylbenzene unit fol

4 one 28 to angelic aldehyde 27, followed by a Horner-Wadsworth-Emmons (HWE) coupling of 32 with glutar

5 aleic anhydrides via oxidation followed by a Horner-Wadsworth-Emmons reaction pathway in very good yi

6 The resulting phosphonate was employed in a Horner-Wadsworth-Emmons condensation with an aldehyde re

7 The approach involves a Horner-Emmons olefination with a suitably protected glyc

8 te to this advanced intermediate involving a Horner-Wadsworth-Emmons coupling of fragments 22 and 25.

9 To approach the desired compounds through a Horner-Wadsworth-Emmons condensation, new indole derivat

10 the macrocyclization was carried out using a Horner-Emmons olefination at the C(2)-C(3) olefin.

11 They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step an

12 ation/methylation sequence to cast ring X, a Horner-Wadsworth-Emmons coupling of WXYZA' ketophosphona

13 acetylation, deprotection of the acetal, and Horner-Emmons olefination-conjugate addition reaction to

14 e, followed by oxidation to the aldehyde and Horner-Wadsworth-Emmons olefination), (ii) conversion to

15 ine-catalyzed sequential alpha-amination and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes a

16 t as amino acid transition state analogs and Horner-Wadsworth-Emmons reagents, respectively.

17 prepared, and alternating Heck coupling and Horner-Wadswoth-Emmons (HWE) reactions were used to coup

18 ed as substrates in attempted Knovenagel and Horner-Wadsworth-Emmons condensations, but elimination w

19 ganotrifluoroborates by using the Wittig and Horner-Wadsworth-Emmons olefination is described.

20 stly, the localizing pitfalls of anisocoria--Horner and Raeder syndromes, physiologic anisocoria, pup

21 or of the pupil in common disorders, such as Horner's syndrome and tonic pupil.

22 hydroboration sequence, a Gais's asymmetric Horner-Wadsworth-Emmons reaction, and a mercury salt cat

23 lculations support the mechanism proposed by Horner in which a hydride is transferred from silicon to

24 prepared from 2-indanones in high yields by Horner-Wadsworth-Emmons reaction.

25 Mutually complementary Horner-Wadsworth-Emmons and Still-Gennari (SG) olefinati

26 amination, an improved version of the Emmons-Horner reaction, and other common reactions.

27 ylation, followed by a vinyl sulfone forming Horner-Wadsworth-Emmons olefination.

28 ractures, LeFort II or III facial fractures, Horner's syndrome, skull base fractures involving the fo

29 metrization protocol developed in our group, Horner-Wadsworth-Emmons olefination, acid-catalyzed keta

30 toms in ICAD are cervical pain and headache, Horner's syndrome, paralysis of the cranial nerves and s

31 Imaging in Horner syndrome is commonly performed, however, imaging

32 Our initial Horner-Wadsworth-Emmons/oxa-Michael approach to the berk

33 nd 23% by physical examination (neck injury, Horner's syndrome).

34 lactone 24 to enone 27 by an intramolecular Horner-Emmons Wittig reaction and epimerization complete

35 assemble the polyene, and an intramolecular Horner-Wadsworth-Emmons olefination to forge the macrocy

36 ehyde allylation reaction, an intramolecular Horner-Wadsworth-Emmons olefination, and a dihydroxylati

37 de macrolactonization through intramolecular Horner-Wadsworth-Emmons olefination, Yamaguchi-Hirao alk

38 in a one-pot benzoyl transfer-intramolecular Horner-Wadsworth-Emmons reaction.

39 of aryloxy-terminated omega chains involving Horner-Emmons elongation of an aldehyde to a methyl enon

40 in multistep synthetic procedures involving Horner-Wadsworth-Emmons olefination reactions and/or Hec

41 cal pain in neck or face with an ipsilateral Horner's syndrome preceding transient or persistent reti

42 erformed, however, imaging yield in isolated Horner syndrome has not been extensively studied.

43 possible to hold-off on imaging of isolated Horner syndrome especially if evidence exists establishi

44 or evaluation in pediatric cases of isolated Horner syndrome is physical examination, urinary catecho

45 A novel Horner-Emmons olefination conjugate addition reaction of

46 ing quinuclidines are shown to undergo novel Horner-Wadsworth-Emmons-type (HWE-type) reactions to giv

47 reaction sequence complements the arsenal of Horner-Wadsworth-Emmons-type coupling reactions.

48 ew the yield of imaging in isolated cases of Horner syndrome in order to better understand if and whe

49 An appropriate evaluation of Horner syndrome and a timely elucidation of the etiology

50 ttempts of intramolecular Still's variant of Horner-Emmons olefination between the C(19)-phosphonocet

51 A high yielding synthetic scheme based on Horner-Wadsworth-Emmons or Pictet-Spengler reactions was

52 yclization with a concomitant imide opening, Horner-Wadsworth-Emmons olefination, and desilylation.

53 zene derivatives were prepared using Heck or Horner methodologies.

54 a combination of Heck coupling and Wittig or Horner reactions of suitable precursor modules.

55 1,2-addition of Grignard reagents, Wittig or Horner-Emmons olefinations, and directed aldol reactions

56 rate the hydroxy group at the C-13 position, Horner-Wadsworth-Emmons olefination to form the C9-C10 b

57 The targets were prepared by a NaH-promoted Horner reaction of tetraethyl(2,5-diiodo-1,4-phenylene)b

58 d sequential 1,5 O --> O silyl rearrangement/Horner-Wadsworth-Emmons reaction used to construct 18, (

59 n chemistry was carried out using repetitive Horner-Wadsworth-Emmons (HWE) reactions of precisely sub

60 orms, XF) have been prepared by a sequential Horner reaction of the bisphosphonate of 2,5-diiodo-1,4-

61 ecursor bicyclic lactam, followed by in situ Horner-Wadsworth-Emmons (HWE) olefination as the key syn

62 ol reactions, the discovery of a spontaneous Horner-Wadsworth-Emmons macrocyclization strategy, and t

63 al and Fmoc-L-valinal, and a resin supported Horner-Wadsworth-Emmons reaction, were treated with cinn

64 BS reduction, Hantzsch's thiazole synthesis, Horner-Wadsworth-Emmons reaction, and Shiina's macrolact

65 glion block, although patients had temporary Horner's syndrome indicating the effectiveness of the bl

66 The Horner method was used to synthesize random copolymers o

67 The Horner-Wadsworth-Emmons condensation of some alpha-phosp

68 The Horner-Wadsworth-Emmons reaction also gave the E-isomer

69 rectly to an amino aldehyde, which after the Horner-Wadsworth-Emmons reaction was elaborated to pinna

70 (+)-asteltoxin (1) has been achieved by the Horner-Emmons olefination of bis(tetrahydrofuran) aldehy

71 s-based pyrroles is also demonstrated in the Horner reaction.

72 widely useful, notably as substrates in the Horner-Wadsworth-Emmons-type olefinations.

73 Other key steps include the Horner-Wadsworth-Emmons reaction and the diastereoselect

74 as prepared in six steps, and the use of the Horner-Emmons olefination to yield the alpha,beta-unsatu

75 gent-growth methodology that made use of the Horner-Wadsworth-Emmons (HWE) reaction.

76 oyed as starting materials for preparing the Horner-Wadsworth-Emmons reagent 4-(diethoxyphosphoryl)-2

77 ne (exTTF-dpq) dyad is described through the Horner-Wardsworth-Emmons olefination methodology from th

78 nd the Davis oxaziridine, in addition to the Horner-Wadsworth-Emmons olefination of N-sulfinyl imines

79 aza-variant analogue is described using the Horner-Wadsworth-Emmons reaction as the key step in comb

80 The AVMB ligands were synthesized using the Horner-Wadsworth-Emmons reaction.

81 sphonate 6, which underwent a phase-transfer Horner-Emmons Wittig reaction with heptadecanal to provi

82 he naphthylidene indenes was developed using Horner-Wittig chemistry that afforded the Z isomer in th

83 unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroetho

84 duction of a double unsatured side chain via Horner-Wadsworth-Emmons reaction and assembly of the nap

85 (compounds 16-23) have been synthesized via Horner-Wadsworth-Emmons reaction involving a monophospho

86 he unsaturated phosphonate 1 as a vinylogous Horner-Wadsworth-Emmons reagent was explored in reaction

87 corporated using an intramolecular Wadsworth-Horner-Emmons olefination of phenylselenylated alpha-hyd

88 ted, again using an intramolecular Wadsworth-Horner-Emmons olefination reaction to give phyllanthine

89 Wittig-Horner reaction of a chiral phosphonate derived from (S)

90 -(E)-decenal, which is subjected to a Wittig-Horner reaction after chlorination in alpha-position.

91 ers (11a-c) has been carried out by a Wittig-Horner reaction of the respective phosphonate esters (10

92 nother double bond employing a common Wittig-Horner prolongation sequence.

93 Key steps include Wittig-Horner olefination of a d-xylofuranose precursor, [I(+)]

94 y a convergent synthesis applying the Wittig-Horner reaction as a key step.

95 red in convergent syntheses using the Wittig-Horner reaction as a key step.

96 y convergent syntheses, employing the Wittig-Horner reaction.

97 which were subjected to Lythgoe type Wittig-Horner coupling with C,D-fragments 35a and 35b.

98 ,19-dinorvitamin D3 were prepared via Wittig-Horner coupling of 25-hydroxy-18-nor Grundmann type keto

99 The synthetic pathway was via Wittig-Horner coupling of the corresponding A-ring phosphine ox