ライフサイエンスコーパス: Hox gene

1 uman Hox loci, but does not itself contain a Hox gene.

2 tions at the promoter region of 37 zebrafish hox genes.

3 keleton requires the coordinated activity of Hox genes.

4 enes, known to act as upstream regulators of Hox genes.

5 development as a consequence of mutations in HOX genes.

6 in marks typically associated with repressed Hox genes.

7 osophila embryo, including four of the eight Hox genes.

8 nt cis-regulatory elements into contact with Hox genes.

9 ith changes in the function or regulation of Hox genes.

10 ly methylated and expressed include multiple HOX genes.

11 he specific induction of Hoxa9 but not other Hox genes.

12 not by changes in the function of primaxial Hox genes.

13 ates gene transcription, including homeobox (HOX) genes.

14 of Polycomb group-mediated repression of the Hox gene Abdominal-B (Abd-B) caused the transformation o

15 ore, gene expression analysis shows that the Hox gene Abdominal-B (Abd-B) represents one of the targe

16 The posterior Hox genes (abdominal-A and Abdominal-B) were required fo

17 Our results support a mechanism in which Hox genes act upstream of Tbx5 to control the axial posi

18 ified lineages and requires lineage-specific Hox gene action to ensure the correct formation of adult

19 ined the role of chromatin regulators during Hox gene activation.

20 esults in abnormal development and defective hox gene activation.

21 SS family members has little effect on early Hox gene activation.

22 ila by a Hox-dependent mechanism, in which a Hox gene affects the expression of genes important for w

23 ecently validated by molecular phylogeny and Hox genes analyses.

24 vo, we interrogated their role in regulating Hox genes and body segment identity using Moz;Bmi1 doubl

25 s, using CRISPR/Cas9 and fate mapping, of 5' hox genes and enhancers in zebrafish that are indispensa

26 e near the N terminus, which is unique among HOX genes and highly conserved in higher mammals.

27 clusters of tandemly duplicated genes (e.g., Hox genes and histones).

28 Here, we describe the function of Hox genes and homothorax (hth), which encodes a Hox co-f

29 s, suggesting extensive interactions between Hox genes and hormone-controlled regulatory networks to

30 se outcome predictors, and overexpression of HOX genes and HOX-gene-embedded microRNAs in low MN1 exp

31 come predictors were down-regulated, whereas HOX genes and HOX-gene-embedded microRNAs were up-regula

32 n is significant in most of the 39 mammalian Hox genes and in other homeobox-containing transcription

33 dentities of these segments are specified by Hox genes and other axis patterning genes during develop

34 the "OFF" and "ON" transcriptional states of HOX genes and other targets by modulation of chromatin s

35 effects of interference with the function of Hox genes and Tc-hth/Tc-exd during metamorphosis did not

36 Rgamma increases the expression of posterior Hox genes and that of marker genes for presomitic mesode

37 esponsible for the synchronous regulation of Hox genes and the molecular function of their colinearit

38 miR-196 injection altered expression of hox genes and the signaling of retinoic acid through the

39 ription factors and segmental expressions of Hox genes and their accessory proteins.

40 ofiles were characterized by upregulation of HOX genes and their embedded microRNAs and downregulatio

41 rprisingly, elevated expression of different Hox genes and various other transcription factors, such

42 Recent studies of HOX genes and X inactivation have provided evidence for

43 We propose that 5'Hoxd genes and Gli3 are part of an interdigital signalli

44 ry origin remains obscure, due to absence of Hox genes (and their evolutionary sisters, the ParaHox g

45 patterning similar to nearby protein-coding Hox genes, and acts on appendicular patterning at least

46 row MSCs express other regionally restricted Hox genes, and femur fractures heal normally in Hox11 mu

47 Low EZH2 levels resulted in derepression of HOX genes, and knockdown of HOXB7 and HOXA9 in the resis

48 nscription factors such as SOX6, POU3F2, and HOX genes; and identify striking examples of adaptive re

49 legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultr

50 homothorax, and extradenticle, and that the Hox gene Antennapedia prevents activation of antennal ge

51 A single Hox gene, Antennapedia (Antp), is primarily responsible

52 In the developing embryo, Hox genes are activated sequentially in time and space a

53 Unexpectedly, multiple Hox genes are derepressed in Hoxc9 mutants, leading to m

54 Hox genes are essential regulators of embryonic developm

55 Wnt and several Hox genes are expressed at the posterior pole, whereas W

56 Paralog group 1 (PG1) hox genes are expressed early in the caudal hindbrain an

57 are clustered in four chromosomal loci; the Hox genes are expressed in nested anterior-posterior and

58 Hox genes are key regulators of development.

59 Hox genes are key regulators of stem cells and tissue pa

60 rphogenesis, and suggest that this and other Hox genes are likely to have important roles during regi

61 transcriptomic analyses show that brachiopod Hox genes are neither strictly temporally nor spatially

62 Thus, Hox genes are not simply regulators of skeletal morpholo

63 Hox genes are renowned for patterning animal development

64 results in ectopic lineages suggesting that Hox genes are required for lineage-specific termination

65 res of subfunctionalisation of paralogues of Hox genes are revealed in the appendages of two species

66 However, Cdx genes and multiple Hox genes are stage-specific targets of Sp1 and are down

67 Mammalian Hox genes are targets of Polycomb proteins and form loca

68 Homeotic (HOX) genes are dysregulated in multiple malignancies, in

69 The homeotic (Hox) genes are highly conserved in metazoans, where they

70 xamples of homeobox containing genes are the Hox genes, arranged on chromosomes in the same order as

71 observe several novel genomic regions (e.g., HOX genes) as being epigenetically regulated.

72 Here we characterize the expression of HoxD genes, as well as the cluster-associated genes Evx2

73 arthropods by altering the role of distinct Hox genes at different levels of their action.

74 ism of action for Psip1 in the regulation of Hox genes but also suggest an unexpected interplay betwe

75 full transcriptional activation of multiple Hox genes but functions independently of the E1 and E2 c

76 ontrolling this spatiotemporal expression of Hox genes, but disentangling their relative contribution

77 families, including the apparent absence of HOX genes, canonical microRNA machinery, and reduced imm

78 etinoic acid drove trunk-related markers and HOX genes characteristic of a posterior identity.

79 mb repressive complex 1 (PRC1) in compacting Hox gene chromatin in mouse embryonic stem cells and sug

80 uster, evolutionarily closely related to the Hox gene cluster.

81 organization of chromatin at and around the HoxD gene cluster and report that although the two TADs

82 ons in 3D interactions within and around the HoxD gene cluster.

83 ral collinearity might contribute to keeping Hox genes clustered.

84 gest spatial network is composed of the four Hox gene clusters and early developmental transcription

85 nding sites within vertebrate and Drosophila Hox gene clusters have been maintained for several hundr

86 s often considered the main force preserving Hox gene clusters in animal genomes.

87 Further we tested, whether paralogs of Hox gene clusters originated from this paddlefish specif

88 correlation between the presence of CTCF and Hox gene clusters throughout the animal kingdom suggests

89 e according to their genomic position within Hox gene clusters.

90 The HoxA and HoxD gene clusters of jawed vertebrates are organized in

91 ties group into three main classes that obey Hox gene collinearity rules and DNA structure prediction

92 s not previously characterized and show that HOX genes confine them to the thoracic segments.

93 volved in cell differentiation and Homeobox (Hox) gene control.

94 Hox genes controlling motor neuron subtype identity are

95 sion in the peripodial epithelium, while the Hox gene Deformed represses labial in this location, thu

96 f mutants containing individual and combined hox gene deletions in a common parental strain reveals a

97 We previously described HOX genes deregulation to be involved in hepatocarcinoge

98 In vertebrates and other metazoans, Hox genes determine cell fate along the anteroposterior

99 udy provides the first in vivo evidence that Hox genes determine oligodendrocyte regional identity in

100 The Hox genes Dfd, Scr, and Antp are expressed in a lineage-

101 briefly introduce the field of evo-devo and Hox genes, discuss functional tools available to study e

102 We find that lamprey hox genes display dynamic segmentally restricted domains

103 As Hox gene disruption often has pleiotropic effects, the r

104 osteology in fossil and modern amniotes with Hox gene distributions within Amniota indicates that a f

105 iation, in part, through MLL degradation and HOX gene down-regulation.

106 In humans, acquired deregulation of HOX genes during adulthood has been linked to carcinogen

107 provided to understand the precise roles of Hox genes during crustacean development.

108 rangement of nucleosomes at the promoters of hox genes during early development.

109 s necessary to erase H3K27me3 from activated Hox genes during embryonic stem cell differentiation.

110 ed in leukemia, both activates and represses Hox genes during hematopoiesis.

111 d resolution and activation of many bivalent Hox genes during mouse ESC differentiation were recapitu

112 d BMI1, respectively, promoted and repressed Hox genes during the shift from the transcriptionally re

113 identity within appendages independently of Hox genes during this stage.

114 tically heritable silencing of the homeotic (HOX) genes during development.

115 ng the transcription of just three homeotic (Hox) genes during embryonic development.

116 shown that the transcriptional activation of Hoxd genes during vertebrate digit development involves

117 tral position for initiating and maintaining HOX gene dysregulation as a driving leukemogenic force.

118 dictors, and overexpression of HOX genes and HOX-gene-embedded microRNAs in low MN1 expressers.

119 s were down-regulated, whereas HOX genes and HOX-gene-embedded microRNAs were up-regulated.

120 Hox genes encode a conserved family of homeodomain trans

121 Hox genes encode highly conserved transcription factors

122 How Hox genes encode this specificity is a paradox, because

123 Vertebrate Hox genes encode transcription factors operating during

124 HOX genes encode transcription factors regulating embryo

125 In vertebrates, 39 Hox genes, encoding homeodomain transcription factors cr

126 nockdown to decipher the function of the six Hox genes expressed in the developing mouth and trunk of

127 e miR-196 family in defining the boundary of Hox gene expression along the anterior-posterior (A-P) e

128 e forelimb field is accompanied by shifts in Hox gene expression along the anterior-posterior axis.

129 We propose that evolutionary shifts in Hox gene expression along the body axis provided a trans

130 easome prevented EZH2 degradation, decreased HOX gene expression and restored drug sensitivity.

131 back to reduce variability while keeping the Hox gene expression at elevated levels.

132 t the homeotic transformations and shifts in Hox gene expression boundaries observed in single Moz an

133 that epigenetically regulated alterations of HOX gene expression can trigger changes in the transcrip

134 tudies demonstrated that Hmx homeodomain and Hox gene expression defined an Hmx(+) rostral subtype an

135 Although shifts in Hox gene expression domains have been postulated to play

136 s been explained as either homogenization of Hox gene expression domains, or retention of standard ve

137 A prevailing paradigm is that changes in Hox gene expression drive evolution of metazoan body pla

138 Retinoic acid (RA) regulates clustered Hox gene expression during embryogenesis and is required

139 HoxA and HoxB complexes evolved to modulate Hox gene expression during mammalian cardiac and endoder

140 to maxillipeds, in which stepwise changes in Hox gene expression have brought about this striking mor

141 In addition, we define how changes in Hox gene expression have generated morphological differe

142 2 functions as master regulator of perturbed HOX gene expression in human acute myeloid leukemia, loc

143 Importantly, the SEC is required for HOX gene expression in leukemic cells, suggesting that c

144 data revealed a coordinated upregulation of HOX gene expression in resistant lines, especially KNS42

145 BMI1 play opposing roles during the onset of Hox gene expression in the ES cell model and during body

146 role in determining the anterior boundary of Hox gene expression in the neural tube during embryogene

147 ore a compact chromatin state and to repress Hox gene expression is not dependent on its histone ubiq

148 port that LMP1 is important to establish the Hox gene expression signature in NPC cell lines and tumo

149 Our results show that coupling of Hox gene expression to segmentation of the hindbrain is

150 Our comprehensive evaluation of HOX gene expression using tiling microarrays, with valid

151 but has no effect on global H3K27me3 level, Hox gene expression, or ES cell self-renewal.

152 ingtin exhibited impaired PRC2 regulation of Hox gene expression, trophoblast giant cell differentiat

153 reciated role during the initiation phase of Hox gene expression, which is critical for the correct s

154 ation with segmentally restricted domains of Hox gene expression.

155 s mature, thus coinciding with a decrease in HOX gene expression.

156 rentiation through dose-dependent effects on Hox gene expression.

157 ates gene expression patterns reminiscent of Hox gene expression.

158 inal reader proteins regulate joint-specific HOX gene expression.

159 the primary mechanism involved in regulating HOX genes expression in the placenta.

160 we show that cis-regulatory elements driving Hoxd gene expression in distal limbs are present in fish

161 igit enhancers are conserved in pythons, and HOXD gene expression in the hindlimb buds progresses to

162 Oct4 also shifted posterior Hox gene-expression boundaries in the extended trunks, t

163 The importance of the Hox gene families in vertebral development was highlight

164 Hoxa5 is a member of the Hox gene family, which plays critical roles in successiv

165 Members of the highly conserved homeobox (HOX) gene family encode transcription factors that confe

166 We report that repressed Hox genes form mutual intra- and interchromosomal intera

167 uced ambiguous although studies of posterior Hox genes from homology group 13 (Hoxa-13 and Hoxd-13) r

168 similarities also require similar changes in Hox gene function is disputed.

169 ng the importance of posterior prevalence in Hox gene function.

170 The products of Hox genes function in assigning positional identity alon

171 There is also emerging evidence that Hox genes function in multiple neuronal classes to shape

172 comparisons of RNAi phenotypes indicate that Hox genes function jointly with Tc-hth and Tc-exd to spe

173 The Hox gene fushi tarazu (ftz) arose as a homeotic gene but

174 Hoxc8 in mice revealed that this midthoracic Hox gene has transient but strong regional expression in

175 nhancer elements that drive expression of 5' Hoxd genes, has yet to be fully elucidated.

176 Hox genes have been shown to be essential in vertebrate

177 ts, and provide examples in which changes in Hox genes have contributed to changes in body plan or mo

178 Among the Hox genes, homeobox C13 (Hoxc13) has been shown to be es

179 Posterior Hox genes (Hox9-13) are critical for patterning the limb

180 date, only the five most posterior groups of Hox genes, Hox9-Hox13, have demonstrated loss-of-functio

181 n humans revealed that mutations in a single Hox gene, HOXA1 (Athabascan Brainstem Dysgenesis Syndrom

182 Of the 39 Hox genes, Hoxa1 is the first to be expressed during emb

183 We show that two Hox genes, Hoxa5 and Hoxc5, control diverse aspects of P

184 We show that a single Hox gene, Hoxc9, has an essential role in organizing the

185 erentiation and it is the earliest expressed Hox gene in the mouse embryo.

186 imilarly, HoxA10 influenced transcription of HOX genes in a Cdx4-dependent manner.

187 Given the importance of both LMO2 and HOX genes in acute leukaemias, we further demonstrated t

188 Remarkably, expression of the Hox genes in both brachiopod species demonstrates coopti

189 The discovery of Hox genes in Drosophila, and their subsequent identifica

190 ts, as well as recent studies of the role of Hox genes in generating regional specification within th

191 ciency also decreased expression of multiple Hox genes in hematopoietic progenitors.

192 ology', which refers to the critical role of HOX genes in metazoan evolution, we propose to introduce

193 SEC is a key regulator in the expression of HOX genes in mixed lineage leukemia (MLL)-based hematolo

194 erases is known to activate transcription of Hox genes in other contexts, we found that individual in

195 LMP1 induces repression of several Hox genes in part via stalling of RNA polymerase II (RNA

196 reports have demonstrated crucial roles for Hox genes in patterning the axial and limb skeleton.

197 b) demonstrate that coordinate activities of Hox genes in sensory neurons and interneurons govern con

198 ling the specific expression patterns of the Hox genes in the BX-C.

199 brachiopod species demonstrates cooption of Hox genes in the chaetae and shell fields, two major lop

200 esults identify novel molecular functions of Hox genes in the development of the male and female repr

201 The role of Hox genes in the formation of cutaneous accessory organs

202 g activity in vitro, decreased expression of Hox genes in the hematopoietic stem cells, and decreased

203 e the complement, cluster, and expression of Hox genes in two brachiopod species, Terebratalia transv

204 on of defined roles for endogenous homeobox (Hox) genes in adult hematopoietic stem and progenitor ce

205 this study, we have analyzed the function of Hoxd genes in delayed growth trajectories by looking at

206 ic TAD subsequently regulates more posterior Hoxd genes in digit cells.

207 eric TAD controls the early transcription of Hoxd genes in forearm cells, whereas the centromeric TAD

208 These new data support an ancestral role for HoxD genes in patterning the fin-folds of jawed vertebra

209 q23-AML facilitate transcription of a set of HOX genes, including HOXA9 and HOXA10.

210 nstrate conserved synteny involving nrf2 and hox genes, indicating that nrf2a and nrf2b are co-orthol

211 re by which some appendages are patterned by Hox gene inputs.

212 Separating hox genes into expressed and non-expressed groups shows

213 The genomic arrangement of Hox genes into four paralogous clusters is a primitive f

214 bless, we recovered coding sequences for all Hox genes involved in amniote limb development, with the

215 s only, that the frequency of silent CpGs in Hox genes is much greater than expectation.

216 s (i.e., piwil1) or early development (i.e., hox genes) is methylated, but the loci are demethylated

217 a segment is determined by the complement of Hox genes it expresses.

218 mi1 elicits a derepression of more posterior Hox genes, leading to a switch in MN fates.

219 upts topological boundaries such that caudal Hox genes leave the repressed domain and become subject

220 d during embryogenesis and the only anterior Hox gene linked to a human syndrome.

221 In mouse embryos, Hox genes located at the 3' end of HoxA and HoxB complex

222 Hox gene loss-of-function causes lineage-specific defect

223 This fate transformation requires the Hox gene mab-5.

224 We hypothesized that HOX genes may be implicated in the development of BE.

225 sult in flies with phenotypes reminiscent of Hox gene misregulation.

226 sults in homeotic transformations typical of Hox gene misregulation.

227 A phylogenetic analysis indicated that Hox gene modules were shared in fish and tetrapod pector

228 ization of oligodendrocytes is controlled by Hox genes, namely Hoxa2 and Hoxb2.

229 ruption of promoter-promoter contacts in the Hox gene network.

230 w highlights the functions and mechanisms of Hox gene networks and their multifaceted roles during ne

231 Hox genes of the Abdominal-B (Abd-B) class regulate gona

232 g the batteries of genes targeted by any one Hox gene over the course of a single developmental proce

233 ves myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undr

234 llele in mouse hemopoietic stem cells causes Hox gene overexpression, enhanced self renewal and expan

235 m1(cA);Flt3(ITD) share a number of features: Hox gene overexpression, enhanced self-renewal, expansio

236 the chicken embryo, activation of posterior Hox genes (paralogs 9-13) in the tail-bud correlates wit

237 During embryonic development, Hox genes participate in the building of a functional di

238 The Hox genes play a central role in patterning the embryoni

239 Hox genes play a crucial role during embryonic patternin

240 Hox genes play evolutionarily conserved roles in specify

241 Our results allow us to define the role Hox genes play in specifying each appendage type in Parh

242 Because hox genes play pivotal developmental roles in bilaterian

243 homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignan

244 e on chromatin and are found associated with Hox gene promoter regions.

245 esponse elements (PREs) of certain Homeobox (Hox) genes, providing a rationale for why Jarid2 was nev

246 ment when the GCR participates in initiating Hoxd gene quantitative collinearity and Hoxd13 expressio

247 We show that Hox gene read-through transcripts can be spliced to prod

248 Hox genes regulate regionalization of the axial skeleton

249 of the previously known interaction between Hox gene regulation and CTCF.

250 in cells and have implications for miRNA and Hox gene regulation during development.

251 Despite numerous layers of Hox gene regulation, these IRES elements are essential f

252 We propose that Hoxd gene regulation in embryonic MBs evolved by hijacki

253 ite both the absence of limbs and an altered Hoxd gene regulation in external genitalia, the limb-ass

254 The latter DNA region is also involved in Hoxd gene regulation in other contexts and strongly inte

255 , once established at a repressed Drosophila HOX gene, remain heritably associated with that gene and

256 s, differentiating its role from neighboring Hox genes, rendering it nonredundant.

257 r LMC neurons by the expression of a variant Hox gene repertoire and by the failure to express a key

258 ession of multiple Hoxb genes and attenuated Hox gene response to exogenous RA treatment in utero.

259 ch translocations leads to overexpression of Hox genes, resulting in a blockage of hematopoietic diff

260 mbryonic and post-embryonic functions of the hox gene Scr in Periplaneta as a way of better understan

261 asts from different joint locations and that HOX gene signatures reflect the joint-specific origins o

262 less, SCM is just as critical for Drosophila Hox gene silencing as canonical subunits of these well-c

263 er than histone tail ubiquitylation, confers Hox gene silencing.

264 in long germ-band insects that express their Hox genes simultaneously, from the ancestral short germ-

265 critical in male fertility), and three with Hox genes (some of which have also previously been deeme

266 On the other hand, Hox genes specify appendage identities along the anterop

267 Although Hox genes specify the differentiation of neuronal subtyp

268 d also demonstrate that mRNAs of three other Hox genes suffer similar and synchronous developmental 3

269 We found that the key Hox gene that orients Q neuroblast migration exhibits in

270 ral tube leads to differential expression of Hox genes that contribute to the specification of motor

271 vertebrate embryogenesis, the expression of Hox genes that define anterior-posterior identity follow

272 domen of insects-and that they have lost the Hox genes that originally specified this region.

273 pression analyses uncovered genes, including HOX genes, that are transcriptionally dysregulated in re

274 ave underscored that in addition to encoding Hox genes, the homeotic clusters contain key noncoding R

275 Unlike clustered HOX genes, the role of nonclustered homeobox gene family

276 Hoxa3 was the first Hox gene to be mutated by gene targeting in mice and is

277 esults reveal multiple regulatory layers for Hox genes to fine-tune transcriptional programs essentia

278 ol modules act over a long range on multiple Hox genes to generate nested patterns of HoxA and HoxB e

279 cture is instrumental in allowing vertebrate Hox genes to pattern disparate parts of the body, includ

280 e cells to assess the response of the target Hoxd genes to these two factors.

281 The shared and specific expression of Hox genes, together with Arx, Zic, and Notch pathway com

282 oic acid-signaling pathway, we disrupt early hox gene transcription, but observe no effect on nucleos

283 been identified, Cdx4 was known to influence HOX gene transcription.

284 a range of regulatory elements required for Hoxd gene transcription, and it is often disrupted and/o

285 In spite of this important role for PG1 hox genes, transcriptional targets of PG1 proteins are n

286 The Drosophila Hox gene Ultrabithorax (Ubx) controls the development of

287 transformation of wings into halteres by the Hox gene Ultrabithorax (Ubx) in Drosophila melanogaster

288 ts across insect species have shown that the hox gene Ultrabithorax (Ubx) is necessary to promote hin

289 The Drosophila Hox gene Ultrabithorax (Ubx) produces a family of protei

290 RNA targets involved in this behavior is the Hox gene Ultrabithorax, whose derepression in two metame

291 he Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate le

292 Hox genes underlie the specification of body segment ide

293 Posterior Hox genes were proposed to be major players in trunk len

294 hat a subset of progressively more posterior Hox genes, which are collinearly activated in vertebral

295 The clustered Hox genes, which are highly conserved across metazoans,

296 a concomitant delay in activation of caudal Hox genes, which are proposed to signal the end of axis

297 Among them are the Hox genes, which define different identities along the a

298 e recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3

299 ession of key developmental genes, including Hox genes whose temporal and spatial expression is tight

300 unction across species, and among paralogous Hox genes within a species, supports a model of function