ライフサイエンスコーパス: I region

1 n the Cdc42 insert domain but not the Switch I region.

2 a conserved asparagine in the GTPase switch-I region.

3 and 238) in the NS5A low complexity sequence I region.

4 human major histocompatibility complex class I region.

5 esent as a cluster within the Fugu MHC class I region.

6 scopy was used to probe changes in the amide I region.

7 genes were discovered in the human MHC class I region.

8 posed, closely aligned and located in switch I region.

9 he corresponding bands assigned in the amide I region.

10 tical in the conformationlly sensitive amide I region.

11 o seen across ethnic groups in the HLA class I region.

12 d adjacent regions, especially in the switch I region.

13 All associated SNPs mapped to the HLA class I region.

14 he corresponding bands assigned in the amide I region.

15 us to examine the role of N45 in the switch I region.

16 independent association within the MHC Class I region.

17 and 10), in CDCl 3 was measured in the amide-I region.

18 eding a critical phenylalanine in the switch I region.

19 alterations in the region encoding the VacA i-region.

20 the NH, CH stretching and bending, and amide I regions.

21 hydrophobic, amide III, amide II, and amide I regions.

22 ncompasses the junction of the class III and I regions.

23 and denaturant are shifted out of the amide I' region.

24 own to possess unusual features in the amide I' region.

25 by a high density of Na+ channels in the AH-IS region.

26 ves of synthase monomer contains half of the ID regions.

27 cting the underlying FTIR bands of the amide I region (1700-1600 cm(-1)) and the water region (3500-3

28 s a more detailed characterization of the LG(I)region (a broader region than the liquid disordered-li

29 ter (HOH-bending) overlapping with the amide I region, a highly stable temperature control unit with

30 Tyr(34) is located within the switch I region adjacent to the nucleotide-binding site.

31 Many of these RF-reactive class I regions also showed positive ELISA reactions with mono

32 A peptide encoding the Switch I region (amino acids 199-216) also stimulated AC2 and A

33 nates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the fra

34 PCR primers that flanked the deleted TbetaR-I region amplified a single band from JK cell genomic DN

35 al region of the 2D IR spectrum of the amide I region, analogous to those in 2D NMR spectroscopy.

36 a disordered loop and helices in the switch I region and a visible switch II loop, which is disorder

37 l conformational rearrangement of the switch I region and additional striking alterations of side cha

38 uding a conserved Lys-45 close to the switch I region and the C-terminal membrane-binding domain of R

39 he overlap between the amide I and non-amide I regions and allow for different scattering efficiencie

40 tty acid synthesis separated by interdomain (ID) regions and predicts that two appropriate halves of

41 rom the observation that neurosteroid action is region and neuron selective.

42 the degree of coupling between the different ID regions, and 4) whether the stability of ID domains i

43 Genes in the human extended class I region are also well conserved in Xenopus, excluding t

44 dicated that large portions of the HLA class I region are conserved among mammals.

45 ermediate, infrared differences in the amide I region are dominated by much larger structural changes

46 We show here that the AG MADS domain and the I region are necessary and sufficient for DNA binding in

47 R) spectra of AFGP8 and AFGP1-5 in the amide I region are quite different.

48 ith experimental data showing that the s and i regions are the key determinants of vacuolating cytoto

49 Intrinsically disordered (ID) regions are disproportionately higher in cell signal

50 owed by reperfusion every 12 h) with the non-IS region as control.

51 e and urea both absorb strongly in the amide I region, as does H2O.

52 These antisera identified I-region associated (Ia) antigens.

53 ce express no detectable classical MHC class I-region associated (Ia) heavy chains, although beta2-mi

54 each had major absorption bands in the amide I region at 1626 and 1636 cm-1 both prior to and after d

55 d the strongest association in the HLA class I region at rs7750641 (p = 1.2 x 10(-92) ; odds ratio [O

56 irst in the axon hillock/initial segment (AH-IS) region because of a locally high density of Na+ chan

57 romosome (BAC) clones spanning the HLA class I region between HLA-C and HLA-E and of YACs extending t

58 Beyond the formation of intermolecular helix I region between U6atac and U12 snRNAs, several other re

59 this complex revealed that the EF-Tu switch I region binds to the non-catalytic surface of AbDsbA.

60 nown, peptides derived from the EF-Tu switch I region bound to AbDsbA with submicromolar affinity.

61 ximal major histocompatibility complex class I region, but approximately a dozen genes in the candida

62 le three-component band fitting of the amide I region can assist in the conformational characterizati

63 Because ID regions commonly fold as part of their intracellular

64 Analysis of the amide I region, emanating from the carbonyl stretch vibration,

65 ing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 inte

66 unctionally distinct regions, 2) whether any ID regions fold upon activation, 3) the degree of coupli

67 sional infrared (2D IR) spectra in the amide I region for aggregates of AcWL(5) peptides with single

68 genes located outside the class II and class I region genes.

69 ed with the presence of the vacA s-, m-, and i-region genotypes in Western countries.

70 over 2.4 Mb pairs including the entire class I region has been isolated as a series of overlapping YA

71 An in vitro assay showed that the region I, region II, and region I+II (D51/E52/E55/D166A) mutant

72 k genes may also be present in the HLA class I region in a subset of DRB1*0404 haplotypes.

73 However, the 32 amino acid Hinge I region in ABP-280 that contains a calpain cleavage sit

74 ditional locus located in the extended class I region in proximity to TRIM27 tagged by a haplotype co

75 racteristic "Z"-shaped pattern for the amide I region in the 2D IR spectrum.

76 ition-state model conformation of the switch I region in this complex where the reoriented switch I r

77 on a conserved Y32 residue within the switch I region in vitro and that in vivo, Ras-Y32 phosphorylat

78 Comparisons of isotope effects on the amide I regions in P(M) minus O spectra demonstrate that amide

79 of the role of the VacA intermediate region (i-region) in toxin activity.

80 Intense bands in the amide I region indicate that a protein conformational change o

81 in this complex where the reoriented switch I region interacts with a conserved rRNA region of the 4

82 ermore, the solution structure of the switch I region is analyzed by pulsed electron-electron double

83 The second half of the Box I region is crucial for the interaction with the basal t

84 In Sec4-GDP, the switch I region is highly disordered and displaced relative to

85 These results indicate that the VacA i-region is an important determinant of VacA effects on

86 s, the genomic organization of the MHC class I region leads to biased expression of a single classica

87 he class III region rather than in the class I region, likely reflecting the ancestral condition.

88 y the major histocompatibility complex class I region (MHC class I) present peptide antigens to cytot

89 Two mutations in the switch I region (MinD box) and one mutation in the switch II re

90 K-Ras Switch-II region motions drive Switch-I region motions, while alpha-helix-3L7 motions control

91 s is located at the N-terminus of the switch I region near the nucleotide binding site whereas the ot

92 have identified a binding site in the helix I region of 14-3-3zeta (residues 202-231) required for b

93 occur (206-220) is equivalent to the Switch I region of a large group of purine nucleotide-binding p

94 Application to the amide I region of a small globular protein reveals regions ass

95 Specific point mutations in the switch I region of Cdc42 abolish binding to and, therefore, act

96 x reveals a novel conformation of the switch I region of Cdc42.

97 A and MICB) are located within the HLA class I region of chromosome 6.

98 stantial conformational change in the Switch I region of EF-G, suggesting that a conformational signa

99 ric clashes with both aa-tRNA and the switch I region of EF-Tu.

100 nce (Arg-Arg-Pro-Thr(203)) within the switch I region of Galpha(13).

101 s were introduced at sites within the switch I region of Galphai to explore the structure and dynamic

102 3 and C5 regions of gp120 and in the cluster I region of gp41 are well exposed on the surface of inta

103 mplete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility compl

104 rine residues in the low complexity sequence I region of NS5A responsible for NS5A phosphorylation; h

105 ng analogies can be drawn between the Switch I region of NtrC and that of p21(ras).

106 2D IR correlation spectra of the amide I region of poly-l-lysine, concanavalin A, ribonuclease

107 rent and that a single residue in the switch I region of Rap proteins (residue 39) contributes consid

108 RasIn1 recognizes residues in the Switch I region of Ras, similar to Raf-RBD, and competes with R

109 ordered and displaced relative to the switch I region of Ras-GDP.

110 o a conserved tyrosine residue in the switch I region of Rho GTPases.

111 ows that conserved amino acids in the switch I region of RhoA are major PLD interaction sites and tha

112 sidues Tyr34, Thr37, and Phe39 in the switch I region of RhoA which are required for p190GD interacti

113 The switch I region of RhoA, which is the common effector domain of

114 to form contacts with helix H and the switch I region of the cognate ARF, suggesting that loop>J may

115 Strong variations in the amide I region of the FTIR difference spectrum, however, refle

116 nding through an interaction with the switch I region of the G protein.

117 cally with the enzymatically critical Switch I region of the head.

118 The interaction of the Switch I region of the kinesin-1 head with the tail is striking

119 approximately 8 Mb of DNA between the class I region of the major histocompatibility complex on huma

120 The amide I region of the protein infrared spectrum is the widely

121 ar optical (NLO) chiral effects in the amide I region of type I collagen was investigated using sum-f

122 at epitopes in the V3, C5, and gp41 cluster I regions of the envelope glycoproteins, since these reg

123 The cbb(I) region of Rhodopseudomonas palustris (Rp. palustris)

124 ponent system has been identified in the cbb(I) region of the nonsulfur purple photosynthetic bacteri

125 of the oldest subfamily is identical to the ID region of the rat BC1 RNA gene, suggesting that the B

126 rs, 10058-F4 and 10074-G5, bound to distinct ID regions of the monomeric c-Myc bHLHZip domain.

127 Intrinsically disordered (ID) regions of the transcription factor proteins have mu

128 ght the importance of fuzzy interfaces, that is, regions of nanometre-scale structure and property gr

129 in silico identification of hot spots, that is, regions of protein binding sites that are major cont

130 We surveyed the "dark" proteome-that is, regions of proteins never observed by experimental s

131 major histocompatibility complex (MHC) class I region on mouse chromosome 17 of strain 129/SvJ (H2bc)

132 Here, we report identification of (i) regions on Yotiao critical to its binding to KCNQ1 an

133 ster that is part of the 'extended MHC class I region' on human chromosome 6.

134 mework improves the classic model, shows how ID regions poise the SHR/NR family for optimal allosteri

135 d transporter genes, defining the true class I region, present in all nonmammalian jawed vertebrates

136 on variable region (V(H)) and switch region (I) region promoters to initiate germ line (non-coding) t

137 n to a major contribution from the HLA class I region, PS susceptibility loci have been mapped to a n

138 The switch I region (residues 40-62) is well ordered in this struct

139 Within the class I region, rs9263871 (C6orf15-HCG22) had the strongest ev

140 and was mapped to the nonclassical MHC class I region (RT1-C/E/M) using intra-MHC recombinant strains

141 HLA-DR region appears more complex than the I region since a second DC-like hybridizing sequence is

142 Interestingly, the synaptic difference is region specific as no differences were found in excit

143 ain of female rats, and that this regulation is region specific.

144 e specific nor completely random but instead is region specific.

145 es indicate that this non-canonical feedback is region specific: it is most prominent in lobules that

146 Re-methylation is region-specific but random with respect to individual

147 These data reveal that ER expression is region-specific within the neonatal amygdala.

148 in series and the beta-adrenergic modulation is region-specific, this modulation seems to be involved

149 a knockout mouse lines, that this regulation is region-specific, with the 5-HT4 receptor upregulated

150 in the switch II region and Glu-37 in switch I region stabilizes the intermediate conformation of alp

151 e in vitro Pit-1 binding sites within the HS-I region suggested a model in which Pit-1 binding at HS-

152 l passage in the NS3 protease or NS5A domain-I regions targeted by the drugs.

153 lass II subregions and also within the class I region than previously estimated.

154 tes in the highly conserved Myc homology box I region that controls c-Myc protein stability by oncoge

155 h FKBP38 through a section within its switch I region that is equivalent to the effector domain of ot

156 of association was observed in the HLA class I region that was fully explained by independent effects

157 the case of Ras, or a mutation in the switch I region that was identified as a contact site between R

158 Four categories of effect were observed: (i) regions that were recruited by patients and controls

159 eral can have multiple functionally distinct ID regions that interact and modulate the stability of i

160 identify energetically favorable sites, that is, regions that tend to bind a variety of molecules.

161 Neither the region (I region) that lies between the MADS and K domains nor t

162 In the switch I region, the side chain of Tyr-32, which undergoes a la

163 Vitiligo risk associated with the MHC class I region thus derives from combined quantitative and qua

164 ands isolated from a broad band in the amide I region using phase-sensitive detection were attributed

165 Homology modeling of the RbgA switch I region using the K-loop GTPase MnmE as a template sugg

166 ed tyrosine at position 32 within the switch I region via Src kinase.

167 with a unique sequence at the missing Hinge I region was also identified (ABP-278).

168 In this model, wall thickening in the IS region was chronically depressed by approximately 37%

169 major histocompatibility complex (MHC) class I region were used to haplotype hh and normal chromosome

170 om infrared absorption of water in the amide I region, which is a serious limitation for measurements

171 Recently, the vacA intermediate (i) region, which is located between the signal (s) and m

172 ts are consistent with the proposal that the ID region, which has no known catalytic activity, associ

173 support the principle of a primordial class I region with few class I genes.

174 a second independent effect in the HLA class I region with SNP, rs9266722 (P = 2.84 x 10(-6)).

175 differ markedly only in part of their amide I regions with the in situ protein having additional pH-

176 tebrates examined to date have a true "class I region" with tight linkage of genes encoding the class

177 This report shows that (i) regions within gp41 distinct from those associated wi