ライフサイエンスコーパス: I-kappa B kinase

1 kappa B, by a kinase complex that contains 2 I kappa B kinases.

2 We analyzed the differential role of I kappa B kinase 1 (IKK1) and I kappa B kinase 2 (IKK2)

3 ppaB (NF-kappaB) signaling pathway involving I kappa B kinase 1/I kappa B kinase alpha (IKK1/IKKalpha

4 ential role of I kappa B kinase 1 (IKK1) and I kappa B kinase 2 (IKK2) in tumor necrosis factor alpha

5 dependent gene expression is mediated by the I kappa B kinase 2 (IKK2/IKK beta).

6 s demonstrated by HSR-mediated inhibition of I kappa B kinase activation and HSR-mediated induction o

7 As expected, NIK expression led to I kappa B kinase activation and induced nuclear transloc

8 presence of I kappa B-alpha mRNA, sustained I kappa B kinase activation, continuous proteasome-media

9 r cells with tumor necrosis factor-alpha, an I kappa B kinase activator, did not alter the suppressiv

10 Moreover, in melanoma cells in which I kappa B kinase activity was inhibited by sulindac to a

11 pha assembled into a complex with negligible I kappa B kinase activity.

12 pa B through expression of a dominant-active I kappa B kinase allows differentiation to proceed to th

13 gnaling pathway involving I kappa B kinase 1/I kappa B kinase alpha (IKK1/IKKalpha) and NF-kappaB-ind

14 The phosphorylation of I kappa B kinase alpha and activation of NF kappa B medi

15 the help of the C-terminal death domain and I kappa B kinase alpha-targeting serines, the C-terminal

16 over, AKT2 interacts with and phosphorylates I kappa B kinase alpha.

17 Finally, we examined the kinase activity of I kappa B kinase-alpha and found that this kinase, unlik

18 ve mutants of NF-kappa B-inducing kinase and I kappa B kinase-alpha.

19 Single genes of interest included I-kappa-B kinase-alpha (CHUK), and a phosphorylation dep

20 up+ cells resulted in a slight activation of I kappa B kinase and in enhanced NF-kappa B DNA binding

21 together, our data implicate involvement of I kappa B kinase and MAPK signaling cascades in NIK-indu

22 r of the MAPK pathway and implicate both the I kappa B kinase and MAPK signaling cascades in NIK-indu

23 de of nuclear factor (NF)-kappa B, including I kappa B kinase and nuclear translocation of NF-kappa B

24 ase (PI3K), the serine/threonine kinase Akt, I kappa B kinases, and finally nuclear factor NF-kappa B

25 We recently identified a mutation in the I-kappa B kinase associated protein (IKBKAP) gene as the

26 peroxisome proliferator-activated receptors, I kappa B kinase beta or nuclear factor kappa B do not a

27 the CD28RE through selective cross-talk with I kappa B kinase-beta (IKK beta).

28 -840 decreased, while ectopic expression of I-kappa B kinase-beta (IKK beta) enhanced reporter gene

29 The I kappa B kinase complex (IKK) mediates activation of th

30 of the inhibitory I kappa B proteins by the I kappa B kinase complex (IKK).

31 ng a cell-permeable peptide inhibitor of the I kappa B-kinase complex, a crucial component of signal

32 on of TAK1, which subsequently activates the I-kappa B kinase complex (IKK) and mitogen-activated pro

33 We found that both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the ph

34 familial dysautonomia patients with IKBKAP (I-kappa-B kinase complex-associated protein) mutation co

35 ion, a Drosophila gene encoding a homolog of I kappa B kinase (DmIkk beta) and Relish, a Rel-family t

36 I-kappa-B kinase e (IKBKE; IKKepsilon) has been recently

37 Interestingly, we demonstrate Gli-regulated I-kappa-B kinase epsilon (IKBKE) and NF-kappaB activity

38 ecifically binding the coiled-coil domain of I kappa B kinase gamma (IKK gamma) to inhibit IKK activi

39 Whereas Rac stimulates the activity of the I kappa B kinase IKK beta, Cdc42 and Rho activate NF kap

40 revious studies have shown an elevated basal I kappa B kinase (IKK) activity in Hs294T melanoma cells

41 on with TNF-alpha induced a >10x increase in I kappa B kinase (IKK) activity that quickly diminished

42 on, I kappa B serine 32 phosphorylation, and I kappa B kinase (IKK) activity were blocked by curcumin

43 lpha persisted as a result of alterations in I kappa B kinase (IKK) activity.

44 pa B DNA binding activity and a reduction in I kappa B kinase (IKK) activity.

45 tors, two recently described serine kinases, I kappa B kinase (IKK) alpha and IKK beta, and increased

46 demonstrated that Hsp27 associates with the I kappa B kinase (IKK) complex and that this interaction

47 Activation of the I kappa B kinase (IKK) complex by LPS induces phosphoryl

48 C-beta)-deficient mice failed to recruit the I kappa B kinase (IKK) complex into lipid rafts, activat

49 pa B proteins are phosphorylated by the same I kappa B kinase (IKK) complex, and their ubiquitination

50 iated by phosphorylation of I kappa B by the I kappa B kinase (IKK) complex, predominantly by the IKK

51 This pathway involves a multisubunit I kappa B kinase (IKK) complex, which includes the IKK a

52 The I kappa B kinase (IKK) complex, which is composed of the

53 Because I kappa B kinase (IKK) is critical in transducing the si

54 I kappa B kinase (IKK) is the converging point for the a

55 he phosphatidylinositol 3' kinase (PI3K)/AKT/I kappa B kinase (IKK) pathway positively regulates NF k

56 Here, we have explored an involvement of the I kappa B kinase (IKK) pathway, associated with nuclear

57 ent with this finding, we also find that the I kappa B kinase (IKK) phospho-acceptor sites on I kappa

58 activates NF-kappaB via interaction with the I kappa B kinase (IKK) signalosome.

59 f NF-kappa B-inducing kinase (NIK), Akt, and I kappa B kinase (IKK) were not changed.

60 O is the essential regulatory subunit of the I kappa B kinase (IKK), encoded by an X-linked gene in m

61 tion contains two catalytic subunits, termed I kappa B kinase (IKK)-1 and IKK-2.

62 rotrimeric G proteins, PI3K, PDK-1, Akt, and I kappa B kinase (IKK).

63 ssociation of SRC-3, but not SRC-1, with the I kappa B kinase (IKK).

64 tly stimulating a key signal transducer, the I kappa B kinase (IKK).

65 the HTLV Tax protein involves stimulation of I kappa B kinase (IKK).

66 ion cascades are initiated converging on the I kappa B kinase (IKK).

67 F-R and represent previously unknown arms of I kappa B kinase (IKK)1-dependent signaling.

68 processing of p100 critically depends on the I kappa B kinase (IKK)alpha/IKK1 subunit of the IKK comp

69 osphorylated and targeted for degradation by I kappa B kinases (IKK alpha and IKK beta).

70 Recently, two related I kappa B kinases (IKK-1 and IKK-2) were identified in i

71 does indeed abolish its ability to activate I kappa B-kinase (IKK) complexes, but paradoxically it a

72 ptide, an established selective inhibitor of I kappa B-kinase (IKK), blocked heregulin-mediated activ

73 I-kappa B kinase (IKK) is a serine/threonine kinase that

74 Interference with cell cycle progression and I-kappa B kinase (IKK)/nuclear factor kappa B (NF-kappaB

75 t activation of NF kappa B demonstrates that I kappa B kinases (IKKs) but not p90rsk are selectively

76 The elevated basal activity of I kappa B kinase in macrophages from Ucp2-/- mice can be

77 059 on p50 homodimer activity, suggesting an I kappa B kinase-independent pathway for p50 homodimer a

78 -acetylcysteine, and dexamethasone prevented I kappa B kinase-induced I kappa B-alpha, but not I kapp

79 MLK3 has also been implicated as an I kappa B kinase kinase in the activation of NF-kappa B.

80 Thus, noncoordinate expression of I kappa B kinases plays a role in determining the cell t

81 The multisubunit I kappa B kinase responsible for this phosphorylation co

82 removes Lys-63-linked ubiquitin chains from I kappa B kinase signaling components and thereby inhibi

83 Indeed, I kappa B kinase, the kinase involved in NF-kappa B acti

84 G-protein activation through PI3K, Akt, and I kappa B kinase to NF-kappa B activation.

85 initially by phosphorylation induced by the I kappa B kinase, which leads to ubiquitination and subs