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3 transcripts derived from IPNV segment A and IBDV segment B and Vero cells were transfected with tran
4 oreign peptides from a replication-competent IBDV and demonstrates the potential of this virus as a v
7 ction, and the autophagy pathway facilitates IBDV replication complex function and virus assembly, wh
9 -based reverse-genetics system developed for IBDV, we generated five chimeric viruses after transfect
11 tidase activity in cell lines permissive for IBDV replication caused a major blockade in assembly and
15 diated release of progeny virions.IMPORTANCE IBDV is the most extensively studied virus in terms of m
17 racteristics of intrabursal T lymphocytes in IBDV-infected chickens and examined whether T cells were
18 immunofluorescence studies, we found that in IBDV-infected cells the mainly nuclear NF45 accumulated
19 in assembly and/or maturation of infectious IBDV particles, as virus yields were reduced markedly.
20 -kappaB inhibitor MG132 completely inhibited IBDV-induced DNA fragmentation, caspase 3 activation, an
21 ), we observed that a large number of intact IBDV virions were arranged in a lattice surrounded by p6
24 pathogenesis, we constructed a cDNA clone of IBDV segment A in which the first and only initiation co
25 sease virus (IBDV) VP3, a major component of IBDV ribonucleoprotein complexes, on the regulation of V
26 in replication in vivo, it induced levels of IBDV neutralizing antibodies that were similar to those
30 ckens were exposed to a pathogenic strain of IBDV (IM), the virus rapidly destroyed B cells in the bu
31 e, pathogenic phenotype, and cell tropism of IBDV, we prepared full-length cDNA clones of a virulent
33 ated in vitro upon stimulation with purified IBDV in a dose-dependent manner (P<0.02), whereas virus-
34 empts were also made to generate recombinant IBDV that displayed foreign epitopes in the exposed loop
37 ed a baculovirus-based system to express the IBDV polyprotein in insect cells and found inefficient f
39 of the study was to identify regions in the IBDV genome that are amenable to the introduction of a s
43 formation of virus-like particles similar to IBDV virions, which correlates with the absence of purom
46 ody 21, which binds specifically to virulent IBDV, the putative amino acids involved in virulence and
49 role of the infectious bursal disease virus (IBDV) VP3, a major component of IBDV ribonucleoprotein c
51 this study, infectious bursal disease virus (IBDV) was used to investigate the role of autophagy in a
52 VP2) of the infectious bursal disease virus (IBDV), a double-stranded RNA virus, is processed at the
53 fe cycle of infectious bursal disease virus (IBDV), a double-stranded RNA virus, we examined the cell
54 of IPNV and infectious bursal disease virus (IBDV), another birnavirus, can support virus rescue in h
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