ライフサイエンスコーパス: ICG

1 ICG also visualized electrical activity induced in livin

2 ICG and Cy5.5 fluorescence was completely absent from th

3 ICG angiograms revealed choriocapillaris loss in large l

4 ICG angiographic CNV surface areas were measured at base

5 ICG strongly labels reticulocytes and weakly labels neut

6 ICG was conjugated to the antibodies daclizumab (Dac), t

7 ICG was found to localize with TBRs greater than 2.0 (me

8 ICG was injected into the mouse tail vein, and images we

9 ICG-(99m)Tc-nanocolloid helped guide surgical excision o

10 ICG-(99m)Tc-nanocolloid was injected intraprostatically,

11 ICG-001 also inhibited C666-1 tumor sphere formation, ac

12 ICG-001 inhibited alpha-SMA expression/transcription in

13 ICG-001 is a novel small-molecule modulator of Wnt/caten

14 ICG-001 is a small-molecule inhibitor that specifically

15 ICG-001 is a specific CBP/beta-catenin antagonist that c

16 ICG-001 potently inhibits survivin gene transcription an

17 ICG-001 selectively blocks the beta-catenin/CBP interact

18 ICG-001 selectively induces apoptosis in transformed cel

19 ICG-001 suppressed beta-catenin-driven gene transcriptio

20 ICG-001 was also found to restore the expression of a tu

21 ICG-001-mediated downregulation of survivin expression e

22 ICG-encapsulated poly(N-isopropylacrylamide) nanoparticl

23 ICG-PDR significantly deteriorated after TIPS (P = .006)

24 ICG-r15 and Lok index were independently related to the

25 ICG-r15 values (<6.7% and <6.9%, respectively) were able

26 = .001]), rate of CG symptom reduction (1.05 ICG points per week for CGT vs 0.75 points per week for

27 sence of CSPH and SPH (LR(-) 0.15 and 0.14); ICG-r15 <10% provided a 97.8% sensitivity (LR(-) 0.042)

28 whereas only the singly modified ASL(Arg1,2)(ICG) with I(34) was able to decode CGA.

29 ion of s(2)C(32) or m(2)A(37) to ASL(Arg1,2)(ICG), the maximum amount of ASL bound to CGU and CGC was

30 igh dual-drug loading ( approximately 92wt%) ICG-EPI NPs showed good physiological stability, prefera

31 SLNs and lymphatic vessels before and after ICG injection.

32 ced by concentration quenching in aggregated ICG imbedded in the mesopourous silica shell to enable b

33 n face (coronal, C-scan) OCT image and of an ICG angiogram, displayed side by side and superimposed,

34 -three consecutive patients who underwent an ICG clearance test and gadoxetate disodium-enhanced MR i

35 , 41.5 years +/- 20.2) were examined with an ICG-enhanced fluorescence molecular tomography (FMT) sys

36 Ultra-widefield AF and ICG angiography in CSC revealed more widespread disease

37 erence tomography (OCT) characterization and ICG-assisted ILM peeling during surgery with intraocular

38 tivariate analysis identified 6 clinical and ICG variables that independently predicted an event with

39 Findings on SD-OCT, FA, digital FAF, and ICG-A images.

40 ized with coronal (C-scans, en face) OCT and ICG angiography simultaneously.

41 The OCT, confocal SLO and ICG fluorescence images were simultaneously presented in

42 echanism of cytotoxicity of ICG solution and ICG conjugated micelles, respectively.

43 baseline and selected follow-up visits) and ICG-A under certain conditions.

44 Indocyanine green angiography (ICG) was used to identify the active areas and these "ho

45 ography (FA), indocyanine green angiography (ICG), optical coherence tomography (OCT), and multifocal

46 Indocyanine-green angiography (ICG-A) may be considered at baseline under certain condi

47 recently described small molecule antagonist ICG-001 corrects these defects in neuronal differentiati

48 omplexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body.

49 he plasma staining that results from aqueous ICG's high affinity for plasma proteins, high contrast w

50 Because ICG has voltage-sensitive properties in the entire heart

51 ied out to establish the correlation between ICG pHLIP imaging and white light pathological assessmen

52 rwent serial clinical evaluation and blinded ICG testing every 2 weeks for 26 weeks and were followed

53 urvivin promoter by CBP that is decreased by ICG-001 in primary ALL.

54 a-catenin signaling pathway was inhibited by ICG-001, a beta-Catenin inhibitor, which reversed the pr

55 rt of selective staining of reticulocytes by ICG.

56 potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory

57 n to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spa

58 We have recently characterized ICG-001, a small molecule specific inhibitor of the beta

59 Among these are two compounds, ICG-001, targeting CREB binding protein (CREBBP), and PK

60 In this study, we have covalently conjugated ICG-NH2 to the pendant carboxyl groups of poly (ethylene

61 tumors were specifically visualized with Dac-ICG.

62 a recent episode of clinical decompensation, ICG can identify patients at increased near-term risk of

63 ng CdTeS QDs was linked to near infrared dye ICG-Der-02 (MPA) by the peptide for measurement in vivo.

64 studied relative to a benchmark cyanine dye (ICG) during photoexcitation with exceptional photostabil

65 5.5, but not Cy5.5 or indocyanine green dye (ICG), bound to MDA-MB-468 cells.

66 ermal toxicity was observed for encapsulated ICG as compared to free ICG at 808 nm laser irradiation

67 different voltage-sensitivity mechanisms for ICG.

68 ncentration, and a more complex response for ICG.

69 ted occur C-terminal to the binding site for ICG-001.

70 Free ICG, at 0.25 mg/kg of patient weight, was intravenous (I

71 ved for encapsulated ICG as compared to free ICG at 808 nm laser irradiation with radiant exposure of

72 oted cellular endocytosis compared with free ICG or EPI.

73 Furthermore, ICG-001-induced recruitment of p300 to the survivin prom

74 Furthermore, ICG-FI findings resulted in modification of the planned

75 Furthermore, ICG-FI findings resulted in modification of the planned

76 tumors from animals injected with DM-Dual Gd-ICG had increased fluorescence (p < 0.05, n = 6).

77 on MR two days after intravenous DM-Dual Gd-ICG injection compared to controls (SNR, CNR, p < 0.05,

78 her a dual-mode, dual-Gadolinium (DM-Dual-Gd-ICG) contrast agent can be used to visualize ovarian tum

79 However, the first-generation ICG-NPs have a short shelf life (<1 month).

80 creases the shelf life of the new-generation ICG-NPs (>6 months).

81 reated the Initiative for Chemical Genetics (ICG), to enable public research using small molecules to

82 ng of the fluorescent dye indocyanine green (ICG) and (99m)Tc-nanocolloid with the drainage pattern o

83 Indocyanine green (ICG) and epirubicin (EPI) could co-self-assemble into sm

84 ance (IR) photographs and indocyanine green (ICG) angiograms.

85 d fluorescein angiography/indocyanine green (ICG) angiography findings, of patients with a disseminat

86 GC) as immunoadjuvant and indocyanine green (ICG) as laser-absorbing dye have shown positive effects

87 ge, clinical potential of indocyanine green (ICG) as PT is limited by its short half-life and ineffic

88 assessed by clearance of indocyanine green (ICG) at 4, 20 and 28 hours.

89 on were determined by the indocyanine green (ICG) clearance test.

90 The near-infrared dye indocyanine green (ICG) could serve as a basis for such a material, but its

91 e was used to encapsulate indocyanine green (ICG) dye in erythrocyte ghost cells at a concentration t

92 by combined injection of indocyanine green (ICG) dye into the anterior chamber and diode laser treat

93 iron oxide particles and indocyanine green (ICG) encapsulated in the NPs as tracers.

94 ity, bile production, and indocyanine green (ICG) extraction.

95 ter the administration of indocyanine green (ICG) for contrast enhancement.

96 escent cells labeled with indocyanine green (ICG) have been observed in retinal and choroidal circula

97 erative injection of free indocyanine green (ICG) in the detection of peritoneal metastases (PM) due

98 by as much as 36.3%, and indocyanine green (ICG) increased signal magnitudes by as much as 38.1%.

99 ilogram of body weight of indocyanine green (ICG) intravenously 24 hours prior to their scheduled pro

100 uorescence; however, only indocyanine green (ICG) is clinically approved.

101 ttering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a nove

102 cated that (1) formulated indocyanine green (ICG) readily penetrated hyperkeratotic PC skin and norma

103 te the performance of the indocyanine green (ICG) retention test as a noninvasive marker of PH and EV

104 Both indocyanine green (ICG) solution and TA suspension, at 50muL, 100muL, and 1

105 Indocyanine green (ICG) was administered intravenously 15 minutes later.

106 complished with NIR using indocyanine green (ICG), a nonspecific dye that has comparatively poor fluo

107 Here we report that indocyanine green (ICG), an infrared fluorescent dye with FDA approval as a

108 ressurized cuff occluding indocyanine green (ICG), demonstrated an increase in vessels afferent to ex

109 ocyanine 5.5 (Cy5.5), and indocyanine green (ICG), filters were selected to allow spectral separation

110 dely used fluorescent dye indocyanine green (ICG), which has FDA approval, exhibits voltage sensitivi

111 tion of the hybrid tracer indocyanine green (ICG)-(99m)Tc-nanocolloid enables both preoperative senti

112 fluorophore outperformed indocyanine green (ICG)-a clinically approved NIR-I dye-in resolving mouse

113 ter systemic injection of indocyanine green (ICG).

114 infrared fluorescent dye [indocyanine green (ICG)] targets low extracellular pH, allowing visualizati

115 icarbocyanine iodide and indocynanine green (ICG), which exhibit distinctly different lifetimes of 1.

116 st 30 on the Inventory of Complicated Grief (ICG).

117 , higher bile flow rate, and greater hepatic ICG uptake compared with SCS livers.

118 es with a particle size of 30-50 nm and high ICG loading.

119 In humans, ICG labels excitable cells and is routinely visualized t

120 uidance, warrants wider evaluation of hybrid ICG-(99m)Tc-nanocolloid as a tracer for sentinel node pr

121 edure was repeated after injection of hybrid ICG-(99m)Tc-nanocolloid the same afternoon in 10 patient

122 ion of the plasma disappearance rate of ICG (ICG-PDR) and various factors derived from MR imaging, in

123 We identified ICG-001, a small molecule that down-regulates beta-caten

124 hotoacoustic imaging was applied to identify ICG-dyed SLNs.

125 luorescence imaging system was used to image ICG fluorescence in biopsy samples.

126 Importantly, ICG-001 does not inhibit the p300/catenin interaction.

127 Importantly, ICG-001, regardless of CBP mutational status and chromos

128 treatment with the small molecule inhibitor, ICG-001, inhibits leptin-induced EMT, invasion, and tumo

129 After cell binding and internalization, ICG dissociates from the targeting antibody, thus activa

130 , the surgery was modified by intraoperative ICG-FI, which detected additional PM not found using vis

131 complete tumor regression in NIR irradiated ICG conjugated micelles compared to ICG solution and con

132 th a standard spectrophotometric analysis (K(ICG)-B) and by a finger-piece method (K(ICG)-F).

133 Indocyanine green elimination constants (K(ICG)) were measured by both a standard spectrophotometri

134 Furthermore, K(ICG) values showed significant correlation with the seve

135 highly satisfactory in the grafts that had K(ICG)-B <0.15 min-1 (y = 0.868x -0.011, r = .955).

136 s (K(ICG)-B) and by a finger-piece method (K(ICG)-F).

137 Correlation of K(ICG) values by the spectrophotometric method with those

138 ox proportional hazard model revealed that K(ICG) on postoperative day 1 was a better predictor of li

139 = 3) before and after injection of 1 mmol/L ICG.

140 rostate tumors, both the laser-ICG and laser-ICG-GC treatments significantly reduced the growth of pr

141 f metastatic prostate tumors, both the laser-ICG and laser-ICG-GC treatments significantly reduced th

142 High-speed, high-magnification ICG angiograms showing individual cell movement were rec

143 n the unilateral ureteral obstruction model, ICG-001 ameliorated renal interstitial fibrosis and supp

144 fficacy of the peptidomimetic small molecule ICG-001, which specifically disrupts beta-catenin-mediat

145 We demonstrate that this UCNP@mSiO2-ICG nanoplatform can perform the following multiple func

146 Our results demonstrated that UCNP@mSiO2-ICG with sealed structures could be systemically deliver

147 d poly(N-isopropylacrylamide) nanoparticles (ICG-NPs) are one of the families of the most successful

148 Adjunct use of NIRF-ICG for (a) intraoperative sentinel lymph node mapping f

149 ectal metastases after the administration of ICG (n = 15) at 3, 6, and 24 hours after injection.

150 Late administration of ICG-001 also effectively attenuated fibrotic lesions in

151 Administration of ICG-001 concurrent with bleomycin prevents fibrosis, and

152 Combination of ICG-001 with cisplatin synergistically suppressed in vit

153 ell containing sealed, high concentration of ICG molecules.

154 photothermal as mechanism of cytotoxicity of ICG solution and ICG conjugated micelles, respectively.

155 This finding suggests better distribution of ICG solution than TA suspension in the suprachoroidal sp

156 This antifibrotic effect of ICG-001 did not involve disruption of Smad signaling.

157 is study, we aimed to evaluate the effect of ICG-001 on the CSC-like population, and the combination

158 ke population, and the combination effect of ICG-001 with cisplatin in the C666-1 EBV-positive NPC ce

159 and investigated the photothermal effects of ICG containing nanocapsules on EGFR-rich tumor cells.

160 The fluorescence of ICG can follow action potentials in artificial neurons a

161 in nude mice, and epifluorescence imaging of ICG, as well as histologic analysis of the explanted liv

162 ood cell populations with distinct levels of ICG uptake.

163 There was avid localization of ICG to the focal lesions at all time points.

164 nto the liver, and real-time measurements of ICG fluorescence were obtained.

165 The lymphatic drainage pattern of ICG-(99m)Tc-nanocolloid is identical to that of (99m)Tc-

166 The trafficking pattern of ICG-labeled cells was compared with that of rhodamine 6G

167 to quantify tissue attenuation properties of ICG in liver parenchyma.

168 relation of the plasma disappearance rate of ICG (ICG-PDR) and various factors derived from MR imagin

169 Results of ICG tests were correlated with various clinical determin

170 s the leak-out and improves the stability of ICG by protecting from rapid hydrolysis.

171 PTT, the combinational chemo-PTT therapy of ICG-EPI NPs with NIR laser irradiation synergistically i

172 Diode laser treatment of ICG saturated episcleral veins causes a chronic elevatio

173 Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstra

174 Equivalent volume of ICG solution led to a significantly smaller IOP elevatio

175 fluorescein angiography, hypofluorescent on ICG angiography, and correlated with choroidal lesions o

176 ur study suggests that change in CNV size on ICG angiography may help the clinician predict the clini

177 n reflectance was enhanced after nigrosin or ICG was injected into the systemic circulation.

178 cessfully characterized in vivo by using Pan-ICG(1:5) and Tra-ICG(1:5), respectively.

179 After 6 hours of PP, ICG clearance increased (P < 0.001), indicating a compen

180 Compared to pure ICG, sealing of mesoporous silica platforms prevents the

181 indocyanine green plasma disappearance rate [ICG-PDR]) was performed.

182 Reinjected ICG-loaded erythrocytes permit routine visualization of

183 h contrast was maintained between reinjected ICG-loaded erythrocytes and their plasma background.

184 easurement, and the ICG 15-minute retention (ICG-r15) test.

185 iopathic crescentic glomerulonephritis (RPGN/ICG), IgA nephropathy (IgA), mesangioproliferative glome

186 ures (simple disease activity index [SDAI]), ICG-enhanced optical imaging, and DCE MR imaging.

187 In the acute stage, ICG-A revealed sharply delineated dense hypofluorescent

188 The strongly ICG-labeled cells did not roll on dermal vascular endoth

189 uggested that ICG labels leukocytes and that ICG can be used to track leukocyte movement in vivo.

190 luorescence intensity in mice confirmed that ICG and Cy5.5 had no favorable binding to tumor regardle

191 Our research confirms that ICG is a voltage-sensitive dye with a dual-component (fa

192 In vivo NIR imaging demonstrated that ICG conjugated micelles prolonged its circulation and in

193 We previously demonstrated that ICG-001, a small molecule specific inhibitor of the beta

194 We report here that ICG-001 (5 mg/kg per day) significantly inhibits beta-ca

195 Results showed that ICG-001 inhibited C666-1 cell growth and reduced express

196 These results suggest that ICG conjugated micelles can be potentially utilized for

197 It has been suggested that ICG labels leukocytes and that ICG can be used to track

198 The ICG elimination test, conducted spectrophotometrically o

199 The ICG fluorescence signal was analyzed with Ad Hoc imaging

200 The ICG is a public-access research facility consisting of a

201 The ICG pHLIP imaging agent marked high-grade urothelial car

202 The ICG seeks to facilitate the cross-fertilization of synth

203 The ICG test was performed after 50 orthotopic liver transpl

204 The ICG-enhanced optical images coregistered accurately with

205 The ICG-labeled cells were made up of two blood cell populat

206 The ICG-r15 test is an effective tool for assessment of PH i

207 ZWC coating did not significantly affect the ICG distribution in tumors due to the rapid release of t

208 estinal endoscopy, HVPG measurement, and the ICG 15-minute retention (ICG-r15) test.

209 To date, the ICG has interacted with 76 biology laboratories from 39

210 though this would not replace endoscopy, the ICG-r15 appears able to identify patients with advanced

211 Furthermore, the ICG-EPI NPs exhibited inappreciable toxicity.

212 This report outlines how the ICG functions, how researchers can take advantage of its

213 DNA stains was further used to identify the ICG-labeled cells.

214 Importantly, the ICG-EPI NPs showed excellent tumor targeting ability wit

215 OCT image and excite the fluorescence in the ICG dye.

216 saline and instilled with a solution of the ICG pHLIP construct, incubated, and rinsed.

217 uated the sensitivity and specificity of the ICG retention test and other noninvasive tools for the d

218 We estimated that the Tth of the ICG-NPs should be controlled at ~38-40 degrees C (slight

219 an AMD scar, a treatable HS was found on the ICG at the border of the disciform scar.

220 hydroxyl or carboxyl function groups on the ICG-NPs for future molecular targeting.

221 A live mixing channel overlaid the ICG sequence on the coronal OCT slices in a fourth panel

222 the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spatially localized chemical

223 seen using white light, so imaging with the ICG pHLIP peptide offers improved early diagnosis of bla

224 These ICG conjugated micelles exhibited significant in vitro p

225 lass, and systolic blood pressure) and three ICG parameters (velocity index, thoracic fluid content i

226 The three ICG parameters combined into a composite score was a pow

227 that can be readily imaged in deep tissues, ICG may have significant utility for clinical and basic

228 radiated ICG conjugated micelles compared to ICG solution and control in a A375 human melanoma tumor

229 erized in vivo by using Pan-ICG(1:5) and Tra-ICG(1:5), respectively.

230 on and subretinal haemorrhage should undergo ICG imaging to look for HS.

231 o identify the cell population that takes up ICG and to study their trafficking pattern in vivo by co

232 hepatocytes, such as LDL storage and uptake, ICG uptake and release, and glycogen storage.

233 Using ICG-001 in a NOD/SCID/IL2Rgamma(-/-) mouse model of engr

234 for intervention in pulmonary fibrosis using ICG-001, a small molecule that specifically inhibits T-c

235 P/beta- and gamma-catenin interactions using ICG-001 leads to differentiation of pre-B ALL cells and

236 CRC can be visualized intraoperatively using ICG-FI.

237 tudy was to explore the possibility of using ICG to monitor cardiac electrical activity.

238 The weakly ICG-labeled cells were identified as neutrophils because

239 o the presence of both CSPH and SPH, whereas ICG-r15 and INR were related to EV.

240 Ultra-widefield ICG angiography revealed dilated choroidal vessels and c

241 AF and 24 of these eyes with ultra-widefield ICG angiography.

242 the interaction between CBP and catenin with ICG-001 results in the differentiation of quiescent drug

243 This information in combination with ICG and fluorescein angiography can help to optimize dir

244 olecular imaging device, in combination with ICG, readily allowed differentiation between normal and

245 re the factors significantly correlated with ICG-PDR (R = 0.87).

246 The liver function correlating with ICG-PDR can be estimated quantitatively from the signal

247 e acetaminophen revealed strong damage, with ICG half-lives significantly higher than in non-treated

248 , even when no change could be detected with ICG angiography.

249 FMT enhanced with ICG provided depth-resolved imaging of synovitis in PIP

250 Dynamic contrast enhancement with ICG was possible.

251 ntagonizing the CBP/catenin interaction with ICG-001 can eliminate drug-resistant CML LICs without de

252 of approximately 120-nm capsules loaded with ICG within salt-cross-linked polyallylamine aggregates,

253 the CBP/beta-catenin signaling pathway with ICG-001 can effectively reduce the CSC-like population a

254 ring the second scintigraphic procedure with ICG-(99m)Tc-nanocolloid.

255 ed on Langendorff rabbit hearts stained with ICG and perfused with electromechanical uncouplers.

256 hese two modalities, when used together with ICG, have the potential to help map SLNs in axillary sta

257 egulated in primary ALL after treatment with ICG-001.

258 ng with confocal SLO views, with and without ICG filtration.