ライフサイエンスコーパス: ICR

1 ICR (>/=50% DS) was associated with higher 1-year rates

2 ICR cell array systems consisting of three or five cells

3 ICR was variably defined if any lesion with diameter ste

4 ICRs were found in 17 patients and were not associated w

5 istributed as follows: CR, 0 (n=386, 42.7%); ICR, >0 to 4 (n=184, 20.4%), >4 to 8 (n=167, 18.5%), >8

6 inating from a cross between C57BL/6J and an ICR-derived outbred line (HR).

7 cently showed that the H19ICR can work as an ICR even when inserted into the normally nonimprinted al

8 g the 37 patients, 22 had a CR and 15 had an ICR.

9 3 domain, confirming that the Peg3-DMR is an ICR for this imprinted domain.

10 Subjects who presented with an ICR at t(1) presented with a significantly reduced cogni

11 By multivariable analysis, ICR (>/=50% DS) was an independent predictor of 1-year m

12 clinical outcomes were stratified by CR and ICR (tertiles of the residual SYNTAX Score: >0-4, >4-8,

13 RESEARCH DESIGN AND ICR mice were food restricted by 50% from gestational da

14 in all cells were simultaneously excited and ICR signals from each cell were independently amplified

15 urier transform mass analyzers (orbitrap and ICR), higher charge also improves signal-to-noise ratio,

16 ut not acid reflux, differed between CRs and ICRs.

17 Within the PCI and CABG arms, ICR (compared with CR) seemed to be a surrogate marker o

18 The findings associating ICR (compared with CR) with higher frequencies of 4-year

19 , respectively, without altering H4R3me2s at ICRs.

20 PSCs harboring abnormal hypermethylation at ICRs of the Dlk1-Gtl2-Dio3 imprinting cluster diminished

21 preserves DNA methylation through stage I at ICRs and meiotic gene promoters and is required for the

22 e 5-methylcytosine oxidation specifically at ICRs.

23 elective, and cell active inhibitor 13 (BAZ2-ICR) of the BAZ2A/B bromodomains through rapid optimizat

24 decided to explore the relationship between ICR, subjective evaluation of cognitive performance and

25 Experiment 1: Intravenously cannulated ICR mice received chow, PN, or PN + BBS injections for 5

26 Compared to CCR, ICR decreased tumor incidence in genetically engineered

27 ld inbred C57BL/6JCrl (B6J), outbred Crl:CD1(ICR) (CD-1), and inbred BALB/cAnNCrl (BALB/c) male mice,

28 However, the direct evidence comparing ICR to CCR with respect to cancer prevention is controve

29 The compensated ICR cell installed in a custom-built 9.4 T FTICR mass sp

30 orporate a custom-built, voltage-compensated ICR cell for Fourier transform ion cyclotron resonance m

31 ctous (21-day) and postcataractous (100-day) ICR/f rats were sectioned and applied to a matrix-assist

32 Despite ICR following PCI, there was no incremental benefit in a

33 With the exception of detecting ICR in S. aureus, Vitek 2 performed reliably for antimic

34 rs SYNTAX trial, angiographically determined ICR has a detrimental impact on long-term clinical outco

35 We have used genetic mouse models to dissect ICR-mediated genetic and epigenetic regulation of imprin

36 Depending on the threshold of percent DS, ICR was present in 17% to 75% of patients with acute cor

37 However, the ectopic ICR remains unmethylated in sperm.

38 Subjects were female ICR mice 8-10 weeks old.

39 CTCF sites at the ICR is required in cis for ICR-mediated imprinted repression at the H19/Igf2 locus.

40 -treated primary pancreatic islet cells from ICR mice to unravel the protective mechanism of berberin

41 H3.1, H3.2, or H3.3 using most OrbiTrap, FT ICR, or TOF mass spectrometers.

42 ourier transform ion cyclotron resonance (FT ICR) instruments; however, the effort and time to produc

43 on cyclotron resonance mass spectrometry (FT ICR MS), can resolve thousands of molecular ions in comp

44 much less than required to produce their FT ICR counterparts.

45 FT-ICR mass spectral data revealed an overall similarity in

46 yclotron resonance mass spectrometry (21T FT-ICR MS).

47 2D FT-ICR MS allows the correlation between precursor and frag

48 the present study, the capabilities of 2D FT-ICR MS are explored with a tryptic digest of cytochrome

49 used electron capture dissociation for 2D FT-ICR MS for the first time, and we recorded two-dimension

50 2D FT-ICR MS has been optimized as a data-independent method f

51 olution FT-ICR MS/MS analysis, but the 2D FT-ICR MS method required only one experimental scan.

52 cyclotron resonance mass spectrometry (2D FT-ICR MS) allows the correlation between precursor and fra

53 ide and proteins within the ICR cell of a FT-ICR mass spectrometer are accomplished through appropria

54 Highly accurate FT-ICR mass measurement is essential for reliable identific

55 d FT-ICR) or continuous IRMPD activation (FT-ICR).

56 at pressures as low as 10(-6) mbar in an FT-ICR mass spectrometer source, and the expected mass reso

57 by electrospray ionization, trapped in an FT-ICR mass spectrometer, and characterized by infrared mul

58 SI-MS) with both time-of-flight (TOF) and FT-ICR analyzers.

59 ificantly reduced by tandem-MS (Q-ToF and FT-ICR) followed by mild collisional or continuous IRMPD ac

60 ucoside-micelle by collisional (Q-ToF and FT-ICR) or continuous IRMPD activation (FT-ICR).

61 clotron resonance mass spectrometry (APPI FT-ICR MS) to identify molecular transformations in oil-res

62 tly after the fire using state-of-the-art FT-ICR (Fourier transform ion cyclotron resonance) and GC x

63 e overall loss of HMW species observed by FT-ICR MS has not previously been documented and is counter

64 A new method combining FT-ICR/MS analysis and Kendrick plots for the characterizat

65 We demonstrate how 2D ECD FT-ICR MS can be implemented to identify peptides and glyco

66 he sequence coverage obtained with 2D ECD FT-ICR MS with the sequence coverage obtained with ECD MS/M

67 The mass spectra acquired by ESI FT-ICR MS of untreated, borohydride-reduced, and borodeuter

68 otron resonance mass spectrometry (LC ESI FT-ICR MS) to determine the sugar composition, linkage patt

69 1% of the DOM molecules identified by ESI FT-ICR MS, may suggest a microbial provenance and high bioa

70 er Transform Ion Cyclotron Resonance (ESI FT-ICR) mass spectrometry and liquid state (1)H NMR spectro

71 lotron resonance mass spectrometry (ESI(-)FT-ICR MS) and physicochemical characterisation analysis (t

72 The ESI(-)-FT-ICR data also showed a clear and evident change in the c

73 ESI(-)-FT-ICR MS is a powerful tool to predict the physicochemical

74 The ESI-FT-ICR MS readings were acquired and the data were correlat

75 rved, as the number of peaks from the ESI-FT-ICR-MS spectra decreased.

76 solid-phase extraction procedure and ESI-FT-ICR-MS which allowed precise evaluation of the DOM molec

77 yclotron resonance mass spectrometry (ESI-FT-ICR-MS) and IR analysis of the isolated cofactor and ref

78 yclotron resonance mass spectrometry (ESI-FT-ICR-MS).

79 yclotron Resonance Mass Spectrometry (ESI-FT-ICR-MS).

80 hybrid quadrupole time-of-flight, or even FT-ICR.

81 re generation of ultrahigh magnetic field FT-ICR MS equipped with harmonized ICR cells.

82 gh H/C values of identified formulas from FT-ICR MS data.

83 Metabolic fingerprints from FT-ICR-MS data could discriminate wines according to the ad

84 FAC)) and the exact mass information from FT-ICR-MS, and thus revealing the extent of sulfur-containi

85 ltrahigh resolution mass analyzers (e.g., FT-ICR MS).

86 ed and successfully installed in a hybrid FT-ICR instrument in place of the standard gas collision ce

87 Hitherto, the use of absorption mode in FT-ICR mass spectrometry has required either specially adap

88 ncy multiples for increased throughput in FT-ICR MS, essential for numerous applications with time co

89 detection limit should become routine in FT-ICR-MS data processing.

90 he ultrahigh mass resolution available in FT-ICR.

91 to apply the absorption-mode routinely in FT-ICR.

92 yclotron resonance mass spectrometry (LTQ FT-ICR MS) to simultaneously measure the isotopic enrichmen

93 In the present study, MALDI-TOF and MALDI-FT-ICR imaging mass spectrometry (MALDI-IMS) combined with

94 lotron resonance mass spectrometry (MALDI-FT-ICR MS) and single cell imaging flow cytometry to detect

95 commonly used in FT-NMR), magnitude-mode (FT-ICR), and power-mode (engineering applications).

96 ier transform ion cyclotron resonance MS (FT-ICR MS) demonstrated that the mass accuracy of the Orbit

97 late with DOM composition, the ability of FT-ICR MS to characterize DOM subpopulations provides uniqu

98 eld provide some distinct advantages over FT-ICR instruments.

99 position data obtained by high resolution FT-ICR mass spectrometry to correctly identify the source o

100 We use high-resolution FT-ICR mass spectrometry to overcome that problem and inves

101 power of 90-220) to ultrahigh resolution FT-ICR MS (resolving power over 400k) permitted the identif

102 lity and precision as the high resolution FT-ICR MS.

103 matched data provided by high-resolution FT-ICR MS/MS analysis, but the 2D FT-ICR MS method required

104 ourier-transform ion cyclotron resonance (FT-ICR) and MS/MS techniques to accurately determine the ma

105 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometer has been demonstrated to provide

106 ourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer to perform MAIV from both interme

107 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometer.

108 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometer.

109 ourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer.

110 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometry data allows the spectra to be pre

111 ourier transform ion cyclotron resonance (FT-ICR) mass spectrometry to identify compositional changes

112 ourier transform ion cyclotron resonance (FT-ICR) MS allows a routine acquisition of the isotopic fin

113 ourier transform ion cyclotron resonance (FT-ICR) MS, and ion mobility spectrometry (IMS).

114 ly and promote absorption-mode in routine FT-ICR experiments.

115 The SID-FT-ICR platform has been tested with several protein comple

116 orm Ion Cyclotron Resonance mass spectra (FT-ICR-MS) of natural organic matter are complex and consis

117 Fourier transform ICR mass spectrometer (FT-ICR MS).

118 on cyclotron resonance mass spectrometry (FT-ICR MS) and quantify DOM photochemical activity using pr

119 d ultrahigh resolution mass spectrometry (FT-ICR MS) enables an improved characterization of complex

120 on cyclotron resonance mass spectrometry (FT-ICR MS) for direct separation and characterization of ta

121 on cyclotron resonance mass spectrometry (FT-ICR MS) is applied to the analysis of the low energy wat

122 on cyclotron resonance mass spectrometry (FT-ICR MS) provides ultrahigh resolution and ultrahigh mass

123 on cyclotron resonance mass spectrometry (FT-ICR MS) technique to characterise in situ chemical compo

124 on cyclotron resonance mass spectrometry (FT-ICR MS) to determine the elemental compositions of DOM m

125 on cyclotron resonance mass spectrometry (FT-ICR MS) typically utilizes an m/z-independent excitation

126 on cyclotron resonance mass spectrometry (FT-ICR MS).

127 on cyclotron resonance mass spectrometry (FT-ICR MS).

128 on cyclotron resonance mass spectrometry (FT-ICR) has been utilized to investigate phenyl radical-ind

129 on cyclotron resonance mass spectrometry (FT-ICR-MS) "top-down" analysis of PA1006 purified from Pae

130 y ultrahigh resolution mass spectrometry (FT-ICR-MS) and excitation emission matrix fluorescence (EEM

131 on cyclotron resonance mass spectrometry (FT-ICR-MS) as a nontargeted technique to assign unambiguous

132 on cyclotron resonance mass spectrometry (FT-ICR-MS) for the analysis of a pyrolysis liquid from brow

133 on cyclotron resonance mass spectrometry (FT-ICR-MS) identified both the photolabile and the photopro

134 ) ultrahigh resolution mass spectrometry (FT-ICR-MS) revealed a strong interaction between DOM and re

135 on cyclotron resonance mass spectrometry (FT-ICR-MS) to determine the biodegradability and molecular

136 on cyclotron resonance mass spectrometry (FT-ICR-MS), combined with chromatographic prefractionation,

137 on Cyclotron Resonance-Mass Spectrometry (FT-ICR-MS), which delivered the molecular formulae and ion

138 on cyclotron resonance mass spectrometry (FT-ICR-MS).

139 d ultrahigh-resolution mass spectrometry (FT-ICR-MS).

140 on cyclotron resonance mass spectrometry (FT-ICR-MS).

141 times higher than those provided by 10 T FT-ICR MS with a standard ICR cell.

142 ple from the deep North Pacific on a 15 T FT-ICR-MS; each of these replicate runs consisted of 500 cu

143 The FT-ICR experiments led to the identification of approximate

144 mited by the slow acquisition rate of the FT-ICR MS (<1 Hz), a database driven retention time compari

145 intact, demonstrating the ability of the FT-ICR to maintain the noncovalent interactions and efficie

146 timal bacteriorhodopsin liberation on the FT-ICR, in comparison to the Q-ToF and Orbitrap instruments

147 re compared, the Q-ToF, Orbitrap, and the FT-ICR, to analyze, under native instrument and buffer cond

148 d in a higher sensitivity relative to the FT-ICR.

149 The TIMS-FT-ICR MS analysis provided, in addition to the heteroatom

150 ciple for further application of OSA-TIMS-FT-ICR MS for the unsupervised analysis of complex mixtures

151 ions (<1%) can be measured using OSA-TIMS-FT-ICR MS with high mobility resolving powers (RIMS up to 2

152 In the case of OSA-TIMS-FT-ICR MS, the TIMS operation sequence, trapping conditions

153 3 KRGRGRPRK [M + 2H](+2) during OSA-TIMS-FT-ICR MS.

154 that allows spectra recorded on unadapted FT-ICR mass spectrometers to be phase corrected, their base

155 Insights generated using FT-ICR-MS analysis can be confirmed and further explored us

156 he rate coefficients were determined with FT-ICR mass spectrometry under single-collision conditions

157 ing organic formulas were identified with FT-ICR-MS in the stormwater runoff and pond outflow water,

158 the level of identification possible with FT-ICR-MS.

159 ted differentially methylated regions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF

160 A closer look at H19 ICR revealed complete erasure in SSCiPSC in contrast to

161 rentially methylated regions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF2 DMR2) w

162 -mediated insulator activity at the IGF2/H19 ICR, increased levels of IGF2 expression, and increased

163 out mice however lacked demethylation of H19 ICR.

164 2 and the H19 imprinting control region (H19 ICR) compared with term infants over the first year of l

165 during gametogenesis at primary regions (H19 ICR).

166 both DMR2 (beta=-2.84, p=0.013) and the H19 ICR (beta=-2.31, p=0.048) compared with term infants at

167 detectable change in methylation at the H19 ICR or promoter.

168 ly, both mutant alleles (H19(ICRIVS) and H19(ICR-8nrCG)) show loss of imprinted repression of paterna

169 ii) CpG depletion outside of CTCF sites (H19(ICR-8nrCG)), which only changes CpG content at the ICR.

170 nts with a history of chronic angina who had ICR post-PCI were randomized 1:1 to oral ranolazine vers

171 upgrade with a novel dynamically harmonized ICR cell, i.e., ParaCell, for mapping isotopically resol

172 tic field FT-ICR MS equipped with harmonized ICR cells.

173 liver short hairpin (shRNA) genes to healthy ICR mice.

174 (mIC1) is replaced by the orthologous human ICR (hIC1) sequence, designated H19(hIC1) We show that h

175 Microdeletions at the human H19/IGF2 ICR (IC1) are proposed to be responsible for IC1 epimuta

176 ck-in mouse in which the endogenous H19/Igf2 ICR (mIC1) is replaced by the orthologous human ICR (hIC

177 mice carry a 1.3 kb deletion at the H19/Igf2 ICR [Delta2,3] removing two of four CCCTC-binding factor

178 gest that insulator activity of the H19/Igf2 ICR varies by cell type and may depend on cell-specific

179 The H19/insulin-like growth factor 2 (Igf2) ICR has a multifunctional role including insulation, act

180 In ICR biosensing, a nanopore coated with an analyte specif

181 DM MS) and demonstrate its implementation in ICR MS.

182 f angiographic complete (CR) and incomplete (ICR) revascularization and its association with the pres

183 or RVV-X (the venom factor X-activator) into ICR mice did not significantly deplete the plasma fibrin

184 A/H-F/V was transplanted subcutaneously into ICR mice for up to 4 weeks to assess its in vivo effect

185 of the nanopore aperture, thus altering its ICR response in a time dependent manner.

186 A characteristic of the known ICRs is that they acquire different epigenetic states, e

187 The maternally methylated KvDMR1 ICR regulates imprinted expression of a cluster of mater

188 Two days after venous cannulation, male ICR (Institute of Cancer Research) mice were randomized

189 xidative stress and hepatic fibrosis in male ICR mice.

190 genomic imprinting is conserved in mammals, ICRs are genetically divergent across species.

191 ces depended on CTCF binding in the maternal ICR allele.

192 cohesin binding at the maternal ICR blocks this interaction by associating with the CTCF

193 ist significantly improved survival of mice (ICR/CD-1) that were otherwise determined to die accordin

194 ponsible for maintaining methylation at most ICRs.

195 o this end, we generated two types of mutant ICRs in the mouse: (i) deletion of intervening sequence

196 miRNAs were extracted from hearts of ICR mice following IPC.

197 The impact of ICR on major adverse cardiac events was similar regardle

198 models to elucidate further the mechanism of ICR-mediated gene regulation.

199 O was the strongest independent predictor of ICR after PCI (hazard ratio: 2.70, 95% confidence interv

200 Multivariate predictors of ICR were determined.

201 /=50%, >/=60%, and >/=70%, the prevalence of ICR after percutaneous coronary intervention was 75%, 55

202 e results strongly implicate a novel role of ICR size and CpG density in paternal H19 repression.

203 ed here significantly expands the utility of ICR biosensing measurements for detecting low-abundance

204 tudy introduces an operational definition of ICRs and suggests to their role as a factor for cognitiv

205 re has been much focus on gametic marking of ICRs as the point of imprint specification, recent mecha

206 lecule MIF antagonist, CPSI-1306, to outbred ICR mice following induction of NIDDM significantly lowe

207 CXC chemokine) levels after CLP in outbred (ICR/CD-1) mice.

208 arks associated with the methylated paternal ICR allele and the bivalent H3K4me2/H3K27me3 mark togeth

209 ack of CTCF--cohesin binding at the paternal ICR is associated with monoallelic interaction between t

210 ning and imaging of pre- and postcataractous ICR/f rat lenses has been established.

211 Rather, ICRs are part of more widespread methylation events that

212 ntion as a novel immune checkpoint receptor (ICR) on chronically stimulated, often dysfunctional, T c

213 Of late, ion current rectification (ICR) biosensing measurements have received a great deal

214 The behavior of ionic current rectification (ICR) in a conical nanopore with its surface modified by

215 ted variations in ion current rectification (ICR) ratios due to the small differences in pore geometr

216 ms and 58 fetuses; imprinting control region ICR strain) and 17.5 (21 dams and 158 fetuses) under res

217 es in the IGF2/H19 imprinted control region (ICR) as well as other genomic CTCF sites.

218 lation at the H19 imprinting control region (ICR) induced by 5-AzaCdR, reduced IGF2, increased H19 ex

219 n at the IGF2-H19 imprinting control region (ICR) result in reciprocal changes in IGF2-H19 expression

220 ethylation at the imprinting control region (ICR), but the underlying mechanism remains largely uncle

221 encompassing the imprinting control region (ICR), concomitant with increased DNA methylation and red

222 ng this potential imprinting control region (ICR).

223 tially methylated imprinting control region (ICR).

224 rnally methylated imprinting control region (ICR).

225 RES was mapped to the intercistronic region (ICR) of a bicistronic mRNA that we cloned from the MDV-t

226 f CpG islands at imprinting control regions (ICR) determines the monoparental expression of a subset

227 ines that act at imprinting control regions (ICRs) and meiotic genes (stage II).

228 n these regions, imprinting control regions (ICRs) and secondary differentially methylated regions (D

229 nt demethylation of imprint control regions (ICRs) associated with increased mRNA expression of the c

230 are regulated by imprinting control regions (ICRs) characterized by DNA methylation of one allele.

231 NA methylation at imprinted control regions (ICRs) is established in gametes and, although largely pr

232 y, all the known imprinting control regions (ICRs) were classified into germ-line or somatic ICRs.

233 elements termed imprinting control regions (ICRs) with their parental origin in gametes through the

234 mono-allelic at imprinting control regions (ICRs), at which it marks the same parental allele as H3K

235 are regulated by imprinting control regions (ICRs), cis-regulatory elements that exhibit allele-speci

236 A methylation at imprinting control regions (ICRs), revealing an allele-specific binding pattern, bin

237 g in mammals are imprinting control regions (ICRs), which are the discrete genetic elements that conf

238 A methylation at imprinting control regions (ICRs).

239 he relevance of isolated cognitive relapses (ICRs ie, those occurring in absence of new sensorimotor

240 ureus with inducible clindamycin resistance (ICR) (n = 30), trimethoprim-sulfamethoxazole-resistant M

241 n (UVPD) within the ion cyclotron resonance (ICR) cell of a Fourier transform-ion cyclotron resonance

242 A multielectrode ion cyclotron resonance (ICR) cell, herein referred to as the "4X cell", for sign

243 f Fourier transform ion cyclotron resonance (ICR) cells as detectors that constitute the first MS arr

244 trap, orbitrap, and ion cyclotron resonance (ICR) mass analyzers (m/z = 400-2000).

245 ransient signals in ion cyclotron resonance (ICR) MS compared to the Fourier transform (FT) processin

246 ssociated with a CR or incomplete responder (ICR).

247 (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects.

248 ce of incomplete coronary revascularization (ICR) after percutaneous coronary intervention in patient

249 life (QOL) in incomplete revascularization (ICR) post-PCI patients.

250 AX Score >0 as incomplete revascularization (ICR).

251 of 5-hydroxymethylcytosine (5hmC) at several ICRs.

252 ions (GRB10 ICR, H19 ICR, KvDMR, SNRPN/SNURF ICR, IGF2 DMR0, and IGF2 DMR2) were analyzed in DNA from

253 s) were classified into germ-line or somatic ICRs.

254 e provided by 10 T FT-ICR MS with a standard ICR cell.

255 arable to the ones obtained for the standard ICR cell on the same mass spectrometer.

256 rmation Collection Rule Supplemental Survey (ICR SS) required analysis of Cryptosporidium and Giardia

257 CRs had fewer weakly acidic events than ICRs (29.5 vs 52; P < .05) and total reflux events (33.5

258 It appears that ICR decreases IGF-1 and leptin and increases adiponectin

259 Thus, the evidence suggests that ICR exerts greater anticancer effect in genetically engi

260 We showed that ICRs were not associated with changes in mood, fatigue l

261 The ICR (Imprinting Control Region) of the Peg3 (Paternally

262 The ICR behavior depends highly on the charged conditions of

263 The ICR is methylated in sperm but not in oocytes, and this

264 e ability of the target analyte to alter the ICR response of the nanopore upon it binding to the aper

265 ether sequences outside of CTCF sites at the ICR are required for paternal H19 repression.

266 TCF binding sites and DNA methylation at the ICR have previously been identified as key cis-acting el

267 difications and CTCF--cohesin binding at the ICR in BWS and SRS together with DNA methylation correla

268 , that sequence outside of CTCF sites at the ICR is required in cis for ICR-mediated imprinted repres

269 ntact CTCF sites nor hypermethylation at the ICR is sufficient for maintaining the fully repressed st

270 cupancy of the insulator protein CTCF at the ICR.

271 rCG)), which only changes CpG content at the ICR.

272 ), which changes size and CpG content at the ICR; and (ii) CpG depletion outside of CTCF sites (H19(I

273 tion does not perturb DNA methylation at the ICR; however, it does disrupt imprinted expression.

274 The high mass accuracy, obtained by the ICR mass analyzer, for both the precursor and product io

275 brain-specific paternal expression from the ICR shows mechanistic similarities with the mouse as wel

276 isolated by quadrupol and fragmented in the ICR cell by the ECD method.

277 odes with radius-dependent efficiency in the ICR cell without the need for prior ion isolation.

278 While repressive functions of the ICR are compromised by the deletion regardless of tissue

279 Paternal but not maternal copies of the ICR become methylated in somatic tissue.

280 The improved performance of the ICR cell provides more symmetric peak shape and better m

281 DNA methylation of the ICR controls the reciprocal imprinting of IGF2 and H19 b

282 Thus, the imprinted maternal allele of the ICR may be a suppressor antagonistic to the active pater

283 onistic to the active paternal allele of the ICR, suggesting a potential intralocus allelic conflict.

284 tervening sequence, approximately 75% of the ICR.

285 e Centrally Conserved Domain upstream of the ICR.

286 the maternal-specific DNA methylation on the ICR was properly established and maintained, causing no

287 We have shown that the ICR that separates the two ORFs functions as an IRES tha

288 By performing the encoding external to the ICR cell, one set of ions can be encoded while the previ

289 of human Naa10p disrupts its binding to the ICR of H19 and Dnmt1 recruitment.

290 ises the fundamental question of whether the ICR plays a species-specific role in regulating imprinti

291 of the IGF2 promoters to associate with the ICR.

292 D of a model peptide and proteins within the ICR cell of a FT-ICR mass spectrometer are accomplished

293 e 1 (Dnmt1) to DNA substrates, including the ICRs of the imprinted allele during S phase.

294 Regardless of the threshold, ICR was strongly associated with 1-year myocardial infar

295 the mechanism of gene dysregulation through ICR epimutations, such as loss or gain of DNA methylatio

296 (51)MnCl2 was intravenously administered to ICR mice which were scanned by dynamic and static PET, f

297 rized on a commercial 10 T Fourier transform ICR mass spectrometer (FT-ICR MS).

298 ng-term prognostic implications of CR versus ICR is unsettled.

299 event rate was increased among patients with ICR using all of the DS cutoffs.

300 p evaluations compared with patients without ICR.