ライフサイエンスコーパス: IDR

1 IDR is also an open source platform that others can use

2 IDR links data from several imaging modalities, includin

3 IDR uptake increased 1.5-fold in the presence of VER, bu

4 IDR-1002 also dampened the IFN-gamma response and repres

5 IDR-1018 is effective in the brain when given systemical

6 IDR-1018 reduced inflammatory mediators produced by LPS-

7 IDR-1018 selectively attenuated hyperinflammatory cytoki

8 IDR-1018 suppresses proinflammatory mediators and cell i

9 IDRs were then assessed for their ability to confer neur

10 phosphotyrosine-containing sequence, pY(173)IDR, does not conform to the canonical recognition motif

11 The anti-inflammatory effects of 3 IDRs was measured in lipopolysaccharide (LPS)-activated

12 ays [IQR 63-303] vs 139.5 days [63.0-309.5]; IDR 0.84 [95% CI 0.51-1.38]), or time to first readmissi

13 genetic platform that uses light to activate IDR-mediated phase transitions in living cells.

14 While all IDR were highly conserved among both seropositive and HI

15 This relaxed structure allows IDRs, which are implicated in the regulation of transcri

16 distribution of timescales of motions in an IDR from picoseconds to nanoseconds.

17 These were based on fusions of an IDR derived from the RNA granule protein FUS (fused in s

18 change by NMR to investigate the state of an IDR that folds upon binding through the observation of t

19 d isolated ID3 transiently interacts with an IDR of ZFP106 in a fashion that disorder of both regions

20 we found ANN to be less potent than DOX and IDR In sensitive cells, ID 50 being the drug concentrati

21 study provided evidence that, unlike DOX and IDR, ANN is not affected by p-gp-mediated MDR.

22 4.5-fold and 2-fold RI decreases of DOX and IDR, respectively, whereas ANN did not change, further c

23 F cell transcriptional responses to FliC and IDR-1018 identified dysfunctional autophagy as the targe

24 OX retention in HL-60/DOX cells 2.8-fold and IDR retention 1.4-fold; unchanged ANN retention indicate

25 ace carbohydrate and JAM-A by the length and IDR mutant viruses.

26 To understand how folded domains and IDRs can cooperate to modulate LLPS, we generated a seri

27 i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive resid

28 The sequence features of the Ash1 IDR are shared by many other IDRs that undergo multisite

29 We show that the unphosphorylated Ash1 IDR adopts coil-like conformations that are expanded and

30 s located at the C-terminal region of AtWRI1(IDR) (3).

31 sphorylation of the PEST motif in the AtWRI1(IDR) (3) domain may affect AtWRI1-mediated plant oil bio

32 other studies, localize the TPO autoantibody IDR to the junction of the CCP-like domain and the much

33 he putative location of the TPO autoantibody IDR.

34 Some interactions between IDRs and folded protein domains rely on short linear mot

35 ions to allow for a localized LLPS driven by IDRs on RNA binding proteins.

36 fically, although the SLiM was surrounded by IDRs, individual intrinsic alpha-helix propensities vari

37 These results show that low-complexity IDRs can modulate LLPS both positively and negatively, d

38 scontinuity were associated with compulsion (IDR 0.973 [95% CI 0.96-0.99, p<0.0001].

39 uster that binds an evolutionarily conserved IDR within the metazoan TFIID transcription complex.

40 water versus POU-treated water consumption (IDR = 1.52; 95% CI: 1.05, 2.20), but there was no associ

41 Extending previous data, IDR-1002 suppressed in vitro inflammatory responses in R

42 nd nonspecific image analysis, we determined IDRs of a diverse set of substances from individual pure

43 d evolution, we focused on a highly diverged IDR in Saccharomyces cerevisiae that is involved in regu

44 How do IDR sequences modulate the functionalities of motifs?

45 gests a new avenue for targeting the elusive IDRs by harnessing certain features of metal-based compl

46 gm for IDR function is that disorder enables IDRs to adopt multiple conformations, expanding the abil

47 ooks that allows remote access to the entire IDR.

48 any transcription factors via their flexible IDRs.

49 One current paradigm for IDR function is that disorder enables IDRs to adopt mult

50 ristics based on amino acid compositions for IDRs with low proline contents.

51 This article formulates IDR prediction as a sequence labeling problem and employ

52 The human homolog of Ubp10, USP36, also has IDRs flanking its catalytic domain, and these IDRs simil

53 When administered 3 hours after LPS+HI, IDR-1018 exerted effects on regulatory molecules of apop

54 cumulation and retention of ANN, idarubicin (IDR), and DOX in the p-gp-negative human leukemia cell l

55 sensitivity to various doses of idarubicin (IDR), daunorubicin (DNR), or mitoxantrone (MTA) gave the

56 erization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource

57 information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions

58 rinsically disordered proteins/regions (IDPs/IDRs) are proteins or peptide segments that fail to form

59 ically disordered proteins and regions (IDPs/IDRs) that do not adopt a dominant well-folded structure

60 ngs highlight the importance of mutations in IDRs and refine the traditional structure-centric view o

61 demonstrate that 20% of disease mutations in IDRs cause local disorder-to-order transitions, which re

62 ion about the impact of disease mutations in IDRs.

63 Using this integration, IDR facilitates the analysis of gene networks and reveal

64 increases the likelihood of long-range intra-IDR interactions that involve both the primary and auxil

65 The binodals of LAF-1 and its IDR display a number of unusual features, including 'hig

66 ultiple, distinct binding modules within its IDRs that are necessary and sufficient for directing pro

67 e and currently a major challenge is linking IDRs to their biological roles from the molecular to the

68 libraries, which demonstrated that the long IDR linking the KIX domain and bromodomain of CBP (terme

69 Most IDR prediction methods use sequence profile to improve a

70 ur data support a model whereby nascent NepR(IDR)-PhyR interactions and REC phosphorylation coordinat

71 , our results demonstrate that AS control of IDR-mediated interactions between hnRNPs represents an i

72 by means of which real-time determination of IDR from continuously changing effective surface areas o

73 matory and autophagosome-clearing effects of IDR-1018, as did a chemical inhibitor of Akt and an acti

74 aromatic amino acids, favoring formation of IDR structures.

75 estigate the anti-inflammatory mechanisms of IDR-1002 in vivo, the PMA-induced mouse ear inflammation

76 Confocal microscopy studies of IDR, ANN, and DOX showed higher intracellular drug compa

77 ID50 sensitive cells) was lower than that of IDR and DOX (2.6 v 40 and 117.5).

78 protein interaction scaffolding abilities of IDRs in the regulation of dynamic protein ubiquitination

79 Over time, sequence-based classifiers of IDRs have become fairly accurate and currently a major c

80 harge patterning on the global dimensions of IDRs.

81 as state of the art in the identification of IDRs, and our self-assessment shows that it significantl

82 Two key properties of IDRs are (i) the occurrence is proteome-wide and (ii) th

83 To examine the roles of IDRs in CBP, we performed yeast-two-hybrid screenings of

84 pothesis, we find that diverged, orthologous IDRs can mostly recapitulate wild-type function and fitn

85 ection, the functional output of orthologous IDRs could be maintained, such that diverse genotypes co

86 e functionalities of primary motifs in other IDRs.

87 res of the Ash1 IDR are shared by many other IDRs that undergo multisite phosphorylation.

88 our findings might be generalizable to other IDRs involved in cell signaling.

89 Our experimental results show that our IDR prediction method AUCpreD outperforms existing popul

90 phorylation of Thr-187 (T187) within the p27 IDR controls entry into S phase of the cell division cyc

91 ver cryptic sequence features within the p27 IDR that influence the efficiency of T187 phosphorylatio

92 re, we designed sequence variants of the p27 IDR to alter charge patterning outside the primary subst

93 the cryptic sequence features of the WT p27 IDR negatively regulate T187 phosphorylation signaling.

94 ential of innate defense regulator peptides (IDRs) was investigated.

95 conformational properties of polyampholytic IDRs are governed as much by linear charge patterning as

96 ubiquitinating enzyme, Ubp10, that possesses IDRs flanking its catalytic protease domain.

97 h makes it challenging to accurately predict IDRs.

98 its predecessor with new modules to predict IDRs and protein-binding sites within them.

99 Predicted IDRs are annotated as protein binding through a novel SV

100 Targeting PTEN IDR and its interaction hubs emerges as a new paradigm f

101 Intrinsic dissolution rate (IDR) has traditionally been determined from a constant s

102 had increased GII [incidence density ratio (IDR) = 1.34; 95% CI: 1.00, 1.79].

103 1.91] vs 2.2 [1.43]; incident density ratio [IDR] 0.97 [95% CI 0.76-1.24]), duration of readmissions

104 y which its intrinsically disordered region (IDR) at the carboxyl-terminus (C-tail) executes its func

105 600-amino acid intrinsic disordered region (IDR) both directs cyclin C-Cdk8 association and serves a

106 posed of an intrinsically disordered region (IDR) followed by a highly conserved amphipathic alpha-he

107 PhyR and an intrinsically disordered region (IDR) of the anti-sigma factor, NepR, by solution NMR spe

108 The intrinsically disordered region (IDR) on MBD2 both reduces exchange between mCpG sites al

109 D2IDR is an intrinsically disordered region (IDR).

110 ly evolving intrinsically disordered region (IDR).

111 y were 100% with both immunodominant region (IDR) and V3 region MAPs.

112 gely restricted to an immunodominant region (IDR) on the extracellular region of the native molecule.

113 PR) is an intrinsically unstructured region (IDR).

114 directed against the immunodominant regions (IDR) of HIV-1 structural proteins.

115 by intrinsically disordered protein regions (IDR) of RNA binding proteins in vitro have the opposite

116 ally disordered proteins (IDPs) and regions (IDRs) in the human proteome together with their lack of

117 ally disordered proteins (IDPs) and regions (IDRs), which represent approximately 30% of the proteome

118 nriched in intrinsically disordered regions (IDRs) and acidic stretches.

119 Intrinsically disordered regions (IDRs) are characterized by their lack of stable secondar

120 oteins and intrinsically disordered regions (IDRs) are ubiquitous in the eukaryotic proteome.

121 omains and intrinsically disordered regions (IDRs) having low amino acid sequence complexity.

122 ized three intrinsically disordered regions (IDRs) in Arabidopsis WRI1, and found that one C-terminal

123 teins have intrinsically disordered regions (IDRs) in their C-terminal domains and that these regions

124 ded within intrinsically disordered regions (IDRs) of proteins are often the sites of posttranslation

125 s encoding intrinsically disordered regions (IDRs) of proteins, in particular those containing glycin

126 onsists of intrinsically disordered regions (IDRs) of varying length.

127 Protein intrinsically disordered regions (IDRs) play an important role in many biological processe

128 Intrinsically disordered regions (IDRs) play important roles in proteins that regulate gen

129 ns contain intrinsically disordered regions (IDRs), which act in unfolded states or by undergoing tra

130 extensive intrinsically disordered regions (IDRs), which are conformationally plastic and do not app

131 d by large intrinsically disordered regions (IDRs).

132 on through intrinsically disordered regions (IDRs).

133 flexible linkers termed interdomain regions (IDRs).

134 cally disordered proteins (IDPs) or regions (IDRs).

135 ordered proteins (IDPs) and protein regions (IDRs) engage in transient, yet specific, interactions wi

136 by intrinsically disordered protein regions (IDRs) have emerged as a ubiquitous mechanism for assembl

137 Intrinsically disordered protein regions (IDRs) lack a well defined three-dimensional structure bu

138 by intrinsically disordered protein regions (IDRs) that undergo multisite Serine/Threonine phosphoryl

139 Innate defense regulator (IDR) peptide-1002 is a synthetic host defense peptide de

140 changes induced by innate defense regulator (IDR)-1018, an anti-inflammatory peptide.

141 e conformational properties of an 81-residue IDR from the S. cerevisiae transcription factor Ash1.

142 s, we built a prototype Image Data Resource (IDR) that collects and integrates imaging data acquired

143 amino acid usage is typical of proline-rich IDRs.

144 nd deleted midpoint and head-proximal sigma1 IDRs to generate DeltaIDR1 and DeltaIDR2 mutant viruses,

145 , but recent studies have shown that similar IDRs mediate specific and critical interactions in other

146 cted through cross-reactivity with other SIV IDR MAPs used in the assay.

147 cipants to their POU water treatment status (IDR = 0.98; 95% CI: 0.90, 1.08).

148 r recognition features present in the C-tail IDR enhance PTEN's protein-protein interactions that are

149 emanate from and are nucleated by the C-tail IDR, which form pliable network-hubs.

150 P-IDP interactions facilitated by its C-tail IDR.

151 bidopsis WRI1, and found that one C-terminal IDR of AtWRI1 (IDR3) affects the stability of AtWRI1.

152 question using the polyampholytic C-terminal IDR of the cell cycle inhibitory protein p27(Kip1) (p27)

153 This study demonstrates that IDR-1002 exhibits strong in vitro and in vivo anti-infla

154 on the mouse ear transcriptome revealed that IDR-1002 reduced sterile inflammation by suppressing the

155 We highlight new evidence suggesting that IDRs are often critical for histone chaperone function a

156 induces DNA bending that is augmented by the IDR region of the protein.

157 heterologous proteins can substitute for the IDR and the hA helix of human thymidylate synthase, indi

158 n simply as an extension or scaffold for the IDR; rather, it provides a specific structural component

159 h a prevalence of motions around 1 ns in the IDR.

160 Localization of the IDR has been a longstanding and difficult goal.

161 nging: in solution-state NMR, signals of the IDR in the interacting region become broad, weak, and of

162 so find that the electrostatic charge of the IDR is correlated with signaling output and, using phylo

163 esidues in Gly/Ser-Tyr-Gly/Ser motifs of the IDR reduced this effect, depending on the number but not

164 conformation of the interacting part of the IDR was determined and subsequently docked onto the stru

165 embrane EGF-like domain as being part of the IDR.

166 otein partner lead to partial folding of the IDR.

167 non-aromatic residues or phosphorylating the IDR raised the phase separation threshold above that of

168 We found that CaM binds directly to the IDR in the C-terminal domain of prestin in a calcium-obl

169 f the CCP-like domain does contribute to the IDR.

170 the minor substitutions observed within the IDR of gp41 of HIV-1 group M subtypes do not affect anti

171 tify the SLiM bound by RCD1, we analyzed the IDRs in three protein partners, DREB2A (dehydration-resp

172 stem to study condensed phases driven by the IDRs of various RNP body proteins, including FUS, DDX4,

173 rable and unfavorable contributions from the IDRs surrounding the SLiM to the interactions with RCD1,

174 yingly stable structural elements within the IDRs.

175 DRs flanking its catalytic domain, and these IDRs similarly contain binding modules important for pro

176 However, these IDRs have only been thought of as linkers that allow fle

177 The conformational properties of these IDRs prior to and following multisite phosphorylation ar

178 these results support a model in which this IDR of Med13 plays a key role in controlling a molecular

179 Thus IDR provides both a novel on-line resource and a softwar

180 Homology to IDR-containing proteins implicated in DNA damage repair

181 These varying responses to IDR, DNR, and MTA indicate that the MiCK assay results c

182 se-response analyses of the sensitivities to IDR, DNR, and MTA of leukemia cells from 4 other patient

183 across the whole board and more sensitive to IDRs longer than 20 amino acids.

184 Topical IDR-1002 treatment successfully dampened PMA-induced ear

185 onoclonal autoantibodies that define the TPO IDR, as well as polyclonal TPO autoantibodies in patient

186 We found that the wild-type IDR promotes LLPS of the polySH3-polyPRM system, decreas

187 n both instances, treatment of CF cells with IDR-1018 abolished the accumulation of LC3 induced by Fl

188 were analyzed in pups that were treated with IDR-1018 either 4 hours before LPS or 3 hours after LPS+

189 We propose that sequence features within IDRs have evolved to ensure an optimal balance of sequen

190 ly more readmissions than the group without (IDR 1.39 [95% CI 1.07-1.79]) and we noted no significant