ライフサイエンスコーパス: IFITM

1 IFITM proteins are important effectors in interferon-med

2 IFITM proteins are located in the plasma membrane and en

3 IFITM proteins deter HIV-1 entry when expressed in targe

4 IFITM proteins impede viral entry, and ZMPSTE24 expressi

5 IFITM-2 and -3 restricted RVFV infection mostly by preve

6 interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum

7 n-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antivir

8 nducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that med

9 t low doses of alpha interferon (IFN-alpha), IFITM-2 and -3 mediated more than half of the antiviral

10 Overexpression of an IFITM protein in MRC5 cells slightly enhanced HCMV produ

11 We found that large fractions of IFITM-2 and IFITM-3 occupy vesicular compartments that are distinct

12 nsmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity a

13 the viral envelope glycoproteins as well as IFITM subcellular localization within the target cell.

14 also mediate a physical association between IFITM proteins, and the loss of this interaction decreas

15 hat are distinct from the vesicles coated by IFITM-1.

16 was restricted by IFITM-2 and -3 but not by IFITM-1, whereas the remaining viruses were equally rest

17 We found that RVFV was restricted by IFITM-2 and -3 but not by IFITM-1, whereas the remaining

18 e data suggest that higher prefrontal cortex IFITM mRNA levels in schizophrenia may be attributable t

19 We have characterized the duck IFITM locus and identified IFITM3 as an important restri

20 We express each IFITM in chicken DF-1 cells and show duck IFITM1 localiz

21 ion film analysis revealed markedly elevated IFITM mRNA levels (+114% and +117%, respectively) in pre

22 Additionally, the ability to evade IFITM restriction contributes to the different interfero

23 mRNA levels were also markedly elevated for IFITM (+304%), multiple cytokines including IL-6 (+493%)

24 ry, and ZMPSTE24 expression is necessary for IFITM antiviral activity.

25 ouse models of neuroinflammation have higher IFITM levels and deficits in gamma-aminobutyric acid (GA

26 The authors sought to clarify whether higher IFITM mRNA levels and other immune-related disturbances

27 re unknown, and it is unclear whether higher IFITM mRNA levels are associated with lower GABA-related

28 ding that schizophrenia subjects with higher IFITM mRNA levels in cortical blood vessels have greater

29 At least three human IFITM proteins-IFITM1, IFITM2, and IFITM3-have antiviral

30 Recent studies have identified IFITM proteins as the first ISG to inhibit viral entry p

31 We also identify IFITM-2 as a BAG3 receptor and show that it signals thro

32 Immune IFITM genes are poorly conserved across species, suggest

33 9%) and interferon-beta (+29%), which induce IFITM expression; lower mRNA levels for Schnurri-2 (-10%

34 HCMV infection inhibited IFITM protein accumulation in the later stages of infect

35 Interestingly, IFITM expression promoted virus uptake and the acidifica

36 0%), a transcriptional inhibitor that lowers IFITM expression; and higher mRNA levels for nuclear fac

37 natural host would result in the evasion of IFITM restriction.

38 We found that large fractions of IFITM-2 and IFITM-3 occupy vesicular compartments that a

39 er, few reports have evaluated the impact of IFITM genes on viral pathogenesis in vivo In this study,

40 However, the cell types that overexpress IFITM messenger RNA (mRNA) in schizophrenia are unknown,

41 interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic vi

42 he interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several d

43 interferon inducible transmembrane protein (IFITM) family transcripts in the prefrontal cortex.

44 he interferon-induced transmembrane protein (IFITM) family.

45 ng interferon-induced transmembrane protein (IFITM) have been reported to inhibit multiple families o

46 or interferon-induced transmembrane protein (IFITM) in the prefrontal cortex.

47 or interferon-induced transmembrane protein (IFITM), which inhibits viral entry and replication-have

48 film and grain counting analyses to quantify IFITM mRNA levels in prefrontal cortex area 9 of 57 schi

49 lators, including those reported to regulate IFITM expression, in the prefrontal cortex from 62 schiz

50 proteins of several different viruses resist IFITM inhibition, the detailed mechanisms are not fully

51 er, little is known about how viruses resist IFITM inhibition.

52 hizophrenia and comparison subjects revealed IFITM mRNA expression in pia mater and blood vessels.

53 chemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry,

54 to infect different host species, suggesting IFITM proteins may provide a crucial barrier for zoonoti

55 We show that IFITM sensitivity of HIV-1 strains is determined by the

56 We also present evidence showing that IFITM family members work as homo- and hetero-oligomers

57 The IFITM grain density over blood vessels was 71% higher in

58 The IFITM mRNA levels were negatively correlated with GABA-r

59 The IFITM proteins confer basal resistance to influenza A vi

60 Although the IFITM locus, which includes IFITM1, -2, -3, and -5, is p

61 Because the IFITM gene family is primarily expressed in the endothel

62 Here we discuss the IFITM proteins, recent work on their mode of action, and

63 that the structural motifs critical for the IFITM proteins' enhancement of HCoV-OC43 infection are d

64 terferon-stimulated proteins, members of the IFITM (interferon-induced transmembrane) family are uniq

65 tion and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific.

66 Both the magnitude and breadth of the IFITM proteins' in vitro effects suggest that they are c

67 ew the discovery and characterization of the IFITM proteins, describe the spectrum of their antiviral

68 ent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of

69 Here, we show that the IFITM locus exists in chickens and is syntenic with the

70 In conclusion, we propose that the IFITM proteins act in a coordinated manner to restrict H

71 Further characterization revealed that the IFITM proteins inhibit the early replication of flavivir

72 ts into the possible mechanisms by which the IFITM family members restrict distinct viruses.

73 exists in chickens and is syntenic with the IFITM locus in mammals.

74 D and genetic markers close to or within the IFITM cluster or RAB31, DUSP1, and ADM genes.

75 onstrated that S-palmitoylation of all three IFITM proteins is essential for anti-HCV activity, where

76 The interferon-induced transmembrane (IFITM) family of proteins have recently been identified

77 The interferon-induced transmembrane (IFITM) proteins are a family of small membrane proteins

78 s have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, r

79 restricted interferon-induced transmembrane (IFITM)-like protein (BRIL) and pigment epithelium-derive

80 that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the repl

81 Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cell

82 The interferon-inducible transmembrane (IFITM) proteins are one class of ISGs that restrict the

83 he induction of IFN-inducible transmembrane (IFITM) proteins.