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1 ctivation of the transcription factor IRF-3 (IFN regulatory factor 3).
2  TBK1, TAK1, and phosphorylation of TBK1 and IFN regulatory factor 3.
3  IFN production in vitro, acting upstream of IFN regulatory factor 3.
4 infected cells are prevented from activating IFN regulatory factor 3.
5 resulting in inhibition of signaling through IFN regulatory factor 3.
6  molecule STING and the transcription factor IFN regulatory factor 3.
7 at specifically phosphorylates and activates IFN regulatory factor 3.
8 phosphorylation and nuclear translocation of IFN regulatory factor-3.
9 nhancement of reporter activity by predicted IFN regulatory factor 3/7 binding sites in the CAD risk
10 assay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21
11  suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway.
12                            It also activates IFN regulatory factor 3/7 through its interaction with T
13 sh IFN; however, it does so in an apparently IFN regulatory factor 3/7-independent manner.
14 umulation without inhibiting dimerization of IFN regulatory factor 3, a protein that is essential for
15                                              IFN regulatory factor 3, a transcription factor that is
16 tion and increases LPS-induced NF-kappaB and IFN regulatory factor 3 activation and IL-10 secretion,
17  complex formation and facilitating TBK1 and IFN regulatory factor 3 activation and the induction of
18 n sMLA-induced IkappaB kinase alpha/beta and IFN regulatory factor 3 activation and with restrained e
19 e regulator of the TRIF pathway via reducing IFN regulatory factor 3 activation.
20  and S1P1 acting through PI3K enhancement of IFN-regulatory factor 3 activation increase IFN-beta exp
21                   Furthermore, we found that IFN-regulatory factor 3 activation was maximized by LPS
22 enhanced AKT, Rac, P21-activated kinase, and IFN regulatory factor 3 activities.
23                                         Both IFN regulatory factor 3 and 7 (IRF-3 and IRF-7) were sug
24 e ability of NP to suppress translocation of IFN regulatory factor 3 and block activation of the inna
25 ence of the transcriptional factors RelA and IFN regulatory factor 3 and IkappaB kinases.
26 y C-HIV, which instead induced activation of IFN regulatory factor 3 and Lyn.
27  which ablates RIG-I signaling of downstream IFN regulatory factor 3 and NF-kappaB activation, attenu
28 RIG-I supports HCV persistence by preventing IFN regulatory factor 3 and NF-kappaB activation.
29 hat viperin/cig5 expression was dependent on IFN regulatory factor 3 and NF-kappaB signaling, and tha
30  of type I interferons through activation of IFN regulatory factor 3 and NFkappaB.
31 e induction of type III IFNs is regulated by IFN regulatory factor 3 and nuclear factor kappaB.
32  inhibit the MyD88-independent activation of IFN regulatory factor 3 and production of IFN-beta in re
33 ing phosphorylation of TANK-binding kinase 1/IFN regulatory factor 3 and production of IFN-beta.
34                            The activation of IFN regulatory factor 3 and the expression of IFN-beta i
35 n the activation of the transcription factor IFN regulatory factor 3 and the molecule UNC93B1, indica
36  site 6.1 kb downstream of ifnb1, along with IFN regulatory factor-3 and CREB binding protein only du
37  In contrast, LPS-induced phosphorylation of IFN regulatory factor-3 and expression of IFN-beta or th
38 ts displayed a significantly higher level of IFN regulatory factor-3 and NF-kappaB activity compared
39 l signaling protein, nuclear localization of IFN regulatory factor 3, and augmentation of IFN-stimula
40 inding kinase 1, activation of NF-kappaB and IFN regulatory factor 3, and induction of IL-8 and IFN-b
41 eta depended on the downstream transcription IFN regulatory factor 3, and on activation of NF-kappaB
42 TLR4 pathway in monocytes by activating Syk, IFN regulatory factor 3, and STAT1, which resulted in en
43 ons with the IPS-1 adaptor protein to signal IFN regulatory factor 3- and NF-kappaB-responsive genes.
44 IFN-beta transcription factors NF-kappaB and IFN regulatory factor 3 are not activated for nuclear tr
45    Similarly, phosphorylation of IkappaB and IFN regulatory factor 3 as well as cytokine expression w
46 ll-like receptor 4 signaling, and subsequent IFN regulatory factor 3 binding to IFN-beta promoter.
47                        Our results show that IFN regulatory factor 3, but not MyD88, mediated IRI-ind
48 mDCs blocked the activation of NF-kappaB and IFN regulatory factor 3 by dsRNA.
49 n-induced ER stress augmented recruitment of IFN regulatory factor-3, CREB binding protein/p300, and
50 irectly present Ag to CD8 T cells through an IFN-regulatory factor 3-dependent process.
51    Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation
52 d nonimmune cells that converges on TBK1 and IFN regulatory factor 3 for activation of IFN-beta gene
53 ain-containing adapter inducing IFN-beta --> IFN regulatory factor 3 --> type I IFN is the major axis
54 IFN-beta (TRIF)-dependent phosphorylation of IFN regulatory factor 3 in addition to TIR-containing ad
55 regates that led to activation of STAT-1 and IFN regulatory factor-3 in human macrophages, indicating
56 nslocation of transcription factors RelA and IFN regulatory factor-3 in IFN-alpha-primed HUVECs befor
57  underwent nuclear translocation of RelA and IFN regulatory factor-3 in response to dsRNA, whereas le
58 uated activation of the transcription factor IFN regulatory factor 3, involved in the MyD88-independe
59 ed cells was caused by an early block in the IFN regulatory factor 3 (IRF-3) activation pathway.
60   The level of IFN induction correlated with IFN regulatory factor 3 (IRF-3) activation, in that IRF-
61 g TLR3 to kinases responsible for activating IFN regulatory factor 3 (IRF-3) and NF-kappaB, transcrip
62 on activated both transcription factors, the IFN regulatory factor 3 (IRF-3) and nuclear factor kappa
63 upt IFN-beta gene transcription induction by IFN regulatory factor 3 (IRF-3) but do so at different p
64 ole of the IKK-related kinase IKKepsilon and IFN regulatory factor 3 (IRF-3) in the activation of ant
65                                 Mice lacking IFN regulatory factor 3 (IRF-3) show increased vulnerabi
66 LP by dsRNA was dependent upon NF-kappaB and IFN regulatory factor 3 (IRF-3) signaling via TLR3 as in
67                                Expression of IFN regulatory factor 3 (IRF-3) stimulated transcription
68 ay partially involve limiting the ability of IFN regulatory factor 3 (IRF-3) to function as a transcr
69  its downstream signaling molecules TRIF and IFN regulatory factor 3 (IRF-3) using a dominant-negativ
70 us correlated with an enhanced activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and ATF-2 in
71 and chemokine genes in a manner dependent on IFN regulatory factor 3 (IRF-3), TANK-binding kinase 1 (
72 y induce the type I IFN cascade, often in an IFN regulatory factor 3 (IRF-3)-dependent fashion.
73 ection-induced transcriptional activation of IFN regulatory factor 3 (IRF-3)-responsive mammalian pro
74 layed activation of the transcription factor IFN regulatory factor 3 (IRF-3).
75 IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/b
76 rotein expression consistent with a role for IFN regulatory factor-3 (IRF-3) in the expression of IL-
77                                              IFN regulatory factor-3 (IRF-3) is a transcription facto
78                              In these cells, IFN regulatory factor-3 (IRF-3) undergoes a sequence of
79 ells without inducing the phosphorylation of IFN-regulatory factor 3 (IRF-3), a latent cellular trans
80  promoter by blocking the phosphorylation of IFN-regulatory factor 3 (IRF-3), a transcription factor
81       We show that influenza B virus induces IFN regulatory factor 3 (IRF3) activation and IFN-lambda
82 TRIF)-dependent signaling pathway leading to IFN regulatory factor 3 (IRF3) activation and induction
83                          Early activation of IFN regulatory factor 3 (IRF3) and NF-kappaB was observe
84 vation of the cellular transcription factors IFN regulatory factor 3 (IRF3) and signal transducers an
85 Consistent with this, the phosphorylation of IFN regulatory factor 3 (IRF3) and the production of IFN
86 genes, and in all systems examined thus far, IFN regulatory factor 3 (IRF3) has been described as an
87 , TLR4, TLR2/4, MyD88, TRIF, MyD88/TRIF, and IFN regulatory factor 3 (IRF3) KO mice, treated them wit
88     H5N1 viruses elicited significantly less IFN regulatory factor 3 (IRF3) nuclear translocation, as
89 ch inhibit IFN induction by targeting either IFN regulatory factor 3 (IRF3) or NF-kappaB, respectivel
90                                        Using IFN regulatory factor 3 (IRF3) phosphorylation as a mark
91                                              IFN regulatory factor 3 (IRF3) regulates early type I IF
92 PEITC preferentially inhibited TLR3-mediated IFN regulatory factor 3 (IRF3) signaling and downstream
93 ntially reduced binding of these factors and IFN regulatory factor 3 (IRF3) to IFN-beta or ISGs promo
94                                              IFN regulatory factor 3 (IRF3), a constitutively express
95 Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3), a transcription factor c
96 tly of MyD88, resulting in the activation of IFN regulatory factor 3 (IRF3), a transcription factor r
97 B activation and virus-induced activation of IFN regulatory factor 3 (IRF3), whereas bone marrow-deri
98           NSP1beta was found to inhibit both IFN regulatory factor 3 (IRF3)- and NF-kappaB-dependent
99 I interferons (IFNs), despite maintenance of IFN regulatory factor 3 (IRF3)-dependent IFN-stimulated
100  beta interferon (IFN-beta) promoter and the IFN regulatory factor 3 (IRF3)-responsive IFN-stimulated
101 ween the transcription factors NF-kappaB and IFN regulatory factor 3 (IRF3).
102 on in mammalian cells requires activation of IFN regulatory factor 3 (IRF3).
103 ppression of early IFN signaling mediated by IFN regulatory factor 3 (IRF3).
104 promoter activity and induces degradation of IFN regulatory factor 3 (IRF3).
105 FN) response by inhibiting activation of the IFN regulatory factor 3 (IRF3).
106 e-associated pathway, both of which activate IFN regulatory factor 3 (IRF3).
107 nscription directed by constitutively active IFN regulatory factor-3 (IRF3).
108  of several transcription factors, including IFN-regulatory factor 3 (IRF3).
109 K1) and its downstream transcription factor, IFN-regulatory factor 3 (IRF3).
110 y the activation of constitutively expressed IFN regulatory factor 3, IRF3, which in turn leads to th
111 infection, type I IFN signaling by STING and IFN regulatory factor 3 is detrimental to the host durin
112 y, we report that signaling through TBK1 and IFN regulatory factor 3 is required for T. cruzi-mediate
113 nse to a self-Ag, DC-intrinsic expression of IFN regulatory factor 3 is required to induce optimal pr
114  after infection with influenza A virus, but IFN regulatory factor-3 is activated and the transcripti
115  of the transcription factors, NF-kappaB and IFN regulatory factor 3, leading to proinflammatory cyto
116 egatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.
117                We have recently described an IFN regulatory factor 3-mediated antiviral gene program
118 me-edited knockout human cells, we show that IFN regulatory factor 3-mediated IFN induction and downs
119    Functional genetic analyses revealed that IFN regulatory factor 3-mediated pathways that resulted
120                               MOV10 enhanced IFN regulatory factor 3-mediated transcription of IFN.
121  require STING, culminating in activation of IFN regulatory factor 3, NF-kappaB, and p38 MAPK.
122 nal IFN were also produced in VLP-inoculated IFN regulatory factor 3 null (IRF3(-/-)) mice, indicatin
123 pression of TRAM-G2A failed to elicit either IFN regulatory factor 3 or NF-kappaB signaling.
124  dependent on its ability to activate either IFN regulatory factor-3 or NF-kappa B but was dependent
125 ining adaptor inducing interferon (IFN) beta-IFN regulatory factor 3 pathway induce less IL-10, and a
126  domain-containing adapter inducing IFN-beta-IFN regulatory factor 3 pathway is required for Ezrin-de
127  we demonstrate the requirement for the TBK1-IFN regulatory factor-3 pathway in host defense against
128 duced activation of the NF-kappaB, MAPK, and IFN regulatory factor-3 pathways and decreased TLR4 degr
129 G aggregation, and TANK-binding kinase 1 and IFN regulatory factor 3 phosphorylation in inflammasome-
130 ANK-binding kinase-1, resulting in decreased IFN regulatory factor 3 phosphorylation.
131 ocation of MAVS to the cytosol and decreased IFN regulatory factor 3 phosphorylation.
132 nt in melanoma 2, DNA-dependent activator of IFN regulatory factor 3, RNA polymerase III, or high-mob
133 IFN-beta, the TLR3 adaptor protein linked to IFN regulatory factor 3 signaling.
134 r DMXAA leading to TANK-binding kinase 1 and IFN regulatory factor 3 signaling.
135  protein, MAVS, that activates NF-kappaB and IFN regulatory factor 3 to induce type-I interferons.
136 so required for gene induction driven by the IFN regulatory factor 3 transcription factor activated b
137 RIF-dependent pathways through NF-kappaB and IFN regulatory factor 3 transcription factors, respectiv
138                            Consequently, the IFN regulatory factor-3 transcription factor, which is r
139 iates with TANK-binding kinase 1 to regulate IFN regulatory factor 3 translocation and phosphorylatio
140  signaling pathways, IL-15, TNF, IL-1, IL-6, IFN regulatory factor 3, type I IFN receptor, adaptive i
141      Specific interaction between KSHV viral IFN regulatory factor 3 (vIRF3) and the HIF-1 alpha subu
142               The activation of NF-kappaB or IFN regulatory factor 3 was found to be unaffected by th
143 he absence of DOK3, the transcription factor IFN regulatory factor 3 was not phosphorylated and could
144  apoptosis could activate NF-kappa B but not IFN regulatory factor-3, yet the activation of NF-kappa

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