ライフサイエンスコーパス: IFN-gamma

1 IFN-gamma and TNF-alpha also affected expression of seve

2 IFN-gamma blocking antibody administered to Sphk2(-/-) m

3 IFN-gamma enhanced the immunosuppressive capacity of all

4 IFN-gamma has been described to differently affect human

5 IFN-gamma neutralization was achieved by using the anti-

6 IFN-gamma or lipopolysaccharide (LPS) polarizes macropha

7 IFN-gamma primes human MCs to activate T cells through s

8 IFN-gamma production by these lymphocytes likely plays a

9 IFN-gamma repressed genes by suppressing the function of

10 IFN-gamma signaling must carefully calibrate an effectiv

11 IFN-gamma suppressed basal expression of genes correspon

12 IFN-gamma treatment to GCSCs induced ZEB1 expression, at

13 IFN-gamma-inducible protein 16 (IFI16) is an immunologic

14 IFN-gamma-primed MCs guide activation of T cells by Stap

15 IFN-gamma-secreting cells were most abundant early and I

16 otaxin-1), CXCL1 (GROalpha), CXCL10 (IP-10), IFN-gamma, IL-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, le

17 L-17 production and the emergence of IL-17(+)IFN-gamma(+) double producers.

18 We discovered a significant IL-17A(+)IFN-gamma(+) (Th17/1) population and determined that the

19 IL-4, IFN-gamma, and TNF-alpha enhanced mucosal permeability i

20 ctors and output of cytokines, such as IL-4, IFN-gamma, IL-17, and IL-10.

21 skewed Th2-type secretion profile (high IL-4/IFN-gamma ratio).

22 atopy was associated with an increased IL-5/IFN-gamma ratio.

23 inflammatory cytokines and chemokines (IL-6, IFN-gamma, TNF-alpha, CXCL1, and CCL2) and extensive spl

24 tokines that demonstrated either high (IL-8, IFN-gamma, IL-2, IL-6, and IL-1beta) or low (IL-15, TNF-

25 uld improve T cell responses by accentuating IFN-gamma-directed immune responses.

26 Finally, cultured fibroblasts activated IFN-gamma and IL-17A cytokine production by autologous,

27 transfer of Th1 cells, opposite to activated IFN-gamma(-/-) Th cells, partially reconstituted CF and

28 cond locus on chromosome region 3q affecting IFN-gamma production triggered by the 6-kDa early secret

29 MSC morphology after IFN-gamma stimulation significantly correlated with immu

30 inactivation in oligodendrocytes aggravated IFN-gamma-induced remyelinating oligodendrocyte death an

31 roduction of three key cytokines: TNF-alpha, IFN-gamma, and IL-2.

32 expression of inflammatory genes (TNF-alpha, IFN-gamma, IL-1beta, IL-6, and CCL2 mRNAs), and attenuat

33 inflammatory cytokines, including TNF-alpha, IFN-gamma, IL-6, and CCL2.

34 ke up soluble and particulate antigens in an IFN-gamma-independent manner.

35 ulture conditions in vitro, as well as in an IFN-gamma-rich inflammatory environment in vivo, Th22 ce

36 to drive switching of Th17 cells towards an IFN-gamma-producing phenotype.

37 nterval [CI], 1.4,1.7], P value < .0001) and IFN-gamma ELISPOT (estimated GMFR = 2.0 [95% CI, 1.6,2.6

38 a markedly increased production of IL-12 and IFN-gamma, but not of TNF-alpha, IL-6, and IL-8 upon sub

39 CD4 T cells were then analyzed for IL-13 and IFN-gamma expression.

40 sis specific and secreted IL-17 or IL-17 and IFN-gamma.

41 eral blood IFN-gamma(+)IL-17(+) (TH1/17) and IFN-gamma(-)IL-17(+) (TH17) CD4(+) T cells display disti

42 surface autoimmunity through both IL-17A and IFN-gamma.

43 ) in the bronchoalveolar fluid, and IL-2 and IFN-gamma cytokines in restimulated splenocyte cultures.

44 ein family, such as absent in melanoma-2 and IFN-gamma-inducible protein (IFI)16, bind dsDNA and form

45 IL-21 and IFN-gamma are coexpressed by Tfh cells during viral infe

46 gside STAT4 to coordinate Tfh cell IL-21 and IFN-gamma production and for promotion of the GC respons

47 mulation of Tfh cells coexpressing IL-21 and IFN-gamma, and suppressed their production of the latter

48 rated significantly lower levels of IL-6 and IFN-gamma (p < 0.0001), which is likely to have resulted

49 le factors, including IL-21, IL-4, IL-9, and IFN-gamma.

50 nsferred CTLs enhances T cell activation and IFN-gamma production in vitro, leading to a significant

51 emonstrate the critical roles of T cells and IFN-gamma in mediating splenic cell apoptosis, parasitem

52 d, as exemplified by their T-bet, CXCR3, and IFN-gamma expression.

53 DENV) was tested using IFN-gamma-ELISPOT and IFN-gamma-ICS on CD8(+) T cells from DENV-infected mice,

54 isease pathogenesis depends on IFN-gamma and IFN-gamma-induced chemokines to promote T-cell recruitme

55 Levels of IFN-gamma and IFN-gamma-inducible chemokines were evaluated by using r

56 cytotoxic T lymphocyte-associated genes and IFN-gamma-inducible chemokines, including CXCL10, in IDH

57 We evaluated tryptophan, indole, and IFN-gamma levels in cervicovaginal lavages from women wi

58 The mTORC1 and IFN-gamma production defects were partially rescued by s

59 ighest level of lymphocyte proliferation and IFN-gamma production.

60 aforementioned cellular immune response and IFN-gamma production.

61 Notably, cytokines IL-6, TNF, and IFN-gamma and chemokines CCL2, CCL3, and CCL4 have been

62 n-2 [IL-2], tumor necrosis factor [TNF], and IFN-gamma) and memory phenotypes (CD27, CD45RA).

63 Some HMOBs were pretreated with an anti-IFN-gamma antibody before PGE2 stimulation.

64 This ET-1 production was inhibited by anti-IFN-gamma and/or TNF-alpha antibody.

65 tion, effects abrogated by neutralizing anti-IFN-gamma antibodies.

66 Additionally, in the presence of anti-IFN-gamma antibodies, SAHM1 downregulated expression of

67 Administration of anti-IFN-gamma antibody led to a decrease in IFN-gamma-positi

68 In mice with MAS, treatment with the anti-IFN-gamma antibody significantly decreased circulating l

69 eutralization was achieved by using the anti-IFN-gamma antibody XMG1.2 in vivo.

70 tion, while PD-1 blockade strongly augmented IFN-gamma, interleukin-2 (IL-2), and TNF-alpha productio

71 eline CD8(+) T cell infiltration or baseline IFN-gamma signature.

72 As bat IFN-gamma induced the type I IFN pathway, its antiviral

73 In the absence of T-bet, IFN-gamma aberrantly induced a type I IFN transcriptomic

74 GAPDH, 3-bromopyruvic acid (3-BrPa), blocks IFN-gamma, but not IL-17A, production in immune cells is

75 Here we show that human peripheral blood IFN-gamma(+)IL-17(+) (TH1/17) and IFN-gamma(-)IL-17(+) (

76 lpha and/or MCP-1 induced expression of both IFN-gamma and IL-27.

77 ay a T cell-intrinsic role in promoting both IFN-gamma and interleukin-17A production during infectio

78 immunological imbalance of Tregs and CD4(+) IFN-gamma(+) cells in the lacrimal gland.

79 gnificant numbers of antigen-specific CD8(+) IFN-gamma-positive cells following injection into BALB/c

80 reased latency; and also increased CD4, CD8, IFN-gamma, and PD-1 transcripts in the TG of latently in

81 ters, including TLRs, B cells, CD4(+) cells, IFN-gamma, and NO, on the level of parasitemia and paras

82 t observed in mice deficient in CD8 T-cells, IFN-gamma or perforin.

83 uced by type II IFN, and the use of chimeric IFN-gamma-sensitive/resistant viruses indicates that int

84 w that within the hematopoietic compartment, IFN-gamma causes ECM by acting redundantly or by targeti

85 The T cell-inflamed GEP contained IFN-gamma-responsive genes related to antigen presentati

86 or locus on chromosome region 8q controlling IFN-gamma production after stimulation with live BCG (Ba

87 One of the crucial IFN-gamma target genes required for control of M. tuberc

88 f several proinflammatory cytokines (GM-CSF, IFN-gamma, IL-1beta, IL-6, and IL-8) across stimuli, a h

89 l tubule cells to the inflammatory cytokines IFN-gamma and TNF-alpha led to inhibition of HNF-1beta t

90 f HDLECs with the pro-inflammatory cytokines IFN-gamma and TNF-alpha synergistically up-regulated PD-

91 expression of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta and RANTES and activation

92 increased production of protective cytokines IFN-gamma, TNF-alpha, and IL-12, as well as recruitment

93 Proinflammatory cytokines, IFN-gamma and IL-17A, produced by T cells contribute syn

94 y as a novel inborn error of IL-12-dependent IFN-gamma immunity associated with susceptibility to par

95 IL-18 production, and lacked NK cell-derived IFN-gamma.

96 interferon (IFN)-gamma or epithelial-derived IFN-gamma in constitutively released or Porphyromonas gi

97 IFN-gamma or with conditioned media-derived IFN-gamma exhibited low levels of Cathepsin K, TRAP, RAN

98 the disease-amplifying role of Th17-derived IFN-gamma in DED pathogenesis.

99 mmatory lymphocytes in diabetes development, IFN-gamma production could represent an attempted limita

100 Genetic ablation of either IFN-gamma signaling or T-bet expression in B cells subst

101 sus unstimulated organoid cultures, elevated IFN-gamma reduced the mRNAs encoding for RANKL, TRAP, an

102 nd decreased expression of the gene encoding IFN-gamma, a known Treg inducer.

103 Identification of excessive IFN-gamma production by blood and lymph node-derived T c

104 Administration of exogenous IFN-gamma or -alpha to CAST mice before or during the fi

105 ation in young, developing mice that express IFN-gamma ectopically in the CNS (both sexes).

106 te-like cells present in the liver expresses IFN-gamma and can confer protection against M. avium inf

107 psis by activating NK cells and facilitating IFN-gamma production.

108 d high levels of the proinflammatory factors IFN-gamma, TNF-alpha, and inducible NO synthase in the T

109 for IL-10, TIM-4(+) B cells are enriched for IFN-gamma.

110 Thus, a novel antiviral mechanism for IFN-gamma has been revealed.

111 8(+) T cell profile of up to four functions (IFN-gamma(+)IL-2(+)Perforin(+)Granzyme B(+)).

112 Recombinant interferon gamma (IFN-gamma) therapy is inefficient, and hematopoietic ste

113 ent premature induction of interferon-gamma (IFN-gamma) expression in T cells and to generate pathoge

114 tations in genes affecting interferon-gamma (IFN-gamma) immunity have contributed to understand the r

115 CD8+ T-cell production of interferon-gamma (IFN-gamma) in response to CMV antigens measured by Quant

116 also known as Gate-16), in interferon-gamma (IFN-gamma)-mediated antimicrobial responses.

117 rowth inhibition occurs by interferon-gamma (IFN-gamma)-mediated depletion of intracellular tryptopha

118 hat preferentially produce interferon-gamma (IFN-gamma).

119 production of the cytokine interferon-gamma (IFN-gamma).

120 Individuals with no known Mtb exposure had IFN-gamma values less than 0.2 IU/ml.

121 ur phenotypic findings, we observed a higher IFN-gamma production in peripheral CD4 memory T cells an

122 s, and when this occurred we observed higher IFN-gamma and TNF-alpha production than in nonblocked co

123 ct from Salmonella infection by priming host IFN-gamma responses.

124 This study addresses how IFN-gamma can suppress activation of diabetogenic CD8(+)

125 ctively, our data provide information on how IFN-gamma mediates the development of cerebral pathology

126 However, IFN-gamma can also participate in tolerance-induction pa

127 When activated in vitro, however, IFN-gamma production by naive wild type and tristetrapro

128 ocytes treated either with recombinant human IFN-gamma or with conditioned media-derived IFN-gamma ex

129 mproved in the presence of recombinant human IFN-gamma, but not rhIL-12.

130 a/beta interferon (IFN-alpha/beta) (type I), IFN-gamma (type II), and IFN-lambda (type III).

131 n sites was tested for the ability to impair IFN-gamma expression.

132 pSTAT4, nuclear translocation, and impaired IFN-gamma production.

133 Importantly, IFN-gamma exposure during activation reduced the cytotox

134 anti-IFN-gamma antibody led to a decrease in IFN-gamma-positive cells, and an increase in IL-5-positi

135 in mice with a macrophage-specific defect in IFN-gamma signaling (termed mice with macrophages insens

136 The physiological role of these proteins in IFN-gamma signaling has not been clarified.

137 itulating CAVD microenvironment, resulted in IFN-gamma release.

138 ultiple T-cell effector cytokines, including IFN-gamma, IL-17, and IL-21.

139 Increased IFN-gamma production was accompanied by a poor germinal

140 Neutralization of IL-10 increased IFN-gamma, IL-6 and TNF-alpha production and improved ba

141 CTLA-4 blockade increased IFN-gamma and CD40L production, while PD-1 blockade stro

142 g by allergen-IgE immune complexes increased IFN-gamma production in B cells of allergic patients dur

143 ector CD8(+), CD4(+) T cells, with increased IFN-gamma, ICOS, granzyme B and perforin expression.

144 icient surrogates) indicated that individual IFN-gamma-induced chemokines have diverse affects and (i

145 irway obstruction is associated with induced IFN-gamma- and IL-10-producing regulatory CD4(+)CD25(+)

146 gressive disease, we observed that inducible IFN-gamma and natural cytotoxicity receptor (NCR) expres

147 SV-1 reactivation in latently HSV-1-infected IFN-gamma-KO mice.

148 e maturation of Th17 cells into inflammatory IFN-gamma-coproducing effector cells.

149 SCFAs inhibited IFN-gamma and IL-17A production in peripheral blood mono

150 We screened the gamma interferon (IFN-gamma) and interleukin-10 (IL-10) responses to 6 HCM

151 n-17A (IL-17A), IL-22, and gamma interferon (IFN-gamma) as well as the antimicrobial peptides CRAMP a

152 he livers of C57BL/6 mice, gamma interferon (IFN-gamma) controls intracellular Leishmania donovani in

153 pe mice were injected with gamma interferon (IFN-gamma) DNA or colony-stimulating factor 1 (CSF-1) DN

154 creased mitogen-stimulated gamma interferon (IFN-gamma) production suggested immunomodulation, which

155 this study, we report that gamma interferon (IFN-gamma) treatment, but not IFN-alpha, -beta, or -lamb

156 ed increased production of gamma interferon (IFN-gamma), IL-5, IL-9, IL-17, and IL-22 and decreased p

157 fected BALB/c mice elicits gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and

158 erebral malaria (ECM) is a gamma interferon (IFN-gamma)-dependent syndrome.

159 at antigen-specific CD8(+) gamma interferon (IFN-gamma)-positive T-cell responses are essential for r

160 ) T cells and Gag-specific gamma interferon (IFN-gamma)-secreting CD8(+) cells, low virus-specific CD

161 Furthermore, gamma interferon (IFN-gamma)-stimulated primary peritoneal neutrophils (PP

162 uction of TLR8-dependent type II interferon (IFN-gamma), TNF-alpha, and IL-12 in myeloid dendritic ce

163 , IL-4, IL-10, IL-17A, and gamma interferon [IFN-gamma]) and rendered T cells refractory to mitogen f

164 antigen-stimulated type 1 (gamma interferon [IFN-gamma], tumor necrosis factor alpha [TNF-alpha], and

165 es or adults, can further differentiate into IFN-gamma-producing CD4(+) T cells.

166 nsic IL-10 enhances whereas B cell-intrinsic IFN-gamma and T-bet suppress GC B cell responses and ant

167 and to control the viral infection involving IFN-gamma secretion.

168 g2(-/-) mice, whereas Rag2(-/-) mice lacking IFN-gamma are more susceptible than either Rag2(-/-) or

169 ears in mice depleted of NK cells or lacking IFN-gamma, and was mimicked by exogenous interleukin-15

170 mpartment with lymphocytes, we observed less IFN-gamma and TNF-alpha production and T lymphocyte prol

171 age of activated NK cells that produced less IFN-gamma upon coculture with M2.

172 rom T cell Notch-deprived mice produced less IFN-gamma, IL-5, and IL-13 than wild-type cells.

173 We showed that naive CAST mice make low IFN-gamma and TNF-alpha responses and have low levels of

174 r tryptophan levels and trended toward lower IFN-gamma levels compared to women with persisting infec

175 cells activated in such a context are mainly IFN-gamma(+), adhere to CFB, and induce their transition

176 h1 and Th17 cells, and inflammatory markers (IFN-gamma, TNF-alpha, and IL-17) in mice with dextran so

177 Flow cytometry was used to measure IFN-gamma, IL-13, IL-9, IL-17, and IL-22 cytokines in CD

178 Mechanistically, IFN-gamma disassembled a subset of enhancers by inducing

179 We revealed that in mMSCs IFN-gamma-induced immunoregulation is mediated by early

180 ation and in a model in which we neutralized IFN-gamma during HDM challenge to support the TH2 respon

181 novel and rare population of nonconventional IFN-gamma-producing cells of hematopoietic origin that w

182 tely restored Th cell proliferation, but not IFN-gamma production.

183 y T (TEM) cells that secrete IL-17A, but not IFN-gamma, was responsible for early IL-17A production.

184 expressing thymomas, produce high amounts of IFN-gamma and sensitize tumors to PD-1/programmed cell d

185 ployed Flow-FISH for single-tube analysis of IFN-gamma transcript and protein profile to simultaneous

186 T cell effectors defined by coexpression of IFN-gamma, IL-2, and CD107a after vaccination.

187 Distributions of IFN-gamma response levels were analyzed in healthy adole

188 s (ISGs) and mediating signals downstream of IFN-gamma.

189 was linked to diminished early expression of IFN-gamma along with profound suppression of CCL2 and CC

190 nd TNF production yet retained expression of IFN-gamma and regulatory T cell-recruiting chemokines.

191 , the magnitude and subsequent expression of IFN-gamma, and of IL-2, depends on calcium-induced de no

192 There were elevated frequencies of IFN-gamma and IL-17A-producing effector T cell populatio

193 This correlated with lower frequencies of IFN-gamma-, IL-5-, and IL-13-producing CD4(+) T cells, r

194 body response, it augmented the frequency of IFN-gamma secreting total T cells, T-helper and CTLs aga

195 tion site mutants still support induction of IFN-gamma expression; however, simultaneous mutation of

196 romoting: (i) early correlated inhibition of IFN-gamma and TNF-alpha production, along IL-10 increase

197 Levels of IFN-gamma and IFN-gamma-inducible chemokines were evalua

198 on, which is characterized by high levels of IFN-gamma.

199 s, and morphology predicted the magnitude of IFN-gamma-enhanced immunosuppressive activity.

200 his was confirmed by in vitro measurement of IFN-gamma production by activated T cells.

201 was steroid-resistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced

202 y depletion of T cells and neutralization of IFN-gamma.

203 The percentage of IFN-gamma-producing CD4(+) and CD8(+) T cells increased

204 t cancer cell clones only in the presence of IFN-gamma within the tumour microenvironment.

205 pathways are both involved in the process of IFN-gamma-regulated odonto/osteogenic differentiation of

206 Production of IFN-gamma and IL-27 was steroid-resistant, and neutraliz

207 T cells and CD8(+) T cells and production of IFN-gamma and IL-4, in an Ag-independent manner.

208 al blood and display increased production of IFN-gamma and IL-4.

209 e of stimulation decreased the production of IFN-gamma and TNF-alpha, T cell proliferation, and the e

210 s, Tbet and GATA3, and reduced production of IFN-gamma by CD8(+) T cells.

211 tro studies confirmed that the production of IFN-gamma by differentiated Th1 cells is more sensitive

212 tic cells (cDC1) promoted ILC1 production of IFN-gamma in a STAT4-dependent manner to limit early vir

213 se exhibited by the individual production of IFN-gamma or IL-2, and a multifunctional CD8(+) T cell p

214 Also, the initial production of IFN-gamma uses translation of preformed mRNA.

215 sponse is characterized by the production of IFN-gamma, and polyfunctional Th1 responses are associat

216 -bet is important for Tfh cell production of IFN-gamma, but not IL-21, and for a robust GC reaction.

217 Tbet, Gata3 and ROR-gammat and production of IFN-gamma, IL-4 and IL-17, respectively.

218 iltrate and increased specific production of IFN-gamma, IL-4, and IL-10.

219 y have contributed to understand the role of IFN-gamma in protection against intracellular pathogens.

220 and antigens caused by reduced secretion of IFN-gamma and IL-2.

221 revealing a disease-associated signature of IFN-gamma-mediated repression.

222 , double-blind, placebo-controlled trials of IFN-gamma-1b in idiopathic pulmonary fibrosis (GIPF-001

223 Disease pathogenesis depends on IFN-gamma and IFN-gamma-induced chemokines to promote T-

224 se cell types with interferon (IFN)-alpha or IFN-gamma induced SAMD9L expression.

225 xin shock, which was prevented by NK cell or IFN-gamma depletion.

226 activated CD4(+) Foxp3(-) (forkhead box P3) IFN-gamma(+) T cells in the heart-draining lymph nodes.

227 had a reduced proportion of polyfunctional (IFN-gamma+/tumor necrosis factor alpha-positive) CD4+ an

228 , vaccine-induced gamma interferon-positive (IFN-gamma(+)) Gag-specific T-cell responses were dominat

229 ap70(low)Syk(low) NK cells failed to produce IFN-gamma and lysed target cells at one third the capaci

230 h1 cells because of their ability to produce IFN-gamma, similar to Th1 cells; however, it is unclear

231 me B and maintained their ability to produce IFN-gamma.

232 vation of a T-cell CD4+ population-producing IFN-gamma.

233 Disease-protective IFN-gamma could be derived from any lymphocyte source an

234 isease phenotypes were rescued in RAG2(-/-), IFN-gamma(-/-), or T cell depleted mice, suggesting IFN-

235 ndent sites results in significantly reduced IFN-gamma expression.

236 Impaired metabolism underlies the reduced IFN-gamma production observed in activated RTEs.

237 Epithelial cells constitutively released IFN-gamma, which was substantially increased by PgLPS.

238 elial cells interact with HMOBs by releasing IFN-gamma to regulate RANKL expression and contribute to

239 Modification of relevant IFN-gamma-dependent pathways in mMSCs was carried out in

240 Macrophages require IFN-gamma signaling to mediate protection, which ultimat

241 hat BC-CML and AML MHC upregulation required IFN-gamma stimulation, whereas CP-CML MHC upregulation w

242 , and Blimp-1, and that more of them secrete IFN-gamma and readily degranulate than non-ThCTL.

243 cells from healthy volunteers also secreted IFN-gamma, IL-13, IL-22, and cytolytic molecules.

244 letion of donor CD4+ T cells increased serum IFN-gamma but reduced IL-2 concentrations, leading to up

245 eated WT mice showed upregulation of several IFN-gamma-inducible genes.

246 Th2 and Tc2 clustered with disease severity, IFN-gamma producing cells were linked with AA duration.

247 ng a panel of cell- and compartment-specific IFN-gamma receptor 2 (IFN-gammaR2)-deficient mice, we sh

248 contact hypersensitivity and hapten-specific IFN-gamma-producing effector T cells.

249 discrete subset of M. tuberculosis-specific IFN-gamma(+)IL-2(-)TNF-alpha(+) CD4 T cells.

250 t into gammadeltaT17 cells and remain stable IFN-gamma producers (gammadeltaT1 cells).

251 IL-18 and are unable to optimally stimulate IFN-gamma production by NK cells.

252 DNA given by IM + EP promoted strong IFN-gamma responses and potent viral inhibition.

253 ma(-/-), or T cell depleted mice, suggesting IFN-gamma and T cell mediated disease mechanisms.

254 cute gammaherpesvirus infection and supports IFN gamma-mediated suppression of viral replication.

255 ated Treg cells induced IL-13 but suppressed IFN-gamma expression in OVA-specific CD4 Tcon cells.

256 optotic gene expression, thereby suppressing IFN-gamma-mediated monocyte and/or macrophage cell death

257 st in vitro system, we show that synergistic IFN-gamma and tumor necrosis factor (TNF) stimulation pr

258 tions, because topical therapies that target IFN-gamma signaling in keratinocytes could be safe and e

259 dividuals who had a change in QuantiFERON-TB IFN-gamma values from less than 0.2 to greater than 0.7

260 ed in serum of both diseases, including Th1 (IFN-gamma, CXCL9, TNF-beta) and Th17 (CCL20) markers.

261 se progression and illustrates that Th1/Th2 (IFN-gamma/ELISA antibodies) assays are important for inf

262 ed susceptibility to EAE, demonstrating that IFN-gamma signaling in DCs mediates their tolerogenic fu

263 Mechanistic analyses reveal that IFN-gamma induces CD70 expression in T cells, and CD70 l

264 2 (IFN-gammaR2)-deficient mice, we show that IFN-gamma causes ECM by signaling within both the hemato

265 Our data show that IFN-gamma induces HLA class II, HLA-DM, CD80, and CD40 e

266 This study showed that IFN-gamma is a master checkpoint regulator for many cyto

267 thout IFN-gamma stimulation, suggesting that IFN-gamma sensitizes these leukemias to T cell killing b

268 The IFN-gamma+CD8+ T cells remained stable in both groups.

269 gen target (ESAT-6), taking into account the IFN-gamma production induced by BCG (IFNgamma-ESAT6BCG).

270 MHC upregulation was independent of both the IFN-gamma receptor (IFN-gammaR) and the IFN-alpha/beta r

271 Thus, glutamine may enhance the IFN-gamma-associated immune response and reduce the rate

272 ly, when Smad7-deficient DCs also lacked the IFN-gamma receptor, the mice regained susceptibility to

273 MAS showed a significant upregulation of the IFN-gamma pathway, as demonstrated by increased mRNA lev

274 r and spleen and increased expression of the IFN-gamma-inducible chemokines Cxcl9 and Cxcl10 in the l

275 n in group 1 ILCs is required to limit their IFN-gamma production, thereby allowing the development o

276 esting a potential protective role for these IFN-gamma-producing cells.

277 low) B cells might serve as a marker of this IFN-gamma-associated dysregulation.

278 n induced by T cells upon activation through IFN-gamma and TNF-alpha.

279 Neutralizing Ab to IFN-gamma, but not IL-17, inhibited nevus development (p

280 Exposure of cells to IFN-gamma has been shown to trigger the expression of pr

281 vivo transition of pathogenic Th17 cells to IFN-gamma producers.

282 A sustained exposure to IFN-gamma led to inhibition of STAT3 activity, which in

283 (termed mice with macrophages insensitive to IFN-gamma [MIIG mice]).

284 (IFN) transcriptional program in response to IFN-gamma signaling.

285 o TNF, by IL-6 via STAT3, and in response to IFN-gamma.

286 oreover, we show that exposure of tumours to IFN-gamma-producing antigen-specific CTLs in vivo result

287 h22 cells displayed marked plasticity toward IFN-gamma production.

288 tumors, Pr20 binding markedly increased upon IFN-gamma treatment, mediated by induction of the immuno

289 Furthermore, using IFN-gamma-deficient Th17 cells, we demonstrate the disea

290 opes to dengue virus (DENV) was tested using IFN-gamma-ELISPOT and IFN-gamma-ICS on CD8(+) T cells fr

291 tastasis and s.c. tumor growth, and this was IFN-gamma dependent.

292 lpha/beta production in human blood, whereas IFN-gamma and TNF-alpha induction is largely TLR8-depend

293 elevant intracellular pathways through which IFN-gamma affects MSC plasticity and the consequence of

294 ts, correlating with disease severity, while IFN-gamma is linked to disease chronicity.

295 Among individuals with IFN-gamma values less than 0.2 IU/ml, 0.2-0.34 IU/ml, 0.

296 We found that injection of mice with IFN-gamma DNA, which enhances the development of M1 macr

297 ells and ex-vivo atherosclerotic tissue with IFN-gamma and TNF-alpha and found they synergistically i

298 DPSCs treated with IFN-gamma and supplemented with pyrrolidine dithiocarbam

299 including oncogenic types, by treatment with IFN-gamma, an antiviral cytokine that is released from s

300 AML and BC-CML stem cells were MHCI+ without IFN-gamma stimulation, suggesting that IFN-gamma sensiti