ライフサイエンスコーパス: IFN-stimulated gene

1 e CXCL10, which is considered an interferon (IFN)-stimulated gene.

2 ne response associated with the induction of IFN-stimulated genes.

3 rols IFN signaling and thereby expression of IFN-stimulated genes.

4 at leads to the transcription of hundreds of IFN-stimulated genes.

5 arietal epithelial cells to express numerous IFN-stimulated genes.

6 duced expression of IFN-beta, IFN-lambda and IFN-stimulated genes.

7 fecting expression of IFN-beta-stimulated or IFN-stimulated genes.

8 mediate-early induction of IFN-beta mRNA and IFN-stimulated genes.

9 hosphorylated STAT1 and the transcription of IFN-stimulated genes.

10 nferred sustained signaling and induction of IFN-stimulated genes.

11 mediate-early induction of beta IFN mRNA and IFN-stimulated genes.

12 low levels of type III IFN protein activate IFN-stimulated genes.

13 production of type I IFN and some classical IFN-stimulated genes.

14 esponsible for feed-forward amplification of IFN-stimulated genes.

15 g proinflammatory cytokines, chemokines, and IFN-stimulated genes.

16 ession of costimulatory molecules and type I IFN-stimulated genes.

17 s increases the expression of IFNbeta and of IFN-stimulated genes.

18 ons (IFNs) and the activation of hundreds of IFN-stimulated genes.

19 e in the transcription of type I interferon (IFN)-stimulated genes.

20 The ubiquitin-like interferon (IFN)-stimulated gene 15 (ISG15) and its specific E1, E2,

21 Interferon (IFN)-stimulated gene 15 (ISG15) is a ubiquitin-like mole

22 10 (IP-10), chemokine ligand 5 (CCL-5), and IFN-stimulated gene 15 (ISG15) expression levels were de

23 IFN-stimulated gene 15 (ISG15) is a ubiquitin homolog th

24 Of these, IFN-stimulated gene 15 (ISG15) is one of the most upregu

25 IFN type I signature with activation of the IFN-stimulated gene 15 (ISG15) pathway.

26 The IFN-stimulated gene 15 (ISG15) system emerges as a major

27 IFN-stimulated gene 15 (ISG15), an IFN-induced ubiquitin

28 n the generation of IFN responses, including IFN-stimulated gene 15 (ISG15), p21(WAF1/CIP1), and Schl

29 on and phosphorylation of STAT molecules and IFN-stimulated gene 15 (ISG15).

30 Minimal IFN-stimulated gene 15 and IFIT1 responses peaked 1-2 wk

31 strate that IFN-inducible eIF4B activity and IFN-stimulated gene 15 protein (ISG15) or IFN-gamma-indu

32 6, IFN-inducible transcript 2/P54, IL-8, and IFN-stimulated gene 15.

33 ubiquitinating and deISGylating (interferon [IFN]-stimulated gene 15 [ISG15]-removing) enzymes on hos

34 ases production of IFNbeta and expression of IFN-stimulated genes 48 h after infection.

35 he IFN regulatory factor 3 (IRF3)-responsive IFN-stimulated gene 54 promoter.

36 appeared not to correlate with induction of IFN-stimulated genes 54 and 56, which were detected in h

37 HCV infection in IHH enhanced IFN-beta and IFN-stimulated gene 56 (ISG56) promoter activities; howe

38 nhibitors also showed the ability to inhibit IFN-stimulated gene 56 induction mediated by TLR4 and TL

39 Using the IFN-stimulated gene 56 promoter-driven firefly luciferas

40 A, 2',5'-oligoadenylate synthetase, and the IFN-stimulated gene 56.

41 RNA knockdown of Socs-1 resulted in induced IFN-stimulated gene-56 and Tlr7 expression following WNV

42 ere attributed to overexpression of Tlr7 and IFN-stimulated gene-56 expression, whereas reduced expre

43 ith an increase in type I IFN production and IFN-stimulated gene accumulation upon infection.

44 the transcriptional induction of hundreds of IFN-stimulated genes, among them sensory pathway compone

45 ading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (

46 e I IFN, as measured by a marked increase in IFN-stimulated genes and a decrease in HCV load.

47 lasts exhibited constitutive upregulation of IFN-stimulated genes and an enhanced type I IFN response

48 The induction of type I IFNs, IFN-stimulated genes and dendritic cell maturation by ch

49 y developed as mESCs express lower levels of IFN-stimulated genes and display weaker antiviral activi

50 emory T cells showed up-regulation of type 1 IFN-stimulated genes and inhibition with histone methylt

51 tent transcription factor of type I IFNs and IFN-stimulated genes and is known as the master regulato

52 ct-acting antiviral normalizes expression of IFN-stimulated genes and NK cell function.

53 WHSC1 and HIRA co-occupied IFN-stimulated genes and supported prolonged H3.3 incorp

54 is primarily mediated through activation of IFN-stimulated genes and T-cell effector mechanisms.

55 cells with etoposide led to the induction of IFN-stimulated genes and the IFN-alpha and IFN-lambda ge

56 type I IFN, despite similar upregulation of IFN-stimulated genes and viral restriction factors.

57 AT pathways, by allowing mRNA translation of IFN-stimulated genes and, ultimately, the induction of t

58 ted a potent interferon-lambda (IFN-lambda), IFN-stimulated gene, and cytokine response in HepG2-HFL

59 duced phosphorylated STAT1, transcription of IFN-stimulated genes, and antitumor activity.

60 nfection, transcription of interferon (IFN), IFN-stimulated genes, and inflammatory genes was induced

61 are able to respond to type I IFNs, express IFN-stimulated genes, and mediate the antiviral effect o

62 ense mechanism through the induction of IFN, IFN-stimulated genes, and other proinflammatory cytokine

63 expression of IFN-alpha, IFN-beta, multiple IFN-stimulated genes, and T cell-polarizing factors with

64 of type I IFN signaling, the highly related IFN-stimulated genes Apolipoprotein L9a and b activate e

65 Specifically, a subset of type I IFN-stimulated genes are not activated in the absence of

66 Enhanced expression of LGP2 suppresses the IFN stimulated genes associated with cytotoxic stress by

67 lpha results in the induction of a subset of IFN-stimulated genes associated with antiviral activity

68 IEGs include not only IFN-stimulated genes, but other nontranscriptionally ind

69 ex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kin

70 interferons (IFNs) induce the expression of IFN-stimulated genes by activating phosphorylation of bo

71 ht to limit the induction of type I IFNs and IFN-stimulated genes by shutting off host cell macromole

72 that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) a

73 FN-beta, myxovirus resistance protein A, and IFN-stimulated genes, compared with C-HIV and CI-HIV.

74 Expression of a set of IFN-stimulated genes comprises an IFN-related DNA damage

75 Additionally, the IFN-stimulated genes Cxcl10, Ifit1, Ifit3, and Mx2 can b

76 L1 also increased the expression of multiple IFN-stimulated genes, directly implicating BAL1 in an IF

77 mCMV infection induced interferon (IFN)-stimulated gene expression by 10- to 100-fold in bo

78 virus along with IFN-beta and IFN-lambda and IFN-stimulated gene expression (tracked by 2'-5'-oligoad

79 A5 restricted HRV infection while increasing IFN-stimulated gene expression and IFN-beta/lambda.

80 h RIG-I signaling reduced IFN production and IFN-stimulated gene expression and increased viral repli

81 leads to persistently high levels of type I IFN-stimulated gene expression and to increased resistan

82 Moreover, analysis of IFN-stimulated gene expression by real-time PCR demonstr

83 solution of type I IFN (IFN-I) responses and IFN-stimulated gene expression during the acute-to-chron

84 JFH-1) infection fails to induce IFN-beta or IFN-stimulated gene expression in Huh-7 cells, and that

85 temic antiviral activity and upregulation of IFN-stimulated gene expression in the upper respiratory

86 IFN signaling correlated with an increase in IFN-stimulated gene expression levels during HEV replica

87 This suppression of IFN-stimulated gene expression occurred because IFN sign

88 Furthermore, these IFNs induced IFN-stimulated gene expression predominantly in monocyte

89 n-deficient UV-irradiated virus, and IFN and IFN-stimulated gene expression was determined by quantit

90 uring or shortly before maximal intrahepatic IFN-stimulated gene expression, but disappeared prior to

91 s not only provoke type I IFN production and IFN-stimulated gene expression, mirroring the response o

92 lls were impaired in their ability to induce IFN-stimulated gene expression, which resulted in enhanc

93 nnate immune response including intrahepatic IFN-stimulated gene expression.

94 both viral proteins impacting 'globally' on IFN-stimulated gene expression.

95 on is associated with upregulation of type I IFN-stimulated gene expression.

96 iption (STAT1), and a general enhancement of IFN-stimulated gene expression.

97 correlated well with functional activity and IFN-stimulated gene expression.

98 ranscription factor central for IFN-beta and IFN-stimulated gene expression.

99 nterferon (IFN-alpha) treatment by impairing IFN-stimulated gene expression.

100 gh the IFN-lambda receptor complex, activate IFN stimulated gene factor 3, and are capable of inducin

101 STAT-1, but not other members of interferon (IFN)-stimulated gene factor 3 (ISGF-3) complex such as S

102 imeric transcription factor complex known as IFN-stimulated gene factor 3 (ISGF3) and the subsequent

103 ponse elements (ISREs) that bind to both the IFN-stimulated gene factor 3 (ISGF3) as well as to IFN r

104 triggered Jak-STAT pathway by binding of the IFN-stimulated gene factor 3 (ISGF3) complex to the ISRE

105 ptosis of macrophages proceeds through tonic IFN-stimulated gene factor 3 (ISGF3) signaling, which le

106 , leading to formation of the heterotrimeric IFN-stimulated gene factor 3 (ISGF3) transcription compl

107 -alpha and IFN-beta) induces the assembly of IFN-stimulated gene factor 3 (ISGF3), a multimeric trans

108 the involvement of JAK1 and TYK2, as well of IFN-stimulated gene factor 3 (ISGF3).

109 ers, gene transcription was mainly driven by IFN-stimulated gene factor 3 (ISGF3).

110 with type I IFNs activates the formation of IFN-stimulated gene factor 3 (STAT1/STAT2/IFN regulatory

111 related with high levels of unphosphorylated IFN-stimulated gene factor 3 (U-ISGF3), which was previo

112 ction of antiviral genes that are induced by IFN-stimulated gene factor 3 and associated with a type

113 ulatory factor 9, a central component of the IFN-stimulated gene factor 3 complex.

114 In this study, we show that IFN-stimulated gene factor 3 containing unphosphorylated

115 Although the identical transcription factor, IFN-stimulated gene factor 3 is activated by either IFN-

116 These data show that IFN-stimulated gene factor 3 or STAT1 homodimers are not

117 While activation of IFN-stimulated gene factor 3 produces a dominant inhibit

118 TAT1- and STAT2-containing complexes such as IFN-stimulated gene factor 3.

119 ISRE), which in other genes bind IRF3 or the IFN-stimulated gene factor-3 (ISGF3) complex.

120 merization to STAT2, and, therefore, reduced IFN-stimulated gene factor-3 binding to DNA and disrupte

121 ated by screening a library of more than 350 IFN-stimulated genes for antiviral activity.

122 Pattern recognition receptors and IFN-stimulated genes had higher basal and IFN-induced ex

123 738409 C>G polymorphisms were genotyped; and IFN-stimulated gene hepatic expression (n = 16) was test

124 e mechanism, we also evaluated the impact on IFN-stimulated gene hepatic expression in a subset of pa

125 represent a heretofore unknown class of non-IFN-stimulated gene IEGs.

126 ction increased expression of representative IFN-stimulated genes (IFIT3, OAS, LMP2, TGTP, and USP18)

127 sible for nucleating PODs, is an interferon (IFN)-stimulated gene, implicating the participation of t

128 An siRNA screen targeting 89 IFN stimulated genes in 14 different cancer cell lines p

129 examined H3.3 incorporation into interferon (IFN)-stimulated genes in confluent mouse NIH3T3 cells ex

130 e induction of type I interferon (IFN-I) and IFN-stimulated genes in cells infected with an IFN-induc

131 ication within Huh7.5.1 cells, also inducing IFN-stimulated genes in co-culture.

132 rn molecules increased induction of IFNs and IFN-stimulated genes in HLSECs.

133 produced by Dicer enhanced the expression of IFN-stimulated genes in MDAH087-N cells resulting in sig

134 serum, and upregulated expression of several IFN-stimulated genes in peripheral blood mononuclear cel

135 miR-BART16 abrogates the production of IFN-stimulated genes in response to IFN-alpha stimulatio

136 profiling revealed a strong up-regulation of IFN-stimulated genes in the blood of treated animals, co

137 nits of HDLs containing IA, the induction of IFN-stimulated genes in the brain was significantly grea

138 s exhibited very limited induction of type I IFN-stimulated genes in the liver compared with chimpanz

139 c cell line THP-1 results in an induction of IFN-stimulated genes in these cells.

140 ompletely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells.

141 ted type I IFNs and several antiviral genes (IFN-stimulated genes) in the intestine by bulk analysis,

142 reatment we detected increased expression of IFN-stimulated genes, including genes for several cytoki

143 Among the 2-5A-induced genes are several IFN-stimulated genes, including IFN-inducible transcript

144 n (IFN) regulatory factor 3 target genes and IFN-stimulated genes, including several subtypes of alph

145 with increased transcription of interferon (IFN)-stimulated genes independent of IFN-alpha, -beta, a

146 udies have revealed unexpected complexity in IFN-stimulated gene induction in vivo.

147 IFN-stimulated gene induction was also delayed in Irf-3(

148 d skin 24 h postinfection where the level of IFN-stimulated gene induction was parasite strain-depend

149 ta reporter mice, and investigation of local IFN-stimulated gene induction) revealed that MyTrCa(-/-)

150 , whereas IFN-lambda provides a long-lasting IFN-stimulated gene induction.

151 hese cells, suggesting that transcription of IFN-stimulated genes is dependent on IFI16.

152 aling that upregulates antiviral interferon (IFN)-stimulated gene (ISG) expression in uninfected remo

153 gorous intrahepatic induction of interferon (IFN)-stimulated gene (ISG) induction is a feature of hep

154 CV persists in the liver despite interferon (IFN)-stimulated gene (ISG) induction; robust induction a

155 sed type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the p

156 , phosphorylated STAT1 (P-STAT1) levels, and IFN-stimulated gene (ISG) expression compared to control

157 dly, we found that GR dramatically inhibited IFN-stimulated gene (ISG) expression in macrophages.

158 es cell type-specific differences in IFN and IFN-stimulated gene (ISG) expression in response to exog

159 However, comparison of IFN-stimulated gene (ISG) expression levels in mock-infe

160 he effect of IL-28B genotypes on IL-28B, and IFN-stimulated gene (ISG) expression, and CMV replicatio

161 lambda proteins (IL28B, IL-29), preactivated IFN-stimulated gene (ISG) expression, and impaired Stat

162 Ns, which trigger antiviral defenses through IFN-stimulated gene (ISG) expression.

163 skin, and lymphoid tissues were examined for IFN-stimulated gene (ISG) induction and infiltration by

164 licons was not correlated with inhibition of IFN-stimulated gene (ISG) mRNA induction, yet ISG induct

165 of the IFN regulatory factor-1 (IRF1) to the IFN-stimulated gene (ISG) promoters.

166 s virus growth by inducing a large number of IFN-stimulated gene (ISG) proteins, several of which hav

167 ber of cellular genes, collectively known as IFN-stimulated gene (ISG) proteins, which act as antivir

168 virus particles are able to induce a strong IFN-stimulated gene (ISG) response in human primary cell

169 with enhanced viral replication and blunted IFN-stimulated gene (ISG) responses.

170 ished, but the specific contribution of each IFN-stimulated gene (ISG) to these biological responses

171 Thus, we hypothesized that an IFN-stimulated gene (ISG) with prosurvival activity migh

172 urther experiments indicated that cGAS is an IFN-stimulated gene (ISG), and two adjacent IFN-sensitiv

173 codes viperin), an enigmatic multifunctional IFN-stimulated gene (ISG).

174 promoter and results in robust expression of IFN-stimulated genes (ISG) in PH5CH8 cells, which are de

175 lving infection, suggesting that a subset of IFN-stimulated genes (ISG) may play a role in the contro

176 We found that a class of IFN-stimulated genes (ISG), frequently associated with t

177 astrocytes a group of genes considered to be IFN-stimulated genes (ISG), suggesting that IL-1beta may

178 cells, they induce transcription of numerous IFN-stimulated genes (ISG), which in turn protect these

179 f genes involved in IFN signaling, including IFN-stimulated genes (ISG).

180 s essential for transcriptional induction of IFN-stimulated genes (ISG).

181 Although the IFN-stimulated gene ISG15 was induced to a similar exten

182 The transcript levels of IFN-stimulated genes ISG15 and ISG56 and protein level o

183 a resulted in the upregulation of four model IFN stimulated genes (ISGs) in HEL-299 and HEL-TERT cell

184 uced the expression of IFN-beta and multiple IFN stimulated genes (ISGs), including Myxovirus resista

185 f genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intr

186 the brain of LCMV-cgPi mice were interferon (IFN)-stimulated genes (ISGs) and included the transcript

187 his study was to examine whether interferon (IFN)-stimulated genes (ISGs) are overexpressed in human

188 hich regulates the expression of interferon (IFN)-stimulated genes (ISGs) by biogenesis of RA.

189 ly demonstrated the induction of interferon (IFN)-stimulated genes (ISGs) by JCV.

190 on by inducing expression of the interferon (IFN)-stimulated genes (ISGs) in Huh7 cells.

191 the function of the HCMV-induced interferon (IFN)-stimulated genes (ISGs) in infected monocytes remai

192 and subsequent up-regulation of interferon (IFN)-stimulated genes (ISGs) in patients with SAVI.

193 es the expression of a subset of interferon (IFN)-stimulated genes (ISGs) in the absence of IFNs.

194 pes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients wi

195 induce the expression of several interferon (IFN)-stimulated genes (ISGs) with antiviral properties s

196 for PRDM16 in suppressing type I interferon (IFN)-stimulated genes (ISGs), including Stat1, in adipoc

197 expression of several antiviral interferon (IFN)-stimulated genes (ISGs).

198 al infection is the induction of interferon (IFN)-stimulated genes (ISGs).

199 n increased expression of IFN-beta and other IFN-stimulated genes (ISGs) (e.g., PKR, MDA5, IRF1, IRF7

200 to IFN treatment, were robustly recruited to IFN-stimulated genes (ISGs) after stimulation.

201 SGF3) transcription complex for induction of IFN-stimulated genes (ISGs) and establishment of an anti

202 viral immunity by inducing the expression of IFN-stimulated genes (ISGs) and mediating signals downst

203 atory networks that control transcription of IFN-stimulated genes (ISGs) and mRNA translation, leadin

204 including IFN-alpha, upregulate an array of IFN-stimulated genes (ISGs) and potently suppress Human

205 Interferon (IFN) and IFN-stimulated genes (ISGs) are amplified during HCV inf

206 Interferon (IFN) and IFN-stimulated genes (ISGs) are amplified during HCV inf

207 tion of IFN-alpha, IFN-beta, and a subset of IFN-stimulated genes (ISGs) as a result of viral infecti

208 We observed increased expression of type 1 IFN-stimulated genes (ISGs) as the predominant transcrip

209 levels of type I and type III IFN genes and IFN-stimulated genes (ISGs) at 37 degrees C.

210 cific subset of genes during infection, with IFN-stimulated genes (ISGs) being the most affected by b

211 P40) proteins each inhibit the production of IFN-stimulated genes (ISGs) by blocking Jak-STAT signali

212 ducible gene I (RIG-I) and several antiviral IFN-stimulated genes (ISGs) expression.

213 Screening of a library of more than 350 IFN-stimulated genes (ISGs) identified interferon-regula

214 The actions of IFN-stimulated genes (ISGs) impart control of virus infe

215 and ovarian carcinoma cell lines, represses IFN-stimulated genes (ISGs) in a BRCA2-dependent manner,

216 t IRF4 directly induced a specific subset of IFN-stimulated genes (ISGs) in a type I IFN-independent

217 cient to induce transcription of a subset of IFN-stimulated genes (ISGs) in an IRF3-dependent, IFN-in

218 sponse, including widespread upregulation of IFN-stimulated genes (ISGs) in blood and lymph nodes.

219 was performed to evaluate the expression of IFN-stimulated genes (ISGs) in both peripheral blood mon

220 uced IFN-beta secretion and transcription of IFN-stimulated genes (ISGs) in both RIG-I(-/-) and MDA-5

221 yocytes, yet there is a greater induction of IFN-stimulated genes (ISGs) in cardiac fibroblasts.

222 ssion of SV40 LT results in the induction of IFN-stimulated genes (ISGs) in human fibroblasts and con

223 e was accompanied by rapid downregulation of IFN-stimulated genes (ISGs) in liver and blood, regardle

224 with constitutively increased expression of IFN-stimulated genes (ISGs) in the liver.

225 We observed a >300-fold reduction in the IFN-stimulated genes (ISGs) MxA and ISG56 following TULV

226 and inhibited the expression of most of the IFN-stimulated genes (ISGs) observed in mock-infected IF

227 hypothesized that there must be a subset of IFN-stimulated genes (ISGs) regulated by IFN-gamma in a

228 However, many IFN-stimulated genes (ISGs) rely on antiviral pathways t

229 formatic analysis, we identified a number of IFN-stimulated genes (ISGs) specifically activated durin

230 To identify IFN-stimulated genes (ISGs) that instigate an antiviral

231 in infected and uninfected cells by inducing IFN-stimulated genes (ISGs) that modulate viral entry, r

232 A typical signature of IFN-stimulated genes (ISGs) was observed with both virus

233 The global induction of IFN-stimulated genes (ISGs) was significantly greater in

234 nonuclear cells and individual expression of IFN-stimulated genes (ISGs) were quantified on IFN thera

235 timulation upregulates hundreds of different IFN-stimulated genes (ISGs), but it is often unclear whi

236 rferon alfa (IFN-alpha) alters expression of IFN-stimulated genes (ISGs), but little is understood ab

237 rferon alfa (IFN-alpha) alters expression of IFN-stimulated genes (ISGs), but little is understood ab

238 autocrine loop and downstream expression of IFN-stimulated genes (ISGs), including chemokines CXCL9

239 infection through the induction of numerous IFN-stimulated genes (ISGs), including important antivir

240 Similar to protein-coding IFN-stimulated genes (ISGs), its induction was dependent

241 e, phosphorylation of Stat2 and induction of IFN-stimulated genes (ISGs), such as MX1, ISG15, IRF7, a

242 hat while each IFN alone induced a number of IFN-stimulated genes (ISGs), the combination resulted in

243 n of selected IFN-regulatory factors (IRFs), IFN-stimulated genes (ISGs), transforming growth factor-

244 e antiviral mechanism of these cytokines, 37 IFN-stimulated genes (ISGs), which are highly inducible

245 o viral infection, the host induces over 300 IFN-stimulated genes (ISGs), which are the central compo

246 a group of antiviral effector proteins, the IFN-stimulated genes (ISGs), which target distinct viral

247 RNA Pol II recruitment to the IRF3-dependent IFN-stimulated genes (ISGs).

248 ly antiviral response by inducing the type-I IFN-stimulated genes (ISGs).

249 ents leading to the induction of hundreds of IFN-stimulated genes (ISGs).

250 nt triggering expression of immediate early, IFN-stimulated genes (ISGs).

251 lar antiviral state through the induction of IFN-stimulated genes (ISGs).

252 nterleukin (IL)-28, and led to expression of IFN-stimulated genes (ISGs).

253 expression of Type III (lambda) IFNs and of IFN-stimulated genes (ISGs).

254 role for this pathway in mRNA translation of IFN-stimulated genes (ISGs).

255 patients display up-regulation of a group of IFN-stimulated genes (ISGs).

256 oteins to suppress activation of a subset of IFN-stimulated genes (ISGs).

257 ts by inducing the expression of hundreds of IFN-stimulated genes (ISGs).

258 ron (IFN) signaling leading to expression of IFN-stimulated genes (ISGs).

259 to induce type I/III interferons (IFNs) and IFN-stimulated genes (ISGs).

260 of IFN regulatory factor 3 (IRF3)-dependent IFN-stimulated genes (ISGs).

261 rogression that depends on the expression of IFN-stimulated genes (ISGs).

262 IFN-alpha and IFN-beta) via the induction of IFN-stimulated genes (ISGs).

263 scades that lead to transcription of IFN and IFN-stimulated genes (ISGs).

264 ased type I IFN activity and upregulation of IFN-stimulated genes (ISGs).

265 n cells through the induction of hundreds of IFN-stimulated genes (ISGs).

266 rted upregulation of innate immune pathways (IFN-stimulated genes [ISGs]) of increasing magnitude wit

267 ated gene, MxA (myxovirus resistance A), the IFN-stimulated gene known to be critical in blocking inf

268 CV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigat

269 DC-specific arrays revealed upregulation of IFN-stimulated genes, most cytokines, and transcription

270 In contrast, mRNA levels of IFN-stimulated genes, Mx and PKR, were greater in PMphi

271 However, the mRNA level of a single IFN-stimulated gene, MxA (myxovirus resistance A), the I

272 Two downstream IFN-stimulated genes, MxA and TRAIL, also show different

273 scription but had elevated levels of certain IFN-stimulated genes, presumably in response to exogenou

274 Huh-7 cells, and that it blocks IFN-beta and IFN-stimulated gene production after transfection of syn

275 n inhibit expression of interferon (IFN) and IFN-stimulated gene products by inducing proteasome-medi

276 mediate-early induction of IFN-beta mRNA and IFN-stimulated gene products such as double-stranded RNA

277 IFN regulatory factor 3, and augmentation of IFN-stimulated gene products.

278 ns of PVM lowered the levels of several ISG (IFN-stimulated gene) proteins as well.

279 approach, we identified a robust interferon (IFN)-stimulated gene response within microglia exposed t

280 to a severe attenuation of IFN-alpha and the IFN-stimulated gene retinoic acid-inducible gene I (RIG-

281 We observed a distinct activation of the IFN-stimulated gene signature with a substantial increas

282 with immune defense activation, inclusive of IFN-stimulated genes (STAT-1 and IRF-7), cytokines, chem

283 ate a number of cellular mRNAs, including an IFN-stimulated gene target, IFIT1/ISG56, by destabilizin

284 type I IFN and upregulated the expression of IFN-stimulated genes (tetherin, IFITM3, and viperin), as

285 h7.5(dif) cells expressed a wider pattern of IFN-stimulated genes than undifferentiated Huh7.5 cells

286 esponses by evading restriction of Ifit1, an IFN-stimulated gene that regulates protein synthesis.

287 ng the induction patterns of closely related IFN-stimulated genes that are located adjacent to one an

288 s an increase in the transcription of type I IFN-stimulated genes that correlated with the observed i

289 o elevated transcription of a large group of IFN-stimulated genes that have antiviral function.

290 N is an accumulated effect of at least three IFN-stimulated genes that probably act on different stag

291 a selective suppression of IFN-alpha and the IFN-stimulated gene TRAIL while simultaneously inducing

292 d gene factor-3 binding to DNA and disrupted IFN-stimulated gene transcription.

293 ulation of protein expression of a subset of IFN-stimulated genes triggered by double-stranded RNA or

294 he ability to induce endogenous IFN-beta and IFN-stimulated genes varies among these cytokines and wa

295 down MYC in the pDC cell line, production of IFN-stimulated genes was dramatically increased and was

296 Robust induction of IFN-stimulated genes was observed in excised skin 24 h p

297 Expression of IFN-stimulated genes was up-regulated in anti-MDA5 DM; h

298 of cell lines that overexpressed individual IFN-stimulated genes, we found that protein kinase R (PK

299 IFN-stimulated genes were also markedly upregulated, wit

300 IFN-stimulated genes were hypo-expressed in the liver of