ライフサイエンスコーパス: IGF-II receptor

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1 ponding MS9II cells overexpressing the human IGF-II receptors.

2 phate/insulin-like growth factor-II (Man-6-P/IGF-II) receptor.

3 Surface iodination and Man-6-P/IGF-II receptor affinity chromatography implicated MHC c

4 Here, we show that the M6P/IGF-II receptor also binds RA with high affinity at a si

5 fibroblast MS cells deficient in the murine IGF-II receptor and corresponding MS9II cells overexpres

6 in mouse L cells overexpressing the Man-6-P/IGF-II receptor and in wild-type mink lung epithelial (M

7 ulin-like growth factor II receptor (Man-6-P/IGF-II receptor) and its ligand beta-glucuronidase has b

8 The effects of IGF-II occur via IGF-II receptors, and not IGF-I receptors, and target bo

9 timulated the phosphorylation of the Man-6-P/IGF-II receptor at 0 degrees C in mouse L cells overexpr

10 ase in the steady-state level of the Man-6-P/IGF-II receptor at the plasma membrane without affecting

11 ular target has been identified as TIP47, an IGF II receptor binding protein.

12 osphate/insulin-like growth factor II (M-6-P/IGF-II) receptor binding to the surface of B lymphoblast

13 Peptides eluted from the Man-6-P/IGF-II receptor-binding fraction of immunoaffinity-purif

14 In BTBR mice, IGF-II, via IGF-II receptor, but not via IGF-I receptor, reverses th

15 In hippocampal slices, IGF-II promotes IGF-II receptor-dependent, persistent long-term potentia

16 also show that the binding of RA to the M6P/IGF-II receptor enhances the primary functions of this r

17 Since insulin-like growth factor II (IGF-II) receptors facilitate the delivery of nascent lys

18 M6P/IGF-II receptor has recently been implicated in fetal de

19 The insulin-like growth factor-II (IGF-II) receptor (IGF2R) regulates the level or activity

20 understanding of the roles of RA and the M6P/IGF-II receptor in development, carcinogenesis, and lyso

21 ld dramatically reduce the number of Man-6-P/IGF-II receptors in the trans-Golgi network, which could

22 ve explored the possibility that the Man-6-P/IGF-II receptor is a substrate of TbetaR-V.

23 osphate (M6P)/insulin-like growth factor-II (IGF-II) receptor is a multifunctional membrane glycoprot

24 covery of the interaction of RA with the M6P/IGF-II receptor may have important implications for our

25 determine the role of ligand valency in M6P/IGF-II receptor-mediated endocytosis, we measured the in

26 TGF-beta stimulated Man-6-P/IGF-II receptor-mediated uptake (approximately 2-fold af

27 These findings suggest that the M6P/IGF-II receptor mediates a RA response pathway that is i

28 strated elevated IGF-II ligand expression in IGF-II receptor-mutant GI tumors, implicating the IGF si

29 IGF-II-dependent memory enhancement requires IGF-II receptors, new protein synthesis, the function of

30 nctional similarities between RA and the M6P/IGF-II receptor, no direct biochemical link has been est

31 o and in vivo phosphorylation of the Man-6-P/IGF-II receptor occurred at the putative phosphorylation

32 that intermolecular cross-linking of the M6P/IGF-II receptor occurs upon binding of a multivalent lig

33 At the cellular level, IGF-II receptor overexpression causes localization of AP

34 Our results show that IGF-II receptor overexpression increases the protein lev

35 These results suggest the Man-6-P/IGF-II receptor serves as an in vitro and in vivo substr

36 upying both Man-6-P-binding sites on the M6P/IGF-II receptor simultaneously did not.

37 M6P/IGF-II receptor solubilized and purified in Triton X-100

38 ults highlight the potential contribution of IGF-II receptor to AD pathology not only by regulating e

39 /insulin-like growth factor II receptor (M6P/IGF-II receptor) undergoes constitutive endocytosis, med

40 Purified bovine Man-6-P/IGF-II receptor was phosphorylated by purified bovine Tb

41 GF-II levels are regulated by binding to the IGF-II receptor, which is inactivated by mutation in hum

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