ライフサイエンスコーパス: IKK gamma

1 IKK gamma/NEMO is the essential regulatory subunit of th

2 IKK gamma/NEMO was demonstrated to shuttle between the c

3 IKK-gamma interacts preferentially with IKK-beta and is

4 IKK-gamma is required for the activation of the transcri

5 An IKK gamma mutant, which interacts with Hsp70, competitiv

6 An IKK-gamma carboxy-terminal truncation mutant that still

7 ing pathway that is independent of Bcl10 and IKK gamma.

8 appaB kinase beta (IKK-beta), IKK-alpha, and IKK-gamma/N, leading to changes in NF-kappaB-dependent g

9 IKK-beta and IKK-gamma are critical for cytokine-induced NF-kappaB fu

10 genes coding for the CD40 ligand (CD40L) and IKK-gamma (NEMO) genes, both X-linked; and mutations of

11 ppaB essential modulator NEMO (also known as IKK-gamma), which is the regulatory subunit of the Ikapp

12 paB essential modifier (NEMO), also known as IKK-gamma, is a member of the I-kappaB kinase complex re

13 and cells from IP patients exhibit defective IKK gamma/NEMO expression but normal expression of IKK c

14 Thus, our findings establish IKK-gamma as a key molecule for adapting an oncoprotein-

15 Expression of exogenous IKK gamma in the mutant cells restored NF-kappa B activa

16 eucine-repeat region of Tax is important for IKK gamma binding.

17 oiled-coil domain of I kappa B kinase gamma (IKK gamma) to inhibit IKK activity and consequently inhi

18 with Hsp70, competitively inhibits the Hsp70-IKK gamma interaction and relieves heat-mediated NF-kapp

19 erestingly, all the Tax mutants defective in IKK gamma binding failed to engage the IKK complex or st

20 Recently, mutations in IKK-gamma (NEMO) have been shown to cause familial incon

21 308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradat

22 rminal putative zinc finger domains of NEMO (IKK gamma) are critical for UV-induced NF-kappa B activa

23 s caused by mutations in a gene called NEMO (IKK-gamma).

24 ecently demonstrated that mutations in NEMO (IKK-gamma), which encodes a critical component of the NF

25 NEMO/IKK gamma is indispensable for activation of the IKKs in

26 r-associated NF-kappa B activator) as a NEMO/IKK gamma-interacting protein via yeast two-hybrid analy

27 The TANK binding domain within NEMO/IKK gamma is required for proper functioning of this IKK

28 aB activation phases, requiring ATM and NEMO/IKK-gamma: The first phase induced TNF-alpha-TNFR1 feedf

29 tion required IKK alpha and IKK beta but not IKK gamma, the regulatory subunit of the IKK complex.

30 y, this mutant cell line lacks expression of IKK gamma, a non-catalytic component of the IKK complex.

31 vide genetic evidence for the requirement of IKK gamma in NF-kappa B signaling triggered by both T-ce

32 ndicate that, in addition to the key role of IKK gamma/NEMO in regulating cytokine-induced IKK activi

33 med NEMO (NF-kappa B essential modulator) or IKK gamma.

34 subunit, and requires the regulatory subunit IKK gamma (NEMO).

35 lpha and IKK beta and the regulatory subunit IKK gamma/nuclear factor-kappa B (NF-kappa B) essential

36 associates with the IKK regulatory subunit, IKK gamma, although the underlying biochemical mechanism

37 entially processed forms of a third subunit, IKK-gamma.

38 tripartite protein-protein interaction, Tax, IKK gamma, and PP2A form a stable ternary complex.

39 We show that the Tax-IKK gamma interaction requires two homologous leucine zi

40 o and in vivo analysis, we demonstrated that IKK gamma/NEMO competed with p65 and IKK alpha for bindi

41 Our data support the notion that IKK gamma-associated PP2A is responsible for the rapid d

42 lecular cloning and sequencing indicate that IKK-gamma is composed of several potential coiled-coil m

43 We propose that the IKK gamma/NEMO-deficient cells trigger an inflammatory r

44 , a human genodermatosis, synthenic with the IKK gamma/NEMO locus.

45 ns affecting the carboxy-terminal end of the IKK-gamma protein, a domain believed to connect the IKK

46 can be rescued by fusing the Tax mutants to IKK gamma.

47 ax, has been shown to interact directly with IKK gamma and activates IKK via a mechanism not fully un

48 Despite their interaction with IKK gamma, PP2A-interaction-defective Tax mutants failed

49 IKK-beta but instead complexes directly with IKK-gamma, a newly characterized component of the IKK co

50 This direct interaction with IKK-gamma correlates with Tax-induced IkappaB-alpha phos

51 logous leucine zipper domains located within IKK gamma.