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1 ntrol granzyme B through upregulation of the IL-12 receptor.
2 nd the interaction of these species with the IL-12 receptor.
3 eedback loop by competitively binding to the IL-12 receptor.
4 n and their competitive interaction with the IL-12 receptor.
5 n and LTalpha possibly through regulation of IL-12 receptor.
6 tat3/Stat4, indicating signaling through the IL-12 receptor.
7 t on Th development is the expression of the IL-12 receptor.
8 , THC injection suppressed the expression of IL-12 receptors.
9 the expression and activity of high affinity IL-12 receptors.
10  T-cell proliferation, IFN-gamma production, IL-12 receptor accumulation, and the IL-12-promoted acqu
11                                The IL-23 and IL-12 receptors also share a subunit, IL-12Rbeta1, that
12 -resident ILC1s in a manner dependent on the IL-12 receptor and STAT4.
13 e conditions, BALB/c T cells fail to express IL-12 receptors and become unresponsive to IL-12, preclu
14 urred even though the level of expression of IL-12 receptors and IL-12-induced Janus kinase phosphory
15 ted by Ag, B10.D2 T cells express functional IL-12 receptors and maintain IL-12 responsiveness.
16  to the effects of IL-2 alone, expression of IL-12 receptors and STAT4 are unaffected or decreased by
17         Through expression of high levels of IL-12 receptors and STAT4, IL-2-primed NK cells show enh
18 by adding neutralizing anti-IL-12 Abs or the IL-12 receptor antagonist p40 homodimer to primary MLC.
19 ated with either anti-IL-12 Abs, or with the IL-12 receptor antagonist p40 homodimer.
20 imers of the p40 subunit of IL-12 are potent IL-12 receptor antagonists in some systems, we have repo
21 p40)2 and their competitive binding with the IL-12 receptor are essential for determining IL-12 bioac
22 IFN-gamma were found to significantly modify IL-12 receptor beta 2 expression after T cell activation
23 ption factor T-box expressed in T cells, and IL-12 receptor beta 2 in CD4(+) T cells from the DLN and
24 ment was shown to suppress the expression of IL-12 receptor beta 2 mRNA, indicating that, in addition
25 lls, IFN-gamma-producing cells expressed the IL-12 receptor beta 2-chain after activation in the pres
26 kin 12 (IL-12) treatment in up-regulation of IL-12 receptor beta(2) mRNA during T(H)1 priming, and in
27  In this study, we ectopically expressed the IL-12 receptor-beta 2 (IL-12R beta 2) bicistronically wi
28                                          The IL-12 receptor-beta 2 (IL-12R beta 2) chain is expressed
29                                              IL-12 receptor beta1 (IL-12Rbeta1) and IL-12Rbeta2 are e
30                  Expression of IL-12 and the IL-12 receptor beta1 (IL-12Rbeta1) and IL-12Rbeta2 subun
31                               They share the IL-12 receptor beta1 (IL-12Rbeta1) as one component of t
32 a the IL-23 receptor (IL-23R) and the shared IL-12 receptor beta1 (IL-12Rbeta1) controls innate and a
33 consists of the unique IL-23R and the common IL-12 receptor beta1 (IL-12Rbeta1).
34 sting of the IL-23 receptor (IL-23R) and the IL-12 receptor beta1 (IL-12Rbeta1).
35  IL-10 production; in addition, they inhibit IL-12 receptor beta2 (IL-12Rbeta2) chain expression.
36 is driven by interleukin (IL)-12 through the IL-12 receptor beta2 (IL-12Rbeta2) chain, whereas differ
37 -12 was associated with a specific defect in IL-12 receptor beta2 (IL-12Rbeta2) mRNA expression by CD
38 nella, the level of mRNA expression encoding IL-12 receptor beta2 (IL-12Rbeta2) subunit was diminishe
39 nfected donors also failed to upregulate the IL-12 receptor beta2 chain (IL-12Rbeta2) in response to
40  This may be due to a down-regulation of the IL-12 receptor beta2 chain (IL-12Rbeta2) that accompanie
41 ive to IL-12 via increased expression of the IL-12 receptor beta2 chain and produced elevated levels
42 ferentiation- or lineage markers such as the IL-12 receptor beta2 chain and the chemokine receptor CC
43 on-gamma (IFN-gamma) alleles and by inducing IL-12 receptor beta2 expression.
44 , inducing STAT5-dependent expression of the IL-12 receptor beta2-chain (IL-12Rbeta2) and the transcr
45 12 programmed T(EM) through induction of the IL-12 receptor beta2.
46    Constitutive expression of high levels of IL-12 receptor by iNKT cells enabled instant IL-12-induc
47 tment also exhibited increased expression of IL-12 receptor chains, suggesting that IL-2 may enhance
48 oid tissues for months after MCMV infection, IL-12 receptor-deficient NK cells failed to expand and w
49 L)-12 treatment blocked Treg expansion in an IL-12 receptor-dependent fashion.
50  an important role for the regulation of the IL-12 receptor during the innate immune response after i
51 me (ACS), spontaneously express interleukin (IL)-12 receptors, even in the absence of antigenic stimu
52  the Fc portion of IgG (FcgammaRIII) and the IL-12 receptor expressed on NK cells.
53 xpressed high levels of CD18 and upregulated IL-12 receptor expression after IL-12 treatment in vivo.
54 sults in an early reduction of high affinity IL-12 receptor expression and activation.
55  demonstrates that Tpm1 exerts its effect on IL-12 receptor expression in a cell-autonomous manner, r
56                         Therefore, increased IL-12 receptor expression might be expected in the host
57 n 12 (IL-12) production from macrophages and IL-12 receptor expression on activated T cells.
58 .D2 and BALB/c mice show distinct control of IL-12 receptor expression.
59 zation of IL-12 in C3H mice blocks increased IL-12 receptor expression.
60         OVA-specific CD8 T cells lacking the IL-12 receptor fail to differentiate or mediate graft re
61 ess both the beta 1 and beta 2 chains of the IL-12 receptor (IL-12R) and tyrosine phosphorylate STAT4
62 y Th2 cells results from a selective loss of IL-12 receptor (IL-12R) beta 2 subunit expression.
63    NK cells costimulated via the FcR and the IL-12 receptor (IL-12R) exhibited enhanced levels of act
64 restingly, p40 was involved in the arrest of IL-12 receptor (IL-12R) IL-12Rbeta1, but not IL-12Rbeta2
65 Methods and Results- We examined the role of IL-12 receptor (IL-12R) signaling in the development of
66 the Fc portion of IgG (FcgammaRIIIa) and the IL-12 receptor (IL-12R), both constitutively expressed o
67                          Two subunits of the IL-12 receptor (IL-12R), IL-12R beta 1 and IL-12R beta 2
68 pment have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-g
69 e results demonstrate that regulation of the IL-12 receptor, independent of IL-4, is a point of contr
70              Costimulation of the T-cell and IL-12 receptors induced the transcription of CD28 in app
71 human NK cells via the IL-2 receptor and the IL-12 receptor induces significant IFN-gamma production,
72 n of naive T cells through their antigen and IL-12 receptors initiates differentiation programs that
73                  Expression of high affinity IL-12 receptors is required for IL-12-mediated IFN-gamma
74 of L. major-infected C3H mice upregulate the IL-12 receptor on CD4(+), CD8(+), and B220(+) cells.
75 ression of the beta1 and beta2 chains of the IL-12 receptor on T cells.
76                             The interleukin (IL)-12 receptor (R)beta2 subunit is the critical molecul
77 diate signals that emanate from the IL-4 and IL-12 receptors, respectively.
78 iation in vivo is consistent with a block in IL-12 receptor signaling, because LSF blocked IL-12-driv
79 st to the direct recruitment of Stat4 by the IL-12 receptor, Stat4 activation by the human IFN-alpha
80 tion of patients and treatment with IL-1 and IL-12 receptor subunit beta 1 (Rb1) antibodies may also
81  cells revealed inadequate expression of the IL-12 receptor, thus establishing a link between CTL dif

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