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     1                                              IL-14 is a cytokine originally identified as a B cell gr
 
     2                              Interleukin 
14 (
IL-14) or high molecular weight B cell growth factor sec
 
     3 ipts of flt3 ligand, lymphotoxin A, TNF, 
and IL-14.                                                  
 
     4 n vivo, IL-14 and IL-2 behave differently 
as IL-14 transcript levels are not reduced by immunosuppres
 
     5                               In vitro, 
both IL-14 and IL-2 transcript levels increase after alloanti
 
     6  inhibition by the down-regulatory 
cytokines IL-14, IL-13, and TGF-beta.                             
 
     7 erase chain reaction techniques, we 
examined IL-14 mRNA transcript levels in human cells and compared
 
     8     This is the first demonstration of 
human IL-14 mRNA regulation in vitro and in vivo.             
 
     9 ration and antibody production, increases 
in IL-14 transcript levels may play a role in alloantibody 
 
    10               Given the important effects 
of IL-14 on B cell proliferation and antibody production, i
 
    11                        The potential role 
of IL-14 in human transplantation has not been examined.   
 
    12 a cytokine encoded by the plus strand of 
the IL-14 gene using exons 3-10.                            
 
    13                                     In 
vivo, 
IL-14 and IL-2 behave differently as IL-14 transcript le
 
    14                                     In 
vivo, 
IL-14 transcript levels were measured in peripheral bloo
 
 
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