ライフサイエンスコーパス: IL-15R alpha

1 exing this cytokine to its soluble receptor, IL-15R alpha.

2 L-2, and an IL-15-specific receptor subunit, IL-15R alpha.

3 completely on parenchymal cell expression of IL-15R alpha and IL-15 but not IL-15R beta.

4 ne unique roles for macrophage expression of IL-15R alpha and show that NK cells rely upon distinct I

5 common gamma (C gamma ) chain, IL-7R alpha , IL-15R alpha; and proliferative responses of T cells in

6 ion most likely involved the alpha receptor (IL-15R alpha) because this high affinity receptor would

7 tion and maturation, expression of IL-15 and IL-15R alpha by both parenchymal and hematopoietic cells

8 We therefore studied the IL-15R alpha chain expression in human gamma delta T cel

9 Since IL-15R alpha chain is necessary and sufficient for IL-15

10 s of the IL-2R in combination with an unique IL-15R alpha chain.

11 ctional similarities between IL-2R alpha and IL-15R alpha chains, the activation-triggered mechanisms

12 To study the expression of human IL-15R alpha chains, we have utilized tagged human IL-15

13 NK cells, and CD4+ and CD8+ T cells express IL-15R alpha chains.

14 provide novel insights into the use of IL-15/IL-15R alpha complexes to relieve tumor-resident T cells

15 re, we report that in vivo delivery of IL-15/IL-15R alpha complexes triggers rapid and significant re

16 ipheral blood following treatment with IL-15/IL-15R alpha complexes, the destruction of solid tumors

17 ha and show that NK cells rely upon distinct IL-15R alpha dependent IL-15 signals than memory CD8(+)

18 a and IL-2R gamma c in the presence of IL-2, IL-15R alpha did not co-precipitate with the IL-2R beta/

19 sue expression of IL-2/IL-2R alpha and IL-15/IL-15R alpha differ.

20 We analyzed the requirements for IL-15 and IL-15R alpha expression by bone marrow-derived or parenc

21 Naive CD8 T cell development required IL-15R alpha expression by both bone marrow-derived and

22 However, whether IL-15R alpha expression by these subsets is necessary fo

23 sufficient for IL-15 binding, regulation of IL-15R alpha expression may represent a new target for T

24 By contrast, IL-15R alpha expression on cells other than T cells is a

25 After memory CD8(+) T cell differentiation, IL-15R alpha expression on DCs selectively supports cent

26 We find that IL-15R alpha expression on macrophages but not dendritic

27 ports central memory CD8(+) T cells, whereas IL-15R alpha expression on macrophages supports both cen

28 hereas memory-phenotype CD8 T cells required IL-15R alpha expression only by hematopoietic cells.

29 ed cell proliferation following knockdown of IL-15R alpha expression.

30 sporine or rapamycin, blocks mitogen-induced IL-15R alpha expression.

31 Despite secretion of IL-15, LCs lack IL-15R-alpha for surface presentation of IL-15.

32 vity increased over time in correlation with IL-15R alpha gene expression.

33 induces proliferation of cells co-expressing IL-15R alpha, IL-2R beta, and IL-2R gamma chains.

34 n of antigenic peptides, which together with IL-15R-alpha/IL-15, break tolerance against WT1 by stimu

35 we have generated four lines of mice lacking IL-15R alpha in various cell types.

36 Interleukin-15 receptor alpha (IL-15R alpha) is a pleiotropically expressed molecule th

37 We found IL-15R alpha mRNA expression in IL-15-stimulated and Ag-

38 LCs synthesize the highest amounts of IL-15R-alpha mRNA and protein, which binds IL-15 for pre

39 By contrast, mice lacking IL-15R alpha on macrophages, DCs, or both, exhibit equiv

40 ffinity receptors, supports the existence of IL-15R alpha on these cells.

41 ion of the high-affinity receptor for IL-15, IL-15R alpha, on T cells is dispensable for the generati

42 genes encoding interferon- alpha , IL-2, and IL-15R alpha (P < .05, for each).

43 To investigate whether IL-15R alpha presented by different cells perform distin

44 These findings may be related to IL-15R alpha's ability to present IL-15 in trans to low-

45 The results suggest the existence of a human IL-15R alpha subunit, although physical evidence of this

46 unexpected results provide insights into how IL-15R alpha supports memory CD8(+) T cells.

47 kin (IL)-15, and IL-15 receptor alpha chain (IL-15R alpha ) were associated with the magnitude of the