ライフサイエンスコーパス: IL-17 receptor

1 cient in Del-1 and LFA-1 or in Del-1 and the IL-17 receptor.

2 d tumor-associated stromal cells, which bear IL-17 receptors.

3 G-CSF, its receptor, and IL-17 receptor A (IL-17RA) are all required to maintain

4 resent the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoi

5 didiasis underscore the preponderant role of IL-17 receptor A (IL-17RA) in preserving mucocutaneous i

6 ttenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn'

7 We have found that although IL-17 receptor A (IL-17RA)(-/-) mice were resistant to e

8 We demonstrate here that IL-23 and the IL-17 receptor A (IL-17RA), which mediates both IL-17A a

9 eneration of airway smooth muscle through an IL-17 receptor A (IL-17RA)-IL-17RC, nuclear factor kappa

10 Inhibition of IL-17 receptor A did not produce a treatment effect in s

11 onses to IL-17A signaling, either because of IL-17 receptor A knockout or wild-type animals that rece

12 Apoe(-/-) mice by use of adenovirus-produced IL-17 receptor A reduced plaque burden in Apoe(-/-) mice

13 s by infecting C3H mice devoid of the common IL-17 receptor A subunit (IL-17RA) and thus deficient in

14 h brodalumab, a competitive inhibitor of the IL-17 Receptor A subunit.

15 n 11c (CD11c)/diphtheria toxin receptor, and IL-17 receptor A(-/-) mice were used to examine T-lympho

16 the fact that disruption of IL-17 signaling (IL-17 receptor A(-/-)) prevented airway neutrophilia in

17 ge peritoneal macrophages, were enriched for IL-17 receptor A, and for protumor and proangiogenic mol

18 ith BA, cholangiocytes were found to express IL-17 receptor A, and the prevalence of IL-17A(+) cells

19 gene expression in vitro, and this requires IL-17 receptor A, tumor necrosis factor receptor-associa

20 s evident in mice deficient in IL-17A or the IL-17 receptor A, which mediates IL-17A signaling, follo

21 t (Apoe(-/-)) mice with IL-17A-deficient and IL-17 receptor A-deficient mice to generate Il17a(-/-)Ap

22 interaction of IL-17A and/or IL-17F with the IL-17 receptor A/C (IL-17RA/C).

23 Their interactions with IL-17 receptors A-E (IL-17RA-E) mediate host defenses wh

24 Over-activating IL-17 receptors abnormally heightens responses to 21% ox

25 of IL-17 before challenge or absence of the IL-17 receptor abrogated the PA14DeltaaroA vaccine's pro

26 wed that in the absence of signaling via the IL-17 receptor adaptor protein Act-1, the protective eff

27 omain containing proteins, which include the IL-17 receptors and an adaptor protein Act1, have essent

28 ) T cells, signaling via the interleukin-17 (IL-17) receptor, and IL-22 production.

29 Because IL-17A and IL-17F, ligands for IL-17 receptor antagonist (IL-17RA), have been shown to

30 ged IFN-gamma(0) mice were treated with anti-IL-17 receptor antibody or sequentially with anti-IL-17

31 ly with anti-IL-17 antibody followed by anti-IL-17 receptor antibody.

32 subunit dynamics, and ligand contacts of the IL-17 receptor are poorly defined.

33 eta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25.

34 We found that mice deficient in IL-17A, IL-17 receptor C (IL-17RC), and adaptor protein Act1 (of

35 ts role in prostate cancers by interbreeding IL-17 receptor C (IL-17RC)-deficient mice with mice that

36 IL-17 receptor C and Pten double KO mice recapitulated t

37 ion of either IL-17 in RA synovial fluids or IL-17 receptor C on HMVECs significantly reduces the ind

38 Loss of IL-17 receptor C or Ab blockade of IL-17A was similarly

39 ube formation are mediated primarily through IL-17 receptor C.

40 Act1 preferentially bound to IL-17 receptor complex, releasing its suppressive effect

41 tal in this setting and tested the impact of IL-17 receptor deficiency or antibody-mediated neutraliz

42 IL-17 receptor-deficient mice showed increased systemic

43 On the other hand, Act1 and IL-17 receptor directly associate likely via homotypic i

44 stinct member of the IL-17 family that binds IL-17 receptor E/A to promote innate defense in epitheli

45 Furthermore, T cells deficient in the IL-17 receptor elicited an accelerated, aggressive wasti

46 rom septic human neonates, expression of the IL-17 receptor emerged as a critical regulatory node.

47 man fibroblasts and do not bind to the human IL-17 receptor extracellular domain.

48 The IL-17/IL-17 receptor family is the newest and least understood

49 We demonstrate here that IL-17 receptor family shares sequence homology in their

50 IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was sele

51 lar domain of members of the interleukin-17 (IL-17) receptor family.

52 talloproteinases, the signaling mechanism of IL-17 receptor has not been understood.

53 e formation of GCs and that mice lacking the IL-17 receptor have reduced GC B cell development and hu

54 protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the mult

55 ence and functional similarities, this novel IL-17 receptor homologue represents a potential human SE

56 Deficiency in IL-23, IL-17A, or IL-17 receptor (IL-17R) and mAb neutralization of CXCR2,

57 Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyn

58 Furthermore, the levels of IL-17 receptor (IL-17R) on the TRAF6-deficient EFs were

59 l involvement of the adaptor protein Act1 in IL-17 receptor (IL-17R) signaling and IL-17-dependent im

60 Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for regu

61 We hypothesized that IL-17 receptor (IL-17R) signaling is critical for G-CSF

62 s pathogen by disrupting IL-17 production or IL-17 receptor (IL-17R) signaling.

63 a U-box E3 ubiquitin ligase, is recruited to IL-17 receptor (IL-17R) upon IL-17 stimulation and is re

64 cted corneas from wild-type mice, those from IL-17 receptor (IL-17R)-deficient mice had significantly

65 ntibodies to VEGF were rendered sensitive in IL-17 receptor (IL-17R)-knockout hosts deficient in T(H)

66 estigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protec

67 ported that female C57BL/6J mice lacking the IL-17 receptor (IL-17RA(KO)) are significantly more susc

68 The signaling mechanisms triggered by the IL-17 receptor (IL-17RA) and related receptors are strik

69 h interaction with its cognate receptor, the IL-17 receptor (IL-17RA).

70 we report that Act1, the key adaptor for the IL-17 receptor (IL-7R), formed a complex with the induci

71 okine receptor 2 (CXCR2) nor interleukin-17 (IL-17) receptor (IL-17R) deficiency changed the severity

72 was reversed in mice lacking both Del-1 and IL-17 receptor, indicating a crucial role for the IL-17/

73 L-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a findin

74 ntly, we observed that the expression of the IL-17 receptor is significantly increased in CTCL skin l

75 w levels of corneal miR-132 were detected in IL-17 receptor knockout mice after HSV infection.

76 hen these cells were cultured with BMMs from IL-17 receptor knockout mice.

77 ar domain since deletion mutants missing the IL-17 receptor-like domain lack this inhibitory effect.

78 s, the function of other IL-17 cytokines and IL-17 receptor-like molecules is unclear.

79 Kras(G12D) induces expression of functional IL-17 receptors on PanIN epithelial cells and also stimu

80 ere, we confirmed that mice deficient in the IL-17 receptor or lacking the ability to secrete IL-17 a

81 17A or transplantation of grafts lacking the IL-17 receptor prevents disease.

82 ng the action of interleukin (IL) 17 with an IL-17 receptor (R):Fc fusion protein inhibits T-cell pro

83 TPL2 acts by linking the IL-17 receptor signal to the activation of TAK1, which i

84 coded by Zc3h12a) is a feedback inhibitor of IL-17 receptor signal transduction.

85 r NEC development, as inhibition of STAT3 or IL-17 receptor signaling attenuated NEC in mice, while I

86 Rather, mice lacking IL-17 receptor signaling had a cell-intrinsic impairment

87 se seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting diffe

88 Cytokine-targeted strategies blocking IL-17 receptor signaling may be beneficial in asthma tre

89 Mechanistically, IL-17 receptor signaling was required for the enhanced p

90 aB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal linea

91 In the absence of IL-17 receptor signaling, IL-17ra(-/-) mice had delayed

92 In the absence of IL-17 receptor signaling, Il17ra(-/-) mice had significa

93 ion with segmented filamentous bacteria, and IL-17 receptor signaling.

94 or adaptive immunity (interleukin (IL)17-F, IL-17 receptor, STAT1, STAT3, antibodies to Th-17 cytoki

95 To date, only one IL-17 receptor subunit has been identified, termed IL-17

96 pe IL-2Rbeta, including up-regulation of the IL-17 receptor subunit IL-17RA.

97 h ubiquitin ligase activity that couples the IL-17 receptor to downstream signaling pathways.

98 wn what molecule(s) directly associates with IL-17 receptor to initiate the signaling.

99 icate Act1 as a membrane-proximal adaptor of IL-17 receptor with an essential role in induction of in

100 ished the homotypic interaction of ACT1 with IL-17 receptors, with no effect on homodimerization.