ライフサイエンスコーパス: IL-27

1 IL-27 affected the survival of activated T lymphocytes,

2 IL-27 also inhibited osteoblast apoptosis through increa

3 IL-27 and IL-10 levels are increased in the lung microen

4 IL-27 and its receptor mRNA are both upregulated in the

5 IL-27 consists of the cytokine subunit p28 and the non-s

6 IL-27 down-regulates SPTBN1 through a TAK-1-mediated MAP

7 IL-27 exerts pleiotropic suppressive effects on naive an

8 IL-27 exerts protective effects in autoimmune diseases l

9 IL-27 has potent antitumoral and antiosteoclastogenic ac

10 IL-27 inhibited the differentiation of podoplanin-expres

11 IL-27 is a cytokine of the IL-12 family that plays a key

12 IL-27 is a heterodimeric cytokine composed of the subuni

13 IL-27 is a pleiotropic member of the IL-6 and IL-12 cyto

14 IL-27 is an anti-HIV cytokine that also modulates monocy

15 IL-27 is an APC-derived IL-6/IL-12 family composite cyto

16 IL-27 is overproduced by tristetraprolin-deficient macro

17 IL-27 is predominantly synthesized by mononuclear phagoc

18 IL-27 signals through the widely expressed IL-27 recepto

19 IL-27 suppressed osteoclastogenesis in an Egr-2-dependen

20 IL-27 treatment in ovariectomized mice suppressed Th17 c

21 IL-27 treatment prevented the loss of trabecular micro-a

22 IL-27 was found to suppress in vitro Th17 and, to a less

23 IL-27, a multifunctional cytokine produced by APCs, anta

24 IL-27, an IL-12 family cytokine, has pleiotropic functio

25 IL-27, IL-10, and inducible T-cell costimulator ligand s

26 IL-27- and IL-35-independent functions of EBI3 could com

27 IL-27-conditioned T helper 1 cells exhibit reduced effec

28 IL-27-induced CD39 decreased the extracellular concentra

29 IL-27-induced type 1 regulatory T (Tr1) cells suppress a

30 25 and down-regulation of IL-6, IL-9, IL-10, IL-27, IFNA4, CSF3, LOC100152038, and LOC100736831 at th

31 tion is associated with loss of IL-6, IL-11, IL-27, and OSM signaling but a largely intact LIF respon

32 ines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory facto

33 dendritic cell (DC) interleukin-12 (IL-12), IL-27, and IL-10 immunity than M68.

34 Thus, the balance of IL-23 vs IL-12/IL-27 signals into CD4(+) effector T cells determines wh

35 -1beta, IL-2, IL-4, IL-10, IL-12beta, IL-13, IL-27, and IFN-gamma genes were examined in 296 chronica

36 nflammatory (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and TGF-beta) cytokines following treatmen

37 y cytokines (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and transforming growth factor beta [TGF-b

38 ssociated with TCR engagement: IL-12, IL-18, IL-27, IL-9, IL-25, and TGF-beta1.

39 rferon-gamma (IFN-gamma) and interleukin 27 (IL-27) altered ILC2 function dependent on the transcript

40 We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of

41 upregulation by IFN-beta and interleukin-27 (IL-27) also increases the surface expression of Env and

42 s (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimm

43 Interleukin-27 (IL-27) and IL-37 are two known anti-inflammatory cytokin

44 hat plasma levels of soluble interleukin-27 (IL-27) are significantly elevated in individuals with hi

45 tients, we now show that low interleukin-27 (IL-27) expression corresponds with an increased incidenc

46 Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases

47 Interleukin-27 (IL-27) is known to control primary CD4(+) T cell respons

48 ture human DCs express functional IL-27R; 3) IL-27 exerts immunosuppressive activity by crippling the

49 ns and after pulsing with a viral Ag; and 4) IL-27 is chemotactic for human DCs.

50 Th17 differentiation, whereas IL-27 or IL-6+IL-27 induced p-STAT3/p-STAT1 ratios < 1, resulting in i

51 deletion of IRF1 in Sirt1-null DCs abolishes IL-27 production and suppresses Th17 differentiation.

52 t mice to demonstrate that p28/CLF activates IL-27-unresponsive cells, indicating that p28/CLF and IL

53 Additionally, IL-27 regulated the expression of B7-H4 on HIV MDSC, and

54 ful for a beneficial manipulation of adverse IL-27(p28) release during sepsis.

55 Although IL-27 signals via a heterodimer of the beta-receptor cha

56 Although IL-27 treatment does not affect expression of macrophage

57 Thus, our data identify an IL-27/NFIL3 signalling axis as a key regulator of effect

58 subset of CD4(+) cells, the Tr1 cells, in an IL-27-dependent manner in vitro and in vivo.

59 generation and expansion of Th17 cells in an IL-27-dependent manner, it is unclear how pathogenic Th1

60 of immunosuppressive IL-10 is promoted in an IL-27-independent manner.

61 ater immediate rise in IL-10 (P = 0.003) and IL-27 (P = 0.04) mRNA levels.

62 ory immunity and further highlight IL-10 and IL-27 as potent therapeutic targets.

63 by induction of interleukin-10 (IL-10)- and IL-27-mediated mechanisms.

64 ls in the small intestine through IL-10- and IL-27-producing dendritic cells.

65 the role of IL-12 family cytokines IL-12 and IL-27 and report that IL-12p35(-/-) mice infected with T

66 red levels of the innate cytokines IL-12 and IL-27.

67 AT1 activation profiles for IL-6, IL-21, and IL-27, as well as for cytokine pairs over time.

68 everal cytokines, including IL-6, IL-21, and IL-27, each of these cytokines has a very different effe

69 a, IL-2, IL-33, TNF-alpha, IL-21, IL-22, and IL-27), from cell-sorted purified CD4+ and CD8+ T cells

70 ap of the transcriptomes induced by IL-6 and IL-27 and few examples in which the cytokines acted in o

71 Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and emplo

72 onse to IFN-gamma, interleukin-6 (IL-6), and IL-27.

73 e produced less IL-10, IL-1R antagonist, and IL-27 compared with WT MPs.

74 that in addition to IFN-alpha, IFN-beta and IL-27 also affect Vpu-mediated BST-2 downregulation and

75 In conclusion, IFN-beta and IL-27 both induce human IL-10, both suppress human Th17

76 n C. parapsilosis, TLR7, NOD2, IFN-beta, and IL-27, and we have identified an important role for IL-2

77 esponsive cells, indicating that p28/CLF and IL-27 signal through different receptors.

78 ified key roles for macrophage IFN-gamma and IL-27 in the regulation of RSV-induced exacerbation of a

79 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-g

80 s highlight critical roles for IFN-gamma and IL-27, downstream of TNF-alpha and MCP-1, in the mechani

81 , IL-13, and IL-17, it induced IFN-gamma and IL-27.

82 P-1 induced expression of both IFN-gamma and IL-27.

83 ansion in the lungs; however, type I IFN and IL-27 have nonredundant roles supporting pulmonary CD8(+

84 weeks postinfection, IL-12, type 1 IFN, and IL-27 were all required for efficient CD8(+) T cell expa

85 fect disease outcome: IL-12, type I IFN, and IL-27.

86 s following parasite antigen stimulation and IL-27 or IL-37 neutralization.

87 e, which generates T-cell responses that are IL-27-independent.

88 Because IL-27 is a potent regulator of cells residing in endoste

89 IFN-beta, IL-27, and IL-10 have been shown to exert a range of sim

90 ent immunoregulatory mechanisms of IFN-beta, IL-27, and IL-10 in human experimental models and in mur

91 genic phenotype, expressing IL-10, TGF-beta, IL-27, and aldehyde dehydrogenase 1A2 but not IL-12 or I

92 ther suggest a complex interrelation between IL-27 and IL-6.

93 eprosy skin lesions suggested a link between IL-27 and the IFN-beta induced IL-10 pathway.

94 s shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over

95 4(+) T cells was partially regulated by both IL-27 and type I IFN signaling.

96 lexible inter-alpha helix loop, and HA-bound IL-27 retained biological activity.

97 M. leprae to induce IL-10 was diminished by IL-27 knockdown.

98 Suppression of Th17-biased EAE by IL-27 is IL-10-independent, in contrast to its mechanism

99 ed for the suppression of Th17-biased EAE by IL-27, in sharp contrast to Th1-biased EAE.

100 the enhanced potential for ROS generation by IL-27.

101 te IL-10 secretion from Tr1 cells induced by IL-27.

102 acrophages, the frequency of F4/80(+)CD11b(+)IL-27(p28)(+) cells was reduced by the addition of IL-10

103 IL-23 counteracts IL-27 and IL-12-mediated effects on Tr-1-development rei

104 The p28 subunit of the composite cytokine IL-27 comprises a polyglutamic acid domain, which is uni

105 macrophage-derived immunoregulatory cytokine IL-27 was identified in modulating Th2 inflammation foll

106 expression of the anti-inflammatory cytokine IL-27 in response to infection.

107 BI3) is a subunit of the composite cytokines IL-27 and IL-35.

108 nd the resulting production of the cytokines IL-27, IL-15, and IL-10.

109 ytokines, Treg-derived IL-35 and APC-derived IL-27, both capable of suppressing Th17 cells and regula

110 At the site of disease, IL-27 was more strongly expressed in skin lesions of pat

111 IFN-beta-driven IL-27 is responsible for the upregulation of IL-10, but

112 vated PBMC cultures and that IFN-beta drives IL-27 production in activated monocytes.

113 of IRF1, a transcription factor that drives IL-27 production.

114 uired for the suppression of IL-17 by either IL-27 or IFN-beta in this model or in de novo differenti

115 9, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inflammatory cytokines; spontaneous

116 IL-27 signals through the widely expressed IL-27 receptor (IL-27R), composed of the ligand-specific

117 es during inflammatory disorders, but so far IL-27 has not been defined as a part of these multifacet

118 and decreased production of IL-10 following IL-27 and IL-37 neutralization and parasite antigen stim

119 s stimulated with parasite antigen following IL-27 or IL-37 neutralization.

120 y IL-10 as a critical suppressing factor for IL-27(p28) production during infection-associated inflam

121 his study describes a regulatory pathway for IL-27 expression and cytotoxic T lymphocyte function med

122 a reveal a previously unappreciated role for IL-27 in modulating CD4(+) T cell chemotactic pathways d

123 a suggest a previously unrecognized role for IL-27 in regulating epithelial cell proliferation and an

124 , this study is the first to show a role for IL-27 in regulating TLR4 expression and function.

125 and we have identified an important role for IL-27 in the immune response against C. parapsilosis Ove

126 nd healing, suggesting an essential role for IL-27 signaling in skin regeneration in vivo.

127 ild-type mice, suggesting a limited role for IL-27.

128 nodes, macrophages are the major source for IL-27; 2) immature and mature human DCs express function

129 Functionally, IL-27 inhibited the ability of IFN-gamma to trigger anti

130 Furthermore, IL-27-induced STAT1-deficient T cells were indistinguish

131 eful by binding free p28 and p35 to generate IL-27 and IL-35.

132 The p28 subunit has been shown to have IL-27-independent biological activities.

133 Heterodimeric IL-27 (p28/EBV-induced gene 3) is an important member of

134 The effects of heterodimeric IL-27 (p28/EBI3) have been implicated in the natural cou

135 However, IL-27 signaling is not required for the therapeutic effe

136 We demonstrate that human IL-27 upregulates IL-10 in T cell-activated PBMC culture

137 udy forms a strong basis for using humanized IL-27 toward the treatment of post-menopausal osteoporos

138 We identified IL-27 as a gp130 cytokine that promoted antiviral CD4(+)

139 antiretroviral treatment, and they identify IL-27 and its specific receptor as a critical immune axi

140 h that beta subunit of IL-27 (Ebi)(-/-) (ie, IL-27-incompetent) DC-RAs were ineffective in inducing f

141 ibuting to regulation of antitumour immunity.IL-27 is one of a number of cytokines that can induce an

142 own about the factors that negatively impact IL-27 expression.

143 Although the mechanisms involved in IL-27 induction are well studied, much less is known abo

144 nd in polarizing immune responses, including IL-27 that exerts pro- and anti-inflammatory functions.

145 tly, C5aR-deficient mice exhibited increased IL-27 expression and fewer Th17 cells and consequently d

146 FN-alpha/beta receptor and STAT1/2 to induce IL-27.

147 ct of dexamethasone on LPS/IFN-gamma-induced IL-27 mRNA and protein levels in the macrophage cell lin

148 lone failed to inhibit LPS/IFN-gamma-induced IL-27 production and AHR in mice.

149 d sensitivity to block LPS/IFN-gamma-induced IL-27 production and AHR via its antioxidative property.

150 e, we found that C5a inhibited IFN-I-induced IL-27 production from macrophages of lupus subjects.

151 ous immune responses to microbial infection, IL-27 contributes to the suppression of host antimicrobi

152 ry IL-12 and IL-23 and the anti-inflammatory IL-27 and IL-35 cytokines.

153 P, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negativ

154 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.

155 trong induction (IL-6) to strong inhibition (IL-27).

156 natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a pot

157 on to bone marrow-derived DCs, PGE2 inhibits IL-27 production in macrophages and in splenic cDC, and

158 PGE2 We showed previously that PGE2 inhibits IL-27 production in murine bone marrow-derived DCs.

159 Interestingly, IL-27 was indispensable for the prevention of colitis by

160 n de novo differentiating Th17 cells, nor is IL-27 signaling required for the suppression of experime

161 LL-IL-27 administration protected mice from T-cell transfer

162 LL-IL-27 also reduced colitis in mice after administration

163 LL-IL-27 also reduced the numbers of CD4(+) and IL-17(+) T

164 LL-IL-27 reduced disease activity scores, pathology feature

165 LL-IL-27 reduces colitis in mice by increasing the producti

166 LL-IL-27 was more effective than either LL-IL-10 or systemi

167 food-grade bacterium Lactococcus lactis (LL-IL-27), and tested its ability to reduce colitis in mice

168 mice to induce colitis; 7.5 weeks later, LL-IL-27 was administered to mice via gavage.

169 Mucosal delivery of LL-IL-27 could be a more effective and safer therapy for in

170 The effects of LL-IL-27 required production of IL-10 by the transferred T

171 Manipulating IL-27 may provide a novel therapeutic strategy for the t

172 Mechanistically, IL-27 feeds back on keratinocytes to stimulate cell prol

173 on murine macrophages blocked IFN-I-mediated IL-27 production, thus permitting the development of Th1

174 The 2 genes encoding mouse IL-27 were synthesized with optimal codon use for L lact

175 We observed IL-27 binding to HA, in accordance with previous studies

176 ively, our results underscore the ability of IL-27 to protect macrophages from HIV-1 infection by dow

177 Abrogation of IL-27 signaling did not affect virus-specific CD8+ T cel

178 The absence of IL-27 signaling accelerated virus control within the CNS

179 ction of IL-23 and decreased accumulation of IL-27 cytokine in M1 type macrophage from IRF3-deficient

180 Although the activity of IL-27 is well characterized in murine immune cells, only

181 underlying the immunosuppressive activity of IL-27, suggesting that this cytokine may function as a h

182 The addition of IL-27 during activation resulted in an increased cell nu

183 s from mice deficient for the alpha-chain of IL-27 receptor failed to induce colitis in Rag(-/-) reci

184 esulted in 3-5-fold higher concentrations of IL-27(p28) in endotoxic shock and polymicrobial sepsis.

185 Contributions of IL-27 to viral pathogenesis were evaluated by infection

186 Importantly, deletion of IL-27 receptor WSX-1 in tristetraprolin-deficient mice (

187 Genetic disruption of IL-27 signaling enhanced the respiratory burst of macrop

188 ed at investigating whether dysregulation of IL-27 expression and function may be involved in pathoge

189 In this report, we study the effect of IL-27 supplementation on ovariectomized estrogen-deficie

190 pted to investigate in detail the effects of IL-27 and IL-2 using several cell lines.

191 The effects of IL-27 were mediated at least in part through induction o

192 kage led to an increase in the expression of IL-27 subunits p28 and EBI-3 in the lungs and lymph node

193 DC-RA expression of IL-27 was important to their induction of CD25(+) lympho

194 his study, we discovered a novel function of IL-27.

195 infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helmin

196 ghlight the unexpected central importance of IL-27 in the generation of robust, high-affinity cellula

197 e have examined the functional importance of IL-27 receptor (IL-27R) signaling in regulating the form

198 l allergic asthma, we show that induction of IL-27 by R848 is critical for the observed ameliorative

199 r Candida parapsilosis-mediated induction of IL-27 in a TLR7-, MyD88-, and NOD2-dependent manner.

200 IFN-beta, STAT1, or STAT2, and inhibition of IL-27 does not appear to be mediated through PKA, exchan

201 propose that the PGE2-induced inhibition of IL-27 in activated cDC represents an important additiona

202 ges completely interrupted the inhibition of IL-27(p28) by IL-10 after TLR4 activation.

203 rface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically

204 d CNS tissues is not affected by the lack of IL-27 signaling in Tregs, suggesting a functional defect

205 Levels of IL-27 in vitro and in vivo were examined and mouse AHR w

206 neuroendocrine system for the modulation of IL-27-dependent acute inflammation.

207 Neutralization of IL-27 completely reversed the therapeutic effect of R848

208 Furthermore, neutralization of IL-27 resulted in more severe colitis in infected IL-10-

209 y, and shifted the transcriptional output of IL-27 from STAT1 to STAT3.

210 eliorate the disease even in the presence of IL-27-responsive conventional CD4 T cells.

211 In vitro, R848 induced production of IL-27 by murine alveolar macrophages and dendritic cells

212 regulation of gene expression and release of IL-27 in sepsis are poorly understood.

213 yD88-dependent and TRIF-dependent release of IL-27(p28).

214 The functional role of IL-27 and CD301b(+) cells is demonstrated by the finding

215 We therefore wanted to examine the role of IL-27 and IL-37 in regulating CD4(+) and CD8(+) T cell r

216 e data provide evidence of a central role of IL-27 for the control of Th2-mediated allergic diseases.

217 To explore the precise role of IL-27 in CAD, we investigated the genetic association be

218 Based on the anti-inflammatory role of IL-27 in cDC and through the generation of Tr1 cells, we

219 ogy, these data define a detrimental role of IL-27 in promoting demyelination by delaying viral contr

220 indings uncover a previously unknown role of IL-27 in regulating Treg function to control autoimmune

221 Surprisingly, however, the role of IL-27 in restricting or shaping effector CD4(+) T cell c

222 This study investigates the role of IL-27 signaling in respiratory syncytial virus (RSV) inf

223 in the spleen may be a significant source of IL-27(p28) during sepsis.

224 le regarding the natural cellular sources of IL-27 in humans and its effects on human immune cells.

225 T cells in vitro, such that beta subunit of IL-27 (Ebi)(-/-) (ie, IL-27-incompetent) DC-RAs were ine

226 ied the events regulating the p28 subunit of IL-27 in endotoxic shock and polymicrobial sepsis follow

227 Supplementation of IL-27 activates Egr-2 to induce IL-10 producing Tr1 cell

228 BN1 markedly increases HIV susceptibility of IL-27-treated macrophages.

229 Targeting of IL-27 therefore represents a novel strategy for the in v

230 s inhibits IRF-1-mediated transactivation of IL-27 gene expression via the PI3K/Akt pathway.

231 sed vaccine adjuvants unexpectedly depend on IL-27 for eliciting CD4(+) and CD8(+) T-cell responses.

232 ssion of experimental asthma is dependent on IL-27.

233 g dependence of R848-mediated suppression on IL-27.

234 how that p28 did not interfere with IL-6- or IL-27-induced signaling, indicating that p28 has no anta

235 esistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resis

236 ed STAT activation, at low molar excess over IL-27.

237 ts reveal that gp130 cytokines (particularly IL-27) are key regulators of CD4(+) T cell responses dur

238 ons in DCs enhances their ability to produce IL-27 and interferon beta (IFN-beta).

239 10 or systemic administration of recombinant IL-27 in reducing colitis in mice.

240 ally, systemic administration of recombinant IL-27 in Treg-specific Il27ra(-/-) mice fails to amelior

241 lly, treatment of monocytes with recombinant IL-27 was sufficient to induce the production of IL-10.

242 otic subjects where we found decreased serum IL-27 levels along with reduced Egr-2 expression.

243 contrast to viral infections at other sites, IL-27 does not play a proinflammatory role during JHMV-i

244 Moreover, soluble IL-27 plasma levels are negatively associated with the b

245 L-27, gene expression levels of the specific IL-27 receptor (IL27RA) in PBMC correlated directly with

246 ast, IL-10 remained fully active to suppress IL-27(p28) with deletion of SOCS3 in Tie2-Cre/SOCS3flox

247 Tristetraprolin suppresses IL-27 production by promoting p28 mRNA degradation.

248 Thus, we demonstrate that IL-27 and IL-37 limit the induction of particular T cell

249 marrow chimera experiments demonstrate that IL-27 dependency is T cell-intrinsic, requiring T-cell e

250 y of inflammation, our data demonstrate that IL-27 is a potent regulator of ROS induction and may be

251 blot and knock down assays demonstrate that IL-27 is able to enhance the potential of superoxide pro

252 We also demonstrate that IL-27 is able to induce extracellular superoxide dismuta

253 In this study, we demonstrate that IL-27 is rapidly and transiently produced by CD301b(+) c

254 We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HI

255 ping reporter mice further demonstrates that IL-27 signaling in Tregs may control stability of Foxp3

256 In this study, we present new evidence that IL-27 promotes monocyte differentiation into macrophages

257 We find that IL-27 signaling suppresses splenic CD4(+) T cell CCR5-de

258 We also found that IL-27, which shares the EBI3 subunit with IL-35, promote

259 Finally, we identify that IL-27 potently increases expression of the antiviral oli

260 Our data indicate that IL-27 has a crucial role in the inhibition of activation

261 Chinese Han population, which indicated that IL-27 might only be an inflammatory marker during the de

262 t in CD4(+) or CD8(+) Tregs, indicating that IL-27 inhibition had differential effects on IL-10 produ

263 eg-specific Il27ra(-/-) mice, we report that IL-27 signaling in Foxp3(+) Tregs is essential for Tregs

264 We have previously reported that IL-27 inhibits HIV-1 replication in primary T cells in t

265 Our data reveal that IL-27 or IL-37 neutralization resulted in significantly

266 Further, we show that IL-27 dependency not only dictates the magnitude of vacc

267 Here, we show that IL-27 induces metallothioneins (MTs) that in turn preven

268 Consistent with these findings, we show that IL-27 induces sufficient p-STAT3 to promote Th17 differe

269 In this article, we show that IL-27, another IL-12 family member, is produced by myelo

270 -associated colitis and further suggest that IL-27 may be a critical factor for controlling intestina

271 The IL-27 complex is formed by the association of the cytoki

272 The IL-27 cytokine and soluble receptor subunits p28 and EBI

273 The IL-27 polyglutamic acid domain is located in a flexible

274 g in HIV control and especially identify the IL-27/IL-27 receptor subunit alpha (IL-27RA) axis as a p

275 ELS was also noted in mice deficient in the IL-27 receptor (IL-27R) after the onset of inflammatory

276 Furthermore, genetic ablation of the IL-27 receptor (Il27Ra(-/-)) attenuates wound healing, s

277 We further show that the IL-27/NFIL3 signalling axis is crucial for the induction

278 ystemically during malaria infection through IL-27 receptor signaling that is supported after CD4(+)

279 Thus, IL-27 appears to be a key cytokine that limits the CCR5-

280 Thus, IL-27 appears to negatively regulate ELS development in

281 Thus, IL-27 functions as a regulatory cytokine during RSV path

282 Thus, IL-27 signaling in DCs limited pathogenic T cell respons

283 Neutralizing Abs to IL-27(p28) improved survival rates, restricted cytokine

284 In addition to IL-27, gene expression levels of the specific IL-27 rece

285 n confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo.

286 f the sympathetic nervous system) related to IL-27 production in primary mouse macrophages.

287 Pre-committed Th17 cells respond to IL-27 and IL-12 by upregulating Blimp1 and adopt a Tr-1-

288 e in vivo, which could be rescued by topical IL-27 treatment.

289 Unexpectedly, IL-27 did not inhibit HIV-1 in T cell lines, whereas IL-

290 The observation that p28/CLF, unlike IL-27, sustains B9 plasmacytoma cell proliferation promp

291 Combined LPS/IFN-gamma strongly upregulates IL-27 production, which has been linked to steroid-resis

292 Using IL-27 alanine mutants, we observed that the p28 polyglut

293 Moreover, in vitro IL-27 enhanced secretion of IFN-gamma whereas it inhibit

294 s were the source of secreted IL-35, whereas IL-27 production by CD11c(+) cells was inhibited.

295 e promotion of Th17 differentiation, whereas IL-27 or IL-6+IL-27 induced p-STAT3/p-STAT1 ratios < 1,

296 nd re-epithelialization in the skin, whereas IL-27 leads to suppression of keratinocyte terminal diff

297 In this study we asked whether IL-27 is produced by human secondary lymphoid organs and

298 ype I and type II interferons, together with IL-27, regulate ILC2 cells to restrict type 2 immunopath

299 F were induced early on after treatment with IL-27 and were required for the differentiation and func

300 Finally, therapeutic vaccination with IL-27-conditioned DCs suppressed established relapsing-r