ライフサイエンスコーパス: IL-2R alpha

1 alpha subunit of the interleukin-2 receptor (IL-2R alpha).

2 ng SP2/Tac tumor xenografts that express the IL-2R alpha.

3 expression of the IL-2 receptor alpha chain (IL-2R alpha), a protein that together with IL-2R beta an

4 b, anti-IL-2 Ab, anti-TNF-alpha Ab, and anti-IL-2R alpha Ab, suggesting that IFN-gamma production fro

5 BF-IgG exhibited both anti-IL-2R alpha and anti-IL-2R beta specificities in binding

6 es mast cell proliferation in the absence of IL-2R alpha and beta.

7 r, the patterns of tissue expression of IL-2/IL-2R alpha and IL-15/IL-15R alpha differ.

8 ructural and functional similarities between IL-2R alpha and IL-15R alpha chains, the activation-trig

9 pharose affinity chromatography, followed by IL-2R alpha and IL-2R beta affinity chromatography and h

10 and Mik beta1 (HuMik beta 1) Abs directed at IL-2R alpha and IL-2R beta, respectively, inhibit IL-2 b

11 activity may be due to cross-linking of the IL-2R alpha and IL-2R beta, thus blocking IL-2 binding a

12 + alphabeta T cells expressed high levels of IL-2R alpha and MHCII, regardless of the gammadelta/alph

13 ique as monitored by serum levels of soluble IL-2R alpha and/or human beta-2-microglobulin (P <.05, t

14 evels of interleukin-2 receptor alpha chain (IL-2R alpha) and major histocompatibility complex class

15 embrane expression of at least the p55IL-2R (IL-2R alpha) and p70IL-2R (IL-2R beta) components of the

16 Expression of IL-2, IL-2R-alpha, and the major G(1) cell cycle regulatory pr

17 We produced bifunctional humanized anti-IL-2R alpha beta Abs (BF-IgG) to combine the specificity

18 In Kit225/K6 (IL-2R alpha beta gamma+) cells, BF-IgG was 10-fold more

19 s were shown to express mRNA and protein for IL-2R alpha, beta and gamma chains.

20 s, RCC-S also partially blocked induction of IL-2R alpha-, beta- and gamma-chain expression when stim

21 The expression of the IL-2R alpha-, beta-, and gamma-chains, CD25, CD122, and

22 to bind to the interleukin 2 receptor alpha (IL-2R alpha; CD25)-expressing tumor cells.

23 Expression of the early activation markers IL-2R alpha chain (CD25) and CD69 on splenic donor CD4(+

24 ur observation that upregulation of both the IL-2R alpha chain and the CD69 activation antigen are in

25 Further, CD25, an IL-2R alpha chain, and lytic granules of NK cells in soc

26 ependent on the IL-2R beta chain but not the IL-2R alpha chain.

27 F42K, and IL-2 mutant that does not bind the IL-2R alpha chain.

28 cellular IL-2, as well as increased CD28 and IL-2R alpha-chain (CD25) expression.

29 the activation-induced up-regulation of the IL-2R alpha-chain (CD25) nor the addition of exogenous I

30 y T cells (Tregs) constitutively express the IL-2R alpha-chain (CD25) on their surface.

31 L-12 is shown to stimulate expression of the IL-2R alpha-chain (CD25) to much higher levels than are

32 dritic cells (hDCs) produce IL-2 and express IL-2R alpha-chain (CD25), but the role of IL-2 in DC fun

33 ion of IL-2 production and its high affinity IL-2R alpha-chain (CD25).

34 effects of humanized anti-Tac (HAT), an anti-IL-2R alpha-chain Ab, and HuMik beta1, an Ab directed at

35 Daclizumab (Dac), an Ab against the IL-2R alpha-chain, inhibits brain inflammation in patien

36 a T cell subset expressed high levels of the IL-2R alpha-chain.

37 ceptors and the IL-2R beta-chain but not the IL-2R alpha-chain.

38 mice bearing a homozygous deficiency of the IL-2R alpha-chain.

39 While IL-2R alpha did co-precipitate with IL-2R beta and IL-2R

40 A minimal oligonucleotide spanning the IL-2R alpha Elf-1 site (-97/-84) bound Elf-1 poorly, but

41 pproach in a clinical trial in patients with IL-2R alpha-expressing leukemias.

42 the physiological importance of IL-2-induced IL-2R alpha expression.

43 Interleukin-2 receptor (IL-2R alpha) expression was, however, unchanged on alveo

44 ta CD2- and CD2+ T cells expressed MHCII and IL-2R alpha following stimulation with SEC1, only a few

45 bodies (mAbs) that were directed against the IL-2R alpha, IL-2R beta, and gamma(c) subunits of IL-2R.

46 etero-trimerization of the receptor subunits IL-2R alpha, IL-2R beta, and gamma(c).

47 pwise assembly from IL-2/IL-2R alpha to IL-2/IL-2R alpha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/ga

48 alpha to IL-2/IL-2R alpha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/gamma(c).

49 rived factor/TRX, originally described as an IL-2R alpha-inducing factor.

50 Surprisingly, IL-2R alpha makes no contacts with IL-2R beta or gamma(c

51 Interestingly, the addition of an anti-IL-2R-alpha monoclonal antibody profoundly inhibited IL-

52 ng SP2/Tac (IL-2R alpha positive) and SP2/0 (IL-2R alpha negative) tumor.

53 Neither IL-2R alpha nor IL-2R beta chains are required for IL-15

54 onger transcription element than the -97/-84 IL-2R alpha oligonucleotide when cloned upstream of a he

55 was significantly inhibited and detection of IL-2R alpha on the PBMCs was reduced.

56 These cells express IL-2R alpha only after culture with specific peptide.

57 However, addition of Abs against IL-2 or IL-2R alpha only partially inhibited the spontaneous pro

58 Neutralizing IL-2, IL-2R alpha, or IL-2R beta inhibited AICD.

59 ration action of these cytokines through the IL-2R alpha pathway.

60 nude mice or into nude mice bearing SP2/Tac (IL-2R alpha positive) and SP2/0 (IL-2R alpha negative) t

61 Thus, IL-2-induced IL-2R alpha promoter activity requires a complex upstrea

62 In contrast, in the context of the IL-2R alpha promoter, conversion of the naturally occurr

63 and appears to negatively regulate the human IL-2R alpha promoter.

64 odeficiency virus-1 long terminal repeat and IL-2R alpha promoters in a kappaB-dependent manner.

65 owth as monitored by serum levels of soluble IL-2R-alpha (sIL-2R-alpha) and soluble beta2-microglobul

66 The IL-2R alpha subunit forms the largest of the three IL-2/

67 IL-15 does not interact physically with the IL-2R alpha subunit.

68 These findings support the principal role of IL-2R alpha to deliver IL-2 to the signaling complex and

69 onsistent with a stepwise assembly from IL-2/IL-2R alpha to IL-2/IL-2R alpha/IL-2R beta to IL-2/IL-2R

70 nt with previously reported functional data, IL-2R alpha was not co-precipitated from the [125I]IL-15

71 mphoma is that very few normal cells express IL-2R alpha, whereas the abnormal T cells in patients wi

72 iation rate and high-affinity interaction of IL-2R alpha with IL-2 at the cell surface.