ライフサイエンスコーパス: IL-4 receptor

1 or SHIP1, two adapter proteins that bind the IL-4 receptor.

2 sthma with both the human 5q31 locus and the IL-4 receptor.

3 ot occur in FAPs expressing knockdown of the IL-4 receptor.

4 include anti-IgE antibodies and the soluble IL-4 receptor.

5 t physically associated with and deactivated IL-4 receptor.

6 ells and dendritic cells need to express the IL-4 receptor.

7 coupling IRS proteins to activated IL-9 and IL-4 receptors.

8 d a cytokine receptor, typically the IL-2 or IL-4 receptors.

9 proliferation in human astroglia expressing IL-4 receptors.

10 human PBMC and tumor lines known to express IL-4 receptors.

11 h the cytoplasmic tail of the interleukin 4 (IL-4) receptor.

12 ated peptide derived from the interleukin 4 (IL-4) receptor.

13 ROS, in turn, promoted IL-4 receptor activation by oxidatively inactivating PTP

14 ROS were not required for the initiation of IL-4 receptor activation.

15 ceptor (BCR) cross-linking or interleukin-4 (IL-4) receptor activation in B cells, and after lipopoly

16 n of interleukin 4 (IL-4), engagement of the IL-4 receptor, activation of signal transducer and activ

17 specially in the context of the proasthmatic IL-4 receptor allele Il4raR576.

18 IL 4 receptor alpha (IL-4Ralpha) expression by non-bone

19 We also asked the role of interleukin (IL)-4 receptor alpha (IL-4Ralpha)-signal transducer and

20 rphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conver

21 The interleukin (IL)-4 receptor alpha-chain (IL-4Ralpha) contains a seque

22 IL-4 signaling through the IL-4 receptor alpha (IL-4Ralpha) chain on CD4(+) T cells

23 The IL-4 receptor alpha (IL-4Ralpha) gene is genetically abr

24 (SCI) associated with impaired induction of IL-4 receptor alpha (IL-4Ralpha) on microglia.

25 a mansoni Here, we report that abrogation of IL-4 receptor alpha (IL-4Ralpha) signaling on B cells in

26 Ablation of IL-4 receptor alpha (IL-4Ralpha) signaling restored the

27 However, when IL-13Ralpha1 combines with IL-4 receptor alpha (IL-4Ralpha), a signaling high affin

28 Through the actions of the IL-4 receptor alpha (IL-4Ralpha), type 2 cytokines resul

29 abrogated by a neutralizing antibody to the IL-4 receptor alpha (IL-4Ralpha)-chain but not to the IL

30 via IL-13 receptor alpha1 (IL-13Ralpha1) and IL-4 receptor alpha (IL-4Ralpha).

31 ES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha).

32 e show that in BALB/c mice deficient for the IL-4 receptor alpha chain (IL-4Ralpha(-/-)), which are u

33 rement of IL-4 and vascular endothelial (VE) IL-4 receptor alpha chain (IL-4Ralpha) signaling in hist

34 nt paradox is explained by observations that IL-4 receptor alpha chain (IL-4Ralpha)-deficient mice an

35 IL-4 receptor alpha chain (IL-4Ralpha)-deficient mice we

36 transduction mechanisms are conferred by the IL-4 receptor alpha chain (IL-4Ralpha).

37 cells, depending on their expression of the IL-4 receptor alpha chain (IL-4Ralpha/CD124).

38 mice with a gain-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) and wild-type (WT)

39 mice with a gain-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) were orally sensit

40 Both IL-4 and IL-4 receptor alpha chain colocalized in eosinophil gran

41 n (IL-2Rbeta) and physically adjacent to the IL-4 receptor alpha chain gene on chromosome 16.

42 hil granules; and after eotaxin-stimulation, IL-4 receptor alpha chain, bearing bound IL-4, was mobil

43 Here we show that a cytokine receptor, the IL-4 receptor alpha chain, mediates eotaxin-stimulated m

44 to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway.

45 tment with monoclonal antibodies to IL-4 and IL-4 receptor alpha chain.

46 ine-phosphorylated peptides derived from the IL-4 receptor alpha chain.

47 Subsequent experiments with IL-13 and IL-4 receptor alpha deficient mice demonstrated that gob

48 ctivating gene (RAG)2 knockout (KO) and RAG2/IL-4 receptor alpha double KO mice showed that inhibitio

49 w cytometry and Western blotting showed that IL-4 receptor alpha expression was elevated in TSK/+ fib

50 that amino acid changes in the 3' end of the IL-4 receptor alpha gene (IL4RA) or closely proximal var

51 in cells expressing a mutation of the human IL-4 receptor alpha in the immunoreceptor tyrosine-based

52 ant pharmacogenetic interaction between anti-IL-4 receptor alpha therapy and IL4RA gene variation, id

53 he AD molecular signature with targeted anti-IL-4 receptor alpha therapy.

54 ials, dupilumab, a fully human mAb targeting IL-4 receptor alpha, markedly improved disease activity,

55 nerated mice with a specific deletion of the IL-4 receptor alpha-chain (IL-4Ralpha) in macrophages an

56 Signaling by the IL-4 receptor alpha-chain (IL-4Ralpha) is a key determin

57 g of STAT5 to the Il4ra locus, which encodes IL-4 receptor alpha-chain (IL-4Ralpha), was essential fo

58 tat6 reside in the cytoplasmic domain of the IL-4 receptor alpha-chain (IL-4Ralpha).

59 Mice deficient for the IL-4 receptor alpha-chain (IL-4Ralpha-/-) retain the cap

60 e BALB/c mice deficient in IL-4 (IL-4-/-) or IL-4 receptor alpha-chain (IL-4Ralpha-/-), we have obser

61 L-2 receptor components, but did not inhibit IL-4 receptor alpha-chain and CD69 expression or the ind

62 n patients with AD is available for the anti-IL-4 receptor alpha-chain antibody dupilumab, but a numb

63 naive B cells expressed significantly higher IL-4 receptor alpha-chain on their cell surface than the

64 d with acute rejection episodes, nor was the IL-4 receptor alpha-chain variant Q576R.

65 These patients were also typed for the IL-4 receptor alpha-chain variant Q576R.

66 ediated by increased expression of Stat6 and IL-4 receptor alpha-chain.

67 d expression of Il4ra, the gene encoding the IL-4 receptor alpha-chain.

68 , caused by Schistosoma mansoni infection in IL-4 receptor alpha-deficient mice (IL-4Ralpha(-/-)), re

69 We now demonstrate that (i) an IL-4 receptor alpha-subunit (IL-4Ralpha)/Stat6-dependent

70 ation, presumably due to upregulation of the IL-4 receptor alpha.

71 (IL-6) polymorphisms and the interleukin-4 (IL-4) receptor alpha-chain variant on posttransplant ren

72 dition, naturally occurring mutations of the IL-4-receptor alpha chain have been identified and impli

73 studies employed artificial mutations of the IL-4-receptor alpha chain using site-directed mutagenesi

74 increases in IL-4 secretion, plasma soluble IL-4 receptor-alpha (IL-4Ralpha) concentration, and T-ce

75 RNA aptamer that blocks the murine or human IL-4 receptor-alpha (IL4Ralpha or CD124) that is critica

76 -4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, includi

77 was independent of signals mediated via the IL-4 receptor and hence occurred upstream of potential a

78 s, despite comparable levels of cell surface IL-4 receptor and phosphorylated Jak2 and STAT6.

79 s linked to the ligand binding domain of the IL-4 receptor and shown to support the IL-4 induced grow

80 alpha chain is an essential component of the IL-4 receptor and signals via STAT6.

81 Expression of cell surface IL-4 receptors and IL-4Ralpha in lysates was constitutiv

82 Our data from infections of IL-4 receptor(-/-) and Stat6(-/-) mice further indicate

83 AIDS-KS cells express surface interleukin-4 (IL-4) receptors, and that IL-4 toxin (IL-4(38-37)-PE38KD

84 ding to the upregulation of CXCR3 through an IL-4-receptor- and eomesodermin-dependent pathway.

85 dicating that this molecule acts as a strong IL-4 receptor antagonist.

86 n development, including anti-IL-13 mAbs and IL-4 receptor antagonists.

87 expression of both MHC class II antigens and IL-4 receptor are completely abrogated, and lymphocytes

88 ed gamma-c restored function to the IL-2 and IL-4 receptors as shown by signal transduction mediated

89 itionally, we show that the requirements for IL-4 receptor binding and Stat6 activation extend to acc

90 yrosine phosphorylation or expression of the IL-4 receptor chains.

91 onal down-regulation of both subunits of the IL-4 receptor complex (CD124, CD132) and are mediated vi

92 f phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p7

93 SOCS-3/IL-4 receptor complexes, however, were increased in db/d

94 The human IL-4 receptor contains a sequence (the 14R motif) center

95 acrophages stimulated with IL-31, but not in IL-4 receptor-deficient macrophages.

96 -infected wild-type and IL-4-deficient mice, IL-4 receptor-deficient mice showed minimal RELMbeta ind

97 ntly, mice deficient in either mast cells or IL-4 receptor displayed greater susceptibility to the in

98 Thus, type I and II IL-4 receptors exert distinct effects on immune response

99 our original hypotheses, IL-4 production and IL-4 receptor expression by T cells are both dispensable

100 "IL-4-dependent pulmonary priming" relies on IL-4 receptor expression on hematopoietic cells and stru

101 terleukin (IL)-4 and IL-13 share the type II IL-4 receptor for cell signaling.

102 er ligand-dependent activation, interleukin (IL)-4 receptor generated reactive oxygen species (ROS) v

103 xpressing memory CD4(+) T cells that induced IL-4 receptor(hi) (IL-4R(hi)) CD206(+) alternatively act

104 The insulin/interleukin-4 (IL-4) receptor (I4R) motif mediates the association of i

105 igated whether a relationship exists between IL-4 receptor (IL-4R) expression and MO persistence in t

106 The IL-4 receptor (IL-4R) in B cells is composed of two chai

107 toplasmic domain of the alpha-subunit of the IL-4 receptor (IL-4R) might be relatively resistant to t

108 hosen as a ligand based on the expression of IL-4 receptor (IL-4R) on most acute myeloid leukemia cas

109 ammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL

110 h2) differentiation is driven by a source of IL-4 receptor (IL-4R) that mobilizes IL-4R signaling pat

111 ypes responsive to IL-4, T cells express one IL-4 receptor (IL-4R) type, IL-4Ralpha/IL-2Rgamma (class

112 that gammadelta17 cells expressed the type I IL-4 receptor (IL-4R), and IL-4 increased STAT6 phosphor

113 DA express moderate- to high-density surface IL-4 receptor (IL-4R), whereas normal pancreatic samples

114 IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13Ralpha1 a

115 IL-4 receptor (IL-4R)-deficient CD8+ T cells specific fo

116 Soluble recombinant human IL-4 receptor (IL-4R; Nuvance; altrakincept) inactivates

117 neck cancer cell lines also express surface IL-4 receptors (IL-4R) and IL-4 binds to IL-4R on one ce

118 IL-4 receptors (IL-4Rs) are also expressed by nonhematop

119 Although IL-4 receptors (IL-4Rs) but not IL-12Rs are expressed on

120 In line with this, gene expression of the IL-4 receptor (Il4ra) and its ligand IL-13 are elevated

121 lar domain was replaced by that of the human IL-4 receptor (IL4Ralpha/GPIbalpha-tg mice).

122 articipation of interleukin-4 (IL-4) and the IL-4 receptor in asthma.

123 the distinct functions of type I and type II IL-4 receptors in vivo.

124 Because the IL-4 receptor is known to signal through the JAK1 and JA

125 gG1 involves tyrosine phosphorylation of the IL-4 receptor, JAK1, JAK3, and STAT6 proteins induced by

126 IL-4 receptor knockout (Il4ra(-/-)) mice, which have red

127 or substrates, or to a failure to upregulate IL-4 receptor levels.

128 atterns are also evident at the cytokine and IL-4 receptor loci.

129 cific responses, we transplanted the insulin IL-4 receptor motif (I4R motif) of the huIL-4R alpha to

130 otif (488PLVIAGNPAYRSFSD) termed the insulin IL-4 receptor motif (I4R motif).

131 n 32D-IRS-1 cells transfected with the human IL-4 receptor mutated in the insulin-lL-4 receptor motif

132 ent understanding of the organization of the IL-4 receptor, of the signaling pathways that are induce

133 te that the concerted activation of TLR2 and IL-4 receptor on dendritic cells is sufficient for this

134 IL-4 also enhanced expression of the IL-4 receptor on microglia, facilitating a "feedforward"

135 vered by cytokines and also suggest that the IL-4 receptor on resting T cells may use a novel signali

136 ls produce IL-4, which attenuates damage via IL-4 receptors on neurons.

137 were dependent on IL-4 acting through type 2 IL-4 receptors on neutrophils.

138 ion resulted in an increase of IFN-gamma and IL-4 receptors on PMCs.

139 escence was used to document the presence of IL-4 receptors on the gastric SOM-secreting cell (D cell

140 Moreover, genetic ablation of IL-4, the IL-4 receptor, or its downstream signaling molecule sign

141 Cotransfection of IL-4 receptor p140 (termed IL-4Rbeta) with gammac or IL-

142 rotein and the protein when complexed to the IL-4 receptor phosphopeptide.

143 pecifically induced by IL-4 and revealed the IL-4-receptor/PI3K/Akt-signaling pathway as a target.

144 sIg) engagement, physiological engagement of IL-4 receptors produced similar levels of Fas resistance

145 IL-4 receptor (R) alpha, the common receptor chain for I

146 aling through both B cell receptor (BCR) and IL-4 receptor (R) converge on the extinction of B7h mRNA

147 stage by anti-interleukin (IL)-4 blockade of IL-4 receptor (R) signaling.

148 At least two distinct receptor components, IL-4 receptor (R)alpha and IL-13Ralpha1, mediate the div

149 Furthermore, the absence of Type II IL-4 receptor signaling is sufficient to attenuate the e

150 tor (TCR) stimulation and was independent of IL-4 receptor signaling through the transcription factor

151 The roles of IL-10 and IL-4 receptor signaling were evaluated in a murine model

152 on was highly dependent on IL-13 and type II-IL-4 receptor signaling.

153 g that GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions wit

154 f the adaptive immune system, eosinophils or IL-4 receptor signalling.

155 gnificant increase in the inhibitory soluble IL-4 receptor (sIL4R).

156 ts studying signaling molecules activated by IL-4 receptor suggest that IL-4 signaling can be subdivi

157 do not express the gamma common chain of the IL-4 receptor, support PV-mediated but not IL-4-dependen

158 Thus, IL-4 receptor-targeted cytotoxin represents a potent age

159 to require signaling contributions from both IL-4 receptor, via STAT6, and CD28, but it cannot be eff

160 Expression of the IL-4 receptor was determined by flow cytometry and Weste

161 monstrated that the gammaC subunit of type I IL-4 receptor was required for robust tyrosine phosphory

162 ellular IL-4Ralpha-chain and in cell surface IL-4 receptors was associated with an inhibition of bios

163 CLL B-cell expression of IL-4 receptors was increased compared to normal B cells.

164 ng mice harboring a disinhibited form of the IL-4 receptor, we developed an adjuvant-free model of pe

165 ac]) and the type II (IL-4Ralpha/-13Ralpha1) IL-4 receptors, whereas IL-13 utilizes only the type II

166 depend upon signaling via the interleukin-4 (IL-4) receptor which conventionally governs the developm

167 of injured neurons by activation of neuronal IL-4 receptors, which potentiated neurotrophin signaling

168 In macrophages, IL-4/-13 bind IL-4 receptors, which signal through insulin receptor su