ライフサイエンスコーパス: IL-5 receptor

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1 al transducing receptor betac subunit of the IL-5 receptor.

2 nteraction with the alpha chain of the human IL-5 receptor.

3 ls and monocytes from patients expressed the IL-5 receptor.

4 s with the alpha subunit of the interleukin (IL) 5 receptor.

5 colony stimulating factor, and the IL-3 and IL-5 receptors.

6 We describe MVF assays for the IL-1 and IL-5 receptors.

7 onent of the GM-CSF, interleukin (IL)-3, and IL-5 receptors.

8 Ras activation through the GM-CSF, IL-3, and IL-5 receptors.

9 is regulated by the restricted expression of IL-5 receptor alpha (IL-5Ralpha), a subunit of high-affi

10 oth monomers were shown to interact with the IL-5 receptor alpha chain with 1:1 stoichiometry and aff

11 al analysis revealed unexpected affinity for IL-5 receptor alpha chain with variants containing E110W

12 eosinophil-specific expression of the human IL-5 receptor alpha gene.

13 Treatment with antibodies targeting IL-5 or IL-5 receptor alpha reduces the frequency of asthma exac

14 Serum levels of IL-5 and IL-5 receptor alpha, but not IgE, were similarly increas

15 Benralizumab targets eosinophils by binding IL-5 receptor alpha, inducing apoptosis through antibody

16 The largely retained IL-5 receptor alpha-chain binding affinities versus rela

17 This mutein was found to retain substantial IL-5 receptor alpha-chain binding but with selectively s

18 This result confirms recent findings that IL-5 receptor alpha-chain recognition can be supported b

19 d benralizumab, a monoclonal antibody to the IL-5 receptor alpha-chain, are comparatively limited, es

20 x D region, which is predicted to engage the IL-5 receptor alpha-chain.

21 generated a 19-aa peptide that binds to the IL-5 receptor alpha/beta heterodimer complex with an aff

22 se findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating a

23 Resting B cells express few, if any, IL-5 receptors and do not respond to the lymphokine.

24 Thus, expression of IL-5 receptors and induction of Ig secretion requires co

25 sL(+) B cells expressed higher levels of the IL-5 receptor, and treating B cells with IL-5 and CD40L

26 have shown that dynamin-2 interacts with the IL-5 receptor-associated tyrosine kinases, Lyn and JAK2,

27 p 2 region, which is predicted to engage the IL-5 receptor beta-chain.

28 the atopic sensitized tissues with either an IL-5 receptor blocking antibody (IL-5ra) or the human re

29 Furthermore, novel data demonstrate IL-5 receptor expression on neutrophils and monocytes in

30 ociate with beta common (betac) chain of the IL-5 receptor (IL-5betacR).

31 The IL-5 receptor (IL-5R) consists of an IL-5-specific alpha

32 logy is critically dependent on IL-5 and the IL-5 receptor (IL-5R), composed of a ligand binding alph

33 kinase, is associated with the interleukin (IL)-5 receptor in eosinophils.

34 e a novel signaling pathway activated by the IL-5 receptor in eosinophils involving the CrkL adapter

35 omers stimulated cell proliferation of human IL-5 receptor positive cells with a concentration depend

36 ortance of charge distribution in functional IL-5 receptor recruitment.

37 We tracked the oligomerization of IL-5 receptor subunits using fluorescence resonance ener

38 matopoietic functions through binding to the IL-5 receptor subunits, alpha and betac.

39 ces including interleukin (IL-)-3, IL-4, and IL-5 receptor subunits, the p65 component of nuclear fac

40 ding alpha-chain of the human interleukin 5 (IL-5) receptor was expressed in its soluble form, lackin

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