ライフサイエンスコーパス: ILD

1 ILD contributed approximately 13% to the excess mortalit

2 ILD pattern was defined by high-resolution computed tomo

3 hly lateralized; or (3) at the center near 0 ILD.

4 patients with alternative idiopathic ILDs (a-ILD; n = 41), and healthy control subjects (n = 127).

5 ished patients with IPF from patients with a-ILD, both individually and in a combined index.

6 entiated patients with IPF from those with a-ILD.

7 imatinib in patients with SSc-related active ILD, our primary aim was to assess the safety of imatini

8 .0001), particularly in patients with active ILD (P<0.0001) compared with those with stable lung func

9 Median survival after ILD diagnosis was only 2.6 years.

10 Common protein regulations across all ILD cases, as well as distinct ILD subsets, were observe

11 with our hypothesis that the GABA(A)R alpha1 ILD contributes directly to the permeation pathway.

12 t mutations within a subdomain of the alpha1 ILD near M3 altered GABA apparent affinity; interestingl

13 Deletion of the alpha1 ILD resulted in a significant increase in GABA EC(50) an

14 TD >/= 205 Gy and HILD < 120 Gy, applying an ILD > 150 Gy).

15 In a multivariable analysis, ILD-associated PH was associated with a 5-fold increase

16 s for SSc, RP, other autoimmune disease, and ILD (with 95% confidence intervals [95% CIs]), and popul

17 ore RP, autoimmune inflammatory disease, and ILD than would be expected by chance.

18 ability of RP, other autoimmune disease, and ILD.

19 Continuous distributions of best ILDs and ILD tuning metrics were observed in all cortices, sugges

20 uroendocrine cell hyperplasia of infancy and ILD, due to mutations in genes affecting surfactant prod

21 results to each other in simulating ITD and ILD coding.

22 oise, degrading the fidelity of both ITD and ILD cues.

23 , which reduced the dynamic range of ITD and ILD response functions and the ability of neurons to sig

24 Using a modeling approach, we assess ITD and ILD sensitivity of the neural filters to natural sounds,

25 conditions, cortical sensitivity to ITD and ILD takes the form of broad contralaterally dominated re

26 teraural time and level differences (ITD and ILD)-that correlate with sound-source locations.

27 ons suggest integrated processing of ITD and ILD.

28 perates in a similar manner on both ITD- and ILD-sensitive neurons, suggesting a shared mechanism ope

29 to amyloid formation of the SP-C protein and ILD.

30 atomyosits (including recalcitrant rash) and ILD.

31 eraural time and level differences (ITDs and ILDs), can be compromised by device processing.

32 As altered the relationship between ITDs and ILDs, introducing large ITD-ILD conflicts in some cases.

33 atients with rheumatoid arthritis-associated ILD (RA-ILD; n = 33), patients with alternative idiopath

34 d treat connective tissue disease-associated ILD (CTD-ILD)--disorders with potentially substantial mo

35 g to the pathogenesis of myositis-associated ILD.

36 , predictors, and mortality of RA-associated ILD.

37 ical trials of systemic sclerosis-associated ILD and idiopathic pulmonary fibrosis and how these less

38 ncoding of ILDs, human and animal behavioral ILD sensitivity is robust to temporal stimulus degradati

39 Here we demonstrate that behavioral ILD sensitivity (in humans) and neural ILD sensitivity (

40 Here we demonstrate that behavioral ILD sensitivity is only modestly degraded with even comp

41 Continuous distributions of best ILDs and ILD tuning metrics were observed in all cortice

42 tical coupling and thermal isolation between ILDs and waveguides.

43 In contrast, one BRICHOS and one non-BRICHOS ILD-associated mutant could not insert into membranes.

44 entities are distinct from those that cause ILD in older children and adults.

45 l lung disease (ILD) cases, (2) characterize ILD subgroups in an unbiased fashion, and (3) identify c

46 fants, who are regarded as having "childhood ILD syndrome"; (4) describe a new pathologic classificat

47 xcluded, neonates and infants with childhood ILD syndrome should be evaluated by a knowledgeable subs

48 les that are highly effective in classifying ILD patients; and (3) stochastic simulation to design, t

49 inhibitory from the other: EI cells) compare ILDs separately over restricted frequency ranges which a

50 in patients with SSc-related PH complicating ILD (PH-ILD) remain unknown.

51 t localization cues are integrated: cortical ILD tuning to broadband sounds is a composite of separat

52 mmon new-onset ILD in India, followed by CTD-ILD and idiopathic pulmonary fibrosis; diagnoses varied

53 (n = 513; exposure, 48.1% air coolers), CTD-ILD in 13.9%, and idiopathic pulmonary fibrosis in 13.7%

54 iew, we address aspects of prognosis for CTD-ILD and what indices might predict outcome, together wit

55 onnective tissue disease-associated ILD (CTD-ILD)--disorders with potentially substantial morbidity a

56 ns might be applied to future studies of CTD-ILD.

57 With a pedestal ILD of 0 dB, ILD increments of 1 dB could be discriminated by some ne

58 An adjudication panel determined ILD hospitalization and death.

59 The lifetime risk of developing ILD was 7.7% for RA patients and 0.9% for non-RA subject

60 The risk of developing ILD was higher in RA patients who were older at the time

61 ies to binaural interaural level difference (ILD) and average binaural level cues were probed in A1 a

62 l plane uses an interaural-level difference (ILD) cue, yet little is known about the synaptic mechani

63 en both ITD and interaural level difference (ILD) cues are available, directional sensitivity in reve

64 is modulated by interaural level difference (ILD) primarily through scaling excitation to different l

65 and robust than interaural level difference (ILD).

66 ences in which interaural level differences (ILD) rapidly fluctuated according to a Gaussian distribu

67 integration of interaural level differences (ILD).

68 structure and interaural level differences (ILDs) from the stimulus envelope.

69 all changes in interaural level differences (ILDs), a cue to horizontal sound location, of pure tones

70 igs to compare interaural level differences (ILDs), a key localization cue, between tones of disparat

71 rences (ITDs), interaural level differences (ILDs), and pinna spectral cues, are all represented in t

72 me differences (ITDs) and level differences (ILDs).

73 tween a side-emitting injection laser diode (ILD) and a dielectric optical waveguide mixer via a grad

74 try (FC) data and interstitial lung disease (ILD) - a systemic sclerosis (SSc, or scleroderma) clinic

75 rlying dyspnea in interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) ar

76 ts with fibrosing interstitial lung disease (ILD) and determine whether there are differences among t

77 s associated with interstitial lung disease (ILD) are how best to define, diagnose, and treat connect

78 across end-stage interstitial lung disease (ILD) cases, (2) characterize ILD subgroups in an unbiase

79 rogressive, fatal interstitial lung disease (ILD) characterized by abnormal extracellular matrix (ECM

80 ts suffering from interstitial lung disease (ILD) due to mutations in the gene of the precursor prote

81 of patients with interstitial lung disease (ILD) has been a subject of debate and controversy.

82 Interstitial lung disease (ILD) has been recognized as an important comorbidity in

83 es on subclinical interstitial lung disease (ILD) has not been studied.

84 haracteristics of interstitial lung disease (ILD) in a large cohort of patients with anti-Jo-1 antibo

85 and prognosis of interstitial lung disease (ILD) in children.

86 recognition that interstitial lung disease (ILD) in infants is often distinct from the forms that oc

87 tities that cause interstitial lung disease (ILD) in infants.

88 RATIONALE: Interstitial lung disease (ILD) is a heterogeneous group of acute and chronic infla

89 or progression of interstitial lung disease (ILD) is controversial.

90 scleroderma), and interstitial lung disease (ILD) is the most common pulmonary manifestation.

91 is a progressive interstitial lung disease (ILD) of unknown origin characterized by epithelial cell

92 Interstitial lung disease (ILD) with pulmonary fibrosis is an important manifestati

93 Interstitial lung disease (ILD), a leading cause of morbidity and mortality in rheu

94 sis (SSc)-related interstitial lung disease (ILD), and imatinib is a potent inhibitor of TGFbeta and

95 ose patients with interstitial lung disease (ILD), whereas mycophenolate mofetil is effective in both

96 e pathogenesis of interstitial lung disease (ILD).

97 cally significant interstitial lung disease (ILD).

98 degeneration, and interstitial lung disease (ILD).

99 association with interstitial lung disease (ILD).

100 y for SSc-related interstitial lung disease (ILD).

101 r associated with interstitial lung disease (ILD).

102 s attributable to interstitial lung disease (ILD).

103 gression of most interstitial lung diseases (ILD) is unpredictable.

104 Interstitial lung diseases (ILDs) are associated with oxidative stress.

105 ressive fibrotic interstitial lung diseases (ILDs) are characterised by major reductions in quality o

106 Interstitial lung diseases (ILDs) are characterized by injury, inflammation, and sca

107 contiguity (automated interlesion distance [ILD]).

108 ns across all ILD cases, as well as distinct ILD subsets, were observed.

109 Residues in the intracellular loop domain (ILD) have recently been shown to define part of the ion

110 liver dose (HILD), and injected liver dose (ILD).

111 olliculus (of chinchilla) effectively encode ILDs despite complete decorrelation of left- and right-e

112 Existing ILD registries have had variable findings.

113 CC; Jaipur, India) with MDD, and experienced ILD experts at the Center for ILD (CILD; Seattle, WA) wi

114 Coarseness of fibrosing ILD (P = .011) and IPF diagnosis (P = .016) were indepen

115 ion DPO is common in patients with fibrosing ILD and is significantly more prevalent in patients with

116 ised 892 consecutive patients with fibrosing ILD, including 456 patients with idiopathic pulmonary fi

117 with IPF than in those with other fibrosing ILDs, and thus, computed tomographic signs of DPO may be

118 2.39 [95% CI 1.21-4.74], P = 0.012), and for ILD in first-degree relatives (1.53 [95% CI 1.04-2.26],

119 dicate that Chit1 is potential biomarker for ILD in SSc and a therapeutic target in SSc-associated lu

120 ective implementation of palliative care for ILD will require multidisciplinary participation from cl

121 nd experienced ILD experts at the Center for ILD (CILD; Seattle, WA) with MDD.

122 function data, 77 (86%) met the criteria for ILD.

123 heumatology (ACR) cohorts were evaluated for ILD.

124 ghest incidence of binaural facilitation for ILD cues corresponding to midline positions, supporting

125 lung attenuation are a novel risk factor for ILD hospitalization and mortality.

126 ratios (Th2/Tc2) (P<0.0001), as observed for ILD.

127 ing responsiveness to emerging therapies for ILD.

128 dothelin receptor antagonists as therapy for ILD secondary to SSc.

129 Neural thresholds for ILD discrimination were determined from the discharge ra

130 s result suggests that, at high frequencies, ILDs provide better directional information than envelop

131 ections from bleomycin-treated mice and from ILD patients.

132 ion were strongly associated with death from ILD.

133 d of mature SP-C in lung tissue samples from ILD patients with mutations in the BRICHOS domain or in

134 e in fibroblasts and in tissue sections from ILD patients and in lungs of bleomycin-treated mice.

135 ted in a subset of subjects with HPS who had ILD but not subjects without lung disease or normal cont

136 at proved effective in correctly identifying ILD patients in the training and validation data sets.

137 = 33), patients with alternative idiopathic ILDs (a-ILD; n = 41), and healthy control subjects (n =

138 uish patients with IPF from other idiopathic ILDs.

139 In ILD and COPD, descriptors alluding to inspiratory diffic

140 ial cytokine that induces fibrotic action in ILD fibroblasts (ILDFbs).

141 to examine all relevant literature on BAL in ILD and provide recommendations concerning the use of BA

142 uced CD44v6-dependent fibroblast function in ILD fibrosis.

143 our understanding of mechanisms involved in ILD and thereby aid in identification of new therapeutic

144 ILD experts, emphasizing the value of MDD in ILD diagnosis.

145 esting the existence of a highly integrative ILD-coding mechanism.

146 Interestingly, ILD processing in all inferior colliculus cell types (EE

147 case report forms: local site investigators, ILD experts at the National Data Coordinating Center (ND

148 ts with IPF compared with those with non-IPF ILD.

149 between ITDs and ILDs, introducing large ITD-ILD conflicts in some cases.

150 f interaural time and level differences (ITD/ILD), which are the timing and intensity differences of

151 l information was analyzed in terms of ITDs, ILDs, and interaural coherence, both for whole stimuli a

152 in encoding interaural time (ITD) and level (ILD) differences, respectively.

153 l differences in the timing (ITD) and level (ILD) of impinging sounds carry critical information abou

154 differences in sound timing (ITD) and level (ILD).

155 ected activity was 3.1 +/- 1.5 GBq, and mean ILD was 143 +/- 49 Gy.

156 In patients with mild to moderate ILD or COPD with similarly reduced inspiratory capacity,

157 ease-related interstitial lung disease (nCTD-ILD).

158 al and fBOS as persons transplanted for nCTD-ILD.

159 1 fashion to controls undergoing LT for nCTD-ILD.

160 nd 76% compared with 91% and 64% in the nCTD-ILD group, respectively.

161 ioral ILD sensitivity (in humans) and neural ILD sensitivity (in single neurons of the chinchilla aud

162 adulthood, allows for study of biomarkers of ILD in a homogeneous population at near-certain risk of

163 ky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers o

164 The classification of ILD syndromes in children greater than 2 years of age is

165 care, with no role earlier in the course of ILD, has created a culture of neglect.

166 dication, 52 participants had a diagnosis of ILD during 75,232 person-years (median, 12.2 yr) of foll

167 Diagnosis of ILD syndromes is based on the summation of history and p

168 imaging studies determined the existence of ILD in anti-Jo-1 antibody-positive individuals whose dat

169 at the LSO plays a role in the extraction of ILD, and that the representation of ILD by LSO neurons m

170 The CT features of ILD in group 1 were always depicted in group 2, with sub

171 ualization and conspicuity of CT features of ILD.

172 The etiology of idiopathic forms of ILD is not understood, making them particularly difficul

173 understanding of several different forms of ILD, including neuroendocrine cell hyperplasia of infanc

174 high molecular and cellular heterogeneity of ILD, common protein regulations are observed, even acros

175 f the inciting events and natural history of ILD, coupled with a lack of effective therapies.

176 The devastating impact of ILD on survival provides evidence that development of be

177 ate predictors, and to explore the impact of ILD on survival.

178 ibody-positive individuals, the incidence of ILD approached 90%.

179 models were used to compare the incidence of ILD between cohorts, to investigate predictors, and to e

180 classification, diagnosis, and management of ILD in children, focusing on neonates and infants under

181 insight into the etiology and management of ILD worldwide.

182 mpared with the outputs of a simple model of ILD processing with a single free parameter, the duratio

183 We developed an inbred mouse model of ILD using vanadium pentoxide (V2O5), the most common for

184 may be useful as a biomarker for outcome of ILD in subjects with HPS.

185 e coding can account for the preservation of ILD sensitivity despite even extreme temporal degradatio

186 osis is challenging because of the rarity of ILD and the fact that the presenting symptoms of ILD oft

187 as were associated with an increased rate of ILD hospitalization (adjusted hazard ratio, 2.6 per 1-SD

188 re also associated with an increased rate of ILD-specific death (adjusted hazard ratio, 2.3; 95% conf

189 ction of ILD, and that the representation of ILD by LSO neurons may set a lower bound on the behavior

190 Twenty participants died as a result of ILD (crude rate, 2.7 per 10,000 person-years).

191 uation areas are associated with the risk of ILD hospitalization and mortality in the general populat

192 Our results emphasize the increased risk of ILD in patients with RA.

193 The lifetime risk of ILD was estimated.

194 We collected samples of ILD tissue (n = 45) and healthy donor control samples (n

195 and the fact that the presenting symptoms of ILD often overlap those of common respiratory disorders.

196 nt of better strategies for the treatment of ILD could significantly lower the excess mortality among

197 hysical performance in the discrimination of ILDs.

198 l programs caused time-varying distortion of ILDs.

199 ry and inhibitory inputs for the encoding of ILDs, human and animal behavioral ILD sensitivity is rob

200 ittle is known about the clinical profile of ILDs in India.

201 her there are differences among the types of ILDs.

202 ce the susceptibility to, or progression of, ILD.

203 The dependence of gain modulation on ILD shown here constitutes a means for space-dependent c

204 Indian origin living in India with new-onset ILD (27 centers, 19 Indian cities, March 2012-June 2015)

205 ty pneumonitis was the most common new-onset ILD in India, followed by CTD-ILD and idiopathic pulmona

206 To characterize new-onset ILDs in India by creating a prospective ILD using multid

207 sensitivity to parametrically varied ITD or ILD cues was measured using fMRI during spatial and nons

208 Consecutive SSc patients with PAH or ILD-associated PH confirmed by right heart catheterizati

209 epresentations on the basis of either D/R or ILD individually.

210 orded IC neurons sensitive to either ITDs or ILDs in anesthetized guinea pig, before, during, and fol

211 proved successful in predicting SSc patient ILD status with a high degree of success (>82% correct c

212 With a pedestal ILD of 0 dB, ILD increments of 1 dB could be discriminat

213 nge of frequencies (0.3-35 kHz) and pedestal ILDs (+/-25 dB) explored in this study.

214 For pedestal ILDs away from 0 dB, the best-threshold ILDs were as low

215 nts from 2 large referral centers who had PH-ILD confirmed by right-sided heart catheterization and w

216 nts with SSc-related PH complicating ILD (PH-ILD) remain unknown.

217 he impact of PAH therapies in SSc-related PH-ILD was examined.

218 ndertaken to evaluate our experience with PH-ILD with regard to the efficacy and safety of PAH therap

219 ciations between anti-Jo-1 antibody-positive ILD and elevated serum levels of C-reactive protein (CRP

220 ciations between anti-Jo-1 antibody-positive ILD and serum levels of CRP as well as the interferon-ga

221 associated with anti-Jo-1 antibody-positive ILD.

222 we study the synaptic currents that process ILD in vivo and use stimuli in which ILD varies around a

223 nset ILDs in India by creating a prospective ILD using multidisciplinary discussion (MDD) to validate

224 ciation between variables of interest and RA-ILD.

225 k factors and autoantibodies can identify RA-ILD and if the addition of investigational biomarkers is

226 with rheumatoid arthritis-associated ILD (RA-ILD; n = 33), patients with alternative idiopathic ILDs

227 findings may facilitate identification of RA-ILD at an earlier stage, potentially leading to decrease

228 or clinical scans (51% with a spectrum of RA-ILD) were selected.

229 nce of clinically evident and subclinical RA-ILD on computed tomography scan in two independent RA co

230 rum of clinically evident and subclinical RA-ILD) and 76 ACR subjects with research or clinical scans

231 r both clinically evident and subclinical RA-ILD.

232 e antibodies was strongly associated with RA-ILD (areas under the curve, 0.88 for BRASS and 0.89 for

233 arthritis (RA), is highly prevalent, yet RA-ILD is underrecognized.

234 tion mean, resulting in large shifts in rate-ILD functions, while their gain adapted to the stimulus

235 ar detection of systematic sclerosis-related ILD compared with the reference standard.

236 Patients with SSc and significant ILD were recruited to this prospective, double-blind, ra

237 at risk of developing clinically significant ILD.

238 y that strengthened the response to specific ILDs.

239 s, studies that directly compare IPF and SSc-ILD are rare.

240 compares the salient features of IPF and SSc-ILD.

241 is-associated interstitial lung disease (SSc-ILD) are thought to have the greatest decline in lung fu

242 derma-related interstitial lung disease (SSc-ILD).

243 Rates of acute rejection were less in SSc-ILD (P = 0.05).

244 provided the MCID estimates for FVC% in SSc-ILD based changes at 12 months from baseline in two clin

245 edict the development and or severity of SSc-ILD have not been validated, and the pathogenetic mechan

246 se state such as the risk or presence of SSc-ILD, the activity of lung involvement and the likelihood

247 Among patients with SSc-ILD in the Scleroderma Lung Study, the rates of progress

248 and molecular methods to detect subclinical ILD.

249 associated with measurements of subclinical ILD in community-dwelling adults.

250 and therapeutic implications of subclinical ILD in populations at risk of developing clinically sign

251 raphy (CT)-based measurements of subclinical ILD, respectively.

252 stages of pulmonary fibrosis or subclinical ILD.

253 imely recognition of children with suspected ILD and initiation of appropriate diagnostic evaluations

254 nostic evaluation of children with suspected ILD.

255 is and management of patients with suspected ILD.

256 nostic evaluation of patients with suspected ILD.

257 The results indicate that ILD mutations interfering with proSP-C BRICHOS activity

258 and modeling data collectively suggest that ILD sensitivity depends on binaural integration of excit

259 The ILD-dependent synaptic scaling and gain adjustment allow

260 This allows the ILD processing pathway to encode envelope information wi

261 provides useful information in assessing the ILD status of SSc patients.

262 ntegration potentiates a unique role for the ILD system in spatial hearing that may be of particular

263 red at a lower (P < 0.05) ventilation in the ILD and COPD groups than in control subjects.

264 ach of these measurements was similar in the ILD and COPD groups.

265 lope ITDs, emphasizing the importance of the ILD-processing pathway for sound localization in reverbe

266 In this study, we investigated the role the ILD of the GABA(A)R alpha1 subunit plays in channel func

267 ximal current amplitude, suggesting that the ILD must be intact for proper receptor function.

268 ordings from the same neuron showed that the ILD tuning of the spikes was sharper than that of the EP

269 Their ILD preference adjusted to match the stimulus distributi

270 with psychophysical data, the best-threshold ILDs of single LSO neurons were comparable with or bette

271 stal ILDs away from 0 dB, the best-threshold ILDs were as low as 0.5 dB, with a median of 2.3 dB.

272 ere were 48 hospitalizations attributable to ILD (crude rate, 6.4 per 10,000 person-years).

273 n auditory cortex believed to be integral to ILD processing (excitatory from one ear, inhibitory from

274 s A1 and rostral SRAF responded maximally to ILD cues favoring more eccentric positions in the contra

275 lower bound on the behavioral sensitivity to ILDs.

276 ion of extent of fibrosis (QLF) and of total ILD (QILD) on HRCT.

277 form of the pro-SP-C BRICHOS domain and two ILD-associated mutants.

278 Paradoxically, while typical ILD-sensitive neurons of the auditory brainstem require

279 tic simulation to design, train and validate ILD risk screening tools.

280 We investigated the site where ILD is detected in the auditory system of barn owls, the

281 process ILD in vivo and use stimuli in which ILD varies around a constant average binaural level (ABL

282 cell types are explained by a model in which ILDs are computed within separate frequency channels and

283 The majority (15 of 20 with ILD-associated PH and 27 of 39 with PAH) received an end

284 Fifty-nine patients (39 with PAH and 20 with ILD-associated PH) were identified.

285 f healthy control subjects and patients with ILD (n = 42 in each group).

286 st and during exercise in both patients with ILD and patients with COPD than in control subjects.

287 sine were markedly elevated in patients with ILD compared with control subjects with receiver operati

288 ll ratios were observed in SSc patients with ILD compared with SSc patients without ILD (P<0.0001), p

289 Patients with ILD had greater diaphragmatic activity, whereas patients

290 ents without lung involvement, patients with ILD show high levels of circulating Chit1 activity that

291 ue citations related to BAL in patients with ILD that were published between 1970 and 2006.

292 The risk of death for RA patients with ILD was 3 times higher than in RA patients without ILD (

293 h imatinib (600 mg/day) in SSc patients with ILD was associated with a large number of AEs.

294 ry-mechanical relationships in patients with ILD, patients with COPD, and healthy control subjects (n

295 al controls, the prognosis for patients with ILD-associated PH is particularly grim.

296 was significantly worse in SSc patients with ILD-associated PH than in those with PAH (1-, 2-, and 3-

297 picuously inaccessible to many patients with ILD.

298 s in the circulating plasma of patients with ILD.

299 between SSc patients with PAH and those with ILD-associated PH and to identify predictors of survival

300 s 3 times higher than in RA patients without ILD (HR 2.86 [95% CI 1.98-4.12]).

301 with ILD compared with SSc patients without ILD (P<0.0001), particularly in patients with active ILD