ライフサイエンスコーパス: IMP

1 IMP (Integrative Multi-species Prediction), originally r

2 IMP 2.0 integrates updated prior knowledge and data coll

3 IMP colocalizes with oskar mRNA at the oocyte posterior,

4 IMP concentrations are directly regulated by Ras, throug

5 IMP concentrations are regulated by Ras through inductio

6 IMP currently supports seven organisms (Homo sapiens, Mu

7 IMP dehydrogenase (IMPDH) catalyzes the pivotal step in

8 IMP dehydrogenase (IMPDH) catalyzes two very different c

9 IMP identifies homologs with conserved functional roles

10 IMP incorporates robust read preprocessing, iterative co

11 IMP integrates prior knowledge and data collections from

12 IMP-1 has growth-promoting activities through stabilizat

13 IMP-3 abundance correlates with tumor aggressiveness and

14 IMPs appear to resume their physiological functions in m

15 IMPs, also known as insulin-like growth factor 2 (IGF2)

16 lood of newborns, indicating that HLA-A*0201/IMP(58-66) Abs are produced in HLA-A*0201(-) mothers and

17 HLA-A*0201/IMP(58-66) Abs were also detected in the cord blood of n

18 d women on delivery, high-titered HLA-A*0201/IMP(58-66) complex-specific IgG Abs were detected in 11

19 e Abs had the same specificity as HLA-A*0201/IMP(58-66)-specific cytotoxic T cells and bound neither

20 tiple targets were detected (4 VIM/OXA-48, 1 IMP-1/NDM, and 1 NDM/KPC).

21 like growth factor 2 mRNA-binding protein-1 (IMP-1) is an oncofetal protein that binds directly to an

22 omonas maltophilia isolate) producing IMP-1, IMP-1-like, IMP-18, GIM-1, SPM-1, VIM-2, VIM-2-like, and

23 a-lactamases (including NDM-1, GIM-1, SPM-1, IMP-1, -2, -7, -8, -18, and -27, and VIM-1, -2, and -7),

24 Here, a comprehensive top down study of 152 IMPs and 277 soluble proteins from human H1299 cells inc

25 ts show that, compared with IMP-1 and IMP-2, IMP-3 is enriched in the nucleus, where it binds the tra

26 Xpert Carba-R assay detected 155 targets (26 IMP-1, 30 VIM, 27 NDM, 33 KPC, 39 OXA-48) within a time

27 veral dietary 5'-NMPs, such as 5'-GMP and 5'-IMP, was carried out at high concentrations of guanine a

28 olypeptide sequences corresponding to actual IMPs, the minimum free energy structure with the wild-ty

29 However, the actual benefits of adding IMP to such a procedure remain undocumented.

30 Additionally, IMP 2.0 implements a new flexible platform for experts t

31 Additionally, IMP identifies homologs with conserved functional roles

32 T1R1 and T1R3 KO mice when MSG + amiloride + IMP was tested suggests that a T1R1 or T1R3 homodimer or

33 t some were able to detect MSG + amiloride + IMP, but only at the higher MSG concentrations.

34 n cells unable to convert IMP to XMP or AMP (IMP dehydrogenase, guaB; adenylosuccinate synthetase, pu

35 Isn1, initially classified as an IMP-specific 5'-nucleotidase, and Sdt1, initially classi

36 products in living cells by simply fusing an IMP target with truncated apolipoprotein A-I, which serv

37 Immune melanization proteases (IMP-1 and IMP-2) and Serpin-1 mediate hemolymph prophenoloxidase c

38 r results show that, compared with IMP-1 and IMP-2, IMP-3 is enriched in the nucleus, where it binds

39 ing drugs as inhibitors of NDM-1, VIM-1, and IMP-7.

40 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-18, and 7 carried no metallo-beta-lactamase (MBL) ge

41 pa) mutants results in Ins accumulation, and IMP-1 expression is reduced in proportion to the increas

42 iosynthesis of AMP, coupling L-aspartate and IMP to form adenylosuccinate.

43 synthetase is encoded by the purP gene, and IMP cyclohydrolase is encoded by the purO gene.

44 teractions for the monophosphates of GMP and IMP in several inert complexes.

45 ied 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP.

46 e binding of another factor to the IBEs, and IMP may serve a different purpose, such as masking IBEs

47 compositions of OMPs, globular proteins and IMPs separately using a training set.

48 al data, MTH1020 is confirmed as an archaeal IMP cyclohydrolase, thus designated as MthPurO.

49 o key enzymes in purine salvage pathways are IMP dehydrogenase (GuaB) and GMP synthase (GuaA), encode

50 ween the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein

51 crom(-2) measured was four times the average IMP density (5686 microm(-2) reported in the freeze-frac

52 BTZs bind the di-zinc centers of B1 (IMP-1; BcII) and B3 (L1) MBLs via the free thiol, but or

53 Barley IMP-1 is expressed in all tissues assayed, and expressio

54 The 1.4 kb barley IMP-1 promoter contains one low temperature response ele

55 d supply during seed development, the barley IMP-1 gene and gene products were studied.

56 hese and other data indicate that the barley IMP-1 gene is regulated at least in part in response to

57 osyltransferase (DRTase, encoded by bb0426), IMP dehydrogenase (GuaB) and GMP synthase (GuaA) catalys

58 Real-time PCR for bla(KPC), bla(SME), bla(IMP), bla(NDM-1), bla(VIM), and bla(OXA-48) was performe

59 etylase HDAC6, the E3 ubiquitin ligase BRAP2/IMP, and a subfamily of deubiquitinating enzymes.

60 Inhibition of Raf-MEK pathway activation by IMP occurs through the inactivation of KSR, a scaffold/a

61 stemin protein degradation in tumor cells by IMP dehydrogenase inhibition or by other small molecules

62 This property is engaged by IMP for modulation of signal amplitude.

63 lates (73) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2

64 ethod to generate Ag-specific "naive" CD8(+) IMP T cells, as well as demonstrate that they are not ho

65 ed by tissue melanization protease (CLIPB8), IMP-1, and Serpin-2.

66 both DNA and RNA in cells unable to convert IMP to XMP or AMP (IMP dehydrogenase, guaB; adenylosucci

67 ition, an X-ray crystal structure of CpIMPDH.IMP.8k is also presented.

68 Inosine 5'-monophosphate dehydrogenase (IMP dehydrogenase or IMPDH) is a promising target for th

69 Km values of IMP and 2'-deoxy-IMP are nearly identical with each substrate supporting

70 ence of IMP than in the presence of 2'-deoxy-IMP.

71 , mice lacking T1R1 or T1R3 could not detect IMP alone, yet some were able to detect MSG + amiloride

72 to other self-MHC class I alleles displaying IMP(58-66), but bound to MHC class I complexes of an HLA

73 nophosphates have distinct interactions in E.IMP.NADP(+) and E.GMP.NADP(+) complexes.

74 -ray crystal structure of a representative E.IMP.inhibitor complex is also presented.

75 This suggests that each IMP contains four prestin molecules, based on the genera

76 MTH1020 gene product in complex with either IMP or 5-aminoimidazole-4-carboxamide ribonucleotide (AI

77 nto how their physiological functions enable IMPs to play a potentially key role in cancer stem cell

78 ar motor switch protein and the guaB-encoded IMP dehydrogenase) were noninfectious, whereas four clon

79 itor of the de novo purine synthetic enzyme, IMP dehydrogenase, leads to the rapid disappearance of n

80 ), which is a potent inhibitor of eukaryotic IMP dehydrogenases (IMPDHs).

81 iaceae and non-Enterobacteriaceae expressing IMP, VIM, KPC, NDM, and/or OXA carbapenemases, by using

82 30-fold higher with TF2-pretargeted Al(18)F-IMP 449 than with the peptide alone.

83 The Al(18)F-IMP 449 was stable for 4 h in serum in vitro, and in ani

84 ability and targeting ability of the Al(18)F-IMP 449 were examined in nude mice bearing LS174T human

85 arly in the bones, than the chelated Al(18)F-IMP 449, which cleared rapidly from the body by urinary

86 Finally, IMP is encapsulated within a user-friendly implementatio

87 K562 cells as a model to explore a role for IMP-3 in cell survival.

88 ression by dendritic cells is sufficient for IMP CD4(+) T cell functional development and prevention

89 yme that irreversibly deaminates AMP to form IMP.

90 laminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (PurH, EC 2.1.2.3/3.5.4.10).

91 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-mediated glucose transporter type 4 (

92 IMPDH derepresses the synthesis of AMP from IMP.

93 member of a novel IMP family, the glutamate IMPs.

94 In the test group, IMP was performed before flap closure, using a round bur

95 HLA*IMP, implemented in C++ and Perl, is available from http

96 HLA*IMP:02 achieves an average 4-digit imputation accuracy o

97 HLA*IMP:02 is based on a graphical representation of haploty

98 HLA*IMP:02 supports imputation of HLA-DPB1 and HLA-DRB3-5, i

99 In African Americans, HLA*IMP:02 performed marginally better than HIBAG pre-built

100 The imputation framework, HLA*IMP, provides a powerful tool for dissecting the archite

101 We present an HLA type imputation model, HLA*IMP:02, designed to operate on a multi-population refere

102 bute Bagging (HIBAG) method outperformed HLA*IMP:02.

103 ng had consistently higher accuracy than HLA*IMP:02.

104 sical leukocyte antigen (HLA) loci using HLA*IMP:02 with a reference panel from the HapMap Project an

105 y (PA), or individual, impoverished housing (IMP).

106 d beta-hairpin loop conformation explain how IMP-6 can evolve through mutations G262S and F218Y into

107 d as inhibitors of the two isoforms of human IMP-dehydrogenase.

108 Bq), and approximately twice that for (123)I-IMP (0.018 mGy/MBq).

109 r mRNA isoform of the proto-oncogene IGF2BP1/IMP-1 led to far more oncogenic transformation than did

110 Imipenemase (IMP), Klebsiella pneumoniae carbapenemase (KPC), and Ver

111 that they can execute material implication (IMP), which is a fundamental Boolean logic operation on

112 EEV capsid protein (C) by the host importin (IMP) alpha/beta1 nuclear transport proteins.

113 pproach to identify members of the importin (IMP) family of nuclear transporters as interactors of Ei

114 utations G262S (yielding IMP-1) and G262A in IMP-6 stabilize the Zn(II) ligand His263 and thus the en

115 sh, complementary to the 44-fold increase in IMP concentration.

116 ed in CE or PA compared to Tg mice reared in IMP housing.

117 roapoptotic protein CYFIP2 is upregulated in IMP-1 knockdown SW480 cells, a novel finding.

118 was 24.3 +/- 1.7% ID/g, whereas for (111)In-IMP-288 alone it was only 0.12 +/- 0.002% ID/g at 16 hou

119 Tumor uptake of the TF10-pretargeted (111)In-IMP-288 was 24.3 +/- 1.7% ID/g, whereas for (111)In-IMP-

120 tility of the pretargeting approach, (111)In-IMP-288 was administered 16 hours after TF10.

121 bavirin (RBV) lies in its ability to inhibit IMP dehydrogenase, which lowers cellular GTP.

122 Interestingly, IMP cells fail to differentiate into other mesodermally-

123 P regeneration by converting excess AMP into IMP, thereby driving forward the myokinase reaction (2AD

124 We present KIR *IMP, a method for imputation of KIR copy number.

125 We show that KIR *IMP is highly accurate and thus allows the study of KIRs

126 However, oocytes lacking IMP localize and translate oskar mRNA normally, illustra

127 s for NDM-1 and two related beta-lactamases, IMP-1 and VIM-2, was identified.

128 philia isolate) producing IMP-1, IMP-1-like, IMP-18, GIM-1, SPM-1, VIM-2, VIM-2-like, and chromosomal

129 he isolates with genes for GES, OXA-48-like, IMP, VIM, KPC, and NDM, respectively, were susceptible t

130 Three mammalian IMP paralogs (IMP1-3) have been identified that are expr

131 eta-lactamases (i.e., NDM-1 (New Delhi MBL), IMP-1 (Imipenemase), SPM-1 (Sao Paulo MBL), and VIM-2 (V

132 microM or 36-84 microM for subclass B1 MBLs (IMP-1 and BcII, respectively), and 10-12 microM for the

133 tibility of Escherichia coli-producing MBLs (IMP-1, Sfh-1, BcII, and GOB-18) and, significantly, an e

134 The Ras effector and E3 ligase family member IMP (impedes mitogenic signal propagation) acts as a ste

135 itin-protein isopeptide ligase family member IMP acts as a steady-state resistor within the Raf-MEK-E

136 Myoinositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo

137 Inosine 5'-monophosphate (IMP) cyclohydrolase catalyzes the cyclization of 5-forma

138 to l-glutamate and inosine 5'-monophosphate (IMP) mixtures in a heterologous expression assay in HEK

139 When inosine 5'-monophosphate (IMP), a ribonucleotide that potentiates the l-glutamate

140 ith its substrate, inosine 5'-monophosphate (IMP), and product, xanthosine 5'-monophosphate (XMP).

141 (FAICAR) synthase and inosine monophosphate (IMP) cyclohydrolase activity.

142 Inosine monophosphate (IMP) dehydrogenase 2 (IMPDH2) is a rate-limiting enzyme

143 s steps 2, 3 and 5 of inosine monophosphate (IMP) synthesis.

144 monophosphate (AMP), inosine monophosphate (IMP), inosine (Ino) and hypoxanthine (Hx), in fish tissu

145 MSG/IMP+ conditions significantly reduced subsequent intake

146 glutamate and inosine 5'-monophosphate (MSG/IMP) provided either alone or in a high-energy, high-car

147 glutamate and inosine 5'-monophosphate (MSG/IMP+) or without added monosodium glutamate and inosine

148 glutamate and inosine 5'-monophosphate (MSG/IMP-) were consumed on 4 nonconsecutive days, and change

149 The addition of MSG/IMP to a low-energy preload had a biphasic effect on app

150 ion also reduced intake independently of MSG/IMP.

151 carbohydrate and protein conditions than MSG/IMP- condition.

152 The addition of the MSG/IMP+ also increased the soup pleasantness and caused an

153 Energy compensation was greater in the MSG/IMP+ carbohydrate and protein conditions than MSG/IMP- c

154 reduced subsequent intake more than the MSG/IMP- condition did irrespective of energy.

155 ield the large lipophilic surfaces of native IMPs.

156 that Rce1 is the founding member of a novel IMP family, the glutamate IMPs.

157 In conclusion, a nuclear IMP-3-HNRNPM complex is important for the efficient synt

158 In the absence of IMP-3, the levels of CCND1, D3 and G1 proteins fall dram

159 Addition of IMP to an OFD procedure used to treat intrabony defects

160 Here, we show that the capacity of IMP to inhibit signal propagation through Raf to MEK is

161 The capacity of IMP to inhibit signal propagation through Raf to MEK is,

162 trial was to investigate the contribution of IMP to the outcomes of open-flap debridement (OFD) treat

163 IMPDH catalyzes the conversion of IMP to XMP via a covalent enzyme intermediate, E-XMP*; M

164 donors leads to preferential development of IMP CD4(+) T cells and partially prevents pathogenesis.

165 The functional development of IMP CD4(+) T cells requires hematopoietic but not thymic

166 inase regulate the functional development of IMP CD4(+) T cells, which suppresses the development of

167 ant IGF-II partially reversed the effects of IMP-3 knockdown on IR-induced apoptosis.

168 xpression of IMP proteins, and especially of IMP-3, to an unfavorable prognosis in numerous types of

169 tiple studies have linked high expression of IMP proteins, and especially of IMP-3, to an unfavorable

170 t-7 comes from suppressing the expression of IMP-1.

171 , proteins encoded by at least one family of IMP genes also have L-galactose-1-P phosphatase activity

172 rogen bonds between the 2'-hydroxyl group of IMP and sequence-invariant residues.

173 ormally occupied by the 2'-hydroxyl group of IMP.

174 The specific importance of IMP-3 for cancer transformation remains poorly understoo

175 Mycophenolic acid (MPA), an inhibitor of IMP-dehydrogenase (IMPDH), is used worldwide in transpla

176 ave been prepared as potential inhibitors of IMP dehydrogenase.

177 the most potent cofactor type inhibitors of IMP dehydrogenase.

178 Knockdown of IMP-3 with siRNA increased susceptibility of cells to IR

179 The nuclear localization of IMP-3 depends on its protein partner HNRNPM and is indis

180 Furthermore, we show that loss of IMP-1 induces Caspase-3- and PARP-mediated apoptosis, an

181 We further show that loss of IMP-1 inhibits Cdc34, Lin-28B, and K-Ras, suppresses SW-

182 have identified the designed F218Y mutant of IMP-1 as an enzyme with superior catalytic efficiency co

183 We also show that overexpression of IMP-1 increases c-Myc and K-Ras expression and LIM2405 c

184 IMPDH catalyzes the oxidation of IMP to XMP with the concomitant reduction of NAD(+), whi

185 ate) are 29-57-fold lower in the presence of IMP than in the presence of 2'-deoxy-IMP.

186 receptor for l-glutamate in the presence of IMP.

187 nzymatic machinery for de novo production of IMP, the first purine nucleotide formed during GTP and A

188 Cytoplasmic retention of IMP-3 and HNRNPM in human cancer cells leads to signific

189 However, the role of IMP-3 in apoptosis is unknown.

190 a third zinc ion close to the active site of IMP-6 mutant S121G was corroborated by our simulations.

191 This was added to a solution of IMP 449 (NOTA-p-Bn-CS-d-Ala-d-Lys(HSG)-d-Tyr-d-Lys(HSG)-

192 The Bateman domain (CBS subdomain) of IMP dehydrogenase (IMPDH), a rate-limiting enzyme of the

193 de, which occurs in the de novo synthesis of IMP, and the conversion of adenylosuccinate to AMP, whic

194 concentrations due, in part, to the taste of IMP.

195 Comparisons of the two types of IMP cyclohydrolase, PurO and PurH, revealed that there a

196 Km values of IMP and 2'-deoxy-IMP are nearly identical with each subs

197 r the identification and characterization of IMPs.

198 ur current understanding of the functions of IMPs during normal development and focuses on a series o

199 neral strategy for in vivo solubilization of IMPs in structurally relevant conformations without the

200 technique, called SIMPLEx (solubilization of IMPs with high levels of expression), allows the direct

201 owever, functional and structural studies of IMPs are hindered by their hydrophobic nature and the fa

202 o groups: control (OFD alone) or test (OFD + IMP).

203 evident in mandibular sites, in which OFD + IMP doubled the radiographic bone gain obtained by OFD a

204 3 and G1) in vivo and in vitro, and yet only IMP-3 regulates the expression of these cyclins in a sig

205 ) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-1

206 No OXA-58-type, NDM-type, VIM-type, or IMP-type producers were detected.

207 lly to IMPbeta1 and IMPalpha2, but not other IMPs, and use a mutated IMPbeta1 derivative to show that

208 alytic site are distinct from those of other IMPs.

209 OTI IMP CD8(+) T cells generated via this method exhibited e

210 ses were the largest and had sparsely packed IMPs.

211 ignating them as invalid metabolic panaceas (IMPs).

212 unt for the size of intramembrane particles (IMPs) expressed in the OHC membrane.

213 most densely packed intramembrane particles (IMPs), whereas the PF-CwC synapses were the largest and

214 T cells are unable to suppress pathogenesis, IMP CD4(+) T cells, which include conventional regulator

215 Intramarrow penetration (IMP) is often incorporated in regenerative periodontal s

216 TF10 and/or TF10-pretargeted hapten-peptide (IMP-288) were conducted in nude mice bearing CaPan1 huma

217 Innate memory phenotype (IMP) CD8(+) T cells are nonconventional alphabeta T cell

218 tive development of innate memory phenotype (IMP, CD44(hi)/CD62L(lo)) CD4(+) T cells.

219 ose determined for myo-inositol 1-phosphate (IMP) and fructose 1,6-bisphosphate (FBP), previously con

220 In the presence of 6-phosphoryl-IMP and GDP (hadacidin absent), the L-aspartate pocket c

221 In the presence of 2'-deoxy-6-phosphoryl-IMP and GDP, however, the L-aspartate pocket is poorly o

222 er 6-phosphoryl-IMP or 2'-deoxy-6-phosphoryl-IMP are identical except for the presence of a cavity no

223 with hadacidin, GDP, and either 6-phosphoryl-IMP or 2'-deoxy-6-phosphoryl-IMP are identical except fo

224 olites of the purine nucleotide cycle (PNC): IMP, adenylosuccinate, and AMP.

225 Integrative multi-species prediction (IMP) is an interactive web server that enables molecular

226 Here we present IMP, a reproducible and modular pipeline for the integra

227 The Influence Maximization Problem (IMP) aims to discover the set of nodes with the greatest

228 alysis confirmed that these isolates produce IMP-4, an MBL carbapenemase not previously published as

229 dent reductive deamination of GMP to produce IMP.

230 vo purine biosynthesis pathway that produces IMP.

231 notrophomonas maltophilia isolate) producing IMP-1, IMP-1-like, IMP-18, GIM-1, SPM-1, VIM-2, VIM-2-li

232 ed to as intermediate mesodermal progenitor (IMP) cells, is capable of unlimited expansion, lacks tum

233 egrative structure determination by programs IMP, Chimera, and BILBOMD, as well as in other applicati

234 erting enzyme 1), an intramembrane protease (IMP) of the endoplasmic reticulum.

235 Immune melanization proteases (IMP-1 and IMP-2) and Serpin-1 mediate hemolymph propheno

236 The RNA-binding protein IMP-3 is an oncofetal protein overexpressed in many huma

237 l (2)efl and the insulin/IGF-binding protein IMP-L2.

238 sulin growth factor II mRNA-binding protein (IMP).

239 cifically with the influenza matrix protein (IMP)-derived peptide(58-66) displayed by HLA-A*0201 comp

240 understanding of integral membrane protein (IMP) structure and function is hampered by the difficult

241 th factor II (IGF-II) mRNA-binding proteins (IMPs), is expressed preferentially in triple-negative br

242 Integral membrane proteins (IMPs) are of great biophysical and clinical interest bec

243 Integral membrane proteins (IMPs) play crucial roles in all cells and represent attr

244 obular proteins and inner membrane proteins (IMPs)).

245 the synthesis of integral membrane proteins (IMPs), the hydrophobic amino acids of the polypeptide se

246 incorporation in integral membrane proteins (IMPs), where poor aqueous solubility and ionization of p

247 s that stabilize integral membrane proteins (IMPs).

248 inal steps in the biosynthesis of the purine IMP.

249 Our earlier studies showed that reducing IMP-3 abundance with siRNAs reduced proliferation of hum

250 ctured upon association with IMPs; resulting IMP-beta-strand peptide complexes resisted aggregation w

251 to l-glutamate mixed with the ribonucleotide IMP.

252 I (MHCI)-dependent generation of Ag-specific IMP CD8(+) T cells using bone marrow chimeras.

253 ases such as KPC, NMC-A, IMI, SME, NDM, SPM, IMP, VIM, and OXA-23, 40, 48, 58, 72, 181, and 232 were

254 As such, IMP-3 is proving to be a highly significant biomarker in

255 The suppressor analysis suggests IMP as the key intermediate in the synthesis of the clas

256 Among its many mRNA targets, IMP-3 binds to and promotes translation of insulin-like

257 d downregulates several of its mRNA targets: IMP-1, Cdc34, and K-Ras.

258 ination complex but is more constrained than IMP in that complex, leading to hydride transfer.

259 and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets.

260 We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth

261 We also found that IMP-1 binds to the coding region and 3'UTR of K-Ras mRNA

262 Given that IMP is not thought to affect mGluRs, behavioral detectio

263 These findings indicate that IMP-1, interrelated with c-Myc, acts upstream of K-Ras t

264 Together, these results indicate that IMP-3 acts in part through the IGF-II pathway to promote

265 Gene reporter assays revealed that IMP-3 acts through the 5' UTR of IGFII mRNA during apopt

266 228 patients with colon cancers reveals that IMP-1 is significantly upregulated in differentiated col

267 These observations suggest that IMP functions as a threshold modulator, controlling sens

268 Results suggest that IMP TM segment partitioning shares important features wi

269 The IMP-based data integration strategy enhances data usage,

270 ld temperature, nutrient limitation, and the IMP dehydrogenase inhibitor mycophenolic acid (MPA).

271 s; the NDM-1 isolate was an outlier, and the IMP isolates and 6/7 MBL-negative isolates clustered sep

272 pes showed positive correlations between the IMP-cluster area and the AMPAR number, indicating a comm

273 with less positive correlations between the IMP-cluster area and the NMDAR number.

274 by exponential enrichment, we identified the IMP-binding element (IBE) UUUAY, a motif that occurs 13

275 orporation of our neurosteroid ligand in the IMP, mouse voltage-dependent anion channel-1 (mVDAC1), a

276 RNA-binding proteins of the IMP family (insulin-like growth factor 2 (IGF2) mRNA-bin

277 Therefore, our implementation of the IMP was framed as an information theoretic problem using

278 ipathic proteic 'shield' that sequesters the IMP from water and promotes its solubilization.

279 By solving the IMP over different numbers of source nodes, an influence

280 the need for detergents or mutations to the IMP itself, as an alternative to extraction and in vitro

281 t maximizes influence is the solution to the IMP.

282 We here show that all three IMPs can directly bind the mRNAs of cyclins D1, D3 and G

283 Thus, IMP-3 might serve as a new drug target to increase sensi

284 In contrast to normal adult tissue, IMP-1 is reexpressed and/or overexpressed in human cance

285 ole-4-carboxamide ribonucleotide (FAICAR) to IMP in the final step of de novo purine biosynthesis.

286 ase (GMPR) catalyzes the reduction of GMP to IMP and ammonia with concomitant oxidation of NADPH.

287 rast, MHCI(-/-) bone marrow does not lead to IMP CD8(+) T cells in wild-type recipients.

288 Wild-type bone marrow gives rise to IMP CD8(+) T cells in MHCI(-/-) recipients, resembling t

289 ruit (Actinidia deliciosa) has similarity to IMP and can hydrolyze l-galactose 1-phosphate (l-Gal 1-P

290 le-carboxamide ribonucleotide transformylase IMP cyclohydrolase, an enzyme not previously known to be

291 ane secondary or primary active transporter (IMP), a periplasmic membrane fusion protein, and an oute

292 nemases and the metallo-beta-lactamases VIM, IMP, and NDM-1, even though NDM-1 was only recently iden

293 r presence of beta-lactamase (bla) NDM, VIM, IMP, KPC, and OXA carbapenemase genes (e.g., blaOXA-23,

294 r presence of beta-lactamase (bla) NDM, VIM, IMP, KPC, and OXA carbapenemase genes (e.g., blaOXA-23,

295 amily of serine carbapenemases, and the VIM, IMP, and NDM-1 metallo-beta-lactamases.

296 uces the hyperbolic black hole of NPs, where IMPs populate the high-effort base.

297 s for the monophosphate of GMP compared with IMP in their respective NADP(+) complexes.

298 Our results show that, compared with IMP-1 and IMP-2, IMP-3 is enriched in the nucleus, where

299 of the Vibrio cholerae IMPDH in complex with IMP/NAD(+) and XMP/NAD(+).

300 nd become restructured upon association with IMPs; resulting IMP-beta-strand peptide complexes resist

301 ve discovered that mutations G262S (yielding IMP-1) and G262A in IMP-6 stabilize the Zn(II) ligand Hi