ライフサイエンスコーパス: IMS

1 IMS anti-Salmonella coated magnetic beads were applied t

2 IMS is a gas-phase electrophoretic technique that enable

3 IMS-generated molecular maps, rich in chemical informati

4 To produce a gold standard, we engaged 80 IMS experts, each to rate the relative quality between 5

5 d, and results showed that the most abundant IMS band corresponds to the most stable candidate struct

6 Thus, the time required for acquiring IMS data does not affect the overall run time of traditi

7 showed the transferability of results across IMS platforms.

8 To directly detect S. typhimurium after IMS, a sandwich immunoassay was implemented into the pro

9 Candidate structures were proposed for all IMS bands observed.

10 Modification of an IMS-capable quadrupole time-of-flight mass spectrometer

11 lite ions were detected within 1 min with an IMS resolving power (Rp) of approximately 100.

12 2 acyl mutants into the mitochondria with an IMS-targeting tag did not recover their ability to suppr

13 oupling of the thin-layer chromatography and IMS.

14 d in brain sampling, analyte extraction, and IMS MS method optimization.

15 cted combinations of the MS, MS(2) , LC, and IMS dimensions can be applied, together with the appropr

16 s conformational heterogeneity, the apparent IMS resolution obtained for proteins at ambient and redu

17 anti-CD24 antibody (referred to as two-bead IMS).

18 nce of copper(II) ions were also analyzed by IMS, and preferential association between the beta-hairp

19 wever, glycolipidomics of the human brain by IMS MS represents an area untouched up to now, because o

20 sion-induced dissociation (CID), followed by IMS analysis.

21 ns in tissue areas that were not measured by IMS; and (iii) enrichment of biological signals and atte

22 Restraints obtained by IMS are used to map the surfactant positions onto the pr

23 allows isolation of CD44(+)/CD24(-) TICs by IMS involving both magnetic beads coated by anti-CD44 an

24 lly used to identify each spot on the TLC by IMS in a few seconds.

25 The data obtained with MCC-IMS and CC-IMS were evaluated, studying both the global and the spe

26 assification percentage obtained with the CC-IMS was 92% as opposed to 87% obtained with MCC-IMS; alt

27 we investigate BTX mixtures using a compact IMS operated at decreased pressure (20 mbar) and high ki

28 imate proline on neuropeptide conformations, IMS-MS experiments were performed on two model peptides

29 The conserved IMS protein Mia40 is essential for the oxidation and imp

30 se in glycan isomer separation, conventional IMS separation occurs on the millisecond time scale, lar

31 ecreasing reaction time, unlike conventional IMS, a quantitative detection with ppbv detection limits

32 Coupling IMS with LAESI-MS also expands the dynamic range by incr

33 Link LRx Longitudinal Prescription database (IMS Health Inc), which includes approximately 60% of all

34 al effort is similar to conventional desktop IMS with overall dimensions of the drift and reaction tu

35 With further development IMS may hold the potential for rapid and complete struct

36 tions, geometric isomers exhibited different IMS arrival time distributions and distinct OzID product

37 ral feature matching between two-dimensional IMS-MS datasets (undeuterated and deuterated) without th

38 ive coupling of linear IMS to MS and diverse IMS/MS arrangements and modalities impossible at ambient

39 tiplexing (SM), and double multiplexing (DM) IMS modes to optimize the signal-to-noise ratio of the m

40 detection in the low ppb range common for DT-IMS.

41 tic drift tube ion mobility spectrometer (DT-IMS) is described.

42 Drift tube ion mobility spectrometers (DT-IMS) separate ions by the absolute value of their low fi

43 DFT/B3LYP/6-31G(d,p) were proposed for each IMS band, and results showed that the most abundant IMS

44 ity parameter, alpha, from classic empirical IMS data of atomic ions, cesium and potassium, each show

45 The new system enables IMS-IMS-MS analysis and other modes of operation: IMS pr

46 ze nanoparticle-protein conjugates, enabling IMS measurements of their conjugate size distribution fu

47 In contrast, ESI-IMS-MS analysis of the amphipol solubilized MPs studied

48 From ESI-IMS-MS derived collision cross sections (CCS), these spe

49 in the gas phase, permitting noncovalent ESI-IMS-MS analysis of MPs from the two major structural cla

50 mobility spectrometry-mass spectrometry (ESI-IMS-MS) is compared systematically with the commonly use

51 Using the TLC-ESI-IMS technique, acceptable separations were achieved for

52 distinct and can be distinguished using ESI-IMS-MS.

53 nt the time scale disparity between the fast IMS separation and the much slower Orbitrap MS acquisiti

54 TWIMS) with different ion sources and faster IMS separations showed the transferability of results ac

55 ime of flight ion mobility spectrometer (FAT-IMS) allows high repetition rates and reaches limits of

56 ir low mass (for MS detection) and size (for IMS detection).

57 onvolves spectra of different molecules from IMS data.

58 Overall, chirp multiplexing of a dual-gate IMS system coupled to an LIT-MS improves ion transmissio

59 GC-IMS was used to detect the volatile compound profile of

60 Due to the two-dimensional nature of GC-IMS measurements, great quantities of data are obtained

61 chromatography-ion mobility spectrometry (GC-IMS) to differentiate lactic acid bacteria (LAB) through

62 The results demonstrated that GC-IMS is a useful technology for bacteria recognition and

63 20 mbar) and high kinetic ion energies (HiKE-IMS).

64 netic energy ion mobility spectrometer (HiKE-IMS) for quantitative gas analysis.

65 separating isomer and isobar ions; however, IMS-MS suffers from decreased peak capacity due to the c

66 Close to ideal IMS resolving power was maintained over a significant ra

67 hat allows direct mass spectrometry imaging (IMS) of agar cultures.

68 ole in immunoassays (IAs) and immunosensing (IMS) platforms for the detection of carcinoembryonic ant

69 It provides a resolving power R > 60 in IMS mode, and R > 40 in each stage of IMS-IMS mode.

70 rometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performin

71 te that our method can discover molecules in IMS data reliably, and hence can help advance the study

72 With 200 times increased IMS duty cycle in HT mode compared with conventional pul

73 lue-a parameter related to the shape of ions-IMS can improve the accuracy of metabolite identificatio

74 In various applications, LAESI-IMS-MS allows for the high-throughput separation and mas

75 results established the feasibility of LAESI-IMS-MS for the analysis and spatial mapping of plant tis

76 lity time-of-flight mass spectrometry (LAESI-IMS-TOF-MS) was used for the analysis of synthetic polym

77 Here, we demonstrate that LAESI-IMS-MS can reveal the binding stoichiometry, copper oxid

78 Using LAESI-IMS-MS for the assessment of amylin-copper(II) interacti

79 ed demonstrate the advantages of using LAESI-IMS-MS for the rapid analysis of intact root nodules, un

80 induced dissociation (OzID) in-line with LC, IMS, and high resolution mass spectrometry.

81 Effective coupling of linear IMS to MS and diverse IMS/MS arrangements and modalities

82 ve of mobility vs electric field over linear IMS based on absolute mobility is much greater orthogona

83 l, the reported measurements suggest that LN-IMS is a potentially simple and robust technique for nan

84 It is also shown that LN-IMS measurements can be used to detect size distribution

85 We specifically employ the LN-IMS system to examine bovine serum albumin binding to go

86 MALDI IMS was used to visualize the distribution of antimicrob

87 opically labeled internal standard for MALDI IMS analysis.

88 ed images were acquired in SPRi and in MALDI IMS for abundant proteins from a single mouse kidney tis

89 a multi-modal molecular imaging (MRI & MALDI IMS) approach was employed to examine the temporal GSK12

90 zation imaging mass spectrometry (SPRi-MALDI IMS) coupled technique competent for the acquisition of

91 The MALDI IMS experimental conditions, such as matrix deposition a

92 terface between the SPRi prism and the MALDI IMS instrument, were also optimized.

93 ioselective SPRi images correlating to MALDI IMS images of different proteins transferred from a sing

94 re found at the inhibition zones using MALDI IMS and were identified using MS/MS molecular networking

95 assisted laser desorption/ionization (MALDI) IMS experiments.

96 Additionally, MALDI-IMS is able to detect three metabolites of doxorubicin,

97 owever, current sample preparation and MALDI-IMS acquisition methods have limitations in preserving m

98 proaches by using a publicly available MALDI-IMS proteomics dataset of a rat brain.

99 This gentle, histology-compatible MALDI-IMS protocol also diminished thermal effects and mechani

100 is pipeline specifically developed for MALDI-IMS data utilizing significant spatial information for i

101 ALDI) imaging mass spectrometry (IMS) (MALDI-IMS) provides a technical means for simultaneous analysi

102 We evaluated our algorithm using a new MALDI-IMS metabolomics dataset of a plant (Eucalypt) leaf.

103 ulting in interfered correspondence of MALDI-IMS data with subsequently acquired immunofluorescent st

104 demonstrate the technical capacity of MALDI-IMS for comprehensive identification of peptidomic regul

105 tigated the histology compatibility of MALDI-IMS to image neuronal lipids in rodent brain tissue with

106 mplified by performing high-resolution MALDI-IMS with subsequent fluorescent amyloid staining in a tr

107 on of MALDI imaging mass spectrometry (MALDI-IMS) and MS/MS molecular networking to study chemistry-b

108 /ionization imaging mass spectrometry (MALDI-IMS) enables acquisition of spatial distribution maps fo

109 Ionization-Imaging Mass Spectrometry (MALDI-IMS) in 'omics' data acquisition generates detailed info

110 /Ionization-Imaging Mass Spectrometry (MALDI-IMS) with confirmation by steady state fluorescence micr

111 MALDI-FTICR imaging mass spectrometry (MALDI-IMS) workflow is described for on-tissue detection, spat

112 sphingolipid ions was then applied to MALDI-IMS of human lung cancer tissues.

113 port summarizes the first study to use MALDI-IMS to analyze drug penetration of a liposomal drug carr

114 performance with conventionally manufactured IMS instruments that also operate in the open air.

115 analysis strategies in which the size of MCC-IMS data is reduced to enable further analysis.

116 eveloped and employed in the analysis of MCC-IMS spectra from 264 breath and ambient air samples.

117 to their large data size, processing of MCC-IMS spectra is still the main bottleneck of data analysi

118 entation types promoting the adoption of MCC-IMS technology in a wide range of diverse application fi

119 d with multicapillary column separation (MCC-IMS) is a well-known technology for detecting volatile o

120 The data obtained with MCC-IMS and CC-IMS were evaluated, studying both the global

121 was 92% as opposed to 87% obtained with MCC-IMS; although in productivity analytical terms, MCC offe

122 get of the highly conserved eukaryotic MIA40 IMS oxidoreductase.

123 Occurring within milliseconds, IMS separation is compatible with modern mass spectromet

124 presented here characterize a mitochondrial IMS-localized protein phosphatase identified in photosyn

125 Many proteins of the mitochondrial IMS contain conserved cysteines that are oxidized to dis

126 The new IMS-Orbitrap MS platform was demonstrated by the analysi

127 peaks can be modeled as sums of the observed IMS conformers; this is strong evidence that ion mobilit

128 We also demonstrate the ability of IMS-MS to screen for inhibitory small molecules in a 96-

129 Here, we report that the addition of IMS to conventional glycoproteomics platforms adds addit

130 The addition of IMS to conventional LC-MS-based metabolomics and lipidom

131 Our method will extend the application of IMS to cell subsets characterized by multiple markers.

132 To enhance the capability of IMS for the analysis of mixtures, it is often used with

133 In this study, a combination of IMS and liquid chromatography-tandem mass spectrometry (

134 Specifically, incorporation of IMS resulted in an increase of 153 differentially abunda

135 o not account for the spatial information of IMS data.

136 petroleum samples, where the integration of IMS and high mass resolution proved essential for accura

137 , our method leverages the spatial nature of IMS data by assuming that nearby locations share similar

138 The data obtained confirms the potential of IMS as a reliable analytical screening technique, which

139 Confidence in the reproducible quality of IMS data is essential for its integration into routine u

140 gh several applications: (i) 'sharpening' of IMS images, which uses microscopy measurements to predic

141 60 in IMS mode, and R > 40 in each stage of IMS-IMS mode.

142 sobaric oligosaccharides, but the utility of IMS to obtain glycan structural information on a site-sp

143 or compound, on xenografts lipidome based on IMS.

144 MS-MS analysis and other modes of operation: IMS prefiltration, IMS-IMS, and full transmission mode.

145 r the detection of AN and UN using MS and/or IMS.

146 t easily extracted from either microscopy or IMS individually.

147 This enabled the novel LC-OzID-IMS-MS configuration where ozonolysis of ionized lipids

148 other modes of operation: IMS prefiltration, IMS-IMS, and full transmission mode.

149 existing commercially available low pressure IMS platforms and an ion mobility peak capacity of appro

150 As a stand-alone instrument, the 3D printed IMS is shown to achieve resolving powers of between 24 a

151 de instrument development and ensure quality IMS results.

152 Quantitative IMS experiments were performed on liver tissue from an a

153 0.25% proved the utility of high resolution IMS-MS for real samples with large interisomeric dynamic

154 for TAG analysis by high imaging resolution IMS.

155 atures, otherwise hidden by lower resolution IMS analyzers, are revealed.

156 The infinitesimal model for partial selfing (IMS) involves an infinite number of loci in a large but

157 AD) combined with immunomagnetic separation (IMS) for detecting Salmonella typhimurium.

158 using bead-based immunomagnetic separation (IMS) that typically enriches cells based on one abundant

159 I) MS combined with ion mobility separation (IMS) can analyze complex formation and provide conformat

160 The utilization of ion mobility separation (IMS) improved the molecular coverage, selectivity, and i

161 W-SLIM) module for ion mobility separations (IMS).

162 uick and cost-effective way to produce small IMS instruments that can compete in performance with con

163 ed differs considerably from that of soluble IMS proteins.

164 ns in the mitochondrial intermembrane space (IMS) and mediated by the estrogen receptor alpha (ERalph

165 isting of an N-terminal intermembrane space (IMS) domain and a C-terminal 16-stranded beta-barrel dom

166 The mitochondrial intermembrane space (IMS) harbors an oxidizing machinery that drives import a

167 roup of proteins in the intermembrane space (IMS) of mitochondria.

168 ed to the mitochondrial intermembrane space (IMS) where it interacts with the mitochondrial oxidoredu

169 me of the mitochondrial intermembrane space (IMS), which can freely exchange small molecules with the

170 e 2 (3betaHSD2) via its intermembrane space (IMS)-exposed charged unstructured loop region.

171 ide bond exposed to the intermembrane space (IMS).

172 nt of the mitochondrial intermembrane space (IMS).

173 ion directly within the intermembrane space (IMS).

174 idues reside within the intermembrane space (IMS).

175 localized at the inner mitochondrial space (IMS), where it interacts through a specific region with

176 ity spectrometry-Orbitrap mass spectrometer (IMS-Orbitrap MS) platform.

177 l-gate drift tube ion mobility spectrometer (IMS) to a linear ion trap mass spectrometer (LIT-MS) via

178 onization (MALDI) imaging mass spectrometry (IMS) (MALDI-IMS) provides a technical means for simultan

179 nct technologies: imaging mass spectrometry (IMS) and microscopy.

180 y studied by ion-mobility mass spectrometry (IMS) and vacuum molecular dynamics (MD) simulations is r

181 Imaging mass spectrometry (IMS) applied to co-cultured microbial communities aims t

182 onization (MALDI) imaging mass spectrometry (IMS) elucidates molecular distributions in thin tissue s

183 Imaging mass spectrometry (IMS) is a maturating technique of molecular imaging.

184 Imaging mass spectrometry (IMS) is quickly becoming a technique of reference to vis

185 In this context, imaging mass spectrometry (IMS) may yield the required information, due to its inhe

186 onization (MALDI) imaging mass spectrometry (IMS) of muscle and abdominal tissue sections identified

187 onization (MALDI) imaging mass spectrometry (IMS), we determined alterations of lipid profiles specif

188 lyses with (live) imaging mass spectrometry (IMS), we observed multiple changes in the molecular and

189 ionization (LDI) imaging mass spectrometry (IMS).

190 key parameter in imaging mass spectrometry (IMS).

191 ion mobility spectrometry-mass spectrometry (IMS-MS) study revealed that tryptic peptide ions contain

192 ion mobility spectrometry-mass spectrometry (IMS-MS) techniques.

193 ion mobility spectrometry-mass spectrometry (IMS-MS) that is capable of rapidly detecting small molec

194 ion mobility spectrometry-mass spectrometry (IMS-MS) work demonstrates that the gas-phase conformatio

195 ds in peptides by ion mobility spectrometry (IMS) analysis of mass spectrometry (MS)-generated epimer

196 combination with ion mobility spectrometry (IMS) and formaldehyde labeling, this novel strategy enab

197 hniques including ion mobility spectrometry (IMS) and liquid chromatography (LC) can separate isomeri

198 were probed using ion mobility spectrometry (IMS) and Monte Carlo minimization (MCM) simulations.

199 ATDs) recorded by ion mobility spectrometry (IMS) can often be interpreted in terms of the coexistenc

200 column coupled to ion mobility spectrometry (IMS) has been explored to classify Iberian ham, to detec

201 Ion mobility spectrometry (IMS) has been shown to be a valuable tool for isomer sep

202 Recently, ion mobility spectrometry (IMS) has been shown to effectively resolve isobaric olig

203 Recently, ion mobility spectrometry (IMS) has been used to support metabolomics and lipidomic

204 Ion mobility spectrometry (IMS) has proven to be useful in separating isomer and is

205 Although ion mobility spectrometry (IMS) has shown great promise in glycan isomer separation

206 Ion mobility spectrometry (IMS) in conjunction with mass spectrometry (MS) has emer

207 vy metals via the ion mobility spectrometry (IMS) in the negative mode.

208 Ion mobility spectrometry (IMS) is a fast and sensitive analytical method which ope

209 Ion mobility spectrometry (IMS) is a gas phase separation technique, which relies o

210 Ion mobility spectrometry (IMS) is increasingly used to describe solution-phase phe

211 metry (MS) and/or ion mobility spectrometry (IMS) is traditionally difficult.

212 Ion mobility spectrometry (IMS) may be used to show separation of atomic ions, whil

213 ompared to recent ion mobility spectrometry (IMS) studies reported in the literature.

214 ersely, gas phase ion mobility spectrometry (IMS) techniques can be used to reliably examine polydisp

215 ted against other ion-mobility spectrometry (IMS) techniques.

216 /l-peptides using ion mobility spectrometry (IMS) was impeded by small collision cross section differ

217 d lampante) using Ion Mobility Spectrometry (IMS) was improved by replacing the multicapillary column

218 he integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap

219 tography (LC) and ion-mobility spectrometry (IMS), in which separation takes place pre-ionization in

220 The progress of ion mobility spectrometry (IMS), together with its association to mass spectrometry

221 V-MS coupled with ion mobility spectrometry (IMS)-MS and tandem mass spectrometry (MS/MS) is shown to

222 nd detected using ion mobility spectrometry (IMS).

223 g and analysis by ion mobility spectrometry (IMS).

224 ctrophoresis, and ion mobility spectrometry (IMS).

225 Ion mobility spectroscopy (IMS)-based trace-compound detectors (TCDs) are powerful

226 The HS-SPME-IMS is precise, selective and sensitive analytical metho

227 Many mobility studies (IMS) of electrospray ions with charge states z reduced t

228 In this study, IMS MS was introduced in human brain ganglioside (GG) re

229 cursor ion isomer components, and subsequent IMS analysis of b ion isomers provided their quantitativ

230 evelop the Individualized Metabolic Surgery (IMS) score using a nomogram.

231 ed through an Interaction Management System (IMS) that facilitates the compilation interaction record

232 M-MS experiments on a range of model systems-IMS CCS standards (Agilent ESI Tune Mix), the monomeric

233 In mild T2DM (IMS score </=25), both procedures significantly improved

234 In severe T2DM (IMS score >95), when clinical features suggest limited f

235 Additionally, it enables tandem IMS-IMS prefiltration in dry gas and in vapor doped gas.

236 S device for protein analysis and how tandem IMS-IMS with dopants could provide better understanding

237 t kinetic and thermodynamic data from tandem-IMS measurements.

238 port the crystal structure of the N-terminal IMS domain of Toc75 from Arabidopsis thaliana, revealing

239 ariations as high as 20%, which suggest that IMS-IMS separation using dried N2 (in one stage) and a d

240 The IMS data acquired using our novel site-specific strategy

241 The IMS housing and electrodes were printed from nonconducti

242 The IMS signals monitoring during a 24-30h period showed the

243 The IMS was manufactured using three-dimensional (3D) printi

244 s found to upregulate the proteasome and the IMS protease OMI.

245 easible reduction of Mia40 substrates by the IMS glutathione pool.

246 aken together, these results demonstrate the IMS-UPRmt activation in SOD1 familial ALS, and suggest t

247 ispensed during 2011 were extracted from the IMS Health Xponent database.

248 These results were derived from the IMS investigation of fresh frozen mouse liver and rabbit

249 Data were retrieved from the IMS LifeLink LRx Longitudinal Prescription database, whi

250 However, the IMS-UPRmt was never studied in a neurodegenerative disea

251 In the IMS a single stable equilibrium genetic variance exists

252 nstrate the presence of glutaredoxins in the IMS and show that limiting amounts of these glutaredoxin

253 that is critical for copper transfer in the IMS and thus for biogenesis of cytochrome c oxidase.

254 Tom22, to activate metabolic activity in the IMS by enhanced phosphate circulation.

255 refully balanced glutaredoxin amounts in the IMS ensure efficient oxidative folding in the reducing e

256 ce mutant SOD1 is known to accumulate in the IMS of neural tissue and cause mitochondrial dysfunction

257 tly, overexpression of glutaredoxin 2 in the IMS results in a more reduced Mia40 redox state and a de

258 We found a significant sex difference in the IMS-UPRmt, because the spinal cords of female, but not m

259 ly initiated by mutant SOD1 localized in the IMS.

260 ation, providing functional insight into the IMS contribution to redox-regulated fusion events.

261 f scratched or cut pieces of strips into the IMS injection port.

262 Thus, we investigated the IMS-UPRmt in the G93A-SOD1 mouse model of familial ALS,

263 consequences on the acquisition time of the IMS experiment and the resulting file size.

264 In the endovascular arm of the IMS III trial, the following time intervals were calcula

265 The high reproducibility of the IMS separation allows spectral feature matching between

266 ay to enhance the separation capacity of the IMS-IMS prefiltration approach.

267 lated that a differential involvement of the IMS-UPRmt could be linked to the longer lifespan of fema

268 ential activation of the ERalpha axis of the IMS-UPRmt.

269 ure trapping ion funnel region preceding the IMS cell.

270 This produced the IMS spectra of several heavy-metal salts, including CdCl

271 from Nielsen (DTCA television ratings), the IMS Health National Prescription Audit (pharmacy sales),

272 eloped algorithm was used to reconstruct the IMS data.

273 Here, we demonstrate that the IMS domain of Tim23 tightly associates with both inner a

274 We recently showed that the IMS glutathione pool is maintained as reducing as that o

275 argeted to the IMS, we demonstrated that the IMS-UPRmt could be specifically initiated by mutant SOD1

276 mport of Tim17 depends on the binding to the IMS protein Mia40, the oxidoreductase activity of Mia40

277 d on introduction of a droplet stream to the IMS reaction region.

278 ch G93A-SOD1 was selectively targeted to the IMS, we demonstrated that the IMS-UPRmt could be specifi

279 l amino acid segment of Tom22 exposed to the IMS.

280 inal chromophore were investigated using the IMS-IMS technique.

281 equilibration of protein disulfides with the IMS glutathione pool is prevented in order to allow oxid

282 -mediated disulfide modifications within the IMS domain are key modulators of reversible Mfn oligomer

283 An important difference between this IMS and other instruments is the absence of a counter ga

284 stry of Transplant Recipients were linked to IMS pharmacy fills (January 1, 2001 to October 1, 2012)

285 etween 52 pairs of ion images from MALDI-TOF IMS datasets of rat brain coronal sections.

286 approximately 30 residues employing trapped IMS with resolving power up to approximately 340, follow

287 The effect of helium upon IMS resolving power was also studied by introducing a He

288 Using IMS CID MS/MS, applied here for the first time to gangli

289 Using IMS MS, the entire series starting from mono- up to octa

290 mployed for the analysis of crude oils using IMS-TOF MS.

291 S(E) approach is also demonstrated utilizing IMS for rapid characterization of small molecules and pe

292 s found for DAACP pairs using traveling-wave IMS (TWIMS) with different ion sources and faster IMS se

293 ew differential or field asymmetric waveform IMS (FAIMS) approach using hydrogen-rich gases was recen

294 of differential or field asymmetric waveform IMS (FAIMS) based on the derivative of mobility vs elect

295 nctionality, or hydrodynamic volume, whereas IMS adds selectivity by macromolecular shape and archite

296 ribution function shifts; the challenge with IMS is to convert nanoparticle-protein conjugates to aer

297 rogen/deuterium exchange (HDX) combined with IMS-MS/MS techniques is demonstrated to offer advantages

298 eticle was also used to diagnose issues with IMS instrumentation such as intermittent losses of pixel

299 pproximately 300 ionic species, whereas with IMS over 1 100 different ions were detected.

300 irect analysis of mouse brain tissue without IMS had yielded approximately 300 ionic species, whereas