ライフサイエンスコーパス: IND

1 IND administration induced significant ulceration, bleed

2 IND evoked robust phosphorylation of Kv1.3, as well as i

3 IND-treated mice had an increased short- and long-term o

4 IND-VFQ scores, on average, increased by 9.2 points from

5 New Drug status from the FDA in April 1992 (IND no. 34671; sponsor, Ann R Kennedy), and studies to e

6 , the same hypothetical impact on world 2050 IND could be achieved by decreasing CH4 emissions by 46%

7 after final US Food and Drug Administration IND approval, reducing the overall timeline by about 3 m

8 Although IND did not bind these sites simultaneously, the presenc

9 Although IND/A alone caused villous atrophy, more-widespread smal

10 Although an IND is not required for use of FMT to treat RCDI, an IND

11 AR-12 is an IND-approved derivative of celecoxib that demonstrated p

12 tory requirements and successfully obtain an IND before they can begin to use FMT as part of their cl

13 ng, preclinical, and clinical sections of an IND for allogeneic islets of Langerhans to treat type 1

14 Food and Drug Administration approval of an IND.

15 ot required for use of FMT to treat RCDI, an IND is strongly encouraged and may ultimately be require

16 sing a GMP-produced wild-type virus under an IND.

17 Similarly, 4MP and IND yielded type II binding spectra that reflected the a

18 st, all calves coinfected with WD534tc/C and IND/A (n = 2) developed diarrhea and shed both viruses,

19 rred in calves coinfected with WD534tc/C and IND/A.

20 istration of eicosapentaenoic acid (EPA) and IND.

21 and 2.51-fold (95% CI 1.32-4.79) for IND and IND/TIO, respectively.

22 der an Investigational New Drug application (IND).

23 ea share identical function with Arabidopsis IND since ethyl methanesulphonate (EMS) mutant alleles a

24 EPA significantly attenuated IND-induced oxidative damage and apoptosis.

25 to demonstrate that the BraA.IND.a and BolC.IND.a genes from B. rapa and B. oleracea share identical

26 opment approach to demonstrate that the BraA.IND.a and BolC.IND.a genes from B. rapa and B. oleracea

27 nt suggesting a general role of Brassicaceae IND genes in preventing valve margin cells from adopting

28 However, in the absence of a tumor context, IND enhanced the intrinsic suppressive function of MDSCs

29 a metric we term international natural debt (IND).

30 optimized a 7 d intranasal insulin delivery (IND) in awake mice to ascertain the biochemical and beha

31 ministration (FDA) investigational new drug (IND) application, unless specifically exempt from IND re

32 ficant increase in investigational new drug (IND) applications for the use of allogeneic islets of La

33 creasing number of Investigational New Drug (IND) applications for therapeutic monoclonal antibodies

34 d clinically under investigational new drug (IND) applications submitted to the U.S. Food and Drug Ad

35 on hERG channels for investigative new drug (IND) applications.

36 can elapse between investigational new drug (IND) approval by the US Food and Drug Administration and

37 ossess an approved investigational new drug (IND) permit to administer FMT for the purpose of conduct

38 ry personnel as an investigational new drug (IND).

39 ues, we have initiated a Phase I Exploratory IND study to determine the biodistribution of the fibril

40 6-7.29) and 2.51-fold (95% CI 1.32-4.79) for IND and IND/TIO, respectively.

41 application, unless specifically exempt from IND requirements, or under the direct oversight of a Rad

42 Furthermore, IND suppressed IFN-gamma production and PGE2 increased I

43 n FEV1 /cumulative dose), when comparing ICS/IND/TIO to ICS/IND.

44 ic compared to single dosing with either ICS/IND (P<.005) or ICS/IND/TIO (P<.05).

45 e dosing with either ICS/IND (P<.005) or ICS/IND/TIO (P<.05).

46 ive dose), when comparing ICS/IND/TIO to ICS/IND.

47 n modeling showed a 3.2-point improvement in IND-VFQ score for every 5-letter improvement in visual a

48 use IND to assess the relative reduction in IND from choosing between CO2(f) and CH4 control measure

49 iotropium (IND/TIO) vs ICS with Indacaterol (IND) over 4 weeks with challenge performed after first a

50 Bicyclic indazole (IND) inhibited catalysis through a single CYP2E1 site (K

51 ridine (SAP), benzothiazole (BZT), indazole (IND), and tetrahydroindazole (THI) series as novel ITK i

52 he valve margin identity factor INDEHISCENT (IND) is responsible for forming the auxin minimum by coo

53 Here, we identify INDEHISCENT (IND), an atypical bHLH protein, that is necessary for fr

54 Arabidopsis is dependent on the INDEHISCENT (IND) gene, the role of which in genetic and hormonal reg

55 eroidal anti-inflammatory drug indomethacin (IND) on MDSCs, depending on whether they were derived fr

56 To test this hypothesis, indomethacin (IND)-treated peripheral blood mononuclear cell (PBL) cul

57 Administration of indomethacin (IND) leads to the formation of lipid rafts and activatio

58 by conjugating the IDO inhibitor, indoximod (IND), to a phospholipid that allows prodrug self-assembl

59 data supported the nomination of CC-671 into IND-enabling studies as a single agent TNBC therapy.

60 Mechanistically, IND reduced arginase activity as well as NO and reactive

61 Immediate neurodeficit (IND) occurred in 79 (4.2%) and delayed in 104 (5.5%).

62 In a model of autoimmune neuroinflammation, IND-treated MDSCs differentiated in TFME attenuated infl

63 e made prediabetic via diet-induced obesity, IND was no longer effective in increasing long-term obje

64 ils the dual and context-dependent action of IND, a drug that serves both as an anti-inflammatory and

65 correlated with the suppressive activity of IND-treated MDSCs.

66 d is required to prevent ectopic activity of IND.

67 Here we perform phylogenetic comparison of IND genes in Arabidopsis and Brassica to identify conser

68 mechanism that results in the expression of IND in a narrow stripe of cells.

69 these sites simultaneously, the presence of IND at the catalytic site blocked binding at the effecto

70 ted the association of either two 4MP or one IND molecule(s) to CYP2E1, respectively.

71 ximately 110) x S. spontaneum (IND 81-146 or IND, 2n approximately 7x approximately 56) interspecific

72 The nanovesicles plus free OX or OX/IND-MSNP induce effective innate and adaptive anti-PDAC

73 , clinical trials (n = 3) and single patient IND (n = 1).

74 ucts were strongly encouraged to prepare pre-IND packets and submit pre-IND meeting requests to the F

75 ed to prepare pre-IND packets and submit pre-IND meeting requests to the Food and Drug Administration

76 cuity, Indian Vision Function Questionnaire (IND-VFQ), and Medical Outcomes Study 36-item Short Form

77 arkably, addition of IFN-gamma also restored IND-suppressed IgG2 but not IgG1.

78 rum officinarum Green German x S. spontaneum IND 81-146, and S. spontaneum PIN 84-1 x S. officinarum

79 tely 11x approximately 110) x S. spontaneum (IND 81-146 or IND, 2n approximately 7x approximately 56)

80 TPM is undergoing NIH-supported IND-enabling studies for clinical evaluation.

81 ndritic spines observed in the human APP(SWE,IND)-expressing transgenic mouse model in vivo.

82 The IND map consisted of 46 marker loci assembled into 10 LG

83 ICS with Indacaterol and Tiotropium (IND/TIO) vs ICS with Indacaterol (IND) over 4 weeks with

84 f oral sodium nitrite and nitrate treatment (IND#115926) displayed increased activation of SIRT3 and

85 We performed a phase I/II trial (IND#70627) of sterile pyrogen-free I-methylene blue to i

86 We use IND to assess the relative reduction in IND from choosin

87 T cells were able to rapidly eradicate Vacc-IND-G from peripheral organs, to mediate delayed-type hy

88 nt vaccinia virus expressing the VSV-G (Vacc-IND-G).

89 lfactory glomeruli, suppression of Kv1.3 via IND had no effect on body weight nor the size and number

90 f WD534tc/C alone or combined with virulent (IND/A) or attenuated (NCDV/A) bovine group A rotaviruses

91 Of the 193 markers analyzed, 61 were IND-specific, 106 were GG-specific, and 26 were heterozy

92 ted in TFME attenuated inflammation, whereas IND-treated MDSCs differentiated in TME aggravated clini

93 ce bearing the LP07 lung adenocarcinoma with IND inhibited the suppressive activity of splenic MDSCs,

94 ct was observed when MDSCs were treated with IND and conditioned media from LP07 tumor cells in vitro