ライフサイエンスコーパス: ING1

1 novel function for YNG1, a yeast homolog of ING1.

2 f the candidate human tumor suppressor gene, ING1.

3 necessary for these biological functions of ING1.

4 underlying the tumor suppressive activity of ING1.

5 the inhibitor of growth family, encodes p37(Ing1), a plant homeodomain (PHD) protein that interacts

6 In addition, ING1, a candidate breast cancer suppressor gene, was iso

7 ogenicity of ING1 and the biological role of ING1 and ING2 need further exploration.

8 tly unknown; however, the PHD domains of the ING1 and ING2 tumor suppressors have been shown recently

9 The basis of the immunogenicity of ING1 and the biological role of ING1 and ING2 need furth

10 e ING1 gene and altered expression levels of ING1 are found in multiple human cancers.

11 are well in line with the suggested role of ing1 as a candidate tumor suppressor gene involved in co

12 Ing1 belongs to the family of evolutionary conserved gen

13 p33(ING1) belongs to a small family of proteins from human,

14 erated mice deficient in all the isoforms of Ing1 by targeted disruption of the exon that is common f

15 Furthermore, these data reveal that p37(Ing1) can negatively regulate cell growth and apoptosis

16 Comparison of ING1 cDNA from normal and tumor tissues showed no mutati

17 modify histones, suggest that members of the ING1 class of proteins may have broad roles in enhancing

18 nd that p53 functions are unperturbed in p37(Ing1)-deficient cells.

19 is study, we have generated and analyzed p37(Ing1)-deficient mice and primary cells to further explor

20 ing1-deficient animals are characterized by reduced size

21 possible involvement of Ing1 in DNA repair, ing1-deficient mice were more sensitive to total body ga

22 These results indicate that a single gene, ing1, encodes both p53-suppressing and p53-activating pr

23 or behavioral abnormalities, indicating that ing1 function is dispensable for the viability of mice u

24 Mutations within the ING1 gene and altered expression levels of ING1 are foun

25 The mammalian ING1 gene encodes a tumor suppressor required for the fu

26 The human ING1 gene encodes nuclear protein p33(ING1), previously

27 This ING1 gene product was also recognized by 2 of 14 allogen

28 The initial member, ING1, has also been proposed to function as a tumor supp

29 These data, and the observations that other ING1 homologs are found in additional yeast complexes th

30 The ING1 immune complexes are active in deacetylating core h

31 Consistent with the possible involvement of Ing1 in DNA repair, ing1-deficient mice were more sensit

32 primary cells to further explore the role of Ing1 in the regulation of cell growth and p53 activity.

33 In addition, loss of p37(Ing1) induces Bax expression and increases DNA damage-in

34 RF3) activation or Hoxa13, Polr2a, Nr4a1, or Ing1 induction, that contribute to this redundancy.

35 e results show that endogenous levels of p37(Ing1) inhibit the proliferation of p53-wild-type and p53

36 Mouse ing1 is transcribed from three differently regulated pro

37 Inhibitor of growth 1 (ING1) is implicated in oncogenesis, DNA damage repair, a

38 ested; however, ectopic expression of either ING1 isoform had no effect on cell proliferation.

39 Embryonic fibroblasts from ing1-knockout mice were similar to the wild-type cells i

40 p33ING1b and p24ING1c, two major products of Ing1 locus and putative coregulators of p53, were elevat

41 The ING1 locus encodes alternative transcripts of p47(ING1a)

42 molecular mechanism for the function of the ING1 locus.

43 Between the two products of ing1, only the longer one forms a complex with p53 detec

44 The ING1 PHD finger recognizes methylated H3K4 but not other

45 3ING1b, which is divergent among a family of ING1 polypeptides, associates with the Sin3 complex thro

46 human ING1 gene encodes nuclear protein p33(ING1), previously shown to cooperate with p53 in cell gr

47 Mouse Ing1 produces two proteins (p31 and p37) from differenti

48 both DNA repair and apoptotic activities of ING1 require the interaction of the C-terminal plant hom

49 te cell growth and offers genetic proof that Ing1 suppresses cell growth and tumorigenesis.

50 Finally, p37(Ing1) suppresses the formation of spontaneous follicular

51 ING1, the founding member of the inhibitor of growth fam

52 Unlike the wild-type ING1, the W235A mutant, overexpressed in the stable clon

53 in human malignancies, impair the ability of ING1 to associate with H3K4me3 or to induce nucleotide r

54 sults indicate that p53 does not require p37(Ing1) to negatively regulate cell growth and offers gene

55 isruption of the exon that is common for all ing1 transcripts.

56 Loss of ing1 was associated with earlier onset and higher incide

57 The candidate tumor suppressor ING1 was identified in a genetic screen aimed at isolati

58 s ING2, sharing 76% nucleotide homology with ING1 was identified in the breast cancer cDNA library.

59 actors that interact with H3K4me3, including ING1, which, in turn, recruits Sin3A.

60 acids, the mouse equivalent of the human p33(ING1), while the third transcript encodes a longer prote

61 l death, linking the tumorigenic activity of ING1 with epigenetic regulation.

62 ferential association of protein products of ING1 with the mSin3 transcriptional corepressor complex.